Robert S. Glickman, D.M.D.

Antibiotic effects on bacterial profile in osteonecrosis of the jaw
Ji X.; Pushalkar S.; Li Y.; Glickman R.; Fleisher K.; Saxena D.
2012 ;18(1):85-95, Oral diseases
Objective: Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. Materials and methods: The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0-2 were enrolled in this study, and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy. Results: The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum Firmicutes with bacterial species, Streptococcus intermedius, Lactobacillus gasseri, Mogibacterium timidum, and Solobacterium moorei, whereas patients without antibiotics had greater amounts of Parvimonas micra and Streptococcus anginosus. Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes. Conclusion: This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions. 2011 John Wiley & Sons A/S
— id: 155456, year: 2012, vol: 18, page: 85, stat: Journal Article,

Risk factors for bisphosphonate-related osteonecrosis of the jaws
Fleisher, Kenneth E; Glickman, Robert S
2011 Apr;69(4):959-959, Journal of oral & maxillofacial surgery
— id: 150847, year: 2011, vol: 69, page: 959, stat: Journal Article,

Antibiotic effects on bacterial profile in osteonecrosis of the jaw. L
Ji X; Pushalkar S; Li Y; Glickman R; Fleisher K; Saxena D
2011 Aug 4;:85-95, Oral diseases
Oral Diseases (2011) doi: 10.1111/j.1601-0825.2011.01848.x Objective: Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. Materials and methods: The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0-2 were enrolled in this study, and patient groups were divided into an antibiotic cohort (n = 10) treated with systemic antibiotic and a non-antibiotic cohort (n = 10) with no prior antibiotic therapy. Results: The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum Firmicutes with bacterial species, Streptococcus intermedius, Lactobacillus gasseri, Mogibacterium timidum, and Solobacterium moorei, whereas patients without antibiotics had greater amounts of Parvimonas micra and Streptococcus anginosus. Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes. Conclusion: This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions
— id: 155349, year: 2011, vol: , page: 85, stat: Journal Article,

Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers
Fleisher, Kenneth E; Welch, Garrett; Kottal, Shailesh; Craig, Ronald G; Saxena, Deepak; Glickman, Robert S
2010 Oct;110(4):509-516, Oral surgery, oral medicine, oral pathology, oral radiology, & endodontics
BACKGROUND AND OBJECTIVE: The most common risk factor for bisphosphonate-related osteonecrosis of the jaws (BRONJ) is dentoalveolar surgery. It has been suggested that reduced serum C-terminal telopeptide (CTX) can determine the degree of osteoclast suppression and may predict the development of BRONJ after dentoalveolar surgery. Although there are many radiographic appearances associated with BRONJ, there are little data that describes changes preceding dentoalveolar surgery. The objective of this retrospective study was: 1) to investigate if reduced serum CTX values (i.e., <150 pg/mL) were associated with BRONJ after dentoalveolar surgery; and 2) to determine if specific radiographic changes are associated with teeth that develop BRONJ after extraction. STUDY DESIGN: A retrospective review of radiographic and/or serum CTX data was performed for 68 patients with a history of bisphosphonate therapy who either underwent dental extraction or were diagnosed with BRONJ in the Department of Oral and Maxillofacial Surgery during the period 2007-2009. Postoperative healing was assessed for 26 patients with reduced serum CTX levels (<150 pg/mL) who either underwent dental extraction or treatment for BRONJ. Preoperative radiographs were evaluated for 55 patients who either healed normally or developed BRONJ after dental extraction. RESULTS: All 26 patients (100%) who had serum CTX levels <150 pg/mL healed successfully after dentoalveolar surgery (20 patients) or after treatment for BRONJ (6 patients). Among the 55 patients who underwent radiographic evaluation, 24 patients (83%) with BRONJ exhibited periodontal ligament (PDL) widening associated with extracted teeth, whereas only 3 patients (11%) who healed normally demonstrated PDL widening. CONCLUSION: These data suggest that radiographic PDL widening may be a more sensitive indicator than CTX testing in predicting risk of BRONJ. Current guidelines that recommend minimal surgical intervention may need to be revised to include alternative strategies for the elimination or management of this pathology
— id: 150840, year: 2010, vol: 110, page: 509, stat: Journal Article,

Controlled Phase III Clinical Trial of Diclofenac Potassium Liquid-Filled Soft Gelatin Capsule for Treatment of Postoperative Dental Pain
Zuniga, John R.; Malmstroem, Hans; Noveck, Robert J.; Campbell, John H.; Christensen, Steven; Glickman, Robert S.; Tomasetti, Boyd J.; Boesing, Stephen E.
2010 ;68(11):2735-2742 NOV, Journal of oral & maxillofacial surgery
Purpose: The purpose of the present study was to assess the safety and efficacy of oral diclofenac potassium liquid-filled soft gelatin capsule (DPSGC) that uses ProSorb dispersion technology (Xanodyne Pharmaceuticals, Inc, licensed from AAIPharma, Wilmington, NC), to treat adult patients with acute pain after third molar extraction. Patients and Methods: In the present multicenter, randomized, double-blind, placebo-controlled trial, patients experiencing a baseline level of pain (>= 50 mm on a 100-mm visual analog scale within 4 hours after surgery) were randomized to receive a single dose of DPSGC at 25, 50, or 100 mg or placebo. Pain intensity and relief were assessed for 6 hours after dosing. The efficacy endpoints included the summed pain intensity difference, total pain relief, and the median time to the onset of perceptible and meaningful pain relief (using the :2-stopwatch method). Results: A total of 249 randomized patients had a significant increase in the summed pain intensity difference and total pain relief values at 3 and 6 hours across all DPSGC-treated groups compared with the placebo group (P < .0001). The onset of perceptible and meaningful pain relief was significantly faster in all DPSGC groups than in the placebo group, including the DPSGC 25-mg group (25 minutes [P = .00021 and 52 minutes [P < .00011 for perceptible and meaningful pain relief, respectively). Significantly fewer patients in the DPSGC groups required rescue medication compared with those in the placebo group (P < .0001). The global evaluation scores were significantly greater for the patients who received DPSGC than for those who received placebo (P < .0001), and more than 65% of DPSGC-treated patients rated the medication as good, very good, or excellent compared with 18% of the placebo-treated patients. DPSGC was generally well tolerated, and no serious adverse events were reported. Conclusions: The results from the present single-dose study of postoperative dental pain suggest that DPSGC offers significant pain relief compared with placebo and that the study medication provided was well tolerated by patients who required pain relief after third molar extraction. (c) 2010 American Association of Oral and Maxillofacial Surgeons Oral Maxillofac Surg 68:2735-2742, 2010
— id: 155203, year: 2010, vol: 68, page: 2735, stat: Journal Article,

Controlled phase III clinical trial of diclofenac potassium liquid-filled soft gelatin capsule for treatment of postoperative dental pain
Zuniga, John R; Malmstrom, Hans; Noveck, Robert J; Campbell, John H; Christensen, Steven; Glickman, Robert S; Tomasetti, Boyd J; Boesing, Stephen E
2010 Nov;68(11):2735-2742, Journal of oral & maxillofacial surgery
PURPOSE: The purpose of the present study was to assess the safety and efficacy of oral diclofenac potassium liquid-filled soft gelatin capsule (DPSGC) that uses ProSorb dispersion technology (Xanodyne Pharmaceuticals, Inc, licensed from AAIPharma, Wilmington, NC), to treat adult patients with acute pain after third molar extraction. PATIENTS AND METHODS: In the present multicenter, randomized, double-blind, placebo-controlled trial, patients experiencing a baseline level of pain (>/= 50 mm on a 100-mm visual analog scale within 4 hours after surgery) were randomized to receive a single dose of DPSGC at 25, 50, or 100 mg or placebo. Pain intensity and relief were assessed for 6 hours after dosing. The efficacy endpoints included the summed pain intensity difference, total pain relief, and the median time to the onset of perceptible and meaningful pain relief (using the 2-stopwatch method). RESULTS: A total of 249 randomized patients had a significant increase in the summed pain intensity difference and total pain relief values at 3 and 6 hours across all DPSGC-treated groups compared with the placebo group (P < .0001). The onset of perceptible and meaningful pain relief was significantly faster in all DPSGC groups than in the placebo group, including the DPSGC 25-mg group (25 minutes [P = .0002] and 52 minutes [P < .0001] for perceptible and meaningful pain relief, respectively). Significantly fewer patients in the DPSGC groups required rescue medication compared with those in the placebo group (P < .0001). The global evaluation scores were significantly greater for the patients who received DPSGC than for those who received placebo (P < .0001), and more than 65% of DPSGC-treated patients rated the medication as good, very good, or excellent compared with 18% of the placebo-treated patients. DPSGC was generally well tolerated, and no serious adverse events were reported. CONCLUSIONS: The results from the present single-dose study of postoperative dental pain suggest that DPSGC offers significant pain relief compared with placebo and that the study medication provided was well tolerated by patients who required pain relief after third molar extraction
— id: 150842, year: 2010, vol: 68, page: 2735, stat: Journal Article,

Case presentations of salivary gland infections
Turner, Michael D; Glickman, Robert
2009 Aug;21(3):359-362, Oral & maxillofacial surgery clinics of North America
Salivary gland infections arise from a wide variety of etiologies: bacteria, localized viruses, systemic viruses, autoimmune diseases, secondary to sialoliths and strictures, and congenital disorders. When dealing with these entities, the diagnosis of the majority of them can be made quickly, although some of the rarer diseases are more difficult to recognize, particularly when they have a more obvious secondary bacterial infection. This article presents six cases and describes their management
— id: 105042, year: 2009, vol: 21, page: 359, stat: Journal Article,

Preface. Salivary gland infections
Turner, Michael D; Glickman, Robert
2009 Aug;21(3):ix-ix, Oral & maxillofacial surgery clinics of North America
— id: 105040, year: 2009, vol: 21, page: ix, stat: Journal Article,

Salivary gland infections
Turner, Michael D; Glickman, Robert; Haug, Richard H
Philadelphia, PA : Saunders, 2009,
— id: 151761, year: 2009, vol: , page: , stat: ,

Tetracycline-guided debridement and cone beam computed tomography for the treatment of bisphosphonate-related osteonecrosis of the jaw: a technical note
Fleisher, Kenneth E; Doty, Steven; Kottal, Shailesh; Phelan, Joan; Norman, Robert G; Glickman, Robert S
2008 Dec;66(12):2646-2653, Journal of oral & maxillofacial surgery
— id: 91092, year: 2008, vol: 66, page: 2646, stat: Journal Article,

The recognition, physiology, and treatment of medication-induced methemoglobinemia: a case report
Turner, Michael D; Karlis, Vasiliki; Glickman, Robert S
2007 Fall;54(3):115-117, Anesthesia progress
Dapsone is a leprostatic agent commonly prescribed for the management of leprosy, malaria, and the immunosuppression-induced infections of Pneumocystis carinii and Toxoplasma gondii. In susceptible patients, methemoglobinemia, a potentially life-threatening event, can occur. We report a case of dapsone-induced methemoglobinemia which was observed during general anesthesia for the management of a fractured mandible. The pathophysiology, diagnosis, and management of dapsone-induced methemoglobinemia will be discussed
— id: 75444, year: 2007, vol: 54, page: 115, stat: Journal Article,

Dental management of the gravid patient
Turner, Michael D; Singh, Fiza; Glickman, Robert S
2006 Nov;72(6):22-27, New York state dental journal
Gravidity is defined as the development of the young in utero. It initiates hormonal, psychological and physiological changes in the female patient, providing the dentist with many questions about the management of these patients. These physiologic alterations, as well as the embryologic development of the fetus, will be discussed along with the treatment alterations that should be considered. The changes are often subtle, but can lead to disastrous complications if proper precautions are not taken. Conversely, appropriate management of routine and dental emergencies can be denied by the practitioner because of misconceptions about pregnancy and fetal tolerance. Anesthetic and pharmacology of agents used in dentistry in treating the pregnant patient will be reviewed
— id: 75443, year: 2006, vol: 72, page: 22, stat: Journal Article,

Clinical implications of cyclo-oxygenase-2 inhibitors for acute dental pain management - Benefits and risks
Spink, M; Bahn, S; Glickman, R
2005 OCT ;136(10):1439-1448, Journal of the American Dental Association
Background. Cyclo-oxygenase-2 inhibitors (COX-2(i)) demonstrate analgesic efficacy for patients who require gastrointestinal safety. The authors discuss the potential benefits and risks of these novel, but expensive, analgesics when used in dentistry. Methods. The authors conducted a MED-LINE search focused on the subject headings of common analgesic drugs and COX-2(i), using peer-reviewing journals limited to the English language. They selected for review 127 articles that met the criteria. They also tried to identify any randomized controlled trials pertinent to dentistry and indicative of evidence-based medicine. Results. When comparing COX isoforms (COX-1 and COX-2), the authors found that overlapping and mutually exclusively properties coexist. COX-2(i) originally were developed to minimize interference with the gastroprotective properties of COX-1 isoform, while selectively preventing prostanoid synthesis expressed solely at sites of bodily trauma or other inflammation. COX-2(i) were found to provide pain relief equal to or slightly exceeding that offered by many mild narcotics. They may avoid some of the serious side effects that can occur with even short-term use of nonselective nonsteroidal anti-inflammatory drugs. Conclusions. The Pharmacodynamics of COX-2(i) reveal an agent that includes analgesic, anti-inflammatory and gastroprotective properties but also allows for an undesirable disruption of the delicate hemodynamic balance. Clinical Implications. Symptomatic and asymptomatic gastroparietic patients who do not have severe cardiovascular, cerebral or renal ischemic disease benefit from use of COX-2(i). Long-term use of these agents in medically compromised patients may prove disastrous
— id: 98037, year: 2005, vol: 136, page: 1439, stat: Journal Article,

Epilepsy in the oral and maxillofacial patient: current therapy
Turner, Michael D; Glickman, Robert S
2005 Jul;63(7):996-1005, Journal of oral & maxillofacial surgery
— id: 56374, year: 2005, vol: 63, page: 996, stat: Journal Article,

Severe corneal edema after temporomandibular joint reconstruction: report of a case
Fleisher, Kenneth E; Hirsch, David L; Pahlavi, Iman Ali; Glickman, Robert
2004 Oct;62(10):1324-1326, Journal of oral & maxillofacial surgery
— id: 91047, year: 2004, vol: 62, page: 1324, stat: Journal Article,

Allelic loss at the GPx-1 locus in cancer of the head and neck
Hu, YJ; Dolan, ME; Bae, R; Yee, H; Roy, M; Glickman, R; Kiremidjian-Schumacher, L; Diamond, AM
2004 ;101(2):97-106 NOV, Biological trace element research
Glutathione peroxidase is a selenium-containing, antioxidant enzyme previously implicated in the risk and development of lung and breast cancer, in part the result of allelic loss at the GPx-1 locus. This study examined allelic loss at the same locus in squamous cell carcinomas of the head and neck. The frequency of a polymorphism at coclon 198 resulting in either a leucine or a proline at that position was surveyed by comparing 133 DNA samples obtained from head and neck tumors and 517 samples obtained from cancer-free individuals. Tumor DNAs exhibited fewer pro/leu heterozygotes as compared to DNA obtained from the cancer-free population. Fewer GPx-1 heterozygotes were verified by determining the frequency of highly polymorphic alanine repeat sequences in the same gene. The analysis revealed an approximately 42%, reduction in heterozygosity in the DNA from the tumor samples. In order to assess loss of heterozygosity (LOH) at the GPx-1 locus, DNA was genotyped from peripheral lymphocytes, tumor tissue, and microscopically normal tissues adjacent to the tumor, derived from the same patients. These studies indicated LOH at the GPx-1 locus in each of the three tumor/normal tissues sample sets examined. Furthermore, LOH in the microscopically normal tissues at the tumor margin occurred in two of the three sample sets examined. These data implicate GPx-1 in the development of squamous cell carcinoma the head and neck and suggest that allelic loss of this gene, or one tightly linked to it, is an early event in the development of this type of malignancy
— id: 154416, year: 2004, vol: 101, page: 97, stat: Journal Article,

Mandibular fracture as a complication of inferior alveolar nerve transposition and placement of endosseous implants: a case report
Karlis, Vasiliki; Bae, Richard D; Glickman, Robert S
2003 ;12(3):211-216, Implant dentistry
Placement of endosseous implants and inferior alveolar nerve transposition is a treatment option for patients with an edentulous posterior mandible with inadequate bone height superior to the inferior alveolar canal. Complications associated with these procedures include infection, prolonged neurosensory disturbances, and/or pathologic fracture. This report presents the surgical management of a patient with a mandible fracture after inferior alveolar nerve transposition with concurrent placement of two endosseous implants
— id: 65997, year: 2003, vol: 12, page: 211, stat: Journal Article,

Chronic sinusitis complicating sinus lift surgery
Doud Galli SK; Lebowitz RA; Giacchi RJ; Glickman R; Jacobs JB
2001 May-Jun;15(3):181-186, American journal of rhinology
Sinusitis has been reported as a complication of sinus lift surgery with antral bone augmentation. The procedure involves the creation of a submucoperiosteal pocket in the floor of the maxillary sinus for placement of a graft consisting of autogenous, allogenic, or alloplastic material. This can result in inadvertent tearing of the mucoperiosteal flap with extrusion of graft material into the antrum. Obstruction of the sinus outflow tract by mucosal edema and particulate graft material may result in sinusitis. We will discuss the clinical presentation and management of 14 cases of chronic sinusitis following sinus lift surgery with alloplastic hydroxyapatite (HA) augmentation of the maxillary antrum
— id: 21120, year: 2001, vol: 15, page: 181, stat: Journal Article,

A model to evaluate bone substitutes for immediate implant placement
Glickman RS; Bae R; Karlis V
2001 ;10(3):209-215, Implant dentistry
A calcified alloplast was evaluated as a gap-filling material around implants placed immediately into fresh extraction sockets. Periodontal measurements and computed tomography scans were obtained to evaluate the clinical effectiveness of the alloplast when compared with demineralized freeze-dried bone. To determine whether this alloplast would be a suitable grafting material, 14 patients were selected to evaluate the extraction socket as a model for routine histologic confirmation of the efficacy and biocompatibility of bone substitutes. The results of this study showed the following: (1) human extraction sockets can be models for the study of bone/implant interaction; (2) the alloplast was well tolerated and demonstrated no inflammation through histologic evaluation of core biopsies; (3) the alloplast was a suitable material when used as a gap-filling graft in sockets around immediately placed implants; and (4) dental computed tomography scans and periodontal measurements around grafted implants 6 months after the procedure provide valuable clinical information about graft healing and osteointegration
— id: 65970, year: 2001, vol: 10, page: 209, stat: Journal Article,

Selenium and immunocompetence in patients with head and neck cancer
Kiremidjian-Schumacher L; Roy M; Glickman R; Schneider K; Rothstein S; Cooper J; Hochster H; Kim M; Newman R
2000 Feb;73(2):97-111, Biological trace element research
This randomized double-blind placebo-controlled study aimed to determine whether oral intake of 200 microg/d of sodium selenite, a dose within the safe and adequate daily intake (50-200 microg/d) recommended by the U.S. Food and Nutrition Board, will abrogate depressed or enhance normal-level immune functions of patients receiving therapy for squamous cell carcinoma of the head and neck. Subjects were given one selenium/placebo tablet/d for 8 wk, beginning on the day of their first treatment for the disease (e.g., surgery, radiation, or surgery and radiation) and their immune functions were monitored. Supplementation with selenium (Se) during therapy resulted in a significantly enhanced cell-mediated immunue responsiveness, as reflected in the ability of the patient's lymphocytes to respond to stimulation with mitogen, to generate cytotoxic lymphocytes, and to destroy tumor cells. The enhanced responsiveness was evident during therapy and following conclusion of therapy. In contrast, patients in the placebo arm of the study showed a decline in immune responsiveness during therapy, which was followed, in some patients, by an enhancement, but the responses of the group remained significantly lower than baseline values. The data also show that at baseline, patients entered in the study had significantly lower plasma Se levels than healthy individuals, and patients in stage I or II of disease had significantly higher plasma selenium levels than patients in stage III or IV of disease
— id: 27861, year: 2000, vol: 73, page: 97, stat: Journal Article,

Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation
Landesberg R; Roy M; Glickman RS
2000 Mar;58(3):297-300, Journal of oral & maxillofacial surgery
PURPOSE: This study compared two methods of preparing platelet-rich plasma (PRP) gel and the levels of PDGF and TGFbeta in each preparation. MATERIALS AND METHODS: Platelet-rich plasma gel was prepared by centrifugation and clotted using the ITA gelling agent (Natrex Technologies Inc, Greenville, NC) or by the addition of thrombin and calcium chloride. The levels of platelet-derived growth factor (PDGF) and transforming growth factor beta (TGFbeta) generated by clot formation were assayed by enzyme-linked immunoassay (ELISA). RESULTS: Both methods of preparation yielded PRP gel in less than 30 minutes. However, the ITA preparation did not require thrombin to achieve adequate gel formation. The levels of PDGF and TGFbeta were similar regardless of which method was used for initiation of clot formation. CONCLUSION: Use of ITA for gel preparation is equivalent to using calcium chloride and thrombin, without the need for special equipment and the risk of coagulopathy
— id: 65962, year: 2000, vol: 58, page: 297, stat: Journal Article,

Selenium and immunocompetence in patients with head and neck cancer
Schumacher, LK; Roy, M; Glickman, R; Schneider, K; Rothstein, S; Cooper, J; Kim, M; Newman, R
1999 MAR 15 ;13(5):A917-A917, FASEB journal
— id: 53933, year: 1999, vol: 13, page: A917, stat: Journal Article,

Right facial edema associated with localized gingival swelling
Karlis V; Glickman RS; Isdith K; Jones JL
1998 Jun;56(6):760-764, Journal of oral & maxillofacial surgery
— id: 66115, year: 1998, vol: 56, page: 760, stat: Journal Article,

Synovial chondromatosis of the temporomandibular joint with intracranial extension
Karlis V; Glickman RS; Zaslow M
1998 Dec;86(6):664-666, Oral surgery, oral medicine, oral pathology, oral radiology, & endodontics
An unusual case of synovial chondromatosis of the temporomandibular joint with intracranial extension, which resulted in complete dehiscence of the floor of the middle cranial fossa, is reported. An overview of the current literature and a discussion of the diagnosis and surgical management of synovial chondromatosis are presented
— id: 66119, year: 1998, vol: 86, page: 664, stat: Journal Article,

Fixation screw for jaw fractures - Reply
Karlis, V; Glickman, RS
1998 ;101(5):1414-1414 APR, Plastic & reconstructive surgery
— id: 154518, year: 1998, vol: 101, page: 1414, stat: Journal Article,

Antral augmentation, osseointegration, and sinusitis: the otolaryngologist's perspective
Zimbler MS; Lebowitz RA; Glickman R; Brecht LE; Jacobs JB
1998 Sep-Oct;12(5):311-316, American journal of rhinology
Osseointegrated dental implants are a widely used method of replacing lost or missing teeth. Resorption of the alveolar ridge of the edentulous posterior maxilla may necessitate augmentation before osseointegration to provide adequate bone for implant fixation. This can be accomplished through an intraoral approach to the maxillary sinus, with elevation of the mucosa of the sinus floor creating a pocket for graft placement. Disruption of the intact sinus mucosa may result in sinusitis, graft infection, or extrusion with secondary formation of an oroantral communication. To treat these patients effectively, the otolaryngologist must be aware of the techniques of sinus augmentation and osseointegration as well as the etiology of associated complications. We will discuss the management of four patients with significant sinus complications, and evaluate the otolaryngologist's role in the preoperative and postoperative care of these patients
— id: 7872, year: 1998, vol: 12, page: 311, stat: Journal Article,

An alternative to arch-bar maxillomandibular fixation
Karlis V; Glickman R
1997 May;99(6):1758-1759, Plastic & reconstructive surgery
This report details a pilot study of the maxillomandibular fixation screw. A longer study with a greater number of patients will allow for better evaluation of this technique
— id: 66109, year: 1997, vol: 99, page: 1758, stat: Journal Article,

Hereditary angioedema: case report and review of management
Karlis V; Glickman RS; Stern R; Kinney L
1997 Apr;83(4):462-464, Oral surgery, oral medicine, oral pathology, oral radiology, & endodontics
The classification, pathophysiology, and treatment of angioedema is reviewed. An overview of acquired and hereditary angioedema is presented with an interesting case report that illustrates the importance of recognition and perioperative management of hereditary angioedema to prevent a potentially fatal outcome
— id: 66108, year: 1997, vol: 83, page: 462, stat: Journal Article,

Using the international normalized ratio to standardize prothrombin time
Stern R; Karlis V; Kinney L; Glickman R
1997 Aug;128(8):1121-1122, Journal of the American Dental Association
The international normalized ratio, or INR, was introduced in 1983 by the World Health Organization, or WHO, Committee on Biological Standards to more accurately assess patients receiving anticoagulation therapy. The INR mandates the universal standardization of prothrombin time. This article describes the method used to calculate INR, as well as its clinical relevance to the practice of dentistry
— id: 66111, year: 1997, vol: 128, page: 1121, stat: Journal Article,

Leiomyosarcoma of the mandible: report of a case and literature review
Karlis V; Zaslow M; Minkowitz G; Glickman RS
1996 Sep;54(9):1127-1130, Journal of oral & maxillofacial surgery
— id: 66106, year: 1996, vol: 54, page: 1127, stat: Journal Article,

Method to verify the accuracy of model surgery and prediction tracing
Omura T; Glickman RS; Super S
1996 ;11(3):265-270, International journal of adult orthodontics & orthognathic surgery
Accuracy of cephalometric tracings and model surgeries is of utmost importance in planning for orthognathic surgery. The technique described allows surgeons to verify position of the models by superimposing a cephalogram of the mounted models over that of the patient. It also reduces the chance of error during actual surgery by placing models in centric relation. Therefore, the possibility of intraoperative complications, and thus longer operating times, is minimized
— id: 66114, year: 1996, vol: 11, page: 265, stat: Journal Article,

Asymptomatic radiolucency associated with a maxillary incisor
Zak MJ; Glickman RS
1995 Aug;53(8):930-933, Journal of oral & maxillofacial surgery
— id: 66097, year: 1995, vol: 53, page: 930, stat: Journal Article,

The aggressive odontogenic fibroma: report of a case
Kinney LA; Bradford J; Cohen M; Glickman RS
1993 Mar;51(3):321-324, Journal of oral & maxillofacial surgery
— id: 66102, year: 1993, vol: 51, page: 321, stat: Journal Article,

Lesch-Nyhan syndrome: report of two cases
Salman RA; Glickman RS; Super S
1987 Jan-Mar;42(1):10-3, 66, Journal of oral medicine
— id: 66086, year: 1987, vol: 42, page: 10, stat: Journal Article,

Splint therapy for electrical burns of the oral commissure in children
Salman RA; Glickman RS; Super S
1987 May-Jun;54(3):161-164, ASDC journal of dentistry for children
Electrical burns of the oral cavity are relatively rare; a case is reported here. An acrylic splint fabricated for the patient helped prevent microstomia and the subsequent development of a deformity
— id: 66087, year: 1987, vol: 54, page: 161, stat: Journal Article,

Chondroblastic osteosarcoma of the mandible 10 years after a squamous cell carcinoma of the contralateral side (report of a case)
Abraham LA; Yamane GM; Glickman RS; Super S; Salman L; Chaudhry AP
1986 Jan-Mar;41(1):4-8, Journal of oral medicine
— id: 66084, year: 1986, vol: 41, page: 4, stat: Journal Article,

Evaluation of anesthetic agents on human mucous membrane: an illustration of experimental protocol using computers
Greenfield, W; Hittelman, E L; Glickman, R
1986 Oct;52(8):22-28, New York state dental journal
— id: 91146, year: 1986, vol: 52, page: 22, stat: Journal Article,

Intraosseous high-grade mucopidermoid carcinoma with four potential microscopic diagnoses
Pierri, L K; Schneider, K L; Super, S; Glickman, R; Salman, L; Yamane, G; Chaudhry, A P
1986 Jan-Mar;41(1):47-50, Journal of oral medicine
— id: 106390, year: 1986, vol: 41, page: 47, stat: Journal Article,

Submandibular space abscess due to Actinobacillus actinomycetemcomitans
Salman RA; Bonk SJ; Salman DG; Glickman RS
1986 Dec;44(12):1002-1005, Journal of oral & maxillofacial surgery
A submandibular space abscess is reported in which a pure culture of Actinobacillus actinomycetemcomitans was identified. The bacterium may often be overlooked as a pathogen due to its slow growth and its requirement for carbon dioxide for primary isolation. As A. actinomycetemcomitans is often resistant to commonly used antibiotics, proper management is based on careful utilization of microbiologic tests and clinical judgement. In this case prompt surgical drainage and appropriate antibiotic therapy resolved the abscess
— id: 66085, year: 1986, vol: 44, page: 1002, stat: Journal Article,

Solitary palatal ulcer
Hupp JR; Layne JM; Glickman RS
1985 May;43(5):365-371, Journal of oral & maxillofacial surgery
— id: 66092, year: 1985, vol: 43, page: 365, stat: Journal Article,

Minocycline induced pigmentation of the oral cavity
Salman RA; Salman DG; Glickman RS; Super S; Salman L
1985 Jul-Sep;40(3):154-157, Journal of oral medicine
— id: 66093, year: 1985, vol: 40, page: 154, stat: Journal Article,

An adenomatoid odontogenic tumor simulating globulo-maxillary cyst
Glickman, R; Super, S; SunderRaj, M; Jain, R; Chaudhry, A
1983 Jan-Mar;38(1):26-30, Journal of oral medicine
— id: 154232, year: 1983, vol: 38, page: 26, stat: Journal Article,

Virus satellite plaques
Wise, E M Jr; Glickman, R S
1972 Jan 14;235(5333):95-96, Nature
— id: 91156, year: 1972, vol: 235, page: 95, stat: Journal Article,

Teichoic acid hydrolase activity in soil bacteria (Bacillus subtilis-sporulation-phosphodiesterase-polyamines-concanavalin A)
Wise, E M Jr; Glickman, R S; Teimer, E
1972 Jan;69(1):233-237, Proceedings of the National Academy of Sciences of the United States of America
Bacterial phosphodiesterases have been found that are capable of cleaving the backbone of teichoic acid. Such enzymes have not been reported previously. An aerobic, gram-negative, rod-shaped bacterium producing this activity was detected and isolated by autoradiography of soil suspensions growing on minimal medium containing (32)P-labeled Bacillus subtilis ATCC 6051 cell walls as the sole phosphorus source. Broken-cell preparations are capable of depolymerizing teichoic acids in media of low ionic strength at near-neutral pH values. An active teichoicase is also present in B. subtilis, ATCC 6051 (the Marburg strain), especially in sporulating cultures
— id: 91154, year: 1972, vol: 69, page: 233, stat: Journal Article,