Stephen B Richardson

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Stephen Richardson

Associate Professor, Department of Medicine

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Research Summary

We investigate the regulation of insulin secretion i. in the physiological state ii. in noninsulin-dependent diabetes in which insulin secretion is defective and pancreatic beta cells fail to respond to glucose. We found that the pancreas contains immunoreactive vasopressin (VP)-like material, that VP is a powerful and unique insulin secretagogue able to stimulate secretion in the absence of glucose while potentiating glucose-induced insulin secretion, and that beta cells express VP receptors which strongly resemble corticotrophic V1b receptors. We are characterizing the beta cell V1 receptor by PCR to determine whether it belongs to the V1b-type or represents a novel subclass of VP receptor.

We also study the role of the GH-IGF1 axis in the development of diabetic retinopathy. Using endothelial cell lines and umbilical vein endothelial cells, we research the signal transduction pathways stimulated by angiogenic growth factors and their interactions with known or putative inhibitors of angiogenesis and endothelial proliferation such as somatostatin and its analogs.

Research Interests

Insulin Secretion in NIDDM Somatostatin Mechanism of Action

Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus
Bruehl, Hannah; Wolf, Oliver T; Sweat, Victoria; Tirsi, Aziz; Richardson, Stephen; Convit, Antonio
2012-02-05; 1872-6240,Brain research - id: 100479, year: 2009 Journal Article

Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes
Gold, S M; Dziobek, I; Sweat, V; Tirsi, A; Rogers, K; Bruehl, H; Tsui, W; Richardson, S; Javier, E; Convit, A
2012-02-05; 0012-186X,Diabetologia - id: 74659, year: 2007 Journal Article

The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosus
Albrecht, Joerg; Taylor, Lynne; Berlin, Jesse A; Dulay, Samuel; Ang, Gina; Fakharzadeh, Steven; Kantor, Jonathan; Kim, Ellen; Militello, Giuseppe; McGinnis, Karen; Richardson, Stephen; Treat, James; Vittorio, Carmela; Van Voorhees, Abby; Werth, Victoria P
2012-08-30; 0022-202X,Journal of investigative dermatology - id: 176788, year: 2005 Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Validation Studies

Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial
Salloway, S; Ferris, S; Kluger, A; Goldman, R; Griesing, T; Kumar, D; Richardson, S
2012-03-07; 0028-3878,Neurology - id: 158736, year: 2004 Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Vasopressin-stimulated insulin secretion and inositol phosphate production: interactions with glucose and phorbol esters
Richardson SB; Laya T; VanOoy M
2012-02-05; 0022-0795,Journal of endocrinology - id: 6728, year: 1995 Journal Article