Leopoldo Nicolas Segal

Biosketch / Results /

Leopoldo Nicolas Segal

Assistant Professor;
Departments of Medicine (Pulmy&CCM Div) and House Staff (MED SB SP)

Clinical Addresses

462 FIRST AVENUE
NBV 7N24
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-6479
Fax: 212-263-8442

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Medical Specialties

Pulmonary Medicine

Medical Expertise

Asthma, Emphysema, Chronic Obstructive Pulmonary Disorder (COPD), Chronic Bronchitis, Bronchiectasis, Pulmonary Function Testing

Languages

Spanish

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Board Certification

2007 — Ab Internal Medicine - Internal Medicine
2009 — Ab Internal Medicine (Pulmonary Disease)
2010 — Ab Internal Medicine (Critical Care Medicine)

Education

1992-1998 — Universidad Nacional De La Plata, Medical Education
2004-2007 — Morristown Memorial Hospital (Internal Medicine), Residency Training
2007-2010 — NYU Medical Center (Pulmonary/Crit. Care), Clinical Fellowships

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Research Interests

My interest is to understand the mechanism by which inflammation occurs in Chronic Obstructive Pulmonary Disease (COPD) leading to lung parenchyma destruction and airway remodeling. In the Andre Cournand Pulmonary Physiology Laboratory we can study the distal airway function in patients with early COPD. My focus is on understanding the mechanisms that occur early in the development of this disease where therapeutic approaches might be more efficacious. Although the lung is classically though to be sterile, in COPD increased bacterial colonization leads to airway inflammation and accelerated airway obstruction. The reliance on culture data and contamination by oral flora has limited the ability to understand the effect of airway bacterial load on airway inflammation in early COPD. The study of the microbiome using ribosomal DNA sequence has now opened an opportunity to directly characterize resident microbial flora without the need for bacterial culture. As a pulmonologist, I have sampled the lower airway by bronchoscopy and have exploited recent development next generation rDNA sequence to define complex microbial communities of commensal lung bacteria that we have called a pneumotype. We have found significant bacterial DNA in subjects with early COPD and we evaluate how this pneumotype affects the innate and humoral immunity in the lung of patients with early COPD. By studying how the lung microbiome alters the lung immune response I hope to understand the physiological changes that occurs early in this disease and we may discover new therapeutic targets for patients with obstructive airways disease.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Airway dysfunction in obesity: response to voluntary restoration of end expiratory lung volume
Oppenheimer, Beno W; Berger, Kenneth I; Segal, Leopoldo N; Stabile, Alexandra; Coles, Katherine D; Parikh, Manish; Goldring, Roberta M
2014 ;9(2):e88015-e88015 e88015, PLoS one
— id: 806932, year: 2014, vol: 9, page: e88015, stat: Journal Article,

Correction: Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation
Segal, Leopoldo N; Alekseyenko, Alexander V; Clemente, Jose C; Kulkarni, Rohan; Wu, Benjamin; Gao, Zhan; Chen, Hao; Berger, Kenneth I; Goldring, Roberta M; Rom, William N; Blaser, Martin J; Weiden, Michael D
2014 ;2:21-21, Microbiome
— id: 1065932, year: 2014, vol: 2, page: 21, stat: Journal Article,

Enrichment of lung microbiome with supraglotic microbes is associated with increased pulmonary inflammation
Segal, Leopoldo N; Alekseyenko, Alexander; Clemente, Jose C; Berger, Kenneth; Goldring, Roberta; Rom, William N; Blaser, Martin J; Weiden, Michael D
2014 Jan;11 Suppl 1:S71-S71 S71, Annals of the American Thoracic Society
— id: 753802, year: 2014, vol: 11 Suppl 1, page: S71, stat: Journal Article,

A brave new world: the lung microbiota in an era of change
Segal, Leopoldo N; Blaser, Martin J
2014 Jan;11 Suppl 1:S21-S27, Annals of the American Thoracic Society
— id: 753922, year: 2014, vol: 11 Suppl 1, page: S21, stat: Journal Article,

Lung Microbiome for Clinicians. New Discoveries about Bugs in Healthy and Diseased Lungs
Segal, Leopoldo N; Rom, William N; Weiden, Michael D
2014 Jan;11(1):108-116, Annals of the American Thoracic Society
— id: 778192, year: 2014, vol: 11, page: 108, stat: Journal Article,

Lung microbiome for clinicians: New discoveries about bugs in healthy and diseased lungs
Segal, LN; Rom, WN; Weiden, MD
2014 ;11(1):108-116, Annals of the American Thoracic Society
— id: 842022, year: 2014, vol: 11, page: 108, stat: Journal Article,

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation
Segal, Leopoldo N; Alekseyenko, Alexander V; Clemente, Jose C; Kulkarni, Rohan; Wu, Benjamin; Chen, Hao; Berger, Kenneth I; Goldring, Roberta M; Rom, William N; Blaser, Martin J; Weiden, Michael D
2013 ;1(1):19-19, Microbiome
— id: 760012, year: 2013, vol: 1, page: 19, stat: Journal Article,

Evaluation of the upper airway and lung microbiomes
Segal, L N; Kulkarni, R; Rom, W; Weiden, M
2012 April 2012;5(2):185-185, Clinical & translational science
— id: 173067, year: 2012, vol: 5, page: 185, stat: Journal Article,

Comparison of WTC Dust Size on Macrophage Inflammatory Cytokine Release In vivo and In vitro
Weiden, Michael D; Naveed, Bushra; Kwon, Sophia; Segal, Leopoldo N; Cho, Soo Jung; Tsukiji, Jun; Kulkarni, Rohan; Comfort, Ashley L; Kasturiarachchi, Kusali J; Prophete, Colette; Cohen, Mitchell D; Chen, Lung-Chi; Rom, William N; Prezant, David J; Nolan, Anna
2012 ;7(7):e40016-e40016 e40016, PLoS one
— id: 174082, year: 2012, vol: 7, page: e40016, stat: Journal Article,

Neutrophils Activate Alveolar Macrophages by Producing Caspase-6-Mediated Cleavage of IL-1 Receptor-Associated Kinase-M
Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Hoshino, Yoshihiko; Segal, Leopoldo N; Fujita, Yoko; Rom, William N; Weiden, Michael D
2011 Jan 1;186(1):403-410, Journal of immunology
— id: 116209, year: 2011, vol: 186, page: 403, stat: Journal Article,

Wtc dust induces GM-CSF in serum of fdny rescue workers with accelerated decline of lung function and in cultured alveolar macrophages
Naveed, B; Comfort, A L; Ferrier, N; Segal, L N; Kasturiarachchi, K J; Kwon, S; Chen, L C; Gordon, T; Cohen, M D; Prophete, C; Rom, W N; Prezant, D J; Nolan, A; Weiden, M
2011 01 May 2011;183(1):-, American journal of respiratory & critical care medicine
— id: 177198, year: 2011, vol: 183, page: , stat: Journal Article,

Residual distal airway dysfunction following weight reduction surgery in morbidly obese subjects with normal spirometry
Oppenheimer, B; Berger, K I; Segal, L; Coles, K; Stabile, A; Scott, C; Parikh, M; Goldring, R M
2011 01 May 2011;183(1):-, American journal of respiratory & critical care medicine
— id: 177204, year: 2011, vol: 183, page: , stat: Journal Article,

Azithromycin suppresses inflammatory cytokines and induces inhibitory transcription factors in alveolar macrophages
Segal, L; Kulkarni, R; Fujita, Y; Nolan, A; Rom, W N; Weiden, M
2011 01 May 2011;183(1):-, American journal of respiratory & critical care medicine
— id: 177206, year: 2011, vol: 183, page: , stat: Journal Article,

Regulatory T cells and Th17 cells in bronchoalveolar lavage
Segal, L; Kulkarni, R; Nolan, A; Weiden, M D; Tse, D B; Rom, W N
2011 01 May 2011;183(1):-, American journal of respiratory & critical care medicine
— id: 177215, year: 2011, vol: 183, page: , stat: Journal Article,

Disparity between proximal and distal airway reactivity during methacholine challenge
Segal, Leopoldo N; Goldring, Roberta M; Oppenheimer, Beno W; Stabile, Alexandra; Reibman, Joan; Rom, William N; Weiden, Michael D; Berger, Kenneth I
2011 Jun;8(3):145-152, COPD: Journal of chronic obstructive pulmonary disease
— id: 134171, year: 2011, vol: 8, page: 145, stat: Journal Article,

HIV-1 and Bacterial Pneumonia in the Era of Antiretroviral Therapy
Segal, Leopoldo N; Methe, Barbara A; Nolan, Anna; Hoshino, Yoshihiko; Rom, William N; Dawson, Rod; Bateman, Eric; Weiden, Michael D
2011 Jun;8(3):282-287, Proceedings of the American Thoracic Society
— id: 134318, year: 2011, vol: 8, page: 282, stat: Journal Article,

Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism
Epstein, Matthew D; Segal, Leopoldo N; Ibrahim, Sherin M; Friedman, Neil; Bustami, Rami
2010 Aug;33(8):1069-1074, Sleep
— id: 159109, year: 2010, vol: 33, page: 1069, stat: Journal Article,

Evolution of pattern of breathing during a spontaneous breathing trial predicts successful extubation
Segal, Leopoldo N; Oei, Erwin; Oppenheimer, Beno W; Goldring, Roberta M; Bustami, Rami T; Ruggiero, Salvatore; Berger, Kenneth I; Fiel, Stanley B
2010 Mar;36(3):487-495, Intensive care medicine
— id: 106592, year: 2010, vol: 36, page: 487, stat: Journal Article,