Irma Sanchez

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Irma Sanchez

Assistant Professor, Department of Pathology
Perlmutter Cancer Center

Contact Info

522 First Avenue
New York, NY 10016



— University of Californa, Berkeley, Graduate Education

Research Summary

Research Information

I am interested in studying the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work focused on the identification and characterization of SEK1/MKK4/JNKK the first known activator for the SAPK/JNK enzyme. I have now turned our attention towards studying the ERK3/MAPK6 enzyme. ERK3 was first identified in 1991 and is highly enriched in the developing nervous system. Interestingly,unlike other members of the MAPK family, ERK3 appears to be restricted to vertebrates as there are no known homologs in yeast or in Drosophila and C. elegans. Using a combination of biochemical, cell biological, and molecular biological approaches we hope to uncover the regulatory controls and cellular role of this very interesting enzyme.

Cell biology: Short RNAs and shortness of breath
Sanchez, Irma; Dynlacht, Brian D
2014-07-07; 0028-0836,Nature - id: 1061982, year: 2014 Comment; Journal Article

Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis
Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D
2012-02-05; 1469-3178,EMBO reports - id: 114826, year: 2010 Journal Article

Cep76, a centrosomal protein that specifically restrains centriole reduplication
Tsang, William Y; Spektor, Alexander; Vijayakumar, Sangeetha; Bista, Bigyan R; Li, Ji; Sanchez, Irma; Duensing, Stefan; Dynlacht, Brian D
2012-02-05; 1878-1551,Developmental cell - id: 99216, year: 2009 Journal Article

SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression
Tsang, William Y; Wang, Leyu; Chen, Zhihong; Sanchez, Irma; Dynlacht, Brian David
2012-02-05; 0021-9525,Journal of cell biology - id: 73586, year: 2007 Journal Article

CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability
Tsang, William Y; Spektor, Alexander; Luciano, Daniel J; Indjeian, Vahan B; Chen, Zhihong; Salisbury, Jeffery L; Sanchez, Irma; Dynlacht, Brian David
2012-02-05; 1059-1524,Molecular biology of the cell - id: 66471, year: 2006 Journal Article