Stephen B Richardson

Biosketch / Results /

Stephen B Richardson, M.D.

Associate Professor;
Department of Medicine (Endocrinology Div)

Clinical Addresses

530 FIRST AVENUE
NEW YORK, NY 10016
Hours: Mon. 2 - 6; Tue. 8 - 12; Wed. 2 - 6; Fri. 8 - 12
Handicap Access: yes
Phone: 212-263-2666
Fax: 212-263-0205

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Medical Specialties

Endocrinology & Metabolism

Medical Expertise

Juvenile Diabetes, Osteoporosis/Metabollic Bone Disease, Gen Endocrinology/Metabolism, Thyroid Disease, Pituitary Disorders, Diabetes

Clinical Responsibilities

interests: diabetes thyroid disease pituitary disease osteoporosis/ metabolic bone disease disorders of calcium metabolism

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, CIGNA EPO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP HMO, HIP MEDICARE, HIP POS, Medicare, OXFORD FREEDOM, Oxford Medicare, Tricare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UPN Elite

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1981 — Ab Internal Medicine - Internal Medicine
1983 — Ab Internal Medicine (Endocrinology, Diabetes & Metabolism)

Education

1966-1971 — Kings College Medical School, UK, Medical Education
1976-1978 — NYU Medical Center (Endocrinology), Clinical Fellowships

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Research Summary

We investigate the regulation of insulin secretion i. in the physiological state ii. in noninsulin-dependent diabetes in which insulin secretion is defective and pancreatic beta cells fail to respond to glucose. We found that the pancreas contains immunoreactive vasopressin (VP)-like material, that VP is a powerful and unique insulin secretagogue able to stimulate secretion in the absence of glucose while potentiating glucose-induced insulin secretion, and that beta cells express VP receptors which strongly resemble corticotrophic V1b receptors. We are characterizing the beta cell V1 receptor by PCR to determine whether it belongs to the V1b-type or represents a novel subclass of VP receptor.

We also study the role of the GH-IGF1 axis in the development of diabetic retinopathy. Using endothelial cell lines and umbilical vein endothelial cells, we research the signal transduction pathways stimulated by angiogenic growth factors and their interactions with known or putative inhibitors of angiogenesis and endothelial proliferation such as somatostatin and its analogs.

Research Interests

Insulin Secretion in NIDDM Somatostatin Mechanism of Action

Research Keywords

beta cell, diabetic retinopathy, insulin, vasopressin

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus
Bruehl, Hannah; Wolf, Oliver T; Sweat, Victoria; Tirsi, Aziz; Richardson, Stephen; Convit, Antonio
2009 Jul 14;1280:186-194, Brain research
— id: 100479, year: 2009, vol: 1280, page: 186, stat: Journal Article,

Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes
Gold, S M; Dziobek, I; Sweat, V; Tirsi, A; Rogers, K; Bruehl, H; Tsui, W; Richardson, S; Javier, E; Convit, A
2007 Apr;50(4):711-719, Diabetologia
— id: 74659, year: 2007, vol: 50, page: 711, stat: Journal Article,

The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosus
Albrecht, Joerg; Taylor, Lynne; Berlin, Jesse A; Dulay, Samuel; Ang, Gina; Fakharzadeh, Steven; Kantor, Jonathan; Kim, Ellen; Militello, Giuseppe; McGinnis, Karen; Richardson, Stephen; Treat, James; Vittorio, Carmela; Van Voorhees, Abby; Werth, Victoria P
2005 Nov;125(5):889-894, Journal of investigative dermatology
— id: 176788, year: 2005, vol: 125, page: 889, stat: Journal Article,

Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial
Salloway, S; Ferris, S; Kluger, A; Goldman, R; Griesing, T; Kumar, D; Richardson, S
2004 Aug;63(4):651-657, Neurology
— id: 158736, year: 2004, vol: 63, page: 651, stat: Journal Article,

Vasopressin-stimulated insulin secretion and inositol phosphate production: interactions with glucose and phorbol esters
Richardson SB; Laya T; VanOoy M
1995 May;145(2):221-226, Journal of endocrinology
— id: 6728, year: 1995, vol: 145, page: 221, stat: Journal Article,

Similarities between hamster pancreatic islet beta (HIT) cell vasopressin receptors and V1b receptors
Richardson, S B; Laya, T; VanOoy, M
1995 Oct;147(1):59-65, Journal of endocrinology
— id: 110638, year: 1995, vol: 147, page: 59, stat: Journal Article,

Timing of exposure to somatostatin relative to growth hormone-releasing factor dictates the rat anterior pituitary cell growth hormone response
Richardson SB; Twente S
1993 Sep;138(3):369-377, Journal of endocrinology
— id: 8357, year: 1993, vol: 138, page: 369, stat: Journal Article,

Somatostatin inhibits vasopressin-stimulated phosphoinositide hydrolysis and influx of extracellular calcium in clonal hamster beta (HIT) cells
Richardson SB; Laya T; Gibson M; Eyler N; Van Ooy M
1992 Dec 15;288(Pt 3):847-851, Biochemical journal
— id: 8356, year: 1992, vol: 288, page: 847, stat: Journal Article,

Anticonvulsants inhibit rat neuronal somatostatin release
Richardson, S B; Twente, S
1992 Feb 7;571(2):230-234, Brain research
— id: 110639, year: 1992, vol: 571, page: 230, stat: Journal Article,

Pre-exposure of rat anterior pituitary cells to somatostatin enhances subsequent growth hormone secretion
Richardson, S B; Twente, S
1991 Jan;128(1):91-95, Journal of endocrinology
— id: 110640, year: 1991, vol: 128, page: 91, stat: Journal Article,

Effects of vasopressin on insulin secretion and inositol phosphate production in a hamster beta cell line (HIT)
Richardson SB; Eyler N; Twente S; Monaco M; Altszuler N; Gibson M
1990 Feb;126(2):1047-1052, Endocrinology
— id: 28859, year: 1990, vol: 126, page: 1047, stat: Journal Article,

Inhibition of hypothalamic somatostatin release by beta-adrenergic antagonists
Richardson, S B; Twente, S
1990 Feb;126(2):1043-1046, Endocrinology
— id: 110641, year: 1990, vol: 126, page: 1043, stat: Journal Article,

EFFECTS OF VASOPRESSIN ON INSULIN-SECRETION - MODULATION BY VIB-TYPE RECEPTORS
Richardson, SB; Gibson, M
1989 Apr;37(2):A459-A459, Clinical research
— id: 31702, year: 1989, vol: 37, page: A459, stat: Journal Article,

Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells
Monaco ME; Levy BL; Richardson SB
1988 Mar 15;151(2):717-724, Biochemical & biophysical research communications
— id: 11153, year: 1988, vol: 151, page: 717, stat: Journal Article,

Evidence that diminished pituitary responsivity to GHRF is secondary to intracellular GH pool depletion
Richardson, S B; Twente, S
1988 Mar;254(3 Pt 1):E358-E364, American journal of physiology
— id: 110643, year: 1988, vol: 254, page: E358, stat: Journal Article,

GHRF causes biphasic stimulation of SRIF secretion from rat hypothalamic cells
Richardson, S; Twente, S; Audhya, T
1988 Dec;255(6 Pt 1):E829-E832, American journal of physiology
— id: 110649, year: 1988, vol: 255, page: E829, stat: Journal Article,

SOMATOSTATIN INHIBITS VASOPRESSIN INDUCED INSULIN-SECRETION AND INOSITOL PHOSPHATE PRODUCTION IN HIT CELLS
RICHARDSON, SB; EYLER, N; MONACO, ME; TWENTE, S
1988 APR ;36(3):A389-A389, Clinical research
— id: 41787, year: 1988, vol: 36, page: A389, stat: Journal Article,

Somatostatin release from dispersed hypothalamic cells: effects of diabetes
Richardson, S B; Twente, S
1987 Nov;30(11):893-898, Diabetologia
— id: 110642, year: 1987, vol: 30, page: 893, stat: Journal Article,

INHIBITION OF GROWTH-HORMONE SECRETION FROM RAT ANTERIOR AND HUMAN-TUMOR PITUITARY-CELLS BY QUERCETIN
Richardson, SB; Twente, S
1987 Apr;35(3):A515-A515, Clinical research
— id: 31194, year: 1987, vol: 35, page: A515, stat: Journal Article,

Inhibition of rat hypothalamic somatostatin release by somatostatin: evidence for somatostatin ultrashort loop feedback
Richardson, S B; Twente, S
1986 May;118(5):2076-2082, Endocrinology
— id: 110644, year: 1986, vol: 118, page: 2076, stat: Journal Article,

INHIBITION OF PITUITARY GROWTH-HORMONE SECRETION AND STIMULATION OF HYPOTHALAMIC SOMATOSTATIN SECRETION INVITRO BY PHLORETIN
RICHARDSON, SB; TWENTE, S
1986 APR ;34(2):A432-A432, Clinical research
— id: 41396, year: 1986, vol: 34, page: A432, stat: Journal Article,

Somatostatin regulation of the CRF-ACTH-cortisol axis
Serby M; Richardson SB; Rypma B; Twente S; Rotrosen JP
1986 Aug;21(10):971-974, Biological psychiatry
— id: 23570, year: 1986, vol: 21, page: 971, stat: Journal Article,

Evidence that the [3H]estradiol-binding protein in pancreas is localized in exocrine cells
Grossman A; Richardson SB; Altszuler N; Lane B
1985 Jun;116(6):2221-2226, Endocrinology
— id: 28864, year: 1985, vol: 116, page: 2221, stat: Journal Article,

ONTOGENY OF NEURAL REGULATION OF GROWTH-HORMONE (GH) - RECIPROCAL ALTERATIONS IN RESPONSIVENESS TO GROWTH HORMONE- RELEASING FACTOR (GRF) AND SOMATOSTATIN (SRIF)
Manzione, M; Richardson, S; Passarelli, J; Brown, C; Kardos, P; Hutchinson, B; Audhya, T; Hollander, CS
1985 ;33(2):A601-A601, Clinical research
— id: 30753, year: 1985, vol: 33, page: A601, stat: Journal Article,

Mouse hypothalamic somatostatin release: roles of calcium and calmodulin
Richardson, S; Twente, S
1985 Jul;117(1):369-375, Endocrinology
— id: 110648, year: 1985, vol: 117, page: 369, stat: Journal Article,

SOMATOSTATIN CAN POTENTIATE GROWTH-HORMONE RELEASE
Richardson, SB; Twente, S; Tracer, H
1985 ;33(2):A313-A313, Clinical research
— id: 30919, year: 1985, vol: 33, page: A313, stat: Journal Article,

Evidence that somatostatin (SRIF14) is the primary coligand in pancreas required for specific binding of [3H]estradiol in pancreatic tissue: demonstration that [3H]estradiol and [125I]SRIF14 form complexes of varying size with a specific binding protein
Grossman A; Richardson SB; Moloshok T; Frangione B
1984 Sep;21(3):279-286, Journal of steroid biochemistry & molecular biology
— id: 9614, year: 1984, vol: 21, page: 279, stat: Journal Article,

SOMATOSTATIN (SRIF) RELEASE FROM RAT HYPOTHALAMIC CELLS IS INHIBITED BY SRIF
RICHARDSON, S; TWENTE, S
1984 ;20(6B):1615-1615, Journal of steroid biochemistry & molecular biology
— id: 40927, year: 1984, vol: 20, page: 1615, stat: Journal Article,

CSF somatostatin in Alzheimer's disease
Serby M; Richardson SB; Twente S; Siekierski J; Corwin J; Rotrosen J
1984 Fall;5(3):187-189, Neurobiology of aging
— id: 23636, year: 1984, vol: 5, page: 187, stat: Journal Article,

Somatostatin enhances binding of [3H]estradiol to a cytosolic protein in rat pancreas. Possible role of oligopeptide coligands in secretion
Band, P; Richardson, S B; Boctor, A M; Grossman, A
1983 Jun 25;258(12):7284-7287, Journal of biological chemistry
— id: 110645, year: 1983, vol: 258, page: 7284, stat: Journal Article,

Somatostatin release from dispersed hypothalamic cells - effects of membrane depolarization, calcium and glucose deprivation
Richardson SB; Greenleaf P; Hollander CS
1983 Apr 25;266(1):75-81, Brain research
— id: 29265, year: 1983, vol: 266, page: 75, stat: Journal Article,

Dopamine stimulates somatostatin release from perifused hypothalamic cells
Richardson SB; Nguyen T; Hollander CS
1983 Jun;244(6):E560-E566, American journal of physiology
— id: 29264, year: 1983, vol: 244, page: E560, stat: Journal Article,

Acetylcholine, melatonin, and potassium depolarization stimulate release of luteinizing hormone-releasing hormone from rat hypothalamus in vitro
Richardson SB; Prasad JA; Hollander CS
1982 Apr;79(8):2686-2689, Proceedings of the National Academy of Sciences of the United States of America
— id: 29267, year: 1982, vol: 79, page: 2686, stat: Journal Article,

DECREASED HYPOTHALAMIC SOMATOSTATIN RELEASE IN DIABETIC RATS
Richardson, SB
1982 ;30(2):A275-A275, Clinical research
— id: 30555, year: 1982, vol: 30, page: A275, stat: Journal Article,

Somatostatin release from rat hypothalamus in vitro: effects of melatonin and serotonin
Richardson SB; Hollander CS; Prasad JA; Hirooka Y
1981 Aug;109(2):602-606, Endocrinology
— id: 29269, year: 1981, vol: 109, page: 602, stat: Journal Article,

NEUROTRANSMITTER MODULATION OF SOMATOSTATIN RELEASE BY THE HYPOTHALAMUS - POSSIBLE MECHANISM FOR REGULATION OF GROWTH- HORMONE SECRETION
Richardson, SB; Nguyen, T; Hollander, CS
1981 ;29(2):A546-A546, Clinical research
— id: 30265, year: 1981, vol: 29, page: A546, stat: Journal Article,

RECIPROCAL LOCAL FEEDBACK OF SOMATOSTATIN (SRIF) AND THYROTROPIN RELEASING HORMONE (TRH) IN DISPERSED CELL-CULTURE OF RAT HYPOTHALAMUS
Hollander, CS; Greene, LW; Rosman, L; Yamauchi, K; Richardson, S; Thaw, C; Deletto, R
1980 ;28(2):A479-A479, Clinical research
— id: 28116, year: 1980, vol: 28, page: A479, stat: Journal Article,

Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro
Richardson SB; Hollander CS; D'Eletto R; Greenleaf PW; Thaw C
1980 Jul;107(1):122-129, Endocrinology
— id: 29272, year: 1980, vol: 107, page: 122, stat: Journal Article,

DOPAMINE (DA) STIMULATES SOMATOSTATIN (SRIF) RELEASE FROM PERIFUSED DISPERSED RAT HYPOTHALAMIC CELLS
Richardson, SB; Hollander, CS; Greenleaf, PW
1980 ;28(2):A544-A544, Clinical research
— id: 28018, year: 1980, vol: 28, page: A544, stat: Journal Article,

ACETYLCHOLINE MODULATES RELEASE OF LUTEINIZING-HORMONE RELEASING FACTOR AND SOMATOSTATIN FROM RAT HYPOTHALAMUS
Richardson, S; Hollander, CS; Greenleaf, P; Diaz, M
1979 ;27(2):A451-A451, Clinical research
— id: 30017, year: 1979, vol: 27, page: A451, stat: Journal Article,

Effects of surface-active agents on neutrophil receptors
Boxer, L A; Richardson, S B; Baehner, R L
1978 Jul;21(1):28-33, Infection & immunity
— id: 110646, year: 1978, vol: 21, page: 28, stat: Journal Article,

HUMAN BETA ENDORPHIN (BETA-END) MODULATES HORMONAL RELEASE FROM ORGAN-CULTURES OF RAT HYPOTHALAMUS
Hollander, CS; Hirooka, Y; Prasad, J; Richardson, S; Ferdinand, P; Thaw, C
1978 ;26(3):A491-A491, Clinical research
— id: 29927, year: 1978, vol: 26, page: A491, stat: Journal Article,

Acute sacroiliitis due to Salmonella okatie
Richardson, S B; Uttley, A H; Pettingale, K W
1977 Jun 4;1(6074):1449-1450, British medical journal (1857-1980)
— id: 110647, year: 1977, vol: 1, page: 1449, stat: Journal Article,