Irma Sanchez

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Irma Sanchez

Assistant Professor, Department of Pathology

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-6162
Irma.Sanchez@nyumc.org

Research Summary

Research Information



I am interested in studying the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work focused on the identification and characterization of SEK1/MKK4/JNKK the first known activator for the SAPK/JNK enzyme. I have now turned our attention towards studying the ERK3/MAPK6 enzyme. ERK3 was first identified in 1991 and is highly enriched in the developing nervous system. Interestingly,unlike other members of the MAPK family, ERK3 appears to be restricted to vertebrates as there are no known homologs in yeast or in Drosophila and C. elegans. Using a combination of biochemical, cell biological, and molecular biological approaches we hope to uncover the regulatory controls and cellular role of this very interesting enzyme.

Cilium assembly and disassembly
Sanchez, Irma; Dynlacht, Brian David. Cilium assembly and disassembly. Nature cell biology. 2016 Jun;18(7):711-717 (2165552)

Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis
Wang, Lei; Lee, Kwanwoo; Malonis, Ryan; Sanchez, Irma; Dynlacht, Brian D. Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife. 2016 May 5;5:?-? (2100872)

Cell biology: Short RNAs and shortness of breath
Sanchez, Irma; Dynlacht, Brian D. Cell biology: Short RNAs and shortness of breath [Comment]. Nature. 2014 Jun 5;510(7503):40-42 (1061982)

Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis
Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D. Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis. EMBO reports. 2010 Oct 15;11(12):969-976 (114826)

Cep76, a centrosomal protein that specifically restrains centriole reduplication
Tsang, William Y; Spektor, Alexander; Vijayakumar, Sangeetha; Bista, Bigyan R; Li, Ji; Sanchez, Irma; Duensing, Stefan; Dynlacht, Brian D. Cep76, a centrosomal protein that specifically restrains centriole reduplication. Developmental cell. 2009 May ;16(5):649-660 (99216)