Herbert H Samuels

Biosketch / Results /

Herbert H Samuels, M.D.

Professor; Helen and Milton A. Kimmelman Professor of Pharmacology; Kimmelman Prof of Pharmacology
Departments of Biochemistry and Molecular Pharmacology and Medicine (Endocrinology Div)

Contact Info

Address
455 First Avenue
Floor 8 Room 835
Public Health Lab
New York, NY 10016

212-263-6279
212-263-6279
Herbert.Samuels@nyumc.org

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Education

— Dr. Samuels was a Research Associate in the lab of Dr. Gordon M. Tomkins' Laboratory of Molecular Biology at the NIAMD until 1970.|, PostDoctoral Training
1965 — NYU School of Medicine, Medical Education
1967 — Dr. Samuels was an Intern and Resident in Medicine at the Albert Einstein College of Medicine completing his training, Residency

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Research Summary

Our research involves the broad aspect of hormone action with a major focus on transcriptional regulation by the nuclear receptors for glucocorticoid hormones, thyroid hormone (T3R), all trans-retinoic acid (RAR), 9-cis retinoic acid (RXR), and vitamin D (VDR). These receptors are members of a subfamily of the steroid hormone receptor superfamily which recognizes similar DNA sequences that contain two or more hexanucleotide DNA-binding half-sites arranged as direct repeats or inverted repeats. We identified a dimerization domain which is embedded within the ligand-binding region in the C-terminal half of T3R, RXR, and RAR which consists of nine hydrophobic heptad repeats. These receptors play important roles in mediating gene expression, development, and differentiation. T3R, RAR, and VDR primarily bind their DNA elements as heterodimers with RXR, which was established using Escherichia coli expressed T3R, RAR, and RXR, purified to homogeneity, as well as with receptors expressed using eukaryotic systems. Our current studies focus on identifying the nuclear factors, including the "core" transcription factors such as TFIIB and TFIID, which interact with T3R, RAR, and RXR and defining their role(s) using in vitro transcription systems. These studies have defined a region in the N-terminus of T3R which specifically interacts with TFIIB. In addition, we are: 1) defining the precise motifs involved in mediating homo- and/or heterodimer formation and transcriptional activation with site-directed mutagenesis; 2) using protein purification and the yeast "two-hybrid" system to identify novel cDNAs which encode factors that interact with different domains of the T3Rs and are functionally important for transcriptional activation or repression; 3) defining the mechanism of action of the verbA oncogene, an avian retroviral counterpart of the a-form of T3R; 4) analyzing the functional role of T3R mutations found in the clinical syndrome of generalized thyroid hormone resistance; and 5) identifying novel antagonists for the RARs and the T3Rs using a computational approach based on the known crystal structure of nuclear hormone receptors (with Matthieu Schapira and Ruben Abaygan).<br>

Research Interests

Hormonal Regulation of Gene Expression

Research Keywords

gene transcription, hormones, nuclear receptors, transcription factors

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All data from NYU Health Sciences Library Faculty Bibliography — -

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Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain
Das, Sharmistha; Yeung, Kay T; Mahajan, Muktar A; Samuels, Herbert H
2014 ;14:852-852, BMC cancer
— id: 1369062, year: 2014, vol: 14, page: 852, stat: Journal Article,

A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli
Tinnikov, Alexander A; Samuels, Herbert H
2013 ;8(4):e61085-e61085 e61085, PLoS one
— id: 301392, year: 2013, vol: 8, page: e61085, stat: Journal Article,

Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation
Yang, Yawei J; Baltus, Andrew E; Mathew, Rebecca S; Murphy, Elisabeth A; Evrony, Gilad D; Gonzalez, Dilenny M; Wang, Estee P; Marshall-Walker, Christine A; Barry, Brenda J; Murn, Jernej; Tatarakis, Antonis; Mahajan, Muktar A; Samuels, Herbert H; Shi, Yang; Golden, Jeffrey A; Mahajnah, Muhammad; Shenhav, Ruthie; Walsh, Christopher A
2012 Nov;151(5):1097-1112, Cell
— id: 197612, year: 2012, vol: 151, page: 1097, stat: Journal Article,

A Novel Transcription Complex That Selectively Modulates Apoptosis of Breast Cancer Cells through Regulation of FASTKD2
Yeung, Kay T; Das, Sharmistha; Zhang, Jin; Lomniczi, Alejandro; Ojeda, Sergio R; Xu, Chong-Feng; Neubert, Thomas A; Samuels, Herbert H
2011 Jun;31(11):2287-2298, Molecular & cellular biology
— id: 132312, year: 2011, vol: 31, page: 2287, stat: Journal Article,

Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate
Goyanka, Ritu; Das, Sharmistha; Samuels, Herbert H; Cardozo, Timothy
2010 Nov;23(11):809-815, Protein engineering, design & selection : PEDS
— id: 113803, year: 2010, vol: 23, page: 809, stat: Journal Article,

Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor
Vukelic, Sasa; Stojadinovic, Olivera; Pastar, Irena; Vouthounis, Constantinos; Krzyzanowska, Agata; Das, Sharmistha; Samuels, Herbert H; Tomic-Canic, Marjana
2010 Jan 15;285(3):1980-1988, Journal of biological chemistry
— id: 114360, year: 2010, vol: 285, page: 1980, stat: Journal Article,

Identification and characterization of a novel nuclear protein complex Involved In nuclear hormone receptor-mediated gene regulation
Garapaty, Shivani; Xu, Chong-Feng; Trojer, Patrick; Mahajan, Muktar A; Neubert, Thomas A; Samuels, Herbert H
2009 Mar 20;284(12):7542-7552, Journal of biological chemistry
— id: 95312, year: 2009, vol: 284, page: 7542, stat: Journal Article,

Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells
Tinnikov, Alexander A; Yeung, Kay T; Das, Sharmistha; Samuels, Herbert H
2009 Feb 15;69(4):1375-1382, Cancer research
— id: 97576, year: 2009, vol: 69, page: 1375, stat: Journal Article,

Statins, inhibitors of cholesterol synthesis, accelerate wound healing via farnesyl pyrophosphate
Vukelic, S; Stojadinovic, O; Pastar, I; Das, S; Samuels, H; Krzyzanowska, A; Brem, H; Tomic-Canic, M
2009 APR ;129(5):S51-S51, Journal of investigative dermatology
— id: 97875, year: 2009, vol: 129, page: S51, stat: Journal Article,

INHIBITORS OF CHOLESTEROL SYNTHESIS, STATINS, ACCELERATE WOUND HEALING
Vukelic, S; Stojadinovic, O; Pastar, I; Das, S; Samuels, H; Krzyzanowska, A; Ragupathi, M; Brem, H; Tomic-Canic, M
2009 MAR-APR ;17(2):A21-A21, Wound repair & regeneration
— id: 97662, year: 2009, vol: 17, page: A21, stat: Journal Article,

Components of the CCR4-NOT Complex Function as Nuclear Hormone Receptor Coactivators via Association with the NRC-interacting Factor NIF-1
Garapaty, Shivani; Mahajan, Muktar A; Samuels, Herbert H
2008 Mar 14;283(11):6806-6816, Journal of biological chemistry
— id: 76777, year: 2008, vol: 283, page: 6806, stat: Journal Article,

Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development
Mahajan, Muktar A; Samuels, Herbert H
2008 ;6:e002-e002, Nuclear receptor signaling
— id: 76769, year: 2008, vol: 6, page: e002, stat: Journal Article,

The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events
Das, Sharmistha; Nwachukwu, Jerome C; Li, Dangsheng; Vulin, Anthony I; Martinez-Caballero, Sonia; Kinnally, Kathleen W; Samuels, Herbert H
2007 Feb;67(4):1775-1782, Cancer research
— id: 156586, year: 2007, vol: 67, page: 1775, stat: Journal Article,

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling
Mahajan, Muktar A; Murray, Audrey; Levy, David; Samuels, Herbert H
2007 Aug;21(8):1822-1834, Molecular endocrinology
— id: 73864, year: 2007, vol: 21, page: 1822, stat: Journal Article,

Studies of the bystander effect associated with intrinsic apoptosis
Martinez-Caballero, S; Lue, J; Huang, E; Das, S; Samuels, HH; Kinnally, KW
2007 ;282(6):567A-567A, Biophysical journal
— id: 103312, year: 2007, vol: 282, page: 567A, stat: Journal Article,

Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas
Mathur, M; Samuels, H H
2007 Jan 11;26(2):277-283, Oncogene
— id: 70300, year: 2007, vol: 26, page: 277, stat: Journal Article,

Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation
Pevsner, Paul H; Naftolin, Frederick; Hillman, Dean E; Miller, Douglas C; Fadiel, Ahmed; Kogus, Alexander; Stern, Arnold; Samuels, Herbert H
2007 ;21(3):429-436, Rapid communications in mass spectrometry
— id: 70734, year: 2007, vol: 21, page: 429, stat: Journal Article,

International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors
Flamant, Frederic; Baxter, John D; Forrest, Douglas; Refetoff, Samuel; Samuels, Herbert; Scanlan, Tom S; Vennstrom, Bjorn; Samarut, Jacques
2006 Dec;58(4):705-711, Pharmacological reviews
— id: 69534, year: 2006, vol: 58, page: 705, stat: Journal Article,

The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain
Tian, Henghe; Mahajan, Muktar A; Wong, Chun Tung; Habeos, Ioanis; Samuels, Herbert H
2006 Sep;20(9):2036-2051, Molecular endocrinology
— id: 68746, year: 2006, vol: 20, page: 2036, stat: Journal Article,

Functional consequences of interactions between thyroid hormone receptors and retinoid X receptor
Li D; Mahajan MA; Samuels HH
2005 ;12(5):356-362, Current opinion in endocrinology & diabetes
— id: 58899, year: 2005, vol: 12, page: 356, stat: Journal Article,

Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development
Mahajan, Muktar A; Samuels, Herbert H
2005 Jun;26(4):583-597, Endocrine reviews
— id: 56108, year: 2005, vol: 26, page: 583, stat: Journal Article,

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis
Afonja, Olubunmi; Juste, Dominique; Das, Sharmistha; Matsuhashi, Sachiko; Samuels, Herbert H
2004 Oct 21;23(49):8135-8145, Oncogene
— id: 46457, year: 2004, vol: 23, page: 8135, stat: Journal Article,

The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells
Li, Dangsheng; Das, Sharmistha; Yamada, Tatsuya; Samuels, Herbert H
2004 May;24(9):3838-3848, Molecular & cellular biology
— id: 43267, year: 2004, vol: 24, page: 3838, stat: Journal Article,

Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer
Li, Dangsheng; Yamada, Tatsuya; Wang, Fang; Vulin, A Igor; Samuels, Herbert H
2004 Feb 27;279(9):7427-7437, Journal of biological chemistry
— id: 42149, year: 2004, vol: 279, page: 7427, stat: Journal Article,

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair
Mahajan, Muktar A; Das, Sharmistha; Zhu, Hong; Tomic-Canic, Marjana; Samuels, Herbert H
2004 Jun;24(11):4994-5004, Molecular & cellular biology
— id: 43266, year: 2004, vol: 24, page: 4994, stat: Journal Article,

PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration
Mathur, Mukul; Das, Sharmistha; Samuels, Herbert H
2003 Aug 7;22(32):5031-5044, Oncogene
— id: 38103, year: 2003, vol: 22, page: 5031, stat: Journal Article,

Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
Schapira, Matthieu; Raaka, Bruce M; Das, Sharmistha; Fan, Li; Totrov, Maxim; Zhou, Zhiguo; Wilson, Stephen R; Abagyan, Ruben; Samuels, Herbert H
2003 Jun 10;100(12):7354-7359, Proceedings of the National Academy of Sciences of the United States of America
— id: 63078, year: 2003, vol: 100, page: 7354, stat: Journal Article,

RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition
Afonja, Olubunmi; Raaka, Bruce M; Huang, Ambrose; Das, Sharmistha; Zhao, Xinyu; Helmer, Elizabeth; Juste, Dominique; Samuels, Herbert H
2002 Nov 7;21(51):7850-7860, Oncogene
— id: 39566, year: 2002, vol: 21, page: 7850, stat: Journal Article,

Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer
Li, Dangsheng; Li, Tong; Wang, Fang; Tian, Heather; Samuels, Herbert H
2002 Aug;22(16):5782-5792, Molecular & cellular biology
— id: 156065, year: 2002, vol: 22, page: 5782, stat: Journal Article,

NRC-Interacting Factor 1 Is a Novel Cotransducer That Interacts with and Regulates the Activity of the Nuclear Hormone Receptor Coactivator NRC
Mahajan, Muktar A; Murray, Audrey; Samuels, Herbert H
2002 Oct;22(19):6883-6894, Molecular & cellular biology
— id: 32315, year: 2002, vol: 22, page: 6883, stat: Journal Article,

Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation
Li D; Wang F; Samuels HH
2001 Dec;21(24):8371-8384, Molecular & cellular biology
— id: 26563, year: 2001, vol: 21, page: 8371, stat: Journal Article,

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors
Mathur M; Tucker PW; Samuels HH
2001 Apr;21(7):2298-2311, Molecular & cellular biology
— id: 20740, year: 2001, vol: 21, page: 2298, stat: Journal Article,

In silico discovery of novel Retinoic Acid Receptor agonist structures
Schapira M; Raaka BM; Samuels HH; Abagyan R
2001 ;1(1):1-1, BioMedCentral structural biology
— id: 20742, year: 2001, vol: 1, page: 1, stat: Journal Article,

A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein
Mahajan MA; Samuels HH
2000 Jul;20(14):5048-5063, Molecular & cellular biology
— id: 11637, year: 2000, vol: 20, page: 5048, stat: Journal Article,

Rational discovery of novel nuclear hormone receptor antagonists
Schapira M; Raaka BM; Samuels HH; Abagyan R
2000 Feb 1;97(3):1008-1013, Proceedings of the National Academy of Sciences of the United States of America
— id: 8562, year: 2000, vol: 97, page: 1008, stat: Journal Article,

A novel multifunctional motif in the amino-terminal A/B domain of T3Ralpha modulates DNA binding and receptor dimerization
Hadzic E; Habeos I; Raaka BM; Samuels HH
1998 Apr 24;273(17):10270-10278, Journal of biological chemistry
— id: 8033, year: 1998, vol: 273, page: 10270, stat: Journal Article,

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
Powers CA; Mathur M; Raaka BM; Ron D; Samuels HH
1998 Jan;12(1):4-18, Molecular endocrinology
— id: 7748, year: 1998, vol: 12, page: 4, stat: Journal Article,

Role of the conserved C-terminal region of thyroid hormone receptor-alpha in ligand-dependent transcriptional activation
Selmi-Ruby S; Casanova J; Malhotra S; Roussett B; Raaka BM; Samuels HH
1998 Mar 16;138(1-2):105-114, Molecular & cellular endocrinology
— id: 7788, year: 1998, vol: 138, page: 105, stat: Journal Article,

Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression
Qi JS; Desai-Yajnik V; Yuan Y; Samuels HH
1997 Dec;17(12):7195-7207, Molecular & cellular biology
— id: 12194, year: 1997, vol: 17, page: 7195, stat: Journal Article,

Interactions of the thyroid hormone receptor with the human immunodeficiency virus type I (HIV-1) long terminal repeat and the HIV-1 tat transactivator
DesaiYajnik, V; Samuels, HH
1996 MAR ;44(3):A237-A237, Journal of investigative medicine
— id: 52949, year: 1996, vol: 44, page: A237, stat: Journal Article,

Differential transactivation potentials of the thyroid hormone receptor alpha and beta isoforms
Hadzic, E; Samuels, HH
1996 MAR ;44(3):A237-A237, Journal of investigative medicine
— id: 52950, year: 1996, vol: 44, page: A237, stat: Journal Article,

Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms [see comments]
Helmer EB; Raaka BM; Samuels HH
1996 Feb;137(2):390-399, Endocrinology
— id: 6914, year: 1996, vol: 137, page: 390, stat: Journal Article,

Molecular interactions of p53 with thyroid hormone nuclear receptors
Qi, JS; DesaiYajnik, V; Samuels, HH
1996 MAR ;44(3):A234-A234, Journal of investigative medicine
— id: 52945, year: 1996, vol: 44, page: A234, stat: Journal Article,

Novel regulation of keratin gene expression by thyroid hormone and retinoid receptors
Tomic-Canic M; Day D; Samuels HH; Freedberg IM; Blumenberg M
1996 Jan 19;271(3):1416-1423, Journal of biological chemistry
— id: 8045, year: 1996, vol: 271, page: 1416, stat: Journal Article,

Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator
Desai-Yajnik V; Hadzic E; Modlinger P; Malhotra S; Gechlik G; Samuels HH
1995 Aug;69(8):5103-5112, Journal of virology
— id: 6817, year: 1995, vol: 69, page: 5103, stat: Journal Article,

A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB
Hadzic E; Desai-Yajnik V; Helmer E; Guo S; Wu S; Koudinova N; Casanova J; Raaka BM; Samuels HH
1995 Aug;15(8):4507-4517, Molecular & cellular biology
— id: 6831, year: 1995, vol: 15, page: 4507, stat: Journal Article,

The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation
Qi JS; Desai-Yajnik V; Greene ME; Raaka BM; Samuels HH
1995 Mar;15(3):1817-1825, Molecular & cellular biology
— id: 6718, year: 1995, vol: 15, page: 1817, stat: Journal Article,

Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
Casanova J; Helmer E; Selmi-Ruby S; Qi JS; Au-Fliegner M; Desai-Yajnik V; Koudinova N; Yarm F; Raaka BM; Samuels HH
1994 Sep;14(9):5756-5765, Molecular & cellular biology
— id: 8470, year: 1994, vol: 14, page: 5756, stat: Journal Article,

Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities
Hao E; Menke JB; Smith AM; Jones C; Geffner ME; Hershman JM; Wuerth JP; Samuels HH; Ways DK; Usala SJ
1994 Jul;8(7):841-851, Molecular endocrinology
— id: 20741, year: 1994, vol: 8, page: 841, stat: Journal Article,

A sequence in the rat Pit-1 gene promoter confers synergistic activation by glucocorticoids and protein kinase-C
Jong MT; Raaka BM; Samuels HH
1994 Oct;8(10):1320-1327, Molecular endocrinology
— id: 7901, year: 1994, vol: 8, page: 1320, stat: Journal Article,

The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation
Au-Fliegner M; Helmer E; Casanova J; Raaka BM; Samuels HH
1993 Sep;13(9):5725-5737, Molecular & cellular biology
— id: 8475, year: 1993, vol: 13, page: 5725, stat: Journal Article,

DIVERSE ACTIVITIES OF THE RETINOIC ACID AND THYROID-HORMONE RECEPTORS ARE MEDIATED BY THE CONSERVED 9TH HEPTAD REPEAT OF THE LIGAND-BINDING DOMAIN
AUFLIEGNER, M; HELMER, E; CASANOVA, J; RAAKA, BM; SAMUELS, HH
1993 APR ;41(2):A188-A188, Clinical research
— id: 54262, year: 1993, vol: 41, page: A188, stat: Journal Article,

Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat
Desai-Yajnik V; Samuels HH
1993 ;106:13-32, Transactions of the Association of American Physicians
— id: 13334, year: 1993, vol: 106, page: 13, stat: Journal Article,

The NF-kappa B and Sp1 motifs of the human immunodeficiency virus type 1 long terminal repeat function as novel thyroid hormone response elements
Desai-Yajnik V; Samuels HH
1993 Aug;13(8):5057-5069, Molecular & cellular biology
— id: 13095, year: 1993, vol: 13, page: 5057, stat: Journal Article,

Interaction of thyroid hormone and retinoic acid receptors on the regulation of the rat growth hormone gene promoter
Garcia-Villalba P; Au-Fliegner M; Samuels HH; Aranda A
1993 Mar 15;191(2):580-586, Biochemical & biophysical research communications
— id: 62149, year: 1993, vol: 191, page: 580, stat: Journal Article,

An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype
Geffner ME; Su F; Ross NS; Hershman JM; Van Dop C; Menke JB; Hao E; Stanzak RK; Eaton T; Samuels HH; et al.
1993 Feb;91(2):538-546, Journal of clinical investigation
— id: 62210, year: 1993, vol: 91, page: 538, stat: Journal Article,

The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element
Park HY; Davidson D; Raaka BM; Samuels HH
1993 Mar;7(3):319-330, Molecular endocrinology
— id: 13239, year: 1993, vol: 7, page: 319, stat: Journal Article,

Conformational changes in chicken thyroid hormone receptor alpha 1 induced by binding to ligand or to DNA
Toney JH; Wu L; Summerfield AE; Sanyal G; Forman BM; Zhu J; Samuels HH
1993 Jan 12;32(1):2-6, Biochemistry
— id: 62151, year: 1993, vol: 32, page: 2, stat: Journal Article,

REGULATION OF THE HIV-1 LTR - INTERACTIONS OF THYROID-HORMONE RECEPTOR WITH RXR, NF-KAPPA-B, SP1, AND TAT
YAJNIK, V; SAMUELS, HH
1993 APR ;41(2):A201-A201, Clinical research
— id: 54264, year: 1993, vol: 41, page: A201, stat: Journal Article,

A CONSERVED HEPTAD MEDIATES HETERODIMER BUT NOT HOMODIMER INTERACTIONS OF RETINOIC ACID AND THYROID-HORMONE RECEPTORS
AUFLIEGNER, M; SAMUELS, HH
1992 APR ;40(2):A301-A301, Clinical research
— id: 51998, year: 1992, vol: 40, page: A301, stat: Journal Article,

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements
Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR
1992 Apr;6(4):502-514, Molecular endocrinology
— id: 62301, year: 1992, vol: 6, page: 502, stat: Journal Article,

EVIDENCE THAT T3 MEDIATED EFFECTS OF THYROID-HORMONE RECE
CASANOVA, J; AUFLIEGNER, M; HELMER, E; SAMUELS, HH
1992 APR ;40(2):A253-A253, Clinical research
— id: 51992, year: 1992, vol: 40, page: A253, stat: Journal Article,

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers
Forman BM; Casanova J; Raaka BM; Ghysdael J; Samuels HH
1992 Mar;6(3):429-442, Molecular endocrinology
— id: 13686, year: 1992, vol: 6, page: 429, stat: Journal Article,

NOVEL REGULATION OF THE PIT-1 PROMOTER BY GLUCOCORTICOIDS
JONG, MTC; RAAKA, BM; SAMUELS, HH
1992 APR ;40(2):A309-A309, Clinical research
— id: 52000, year: 1992, vol: 40, page: A309, stat: Journal Article,

THYROID-HORMONE RECEPTOR STIMULATES THE HIV-1-LTR BY BINDING TO AND ACTIVATING THE VIRAL NF-KAPPA-B AND SP1 DNA ELEMENTS
YAJNIK, V; SAMUELS, HH
1992 APR ;40(2):A301-A301, Clinical research
— id: 51997, year: 1992, vol: 40, page: A301, stat: Journal Article,

Influence of thyroid hormone on ADP-ribosylation of nuclear proteins in cultured GH1 cells
Aranda A; Copp RP; Pascual A; Samuels HH
1991 Feb 25;279(2):179-183, FEBS letters
— id: 63082, year: 1991, vol: 279, page: 179, stat: Journal Article,

Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine
Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR
1991 Apr;5(4):542-548, Molecular endocrinology
— id: 63080, year: 1991, vol: 5, page: 542, stat: Journal Article,

pEXPRESS: a family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro
Forman BM; Samuels HH
1991 Aug 30;105(1):9-15, Gene
— id: 13937, year: 1991, vol: 105, page: 9, stat: Journal Article,

Cloning and partial sequence of a cDNA for rabbit prothrombin
Karpatkin M; Tang ZC; Meer J; Blei F; Samuels HH
1991 Jun 15;62(6):757-763, Thrombosis research
— id: 13995, year: 1991, vol: 62, page: 757, stat: Journal Article,

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding
Lucas PC; Forman BM; Samuels HH; Granner DK
1991 Oct;11(10):5164-5170, Molecular & cellular biology
— id: 62277, year: 1991, vol: 11, page: 5164, stat: Journal Article,

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding
Lucas PC; Forman BM; Samuels HH; Granner DK
1991 Dec;11(12):6343-6343, Molecular & cellular biology
— id: 63079, year: 1991, vol: 11, page: 6343, stat: Journal Article,

A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene
Lucas PC; O'Brien RM; Mitchell JA; Davis CM; Imai E; Forman BM; Samuels HH; Granner DK
1991 Mar 15;88(6):2184-2188, Proceedings of the National Academy of Sciences of the United States of America
— id: 63081, year: 1991, vol: 88, page: 2184, stat: Journal Article,

DOMINANT NEGATIVE POTENCY OF MUTANT T3 RECE
MEIER, CA; MCCLASKEY, JH; USALA, SJ; DICKSTEIN, BM; MUCHMORE, P; BERCU, BB; SAMUELS, HH; WEINTRAUB, BD
1991 APR ;39(2):A293-A293, Clinical research
— id: 51616, year: 1991, vol: 39, page: A293, stat: Journal Article,

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation
Selmi S; Samuels HH
1991 Jun 25;266(18):11589-11593, Journal of biological chemistry
— id: 13993, year: 1991, vol: 266, page: 11589, stat: Journal Article,

Oligomeric binding of T3 receptor is required for maximal T3 response
Williams GR; Harney JW; Forman BM; Samuels HH; Brent GA
1991 Oct 15;266(29):19636-19644, Journal of biological chemistry
— id: 62185, year: 1991, vol: 266, page: 19636, stat: Journal Article,

STIMULATORY, INHIBITORY, AND SYNERGISTIC EFFECTS OF RECEPTORS FOR THYROID-HORMONE AND RETINOIC ACID - ROLE OF LIGAND AND IMPLICATIONS FOR MORPHOGENESIS AND DEVELOPMENT
Au, M; Forman, BM; Casanova, J; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31968, year: 1990, vol: 38, page: A475, stat: Journal Article,

Dimerization among nuclear hormone receptors
Forman BM; Samuels HH
1990 Jul;2(7):587-594, New biologist
— id: 63084, year: 1990, vol: 2, page: 587, stat: Journal Article,

Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
Forman BM; Samuels HH
1990 Sep;4(9):1293-1301, Molecular endocrinology
— id: 62300, year: 1990, vol: 4, page: 1293, stat: Journal Article,

COOPERATIVE AND ANTAGONISTIC INTERACTIONS AMONG THYROID-HORMONE, VITAMIN-D AND RETINOIC ACID RECEPTOR HETERODIMERS
Forman, BM; Selmi, S; Casanova, J; Pike, JW; Samuels, HH
1990 Apr;38(2):A445-A445, Clinical research
— id: 31967, year: 1990, vol: 38, page: A445, stat: Journal Article,

THE GENERALIZED THYROID-HORMONE RESISTANCE SYNDROME - SIMULATION OF THE DOMINANT NEGATIVE PHENOTYPE INVITRO WITH LIGAND-BINDING MUTANTS OF THE THYROID-HORMONE RECEPTOR
Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1990 Apr;38(2):A288-A288, Clinical research
— id: 31957, year: 1990, vol: 38, page: A288, stat: Journal Article,

The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters
Fox SR; Jong MT; Casanova J; Ye ZS; Stanley F; Samuels HH
1990 Jul;4(7):1069-1080, Molecular endocrinology
— id: 63083, year: 1990, vol: 4, page: 1069, stat: Journal Article,

THE GROWTH-HORMONE GENE PROMOTER BINDS A 38 KDA PROTEIN IN ASSOCIATION WITH THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-PIT-1/GHF-1
Fox, SR; Copp, RP; Samuels, HH
1990 Apr;38(2):A296-A296, Clinical research
— id: 31958, year: 1990, vol: 38, page: A296, stat: Journal Article,

CELL-SPECIFIC REGULATION OF TRANSCRIPTION FROM THE BETA-2 ADRENERGIC-RECEPTOR PROMOTER BY THYROID AND GLUCOCORTICOID HORMONES
Helmer, E; Raaka, BM; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31969, year: 1990, vol: 38, page: A475, stat: Journal Article,

THE SYNTHETIC STEROID RU486 FUNCTIONS BOTH AS A GLUCOCORTICOID AGONIST AND ANTAGONIST
Raaka, BM; Erlich, WJ; Finnerty, M; Russo, MA; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31970, year: 1990, vol: 38, page: A475, stat: Journal Article,

Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes
Tomic M; Jiang CK; Epstein HS; Freedberg IM; Samuels HH; Blumenberg M
1990 Nov;1(12):965-973, Cell regulation
— id: 14309, year: 1990, vol: 1, page: 965, stat: Journal Article,

RETINOIC ACID AND THYROID-HORMONE FUNCTION INDEPENDENTLY AND SYNERGISTICALLY TO REGULATE GROWTH-HORMONE GENE-EXPRESSION
Au, M; Aranda, A; Samuels, HH
1989 Apr;37(2):A530-A530, Clinical research
— id: 31707, year: 1989, vol: 37, page: A530, stat: Journal Article,

Identification of an adenosine 3',5'-monophosphate (cAMP)-responsive region in the rat growth hormone gene: evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression
Copp RP; Samuels HH
1989 May;3(5):790-796, Molecular endocrinology
— id: 10665, year: 1989, vol: 3, page: 790, stat: Journal Article,

IDENTIFICATION OF A CAMP-RESPONSIVE REGION IN THE RAT GROWTH- HORMONE GENE - EVIDENCE FOR INDEPENDENT AND SYNERGISTIC EFFECTS OF CAMP AND THYROID-HORMONE
Copp, RP; Samuels, HH
1989 Apr;37(2):A357-A357, Clinical research
— id: 31698, year: 1989, vol: 37, page: A357, stat: Journal Article,

A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors
Forman BM; Yang CR; Au M; Casanova J; Ghysdael J; Samuels HH
1989 Oct;3(10):1610-1626, Molecular endocrinology
— id: 10483, year: 1989, vol: 3, page: 1610, stat: Journal Article,

LOCALIZATION OF A TRANSCRIPTIONAL REGULATORY DOMAIN OF A THYROID-HORMONE RECEPTOR C-ERBA THAT IS ACTIVE IN THE ABSENCE OF HORMONE-BINDING AND DNA-BINDING
Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1989 Apr;37(2):A596-A596, Clinical research
— id: 31718, year: 1989, vol: 37, page: A596, stat: Journal Article,

IDENTIFICATION OF 2 NUCLEAR PROTEINS WHICH BIND SEQUENCES NECESSARY FOR CELL-SPECIFIC EXPRESSION OF BOTH THE GROWTH- HORMONE AND PROLACTIN GENES
Fox, SR; Forman, BM; Casanova, J; Stanley, F; Samuels, HH
1989 Apr;37(2):A596-A596, Clinical research
— id: 31719, year: 1989, vol: 37, page: A596, stat: Journal Article,

Characterization of the domain structure of chick c-erbA by deletion mutation: in vitro translation and cell transfection studies
Horowitz ZD; Yang CR; Forman BM; Casanova J; Samuels HH
1989 Jan;3(1):148-156, Molecular endocrinology
— id: 10856, year: 1989, vol: 3, page: 148, stat: Journal Article,

THE HERPES-SIMPLEX VIRAL THYMIDINE KINASE GENE PROMOTER IS TRANSCRIPTIONALLY ACTIVATED BY THYROID-HORMONE RECEPTOR
Park, HY; Samuels, HH
1989 Apr;37(2):A535-A535, Clinical research
— id: 31710, year: 1989, vol: 37, page: A535, stat: Journal Article,

The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit
Raaka BM; Finnerty M; Samuels HH
1989 Feb;3(2):332-341, Molecular endocrinology
— id: 10729, year: 1989, vol: 3, page: 332, stat: Journal Article,

Thyroid hormone receptors and action: the 5'-flanking region of the rat growth hormone gene can mediate regulated gene expression
Samuels HH; Casanova J; Copp RP; Janocko L; Raaka BM; Sahnoun H; Yaffe BM
1989 ;15(4):495-545, Endocrine research
— id: 10779, year: 1989, vol: 15, page: 495, stat: Journal Article,

Regulation of gene expression by thyroid hormone
Samuels HH; Forman BM; Horowitz ZD; Ye ZS
1989 ;51:623-639, Annual review of physiology
— id: 10831, year: 1989, vol: 51, page: 623, stat: Journal Article,

Tumoral calcium pyrophosphate deposition disease
Sissons, H A; Steiner, G C; Bonar, F; May, M; Rosenberg, Z S; Samuels, H; Present, D
1989 ;18(2):79-87, Skeletal radiology
— id: 511592, year: 1989, vol: 18, page: 79, stat: Journal Article,

Cholera toxin affects nuclear ADP-ribosylation in GH1 cells
Aranda, A; Pascual, A; Copp, R; Samuels, H
1988 Jan;150(1):323-328, Biochemical & biophysical research communications
— id: 583062, year: 1988, vol: 150, page: 323, stat: Journal Article,

CHOLERA-TOXIN AFFECTS NUCLEAR ADP-RIBOSYLATION IN GH1 CELLS
ARANDA, A; PASCUAL, A; COPP, R; SAMUELS, H
1988 JAN 15 ;150(1):323-328, Biochemical & biophysical research communications
— id: 41863, year: 1988, vol: 150, page: 323, stat: Journal Article,

c-erbA protooncogenes mediate thyroid hormone-dependent and independent regulation of the rat growth hormone and prolactin genes
Forman BM; Yang CR; Stanley F; Casanova J; Samuels HH
1988 Oct;2(10):902-911, Molecular endocrinology
— id: 10956, year: 1988, vol: 2, page: 902, stat: Journal Article,

EXPRESSION OF THYROID-HORMONE RECEPTOR RELATED PROTO-ONCOGENE ERBA PROTEINS LEADS TO HORMONE-INDEPENDENT REGULATION OF RAT GROWTH-HORMONE AND PROLACTIN GENES
Forman, BM; Yang, CR; Stanley, F; Casanova, J; Samuels, HH
1988 Apr;36(3):A552-A552, Clinical research
— id: 31507, year: 1988, vol: 36, page: A552, stat: Journal Article,

Analysis of photoaffinity label derivatives to probe thyroid hormone receptor in human fibroblasts, GH1 cells, and soluble receptor preparations
Horowitz ZD; Sahnoun H; Pascual A; Casanova J; Samuels HH
1988 May 15;263(14):6636-6642, Journal of biological chemistry
— id: 11091, year: 1988, vol: 263, page: 6636, stat: Journal Article,

CHARACTERIZATION OF DOMAIN-STRUCTURE OF THE CHICK C-ERBA CDNA BY DELETION MUTATION - INVITRO TRANSLATION AND TRANSFECTION STUDIES
Horowitz, Z; Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1988 Apr;36(3):A385-A385, Clinical research
— id: 31496, year: 1988, vol: 36, page: A385, stat: Journal Article,

Identification of the cis-acting elements and trans-acting factors that mediate cell-specific and thyroid hormone stimulation of growth hormone gene expression
Samuels HH; Aranda A; Casanova J; Copp RP; Flug F; Forman BM; Horowitz ZD; Janocko L; Park HY; Pascual A; et al.
1988 ;44:53-114, Recent progress in hormone research
— id: 63085, year: 1988, vol: 44, page: 53, stat: Journal Article,

Regulation of gene expression by thyroid hormone
Samuels HH; Forman BM; Horowitz ZD; Ye ZS
1988 Apr;81(4):957-967, Journal of clinical investigation
— id: 11135, year: 1988, vol: 81, page: 957, stat: Journal Article,

CONTROL OF RAT PROLACTIN GENE-EXPRESSION - L-T3 HAS BOTH POSITIVE AND NEGATIVE EFFECTS IN DIFFERENT CELL-LINES
Stanley, FM; Casanova, J; Samuels, HH
1988 Apr;36(3):A391-A391, Clinical research
— id: 31497, year: 1988, vol: 36, page: A391, stat: Journal Article,

Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation
Ye ZS; Forman BM; Aranda A; Pascual A; Park HY; Casanova J; Samuels HH
1988 Jun 5;263(16):7821-7829, Journal of biological chemistry
— id: 11066, year: 1988, vol: 263, page: 7821, stat: Journal Article,

Rat growth hormone gene expression: both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation
Ye ZS; Forman BM; Park HY; Casanova J; Samuels HH
1988 ;101:42-53, Transactions of the Association of American Physicians
— id: 11262, year: 1988, vol: 101, page: 42, stat: Journal Article,

RAT GROWTH-HORMONE GENE-EXPRESSION - BOTH CELL-SPECIFIC AND THYROID-HORMONE RESPONSE ELEMENTS ARE REQUIRED FOR THYROID- HORMONE REGULATION
Ye, ZS; Forman, BM; Park, HY; Casanova, J; Samuels, HH
1988 Apr;36(3):A610-A610, Clinical research
— id: 31515, year: 1988, vol: 36, page: A610, stat: Journal Article,

cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone
Flug F; Copp RP; Casanova J; Horowitz ZD; Janocko L; Plotnick M; Samuels HH
1987 May 5;262(13):6373-6382, Journal of biological chemistry
— id: 63086, year: 1987, vol: 262, page: 6373, stat: Journal Article,

Photoaffinity labeling of thyroid hormone receptors
Horowitz ZD; Samuels HH
1987 ;33(2-3):317-332, Pharmacology & therapeutics
— id: 11421, year: 1987, vol: 33, page: 317, stat: Journal Article,

CONTROL OF GROWTH-HORMONE GENE-EXPRESSION BY THYROID-HORMONE
Samuels, HH; Copp, RP; Casanova, J; Janocko, L; Plotnick, M; Ye, ZS
1987 Mar 1;46(3):791-791, Federation proceedings (Federation of American Societies for Experimental Biology)
— id: 31266, year: 1987, vol: 46, page: 791, stat: Journal Article,

Cell- and sequence-specific binding of nuclear proteins to 5'-flanking DNA of the rat growth hormone gene
Ye ZS; Samuels HH
1987 May 5;262(13):6313-6317, Journal of biological chemistry
— id: 63087, year: 1987, vol: 262, page: 6313, stat: Journal Article,

LOCALIZATION OF HORMONE REGULATORY ELEMENTS OF THE RAT GROWTH-HORMONE GENE
FLUG, F; PLOTNIK, M; CASANOVA, J; COPP, RP; SAMUELS, HH
1986 APR ;34(2):A714-A714, Clinical research
— id: 41411, year: 1986, vol: 34, page: A714, stat: Journal Article,

Stimulation of facilitated [3H]uridine transport by thyroid hormone in GH1 cells. Evidence for regulation by the thyroid hormone nuclear receptor
Stanley F; Tsai JS; Samuels HH
1986 Jul 15;261(20):9400-9404, Journal of biological chemistry
— id: 62194, year: 1986, vol: 261, page: 9400, stat: Journal Article,

5'-Flanking DNA of the rat growth hormone gene mediates regulated expression by thyroid hormone
Casanova J; Copp RP; Janocko L; Samuels HH
1985 Sep 25;260(21):11744-11748, Journal of biological chemistry
— id: 63089, year: 1985, vol: 260, page: 11744, stat: Journal Article,

Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form
McIntyre WR; Samuels HH
1985 Jan 10;260(1):418-427, Journal of biological chemistry
— id: 63090, year: 1985, vol: 260, page: 418, stat: Journal Article,

Effects of molybdate on steroid receptors in intact GH1 cells. Evidence for dissociation of an intracellular 10 S receptor oligomer prior to nuclear accumulation
Raaka BM; Finnerty M; Sun E; Samuels HH
1985 Nov 15;260(26):14009-14015, Journal of biological chemistry
— id: 63088, year: 1985, vol: 260, page: 14009, stat: Journal Article,

MOLYBDATE INHIBITS NUCLEAR ACCUMULATION AND INCREASES THE HALF-LIFE OF THE ESTROGEN-RECEPTOR IN GH CELLS
Raaka, BM; Finnerty, M; Samuels, HH
1985 ;44(5):1474-1474, Federation proceedings (Federation of American Societies for Experimental Biology)
— id: 30952, year: 1985, vol: 44, page: 1474, stat: Journal Article,

5'-flanking DNA sequences of the growth hormone gene mediates thyroid hormone stimulation of growth hormone gene transcription
Samuels HH; Casanova J; Copp RP; Janocko L
1985 ;98:55-65, Transactions of the Associatio