Irma Sanchez

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Irma Sanchez, Ph.D.

Assistant Professor;
Department of Pathology

Contact Info

NYU Medical Center
550 First Avenue Floor 11th floor Room 1110
Smilow Research Building
New York, NY 10016


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— University of Californa, Berkeley, Graduate Education

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Research Summary

Research Information

I am interested in studying the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work focused on the identification and characterization of SEK1/MKK4/JNKK the first known activator for the SAPK/JNK enzyme. I have now turned our attention towards studying the ERK3/MAPK6 enzyme. ERK3 was first identified in 1991 and is highly enriched in the developing nervous system. Interestingly,unlike other members of the MAPK family, ERK3 appears to be restricted to vertebrates as there are no known homologs in yeast or in Drosophila and C. elegans. Using a combination of biochemical, cell biological, and molecular biological approaches we hope to uncover the regulatory controls and cellular role of this very interesting enzyme.

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All data from NYU Health Sciences Library Faculty Bibliography — -


Cell biology: Short RNAs and shortness of breath
Sanchez, Irma; Dynlacht, Brian D
2014 Jun;510(7503):40-42, Nature
— id: 1061982, year: 2014, vol: 510, page: 40, stat: Journal Article,

Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis
Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D
2010 Dec;11(12):969-976, EMBO reports
— id: 114826, year: 2010, vol: 11, page: 969, stat: Journal Article,

Cep76, a centrosomal protein that specifically restrains centriole reduplication
Tsang, William Y; Spektor, Alexander; Vijayakumar, Sangeetha; Bista, Bigyan R; Li, Ji; Sanchez, Irma; Duensing, Stefan; Dynlacht, Brian D
2009 May;16(5):649-660, Developmental cell
— id: 99216, year: 2009, vol: 16, page: 649, stat: Journal Article,

SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression
Tsang, William Y; Wang, Leyu; Chen, Zhihong; Sanchez, Irma; Dynlacht, Brian David
2007 Aug 13;178(4):621-633, Journal of cell biology
— id: 73586, year: 2007, vol: 178, page: 621, stat: Journal Article,

CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability
Tsang, William Y; Spektor, Alexander; Luciano, Daniel J; Indjeian, Vahan B; Chen, Zhihong; Salisbury, Jeffery L; Sanchez, Irma; Dynlacht, Brian David
2006 Aug;17(8):3423-3434, Molecular biology of the cell
— id: 66471, year: 2006, vol: 17, page: 3423, stat: Journal Article,

New insights into cyclins, CDKs, and cell cycle control
Sanchez, Irma; Dynlacht, Brian David
2005 Jun;16(3):311-321, Seminars in cell & developmental biology
— id: 56026, year: 2005, vol: 16, page: 311, stat: Journal Article,

A novel mechanism for mitogen-activated protein kinase localization
Bind, Eric; Kleyner, Yelena; Skowronska-Krawczyk, Dorota; Bien, Emily; Dynlacht, Brian David; Sanchez, Irma
2004 Oct;15(10):4457-4466, Molecular biology of the cell
— id: 48210, year: 2004, vol: 15, page: 4457, stat: Journal Article,

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
Goillot E; Raingeaud J; Ranger A; Tepper RI; Davis RJ; Harlow E; Sanchez I
1997 Apr 1;94(7):3302-3307, Proceedings of the National Academy of Sciences of the United States of America
— id: 63556, year: 1997, vol: 94, page: 3302, stat: Journal Article,

Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway
Kuroki DW; Minden A; Sanchez I; Wattenberg EV
1997 Sep 19;272(38):23905-23911, Journal of biological chemistry
— id: 63555, year: 1997, vol: 272, page: 23905, stat: Journal Article,

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
Woo MS; Sanchez I; Dynlacht BD
1997 Jul;17(7):3566-3579, Molecular & cellular biology
— id: 33151, year: 1997, vol: 17, page: 3566, stat: Journal Article,

Transcriptional control of the cell cycle
Sanchez I; Dynlacht BD
1996 Jun;8(3):318-324, Current opinion in cell biology
— id: 33154, year: 1996, vol: 8, page: 318, stat: Journal Article,

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase
Pombo CM; Kehrl JH; Sanchez I; Katz P; Avruch J; Zon LI; Woodgett JR; Force T; Kyriakis JM
1995 Oct 26;377(6551):750-754, Nature
— id: 63552, year: 1995, vol: 377, page: 750, stat: Journal Article,

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
Sanchez I; Hughes RT; Mayer BJ; Yee K; Woodgett JR; Avruch J; Kyriakis JM; Zon LI
1994 Dec 22-29;372(6508):794-798, Nature
— id: 63553, year: 1994, vol: 372, page: 794, stat: Journal Article,

Glucocorticoids reversibly arrest rat hepatoma cell growth by inducing an early G1 block in cell cycle progression
Sanchez I; Goya L; Vallerga AK; Firestone GL
1993 Mar;4(3):215-225, Cell growth & differentiation
— id: 63554, year: 1993, vol: 4, page: 215, stat: Journal Article,