Leopoldo Nicolas Segal

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Leopoldo Segal

Assistant Professor, Department of Medicine
Medicine

Contact Info

Address
462 First Avenue
New York, NY 10016

212/263-6886

Research Interests

My interest is to understand the mechanism by which inflammation occurs in Chronic Obstructive Pulmonary Disease (COPD) leading to lung parenchyma destruction and airway remodeling. In the Andre Cournand Pulmonary Physiology Laboratory we can study the distal airway function in patients with early COPD. My focus is on understanding the mechanisms that occur early in the development of this disease where therapeutic approaches might be more efficacious. Although the lung is classically though to be sterile, in COPD increased bacterial colonization leads to airway inflammation and accelerated airway obstruction. The reliance on culture data and contamination by oral flora has limited the ability to understand the effect of airway bacterial load on airway inflammation in early COPD. The study of the microbiome using ribosomal DNA sequence has now opened an opportunity to directly characterize resident microbial flora without the need for bacterial culture. As a pulmonologist, I have sampled the lower airway by bronchoscopy and have exploited recent development next generation rDNA sequence to define complex microbial communities of commensal lung bacteria that we have called a pneumotype. We have found significant bacterial DNA in subjects with early COPD and we evaluate how this pneumotype affects the innate and humoral immunity in the lung of patients with early COPD. By studying how the lung microbiome alters the lung immune response I hope to understand the physiological changes that occurs early in this disease and we may discover new therapeutic targets for patients with obstructive airways disease.

A lung microbiome enriched in anaerobes is associated with a blunted TLR response
Friedman, E; Segal, L N; Clemente, J C; Wikoff, W R; Li, Y; Rom, W N; Fiehn, O; Blaser, M J; Weiden, M D. A lung microbiome enriched in anaerobes is associated with a blunted TLR response [Meeting Abstract]. American journal of respiratory & critical care medicine. 2015 2015;191:- (1840342)

Role of microbiota and tcr specificity in th17 mediated airway inflammation
Koralov, S B; Fogli, L; Sundrud, M; Grunig, G; Durbin, J; Segal, L N. Role of microbiota and tcr specificity in th17 mediated airway inflammation [Meeting Abstract]. American journal of respiratory & critical care medicine. 2015 2015;191:- (1840412)

The lung microbiome in rheumatoid arthritis and associated local/systemic autoimmunity
Scher, J U; Joshua, V; Ubeda, C; Artacho, A; Segal, L; Catrina, A I. The lung microbiome in rheumatoid arthritis and associated local/systemic autoimmunity [Meeting Abstract]. Arthritis & rheumatology. 2015 October 2015;67:- (1904032)

The lung microbiome in rheumatoid arthritis and local/systemic autoimmunity
Scher, J; Ubeda, C; Segal, L; Vijay, J; Artacho, A; Catrina, A. The lung microbiome in rheumatoid arthritis and local/systemic autoimmunity [Meeting Abstract]. Annals of the rheumatic diseases. 2015 June 2015;74:211-211 (1925302)

Harnessing the Early-Life Microbiota to Protect Children with Cystic Fibrosis
Segal, Leopoldo N; Blaser, Martin J. Harnessing the Early-Life Microbiota to Protect Children with Cystic Fibrosis [Editorial]. Journal of pediatrics. 2015 Jul;167(1):16-18.e1 (1649122)