Harry H Shen, M.D.

Functional recovery of a patient with complex regional pain syndrome in an inpatient pain rehabilitation program : a case report
Feldman DD; Vitale KC; Gusmorino P; Snow B; Shen H; Jimenez A; Moroz A; Knotkova H
2008 ;1(3):319-326, Journal of pain management
— id: 90956, year: 2008, vol: 1, page: 319, stat: Journal Article,

Prevalence and impact of alcohol use among patients with HIV-HCV coinfection: A prospective national multicenter study
Bini, EJ; Currie, S; Anand, BS; Shen, H; Brau, N; Schmidt, WN; Cheung, R; Morgan, TR; Chang, KM; Pedrosa, MC; Aytaman, A; Wright, TL; VA HCV-001 Study Grp
2007 ;132(4):A776-A777, Gastroenterology
— id: 108204, year: 2007, vol: 132, page: A776, stat: Journal Article,

Does gender matter? A prospective evaluation of risk factors for HCV infection and treatment candidacy in women
Currie, S; Shen, H; Brau, N; Anand, BS; Aytaman, A; Chang, KM; Cheung, RCM; Morgan, TR; Pedrosa, M; Schmidt, WN; Monto, A; McQuaid, R; Wright, TL; Bini, EJ
2007 ;46(4):890-890, Hepatology
— id: 108205, year: 2007, vol: 46, page: 890, stat: Journal Article,

Alcohol use in US veterans: A multicenter study of 4,061 hepatitis C-infected patients
Anand, BS; DeBakey, ME; Currie, S; Bini, EJ; Shen, H; Ho, SB; Dieperink, E; Wright, TL
2005 ;42(4):423A-423A, Hepatology
— id: 108211, year: 2005, vol: 42, page: 423A, stat: Journal Article,

Significant variation between HCV treatment acceptance and enrollment rates among sites in a large multicenter national study
Currie, SL; Wright, TL; Bini, EJ; Shen, H; Yee, HS; VA-HCV 001 Res Grp
2005 ;128(4):A700-A700, Gastroenterology
— id: 108213, year: 2005, vol: 128, page: A700, stat: Journal Article,

African Americans and less educated patients with chronic hepatitis C are less likely to be tested for hepatitis A immunity and hepatitis B infectivity
Yee, HS; Currie, SL; Pedrosa, MC; Anand, BS; Shen, H; Bini, EJ; Jeffers, LJ; Wright, TL; VA-HCV-001 Study Group
2005 ;128(4):A772-A772, Gastroenterology
— id: 108220, year: 2005, vol: 128, page: A772, stat: Journal Article,

Recent alcohol use but not prior alcohol use influences hepatitis C antiviral treatment adherence and outcomes: Results of a national multicenter study
Anand, BS; Currie, SL; Bini, EJ; Ho, SB; Dieperink, E; Shen, H; Wright, TL; VA-HCV-001 Study Grp
2004 ;40(4):316A-317A, Hepatology
— id: 108221, year: 2004, vol: 40, page: 316A, stat: Journal Article,

National multicenter study of eligibility for interferon and ribavirin therapy in patients coinfected with HIV and hepatitis C
Bini, EJ; Currie, S; Shen, H; Brau, N; Schmidt, W; Wright, TL; VA HCV-001 Res Grp
2004 ;126(4):A695-A695, Gastroenterology
— id: 108224, year: 2004, vol: 126, page: A695, stat: Journal Article,

Prevalence and predictors of HIV coinfection in patients with chronic hepatitis C: A US multicenter study
Bini, EJ; Currie, S; Shen, H; Brau, N; Schmidt, W; Wright, TL; VA HCV-001 Res Grp
2004 ;126(4):A672-A672, Gastroenterology
— id: 108223, year: 2004, vol: 126, page: A672, stat: Journal Article,

Black patients infected with HCV genotype 1 have a lower sustained viral reponse (SVR) rate to therapy with interferon plus ribavirin than white patients, and this is explained by their lower neutrophil count. A prospective multicenter study of 813 US vete
Brau, N; Bini, EJ; Currie, S; Shen, H; Anand, BS; Hu, KQ; Ho, SB; Johnson, D; Schmidt, WN; King, PD; Cheung, R; Rossi, SJ; Jeffers, LJ; Wright, TL
2004 ;40(4):465-465, Journal of hepatology
— id: 108225, year: 2004, vol: 40, page: 465, stat: Journal Article,

Epidemiology of hepatitis C infection and eligibility for antiviral therapy among US veterans
Bini, EJ; Brau, N; Currie, S; Shen, H; Anand, B; Hu, KQ; Jeffers, L; Ho, SB; Johnson, D; Schmidt, W; King, P; Cheung, R; Morgan, T; Awad, J; Pedrosa, M; Chang, KM; Aytaman, A; Simon, F; Hagedorn, C; Moseley, R; Ahmad, J; Mendenhall, C; Rossi, S; Wright, T
2003 ;38(4):603-603, Hepatology
— id: 108231, year: 2003, vol: 38, page: 603, stat: Journal Article,

Treatment of chronic hepatitis C with interferon alfa-2b and ribavirin in the community-based practice. A prospective study of 813 US veterans
Brau, N; Bini, EJ; Currie, S; Shen, H; Anand, BS; Hu, KQ; Ho, SB; Johnson, D; Schmidt, WN; King, PD; Cheung, RC; Rossi, SJ; Jeffers, LJ; Wright, TL
2003 ;38(4):1009-1009, Hepatology
— id: 108234, year: 2003, vol: 38, page: 1009, stat: Journal Article,

Hepatic steatosis in patients with chronic hepatitis C: A multicenter study of US veterans
Hu, KQ; Cheung, RC; Currie, S; Bini, EJ; Shen, H; Anand, B; Jeffers, LJ; Ho, SB; Brau, N; Schmidt, WN; McCracken, J; Rossi, SJ; Wright, TL
2003 ;38(4):589-589, Hepatology
— id: 108238, year: 2003, vol: 38, page: 589, stat: Journal Article,

Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment
Crosby, Jeffrey R; Shen, H H; Borchers, M T; Justice, J P; Ansay, T; Lee, J J; Lee, N A
2002 Jan;282(1):L99-108, American journal of physiology. Lung cellular & molecular physiology
CD4(+) T cells have a critical role in the development of allergic pulmonary inflammation, including the recruitment of eosinophils to the airway lumen and interstitium. The expression of interleukin (IL)-5 by CD4(+) cells has, in particular, often been lionized as the central link between allergic inflammation and the concomitant expansion or recruitment of eosinophils. The mechanism(s) by which CD4(+) T cells mediates eosinophil recruitment was assessed with gene knockout mice deficient for T cells or T cell subtypes and a unique IL-5 transgenic mouse (line NJ.1726) that constitutively overexpresses this cytokine in the lung epithelium. Pulmonary IL-5 expression is significantly attenuated in T cell- and CD4(+) but not CD8(+) cell-deficient animals, suggesting an obvious explanation for the lack of eosinophils in the lungs of T cell-deficient and CD4(-/-) mice. However, although the constitutive expression of IL-5 in the lung epithelium of NJ.1726 mice elicited an eosinophilia in the airway lumen of both naive and ovalbumin-treated mice, in the absence of CD4(+) cells, allergen-mediated eosinophil recruitment to the bronchoalveolar lavage fluid was abolished. Moreover, intranasal instillation of the potent eosinophil-specific chemokine eotaxin-2 was incapable of eliciting eosinophil recruitment in naive and ovalbumin-treated NJ.1726 CD4(-/-) mice, suggesting that eosinophil trafficking during allergic inflammatory responses is a consequence of a CD4(+) cell-mediated event(s) in addition to IL-5 expression and the establishment of a pulmonary chemokine gradient
— id: 76407, year: 2002, vol: 282, page: L99, stat: Journal Article,

Spontaneous fluctuations in cerebral oxygen supply. An introduction
Hudetz, A G; Biswal, B B; Shen, H; Lauer, K K; Kampine, J P
1998 ;454:551-559, Advances in experimental medicine & biology
Spontaneous, low frequency (4-12 cpm) fluctuations, independent of the cardiac and respiratory cycles, in human and animal brains were first recorded with the O2 polarographic technique in the late 1950s. They were seen in NADH and cytochrome oxidase and associated with spontaneous vasomotion pial and large cerebral arteries. Renewed interest in spontaneous fluctuations was generated by studies with laser-Doppler flowmetry (LDF), reflectance oximetry and functional MRI. Spontaneous fluctuations were consistently produced when cerebral perfusion was challenged by systemic or local manipulations; the fluctuation amplitude reached 30-40% of the mean. The most potent stimuli are hypotension, hyperventilation, cerebral artery occlusion and cerebral vasoconstriction elicited, for example, by a nitric oxide synthase inhibitor but not by indomethacin. The fluctuations are suspended by CO2 and halothane at concentrations that produce hyperemia. Recently, spontaneous fluctuations were recorded by LDF microprobes in areas as small as 130 microns and by video-microscopy in single capillaries. The fluctuations were absent in severe, focally ischemic brain territories. The dependence of spontaneous fluctuations on intravascular pressure argues for the importance of a myogenic mechanism, however, neuronal modulation may also play a role. Coherence of small vessel vasomotion may be required for the emergence of regional flow fluctuations. There is a need to elucidate the spatial and frequency domains in which fluctuations are present under normal physiological conditions and those in which they may reflect brain injury and pathologies of diagnostic or prognostic value
— id: 92947, year: 1998, vol: 454, page: 551, stat: Journal Article,

Low temperature induces oocytes p34cdc2 synthesis and accumulation -- the acquisition of competence to resume meiosis in toad oocytes
Lu JN; Zheng G; Shen H; Liu CJ; Tso JK
1996 ;6:115-124, Cell research
— id: 99193, year: 1996, vol: 6, page: 115, stat: Journal Article,

Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4
Lee, S H; Gregersen, P K; Shen, H H; Nunez-Roldan, A; Silver, J; Winchester, R J
1984 ;4 Suppl:17-23, Rheumatology international
Among individuals with rheumatoid arthritis the presence of the polymorphic Ia antigen epitope detected by the monoclonal antibody 109d6 is more strongly correlated with disease susceptibility than are other specificities, such as HLA DR4, DRw53 (MT3) or the antigenic determinant, defined by the monoclonal antibody 17-3-3S. The cells of 93% of Caucasian and Hispanic patients react with the 109d6 reagent. As was the case in normal individuals, all DR4-positive patients express the 109d6 determinant; however, 26% of those with rheumatoid arthritis have the epitope recognized by antibody 109d6, but lack the specificity DR4. Of these, one-third expresses only HLA DR1 and DQw1 (MT1, MB1) determinants. Studies of family members reveal that here the determinants 109d6, DR1, and DQw1 are encoded by the same unusual haplotype. In certain other individuals with rheumatoid arthritis who express DR4, DRw53, and the 109d6 determinants, family studies show that the 109d6 epitope is encoded not only by the haplotype specifying DR4 but also by the opposite haplotype that does not bear the genes for DR4. This suggests that homozygosity for certain Ia epitopes is relevant to determining the disease-susceptibility state. These studies emphasize the utility of monoclonal antibodies as reagents for the recognition of Ia epitopes that are more closely involved in the determination of disease susceptibility than are allomorphic molecules detected by conventional typing alloantisera
— id: 93201, year: 1984, vol: 4 Suppl, page: 17, stat: Journal Article,