Biosketch / Results /

David Ron, M.D.

Adjunct Professor; Coord Molecular Pathogenesis Prog
Departments of Medicine (Skirball), Cell Biology (Skirball) and Molecular Pathogenesis

Contact Info

Address
540 First Avenue
Floor 3 Room Lab-10
Skirball Institute
New York, NY 10016

212-263-7786
212-263-8951
david.ron@med.nyu.edu


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Education

1980 — Technion, Medical Education
1980 — Mount Sinai Medical Center, NYC, Internship
1987 — Internal Medicine at Mount Sinai Medical Center, NYC, Residency
1989 — Fellowship in Endocrinology at Massachusetts General Hospital, Boston,, Clinical Fellowships

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Research Summary

The folding state of polypeptides is easily perturbed by adverse conditions. Failure to properly fold polypeptides into the appropriate three-dimensional structure impacts directly on the ability to synthesize useful proteins and introduces a measure of inefficiency into the cells economy. But protein malfolding has an additional consequence that is unrelated to the lack of properly folded polypeptides but is rather mediated by the presence of malfolded ones. Numerous genetic and biochemical observations suggest that structures elaborated by polypeptides that fail to attain their proper three dimensional fold may exert a deleterious effect on cellular function. This process, also referred to as proteotoxicity, appears to be particularly important to the fate of non-renewable cells of long-lived organisms in which accumulating malfolded proteins can exert their deleterious effects over extended periods of time. The hypothesized contribution of such proteotoxins to cellular aging fits our intuitive notions of aging as a time and use-dependent process. The progressive aging of the human population has led to an increase in the incidence of diseases hypothesized to be associated with various forms of proteotoxicity. These include not only the classic examples of the Amyloidoses, Prion disorders, Alzheimer''''''''s disease and various forms of Parkinsonism - in all of which the accumulation of abnormal proteins can be readily observed - but also, we hypothesize, others such as type-II diabetes mellitus in which low-levels protein malfolding in the secretory pathway, over time, might contribute to exhaustion of the insulin-producing islet beta cell.

The long-term goal of our research is to identify new components of the cellular response to proteotoxic stress and to integrate these into an understanding of pathophysiology of common human diseases. We expect that our basic research program into the biochemistry, cell biology and genetics of the cellular response to proteotoxins will contribute to the scaffold upon which translational research can later build to create pharmacological tools to manipulate the responses to favorable ends.




Research Interests

Malfolded proteins, Cellular Degeneration and Human Disease

Research Keywords

aging, endoplasmic reticulum, protein folding, signal transduction

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury
Le Pape, Sylvain; Dimitrova, Elena; Hannaert, Patrick; Konovalov, Alexander; Volmer, Romain; Ron, David; Thuillier, Raphael; Hauet, Thierry
2014 Jun;:?-? e1004197, FEBS letters
— id: 1036922, year: 2014, vol: , page: ?, stat: Journal Article,

PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases
Lin, Yifeng; Huang, Guangcun; Jamison, Stephanie; Li, Jin; Harding, Heather P; Ron, David; Lin, Wensheng
2014 Feb;184(2):507-519, American journal of pathology
— id: 919262, year: 2014, vol: 184, page: 507, stat: Journal Article,

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology
Liu, Haiyun; Huang, Lei; Bradley, Jillian; Liu, Kebin; Bardhan, Kankana; Ron, David; Mellor, Andrew L; Munn, David H; McGaha, Tracy L
2014 Feb;34(3):428-438, Molecular & cellular biology
— id: 919252, year: 2014, vol: 34, page: 428, stat: Journal Article,

Hypothalamic eIF2alpha signaling regulates food intake
Maurin, Anne-Catherine; Benani, Alexandre; Lorsignol, Anne; Brenachot, Xavier; Parry, Laurent; Carraro, Valerie; Guissard, Christophe; Averous, Julien; Jousse, Celine; Bruhat, Alain; Chaveroux, Cedric; B'chir, Wafa; Muranishi, Yuki; Ron, David; Penicaud, Luc; Fafournoux, Pierre
2014 Feb;6(3):438-444, Cell reports
— id: 919282, year: 2014, vol: 6, page: 438, stat: Journal Article,

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation
Ravindran, Rajesh; Khan, Nooruddin; Nakaya, Helder I; Li, Shuzhao; Loebbermann, Jens; Maddur, Mohan S; Park, Youngja; Jones, Dean P; Chappert, Pascal; Davoust, Jean; Weiss, David S; Virgin, Herbert W; Ron, David; Pulendran, Bali
2014 Jan;343(6168):313-317, Science
— id: 919272, year: 2014, vol: 343, page: 313, stat: Journal Article,

Ero1-alpha and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases
Araki, Kazutaka; Iemura, Shun-ichiro; Kamiya, Yukiko; Ron, David; Kato, Koichi; Natsume, Tohru; Nagata, Kazuhiro
2013 Sep;202(6):861-874, Journal of cell biology
— id: 919242, year: 2013, vol: 202, page: 861, stat: Journal Article,

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox
Avezov, Edward; Cross, Benedict C S; Kaminski Schierle, Gabriele S; Winters, Mikael; Harding, Heather P; Melo, Eduardo Pinho; Kaminski, Clemens F; Ron, David
2013 Apr;201(2):337-349, Journal of cell biology
— id: 919202, year: 2013, vol: 201, page: 337, stat: Journal Article,

The unfolded protein response element IRE1alpha senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling
Cho, Jin A; Lee, Ann-Hwee; Platzer, Barbara; Cross, Benedict C S; Gardner, Brooke M; De Luca, Heidi; Luong, Phi; Harding, Heather P; Glimcher, Laurie H; Walter, Peter; Fiebiger, Edda; Ron, David; Kagan, Jonathan C; Lencer, Wayne I
2013 May;13(5):558-569, Cell host & microbe
— id: 919212, year: 2013, vol: 13, page: 558, stat: Journal Article,

Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila
Coelho, Dina S; Cairrao, Fatima; Zeng, Xiaomei; Pires, Elisabete; Coelho, Ana V; Ron, David; Ryoo, Hyung Don; Domingos, Pedro M
2013 Nov;5(3):791-801, Cell reports
— id: 700742, year: 2013, vol: 5, page: 791, stat: Journal Article,

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice
D'Antonio, Maurizio; Musner, Nicolo; Scapin, Cristina; Ungaro, Daniela; Del Carro, Ubaldo; Ron, David; Feltri, M Laura; Wrabetz, Lawrence
2013 Apr;210(4):821-838, Journal of experimental medicine
— id: 919182, year: 2013, vol: 210, page: 821, stat: Journal Article,

Role for the obesity-related FTO gene in the cellular sensing of amino acids
Gulati, Pawan; Cheung, Man Ka; Antrobus, Robin; Church, Chris D; Harding, Heather P; Tung, Yi-Chun Loraine; Rimmington, Debra; Ma, Marcella; Ron, David; Lehner, Paul J; Ashcroft, Frances M; Cox, Roger D; Coll, Anthony P; O'Rahilly, Stephen; Yeo, Giles S H
2013 Feb;110(7):2557-2562, Proceedings of the National Academy of Sciences of the United States of America
— id: 919162, year: 2013, vol: 110, page: 2557, stat: Journal Article,

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis
Lin, Wensheng; Lin, Yifeng; Li, Jin; Fenstermaker, Ali G; Way, Sharon W; Clayton, Benjamin; Jamison, Stephanie; Harding, Heather P; Ron, David; Popko, Brian
2013 Apr;33(14):5980-5991, Journal of neuroscience
— id: 919192, year: 2013, vol: 33, page: 5980, stat: Journal Article,

The ER stress transducer IRE1beta is required for airway epithelial mucin production
Martino, M B; Jones, L; Brighton, B; Ehre, C; Abdulah, L; Davis, C W; Ron, D; O'Neal, W K; Ribeiro, C M P
2013 May;6(3):639-654, Mucosal immunology
— id: 425822, year: 2013, vol: 6, page: 639, stat: Journal Article,

The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic beta cells by blocking PERK-mediated translational attenuation
Ozasa, Riwa; Okada, Tetsuya; Nadanaka, Satomi; Nagamine, Takahiko; Zyryanova, Alisha; Harding, Heather; Ron, David; Mori, Kazutoshi
2013 ;38(2):183-195, Cell structure & function
— id: 919222, year: 2013, vol: 38, page: 183, stat: Journal Article,

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification
Tomasio, Susana M; Harding, Heather P; Ron, David; Cross, Benedict C S; Bond, Peter J
2013 Oct;9(10):2408-2416, Molecular bioSystems
— id: 919232, year: 2013, vol: 9, page: 2408, stat: Journal Article,

Negative feedback by IRE1beta optimizes mucin production in goblet cells
Tsuru, Akio; Fujimoto, Naoko; Takahashi, Satsuki; Saito, Michiko; Nakamura, Daisuke; Iwano, Megumi; Iwawaki, Takao; Kadokura, Hiroshi; Ron, David; Kohno, Kenji
2013 Feb;110(8):2864-2869, Proceedings of the National Academy of Sciences of the United States of America
— id: 249432, year: 2013, vol: 110, page: 2864, stat: Journal Article,

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
Volmer, Romain; van der Ploeg, Kattria; Ron, David
2013 Mar;110(12):4628-4633, Proceedings of the National Academy of Sciences of the United States of America
— id: 919172, year: 2013, vol: 110, page: 4628, stat: Journal Article,

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load
Chambers, Joseph E; Petrova, Kseniya; Tomba, Giulia; Vendruscolo, Michele; Ron, David
2012 Aug;198(3):371-385, Journal of cell biology
— id: 178318, year: 2012, vol: 198, page: 371, stat: Journal Article,

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
Cross, Benedict C S; Bond, Peter J; Sadowski, Pawel G; Jha, Babal Kant; Zak, Jaroslav; Goodman, Jonathan M; Silverman, Robert H; Neubert, Thomas A; Baxendale, Ian R; Ron, David; Harding, Heather P
2012 Apr;109(15):E869-E878, Proceedings of the National Academy of Sciences of the United States of America
— id: 165427, year: 2012, vol: 109, page: E869, stat: Journal Article,

New twists in the unfolded protein response
Cross, Benedict C S; Ron, David
2012 ;1:e00243-e00243 e00243, eLife
— id: 919132, year: 2012, vol: 1, page: e00243, stat: Journal Article,

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human beta-cell apoptosis
Cunha, Daniel A; Igoillo-Esteve, Mariana; Gurzov, Esteban N; Germano, Carla M; Naamane, Najib; Marhfour, Ihsane; Fukaya, Makiko; Vanderwinden, Jean-Marie; Gysemans, Conny; Mathieu, Chantal; Marselli, Lorella; Marchetti, Piero; Harding, Heather P; Ron, David; Eizirik, Decio L; Cnop, Miriam
2012 Nov;61(11):2763-2775, Diabetes
— id: 919092, year: 2012, vol: 61, page: 2763, stat: Journal Article,

Apoprotein B: quality control early and late in the secretory pathway for this atherogenic protein
Fisher, E A; Ginsberg, H N; Ron, D; Williams, K J; Brodsky, J L
2012 April, 2012;26:-, FASEB journal
— id: 178107, year: 2012, vol: 26, page: , stat: Journal Article,

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
Harding, Heather P; Zyryanova, Alisa F; Ron, David
2012 Dec;287(53):44338-44344, Journal of biological chemistry
— id: 919142, year: 2012, vol: 287, page: 44338, stat: Journal Article,

Increased intestinal lipid absorption caused by Ire1beta deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice
Iqbal, Jahangir; Queiroz, Joyce; Li, Yan; Jiang, Xian-Cheng; Ron, David; Hussain, M Mahmood
2012 Jun;110(12):1575-1584, Circulation research
— id: 919082, year: 2012, vol: 110, page: 1575, stat: Journal Article,

Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells
Landau, Guy; Ran, Avichai; Bercovich, Zippi; Feldmesser, Ester; Horn-Saban, Shirley; Korkotian, Eduard; Jacob-Hirsh, Jasmine; Rechavi, Gideon; Ron, David; Kahana, Chaim
2012 Oct;287(43):35825-35837, Journal of biological chemistry
— id: 919112, year: 2012, vol: 287, page: 35825, stat: Journal Article,

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate
Ma, Marcella; Harding, Heather P; O'Rahilly, Stephen; Ron, David; Yeo, Giles S H
2012 Jun;444(2):183-187, Biochemical journal
— id: 919062, year: 2012, vol: 444, page: 183, stat: Journal Article,

The amino acid sensor GCN2 biases macronutrient selection during aging
Maurin, Anne-Catherine; Chaveroux, Cedric; Lambert-Langlais, Sarah; Carraro, Valerie; Jousse, Celine; Bruhat, Alain; Averous, Julien; Parry, Laurent; Ron, David; Alliot, Josette; Fafournoux, Pierre
2012 Feb;51(1):119-126, European journal of nutrition
— id: 159341, year: 2012, vol: 51, page: 119, stat: Journal Article,

New insights into translational regulation in the endoplasmic reticulum unfolded protein response
Pavitt, Graham D; Ron, David
2012 Jun;4(6):183-187, Cold Spring Harbor perspectives in biology
— id: 919072, year: 2012, vol: 4, page: 183, stat: Journal Article,

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation
Ron, David; Harding, Heather P
2012 Dec;4(12):44338-44344, Cold Spring Harbor perspectives in biology
— id: 919152, year: 2012, vol: 4, page: 44338, stat: Journal Article,

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds
Zak, Jaroslav; Ron, David; Riva, Elena; Harding, Heather P; Cross, Benedict C S; Baxendale, Ian R
2012 Aug;18(32):9901-9910, Chemistry (Weinheim an der Bergstrasse, Germany)
— id: 919102, year: 2012, vol: 18, page: 9901, stat: Journal Article,

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice
Zito, Ester; Hansen, Henning Gram; Yeo, Giles S H; Fujii, Junichi; Ron, David
2012 Oct;48(1):39-51, Molecular cell
— id: 919122, year: 2012, vol: 48, page: 39, stat: Journal Article,

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism
Birkenfeld, Andreas L; Lee, Hui-Young; Majumdar, Sachin; Jurczak, Michael J; Camporez, Joao Paulo; Jornayvaz, Francois R; Frederick, David W; Guigni, Blas; Kahn, Mario; Zhang, Dongyang; Weismann, Dirk; Arafat, Ayman M; Pfeiffer, Andreas F; Lieske, Stefanie; Oyadomari, Seiichi; Ron, David; Samuel, Varman T; Shulman, Gerald I
2011 Oct;286(42):36163-36170, Journal of biological chemistry
— id: 163512, year: 2011, vol: 286, page: 36163, stat: Journal Article,

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load
Chin, King-Tung; Kang, Guoxin; Qu, Jiaxiang; Gardner, Lawrence B; Coetzee, William A; Zito, Ester; Fishman, Glenn I; Ron, David
2011 Aug;25(8):2583-2591, FASEB journal
— id: 135555, year: 2011, vol: 25, page: 2583, stat: Journal Article,

The structure of the PERK kinase domain suggests the mechanism for its activation
Cui, Wenjun; Li, Jingzhi; Ron, David; Sha, Bingdong
2011 May;67(Pt 5):423-428, Acta crystallographica. Section D, Biological crystallography
— id: 919022, year: 2011, vol: 67, page: 423, stat: Journal Article,

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response
Fribley, Andrew M; Cruz, Patricia G; Miller, Justin R; Callaghan, Michael U; Cai, Peter; Narula, Neha; Neubig, Richard R; Showalter, Hollis D; Larsen, Scott D; Kirchhoff, Paul D; Larsen, Martha J; Burr, Douglas A; Schultz, Pamela J; Jacobs, Renju R; Tamayo-Castillo, Giselle; Ron, David; Sherman, David H; Kaufman, Randal J
2011 Sep;16(8):825-835, Journal of biomolecular screening
— id: 919042, year: 2011, vol: 16, page: 825, stat: Journal Article,

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides
Gao, Ningguo; Shang, Jie; Huynh, Dang; Manthati, Vijaya L; Arias, Carolina; Harding, Heather P; Kaufman, Randal J; Mohr, Ian; Ron, David; Falck, John R; Lehrman, Mark A
2011 Sep;22(17):2994-3009, Molecular biology of the cell
— id: 136999, year: 2011, vol: 22, page: 2994, stat: Journal Article,

A deregulated integrated stress response promotes interferon-gamma-induced medulloblastoma
Lin, Wensheng; Lin, Yifeng; Li, Jin; Harding, Heather P; Ron, David; Jamison, Stephanie
2011 Oct;89(10):1586-1595, Journal of neuroscience research
— id: 919032, year: 2011, vol: 89, page: 1586, stat: Journal Article,

Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2
Marion, Vincent; Sankaranarayanan, Selvakumari; de Theije, Chiel; van Dijk, Paul; Lindsey, Patrick; Lamers, Marinus C; Harding, Heather P; Ron, David; Lamers, Wouter H; Kohler, S Eleonore
2011 Mar;286(11):8866-8874, Journal of biological chemistry
— id: 918982, year: 2011, vol: 286, page: 8866, stat: Journal Article,

Cell biology. A translational pause to localize
Ron, David; Ito, Koreaki
2011 Feb;331(6017):543-544, Science
— id: 918992, year: 2011, vol: 331, page: 543, stat: Journal Article,

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Tabas, Ira; Ron, David
2011 Mar;13(3):184-190, Nature cell biology
— id: 919002, year: 2011, vol: 13, page: 184, stat: Journal Article,

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
Tsaytler, Pavel; Harding, Heather P; Ron, David; Bertolotti, Anne
2011 Apr;332(6025):91-94, Science
— id: 919012, year: 2011, vol: 332, page: 91, stat: Journal Article,

The unfolded protein response: from stress pathway to homeostatic regulation
Walter, Peter; Ron, David
2011 Nov;334(6059):1081-1086, Science
— id: 919052, year: 2011, vol: 334, page: 1081, stat: Journal Article,

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
Wang, Ding; Zavadil, Jiri; Martin, Leenus; Parisi, Fabio; Friedman, Eugene; Levy, David; Harding, Heather; Ron, David; Gardner, Lawrence B
2011 Sep;31(17):3670-3680, Molecular & cellular biology
— id: 136513, year: 2011, vol: 31, page: 3670, stat: Journal Article,

Disulphide production by Ero1alpha-PDI relay is rapid and effectively regulated
Appenzeller-Herzog, Christian; Riemer, Jan; Zito, Ester; Chin, King-Tung; Ron, David; Spiess, Martin; Ellgaard, Lars
2010 Oct 6;29(19):3318-3329, EMBO journal
— id: 133811, year: 2010, vol: 29, page: 3318, stat: Journal Article,

A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity
Blais, Jaime D; Chin, King-Tung; Zito, Ester; Zhang, Yuhong; Heldman, Nimrod; Harding, Heather P; Fass, Deborah; Thorpe, Colin; Ron, David
2010 Jul 2;285(27):20993-21003, Journal of biological chemistry
— id: 110660, year: 2010, vol: 285, page: 20993, stat: Journal Article,

Transcriptional regulation of VEGF-A by the unfolded protein response pathway
Ghosh, Rajarshi; Lipson, Kathryn L; Sargent, Karen E; Mercurio, Arthur M; Hunt, Joan S; Ron, David; Urano, Fumihiko
2010 ;5(3):e9575-e9575, PLoS one
— id: 134329, year: 2010, vol: 5, page: e9575, stat: Journal Article,

The mitochondrial U
Haynes, Cole M; Ron, David
2010 Nov 15;123(Pt 22):3849-3855, Journal of cell science
— id: 140034, year: 2010, vol: 123, page: 3849, stat: Journal Article,

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
Haynes, Cole M; Yang, Yun; Blais, Steven P; Neubert, Thomas A; Ron, David
2010 Feb 26;37(4):529-540, Molecular cell
— id: 107928, year: 2010, vol: 37, page: 529, stat: Journal Article,

The unfolded protein response in lung disease
Marcinak, Stefan J; Ron, David
2010 Nov;7(6):356-362, Proceedings of the American Thoracic Society
— id: 918972, year: 2010, vol: 7, page: 356, stat: Journal Article,

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells
Masciarelli, Silvia; Fra, Anna M; Pengo, Niccolo; Bertolotti, Milena; Cenci, Simone; Fagioli, Claudio; Ron, David; Hendershot, Linda M; Sitia, Roberto
2010 Mar;47(6):1356-1365, Molecular immunology
— id: 133476, year: 2010, vol: 47, page: 1356, stat: Journal Article,

Modeling the endoplasmic reticulum unfolded protein response
Onn, Amos; Ron, David
2010 Aug;17(8):924-925, Nature structural & molecular biology
— id: 918962, year: 2010, vol: 17, page: 924, stat: Journal Article,

Prospects for tuning the UPR
Ron, D
2010 APR ;88(2):411-411, Biochemistry & cell biology
— id: 110001, year: 2010, vol: 88, page: 411, stat: Journal Article,

Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR
Tao, Jiahui; Petrova, Kseniya; Ron, David; Sha, Bingdong
2010 Apr 16;397(5):1307-1315, Journal of molecular biology
— id: 133489, year: 2010, vol: 397, page: 1307, stat: Journal Article,

The endoplasmic reticulum stress response in the pancreatic beta-cell
Volchuk, A.; Ron, D.
2010 OCT ;12(10):48-57, Diabetes, obesity & metabolism
— id: 113931, year: 2010, vol: 12, page: 48, stat: Journal Article,

Structural Determinants of PERK Inhibitor Potency and Selectivity
Wang, Hong; Blais, Jaime; Ron, David; Cardozo, Timothy
2010 Dec;76(6):480-495, Chemical biology & drug design
— id: 114511, year: 2010, vol: 76, page: 480, stat: Journal Article,

Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
Wiseman, R Luke; Zhang, Yuhong; Lee, Kenneth P K; Harding, Heather P; Haynes, Cole M; Price, Joshua; Sicheri, Frank; Ron, David
2010 Apr 23;38(2):291-304, Molecular cell
— id: 109521, year: 2010, vol: 38, page: 291, stat: Journal Article,

SnapShot: The Unfolded Protein Response
Wiseman, RL; Haynes, CM; Ron, D
2010 FEB 19 ;140(4):590-U162, Cell
— id: 107742, year: 2010, vol: 140, page: 590, stat: Journal Article,

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
Ye, Jiangbin; Kumanova, Monika; Hart, Lori S; Sloane, Kelly; Zhang, Haiyan; De Panis, Diego N; Bobrovnikova-Marjon, Ekaterina; Diehl, J Alan; Ron, David; Koumenis, Constantinos
2010 Jun;29(12):2082-2096, EMBO journal
— id: 918952, year: 2010, vol: 29, page: 2082, stat: Journal Article,

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjogren syndrome
Zhao, Lihong; Rosales, Christine; Seburn, Kevin; Ron, David; Ackerman, Susan L
2010 Jan 1;19(1):25-35, Human molecular genetics
— id: 133486, year: 2010, vol: 19, page: 25, stat: Journal Article,

ERO1-{beta}, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis
Zito, Ester; Chin, King-Tung; Blais, Jaime; Harding, Heather P; Ron, David
2010 Mar 22;188(6):821-832, Journal of cell biology
— id: 108799, year: 2010, vol: 188, page: 821, stat: Journal Article,

Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin
Zito, Ester; Melo, Eduardo Pinho; Yang, Yun; Wahlander, Asa; Neubert, Thomas A; Ron, David
2010 Dec 10;40(5):787-797, Molecular cell
— id: 115430, year: 2010, vol: 40, page: 787, stat: Journal Article,

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development
Harding, Heather P; Zhang, Yuhong; Scheuner, Donalyn; Chen, Jane-Jane; Kaufman, Randal J; Ron, David
2009 Feb 10;106(6):1832-1837, Proceedings of the National Academy of Sciences of the United States of America
— id: 94497, year: 2009, vol: 106, page: 1832, stat: Journal Article,

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
Li, G; Mongillo, M; Chin, KT; Harding, H; Ron, D; Marks, AR; Tabas, I
2009 SEP 21 ;186(6):783-792, Journal of cell biology
— id: 102950, year: 2009, vol: 186, page: 783, stat: Journal Article,

Divergent effects of PERK and IRE1 signaling on cell viability
Lin, Jonathan H; Li, Han; Zhang, Yuhong; Ron, David; Walter, Peter
2009 ;4(1):e4170-e4170, PLoS one
— id: 94499, year: 2009, vol: 4, page: e4170, stat: Journal Article,

Targeting of mRNAs to their sites of unconventional splicing in the unfolded protein response
Ron, David
2009 Apr 24;34(2):133-134, Molecular cell
— id: 100518, year: 2009, vol: 34, page: 133, stat: Journal Article,

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP
Thorp, Edward; Li, Gang; Seimon, Tracie A; Kuriakose, George; Ron, David; Tabas, Ira
2009 May;9(5):474-481, Cell metabolism
— id: 133684, year: 2009, vol: 9, page: 474, stat: Journal Article,

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
Wang, Qiuyan; Mora-Jensen, Helena; Weniger, Marc A; Perez-Galan, Patricia; Wolford, Chris; Hai, Tsonwin; Ron, David; Chen, Weiping; Trenkle, William; Wiestner, Adrian; Ye, Yihong
2009 Feb 17;106(7):2200-2205, Proceedings of the National Academy of Sciences of the United States of America
— id: 94498, year: 2009, vol: 106, page: 2200, stat: Journal Article,

Thioredoxin-related Protein 32 Is an Arsenite-regulated Thiol Reductase of the Proteasome 19 S Particle
Wiseman, R Luke; Chin, King-Tung; Haynes, Cole M; Stanhill, Ariel; Xu, Chong-Feng; Roguev, Assen; Krogan, Nevan J; Neubert, Thomas A; Ron, David
2009 May 29;284(22):15233-15245, Journal of biological chemistry
— id: 99210, year: 2009, vol: 284, page: 15233, stat: Journal Article,

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling
Woo, CW; Cui, DY; Arellano, J; Dorweiler, B; Harding, H; Fitzgerald, KA; Ron, D; Tabas, I
2009 DEC ;11(12):1473-U203, Nature cell biology
— id: 105630, year: 2009, vol: 11, page: 1473, stat: Journal Article,

An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation
Harding, Heather P; Lackey, Jeremy G; Hsu, Hao-Chi; Zhang, Yuhong; Deng, Jing; Xu, Rui-Ming; Damha, Masad J; Ron, David
2008 Feb;14(2):225-232, RNA
— id: 76337, year: 2008, vol: 14, page: 225, stat: Journal Article,

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA
Iqbal, Jahangir; Dai, Kezhi; Seimon, Tracie; Jungreis, Rivka; Oyadomari, Miho; Kuriakose, George; Ron, David; Tabas, Ira; Hussain, M Mahmood
2008 May;7(5):445-455, Cell metabolism
— id: 94505, year: 2008, vol: 7, page: 445, stat: Journal Article,

Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p
Lackey, Jeremy G; Ron, David; Damha, Masad J; Harding, Heather P
2008 ;(52):475-476, Nucleic acids symposium series (2004)
— id: 94502, year: 2008, vol: , page: 475, stat: Journal Article,

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma
Lin, Wensheng; Kunkler, Phillip E; Harding, Heather P; Ron, David; Kraig, Richard P; Popko, Brian
2008 Nov;173(5):1508-1517, American journal of pathology
— id: 94500, year: 2008, vol: 173, page: 1508, stat: Journal Article,

Novel function of PERK as a mediator of force-induced apoptosis
Mak, Baldwin C; Wang, Qin; Laschinger, Carol; Lee, Wilson; Ron, David; Harding, Heather P; Kaufman, Randal J; Scheuner, Donalyn; Austin, Richard C; McCulloch, Christopher A
2008 Aug 22;283(34):23462-23472, Journal of biological chemistry
— id: 94503, year: 2008, vol: 283, page: 23462, stat: Journal Article,

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
Oyadomari, Seiichi; Harding, Heather P; Zhang, Yuhong; Oyadomari, Miho; Ron, David
2008 Jun;7(6):520-532, Cell metabolism
— id: 79415, year: 2008, vol: 7, page: 520, stat: Journal Article,

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice
Pennuto, Maria; Tinelli, Elisa; Malaguti, Mariachiara; Del Carro, Ubaldo; D'Antonio, Maurizio; Ron, David; Quattrini, Angelo; Feltri, M Laura; Wrabetz, Lawrence
2008 Feb 7;57(3):393-405, Neuron
— id: 94507, year: 2008, vol: 57, page: 393, stat: Journal Article,

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3
Petrova, Kseniya; Oyadomari, Seiichi; Hendershot, Linda M; Ron, David
2008 Nov 5;27(21):2862-2872, EMBO journal
— id: 90769, year: 2008, vol: 27, page: 2862, stat: Journal Article,

How IRE1 reacts to ER stress
Ron, David; Hubbard, Stevan R
2008 Jan 11;132(1):24-26, Cell
— id: 76457, year: 2008, vol: 132, page: 24, stat: Journal Article,

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
Song, Benbo; Scheuner, Donalyn; Ron, David; Pennathur, Subramaniam; Kaufman, Randal J
2008 Oct;118(10):3378-3389, Journal of clinical investigation
— id: 94501, year: 2008, vol: 118, page: 3378, stat: Journal Article,

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation
Su, Qiaozhu; Wang, Shuo; Gao, Hong Qing; Kazemi, Shirin; Harding, Heather P; Ron, David; Koromilas, Antonis E
2008 Jan 4;283(1):469-475, Journal of biological chemistry
— id: 94508, year: 2008, vol: 283, page: 469, stat: Journal Article,

Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment
Tao, Jiahui; Wu, Yunkun; Ron, David; Sha, Bingdong
2008 Feb 1;64(Pt 2):108-110, Acta crystallographica. Section F. Structural biology & crystallization communications
— id: 94506, year: 2008, vol: 64, page: 108, stat: Journal Article,

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans
Yun, Chi; Stanhill, Ariel; Yang, Yun; Zhang, Yuhong; Haynes, Cole M; Xu, Chong-Feng; Neubert, Thomas A; Mor, Adam; Philips, Mark R; Ron, David
2008 May 13;105(19):7094-7099, Proceedings of the National Academy of Sciences of the United States of America
— id: 94504, year: 2008, vol: 105, page: 7094, stat: Journal Article,

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
Ding, Wen-Xing; Ni, Hong-Min; Gao, Wentao; Yoshimori, Tamotsu; Stolz, Donna B; Ron, David; Yin, Xiao-Ming
2007 Aug;171(2):513-524, American journal of pathology
— id: 94509, year: 2007, vol: 171, page: 513, stat: Journal Article,

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
Haynes, Cole M; Petrova, Kseniya; Benedetti, Cristina; Yang, Yun; Ron, David
2007 Oct;13(4):467-480, Developmental cell
— id: 75456, year: 2007, vol: 13, page: 467, stat: Journal Article,

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
Lin, Wensheng; Bailey, Samantha L; Ho, Hanson; Harding, Heather P; Ron, David; Miller, Stephen D; Popko, Brian
2007 Feb;117(2):448-456, Journal of clinical investigation
— id: 71592, year: 2007, vol: 117, page: 448, stat: Journal Article,

Signal integration in the endoplasmic reticulum unfolded protein response
Ron, David; Walter, Peter
2007 Jul;8(7):519-529, Nature reviews. Molecular cell biology
— id: 73382, year: 2007, vol: 8, page: 519, stat: Journal Article,

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux
Shang, Jie; Gao, Ningguo; Kaufman, Randal J; Ron, David; Harding, Heather P; Lehrman, Mark A
2007 Feb 26;176(5):605-616, Journal of cell biology
— id: 71591, year: 2007, vol: 176, page: 605, stat: Journal Article,

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response
Benedetti, Cristina; Haynes, Cole M; Yang, Yun; Harding, Heather P; Ron, David
2006 Sep;174(1):229-239, Genetics
— id: 69577, year: 2006, vol: 174, page: 229, stat: Journal Article,

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses
Berlanga, Juan J; Ventoso, Ivan; Harding, Heather P; Deng, Jing; Ron, David; Sonenberg, Nahum; Carrasco, Luis; de Haro, Cesar
2006 Apr 19;25(8):1730-1740, EMBO journal
— id: 71597, year: 2006, vol: 25, page: 1730, stat: Journal Article,

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
Blais, Jaime D; Addison, Christina L; Edge, Robert; Falls, Theresa; Zhao, Huijun; Wary, Kishore; Koumenis, Costas; Harding, Heather P; Ron, David; Holcik, Martin; Bell, John C
2006 Dec;26(24):9517-9532, Molecular & cellular biology
— id: 71594, year: 2006, vol: 26, page: 9517, stat: Journal Article,

Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses
Clase, Amanda C; Dimcheff, Derek E; Favara, Cynthia; Dorward, David; McAtee, Frank J; Parrie, Lindsay E; Ron, David; Portis, John L
2006 Sep;169(3):1026-1038, American journal of pathology
— id: 71596, year: 2006, vol: 169, page: 1026, stat: Journal Article,

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae
Elefteriou, Florent; Benson, M Douglas; Sowa, Hideaki; Starbuck, Michael; Liu, Xiuyun; Ron, David; Parada, Luis F; Karsenty, Gerard
2006 Dec;4(6):441-451, Cell metabolism
— id: 71593, year: 2006, vol: 4, page: 441, stat: Journal Article,

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice
Huang, Guojin; Yao, Jian; Zeng, Weizhong; Mizuno, Yusuke; Kamm, Kristine E; Stull, James T; Harding, Heather P; Ron, David; Muallem, Shmuel
2006 Jan 1;119(Pt 1):153-161, Journal of cell science
— id: 71600, year: 2006, vol: 119, page: 153, stat: Journal Article,

Deficiency of IRE1 beta in cholesterol-fed mice leads to the induction of intestinal microsomal triglyceride transfer protein and increased chylomicron secretion
Iqbal, J; DeVries, T; Dai, K; Ron, D; Tabas, I; Hussain, M
2006 MAY ;26(5):E43-E43, Arteriosclerosis, thrombosis, & vascular biology
— id: 63865, year: 2006, vol: 26, page: E43, stat: Journal Article,

Interferon-gamma inhibits central nervous system remyelination through a process modulated by ER stress
Lin, W; Kemper, A; Dupree, JL; Harding, HP; Ron, D; Popko, B
2006 MAR ;96(1):57-57, Journal of neurochemistry
— id: 62903, year: 2006, vol: 96, page: 57, stat: Journal Article,

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
Lin, Wensheng; Kemper, April; Dupree, Jeffrey L; Harding, Heather P; Ron, David; Popko, Brian
2006 May;129(Pt 5):1306-1318, Brain
— id: 71598, year: 2006, vol: 129, page: 1306, stat: Journal Article,

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK
Marciniak, Stefan J; Garcia-Bonilla, Lidia; Hu, Junjie; Harding, Heather P; Ron, David
2006 Jan 16;172(2):201-209, Journal of cell biology
— id: 71599, year: 2006, vol: 172, page: 201, stat: Journal Article,

Endoplasmic reticulum stress signaling in disease
Marciniak, Stefan J; Ron, David
2006 Oct;86(4):1133-1149, Physiological reviews
— id: 71595, year: 2006, vol: 86, page: 1133, stat: Journal Article,

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload
Oyadomari, Seiichi; Yun, Chi; Fisher, Edward A; Kreglinger, Nicola; Kreibich, Gert; Oyadomari, Miho; Harding, Heather P; Goodman, Alan G; Harant, Hanna; Garrison, Jennifer L; Taunton, Jack; Katze, Michael G; Ron, David
2006 Aug 25;126(4):727-739, Cell
— id: 69025, year: 2006, vol: 126, page: 727, stat: Journal Article,

C/EBP homologous protein is necessary for normal osteoblastic function
Pereira, Renata C; Stadmeyer, Lisa; Marciniak, Stefan J; Ron, David; Canalis, Ernesto
2006 Feb 15;97(3):633-640, Journal of cellular biochemistry
— id: 71602, year: 2006, vol: 97, page: 633, stat: Journal Article,

Cell biology. Stressed cells cope with protein overload
Ron, David
2006 Jul 7;313(5783):52-53, Science
— id: 66468, year: 2006, vol: 313, page: 52, stat: Journal Article,

Targeting translation in hypoxic tumors
Ron, David; Hinnebusch, Alan G
2006 Apr 25;1(3):145-148, ACS chemical biology
— id: 70317, year: 2006, vol: 1, page: 145, stat: Journal Article,

Translation attenuation by PERK in response to ER stress rectifies impaired Glc(3)Man(9)GlcNAc(2)-P-P-dolichol synthesis and N-linked glycosylation
Shang, J; Gao, NG; Kaufman, RJ; Ron, D; Harding, HP; Lehrman, MA
2006 NOV ;16(11):1120-1121, Glycobiology
— id: 69303, year: 2006, vol: 16, page: 1120, stat: Journal Article,

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity
Stanhill, Ariel; Haynes, Cole M; Zhang, Yuhong; Min, Guangwei; Steele, Matthew C; Kalinina, Juliya; Martinez, Enid; Pickart, Cecile M; Kong, Xiang-Peng; Ron, David
2006 Sep 15;23(6):875-885, Molecular cell
— id: 69075, year: 2006, vol: 23, page: 875, stat: Journal Article,

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
Bi, Meixia; Naczki, Christine; Koritzinsky, Marianne; Fels, Diane; Blais, Jaime; Hu, Nianping; Harding, Heather; Novoa, Isabelle; Varia, Mahesh; Raleigh, James; Scheuner, Donalyn; Kaufman, Randal J; Bell, John; Ron, David; Wouters, Bradly G; Koumenis, Constantinos
2005 Oct 5;24(19):3470-3481, EMBO journal
— id: 71605, year: 2005, vol: 24, page: 3470, stat: Journal Article,

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
Boyce, Michael; Bryant, Kevin F; Jousse, Celine; Long, Kai; Harding, Heather P; Scheuner, Donalyn; Kaufman, Randal J; Ma, Dawei; Coen, Donald M; Ron, David; Yuan, Junying
2005 Feb 11;307(5711):935-939, Science
— id: 72850, year: 2005, vol: 307, page: 935, stat: Journal Article,

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
Costa-Mattioli, Mauro; Gobert, Delphine; Harding, Heather; Herdy, Barbara; Azzi, Mounia; Bruno, Martin; Bidinosti, Michael; Ben Mamou, Cyrinne; Marcinkiewicz, Edwige; Yoshida, Madoka; Imataka, Hiroaki; Cuello, A Claudio; Seidah, Nabil; Sossin, Wayne; Lacaille, Jean-Claude; Ron, David; Nader, Karim; Sonenberg, Nahum
2005 Aug 25;436(7054):1166-1173, Nature
— id: 72844, year: 2005, vol: 436, page: 1166, stat: Journal Article,

The dynamic ER: experimental approaches and current questions
Federovitch, Christine M; Ron, David; Hampton, Randolph Y
2005 Aug;17(4):409-414, Current opinion in cell biology
— id: 62635, year: 2005, vol: 17, page: 409, stat: Journal Article,

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
Harding, Heather P; Zhang, Yuhong; Khersonsky, Sonya; Marciniak, Stefan; Scheuner, Donalyn; Kaufman, Randal J; Javitt, Norman; Chang, Young-Tae; Ron, David
2005 Dec;2(6):361-371, Cell metabolism
— id: 71601, year: 2005, vol: 2, page: 361, stat: Journal Article,

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients
Kantor, Liraz; Harding, Heather P; Ron, David; Schiffmann, Raphael; Kaneski, Christine R; Kimball, Scot R; Elroy-Stein, Orna
2005 Oct;118(1):99-106, Human genetics
— id: 72847, year: 2005, vol: 118, page: 99, stat: Journal Article,

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
Lin, Wensheng; Harding, Heather P; Ron, David; Popko, Brian
2005 May 23;169(4):603-612, Journal of cell biology
— id: 72848, year: 2005, vol: 169, page: 603, stat: Journal Article,

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
Maurin, Anne-Catherine; Jousse, Celine; Averous, Julien; Parry, Laurent; Bruhat, Alain; Cherasse, Yoan; Zeng, Huiqing; Zhang, Yuhong; Harding, Heather P; Ron, David; Fafournoux, Pierre
2005 Apr;1(4):273-277, Cell metabolism
— id: 72846, year: 2005, vol: 1, page: 273, stat: Journal Article,

[GCN2 regulates feeding behavior to maintain amino acid homeostasis in omnivores]
Maurin, Anne-Catherine; Jousse, Celine; Balage, Michelle; Averous, Julien; Parry, Laurent; Bruhat, Alain; Cherasse, Yoan; Zeng, Huiqing; Zhang, Yuhong; Harding, Heather; Ron, David; Fafournoux, Pierre
2005 Oct;21(10):799-801, M/S: medecine sciences
— id: 71603, year: 2005, vol: 21, page: 799, stat: Journal Article,

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
Munn, David H; Sharma, Madhav D; Baban, Babak; Harding, Heather P; Zhang, Yuhong; Ron, David; Mellor, Andrew L
2005 May;22(5):633-642, Immunity
— id: 72849, year: 2005, vol: 22, page: 633, stat: Journal Article,

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
Silva, Robert M; Ries, Vincent; Oo, Tinmarla Frances; Yarygina, Olga; Jackson-Lewis, Vernice; Ryu, Elizabeth J; Lu, Phoebe D; Marciniak, Stefan J; Ron, David; Przedborski, Serge; Kholodilov, Nikolai; Greene, Lloyd A; Burke, Robert E
2005 Nov;95(4):974-986, Journal of neurochemistry
— id: 596182, year: 2005, vol: 95, page: 974, stat: Journal Article,

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate
Skalet, Alison H; Isler, Jennifer A; King, Leslie B; Harding, Heather P; Ron, David; Monroe, John G
2005 Dec 2;280(48):39762-39771, Journal of biological chemistry
— id: 71604, year: 2005, vol: 280, page: 39762, stat: Journal Article,

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis
Hartman, Matthew G; Lu, Dan; Kim, Mi-Lyang; Kociba, Gary J; Shukri, Tala; Buteau, Jean; Wang, Xiaozhong; Frankel, Wendy L; Guttridge, Denis; Prentki, Marc; Grey, Shane T; Ron, David; Hai, Tsonwin
2004 Jul;24(13):5721-5732, Molecular & cellular biology
— id: 43030, year: 2004, vol: 24, page: 5721, stat: Journal Article,

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response
Jiang, Hao-Yuan; Wek, Sheree A; McGrath, Barbara C; Lu, Dan; Hai, Tsonwin; Harding, Heather P; Wang, Xiaozhong; Ron, David; Cavener, Douglas R; Wek, Ronald C
2004 Feb;24(3):1365-1377, Molecular & cellular biology
— id: 42130, year: 2004, vol: 24, page: 1365, stat: Journal Article,

Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1
Klint, Peter; Hellman, Ulf; Wernstedt, Christer; Aman, Pierre; Ron, David; Claesson-Welsh, Lena
2004 Apr;16(4):515-520, Cellular signalling
— id: 42132, year: 2004, vol: 16, page: 515, stat: Journal Article,

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
Lu, Phoebe D; Jousse, Celine; Marciniak, Stefan J; Zhang, Yuhong; Novoa, Isabel; Scheuner, Donalyn; Kaufman, Randal J; Ron, David; Harding, Heather P
2004 Jan 14;23(1):169-179, EMBO journal
— id: 42131, year: 2004, vol: 23, page: 169, stat: Journal Article,

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Feng, Bo; Yao, Pin Mei; Li, Yankun; Devlin, Cecilia M; Zhang, Dajun; Harding, Heather P; Sweeney, Michele; Rong, James X; Kuriakose, George; Fisher, Edward A; Marks, Andrew R; Ron, David; Tabas, Ira
2003 Sep;5(9):781-792, Nature cell biology
— id: 37270, year: 2003, vol: 5, page: 781, stat: Journal Article,

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
Harding, Heather P; Zhang, Yuhong; Zeng, Huiquing; Novoa, Isabel; Lu, Phoebe D; Calfon, Marcella; Sadri, Navid; Yun, Chi; Popko, Brian; Paules, Richard; Stojdl, David F; Bell, John C; Hettmann, Thore; Leiden, Jeffrey M; Ron, David
2003 Mar;11(3):619-633, Molecular cell
— id: 39258, year: 2003, vol: 11, page: 619, stat: Journal Article,

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells
Jousse, Celine; Oyadomari, Seiichi; Novoa, Isabel; Lu, Phoebe; Zhang, Yuhong; Harding, Heather P; Ron, David
2003 Nov 24;163(4):767-775, Journal of cell biology
— id: 42133, year: 2003, vol: 163, page: 767, stat: Journal Article,

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes
Kimball, Scot R; Horetsky, Rick L; Ron, David; Jefferson, Leonard S; Harding, Heather P
2003 Feb;284(2):C273-C284, American journal of physiology. Cell physiology
— id: 38134, year: 2003, vol: 284, page: C273, stat: Journal Article,

Stress-induced gene expression requires programmed recovery from translational repression
Novoa, Isabel; Zhang, Yuhong; Zeng, Huiqing; Jungreis, Rivka; Harding, Heather P; Ron, David
2003 Mar 3;22(5):1180-1187, EMBO journal
— id: 38135, year: 2003, vol: 22, page: 1180, stat: Journal Article,

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Calfon, Marcella; Zeng, Huiqing; Urano, Fumihiko; Till, Jeffery H; Hubbard, Stevan R; Harding, Heather P; Clark, Scott G; Ron, David
2002 Jan 3;415(6867):92-96, Nature
— id: 27253, year: 2002, vol: 415, page: 92, stat: Journal Article,

Activation of GCN2 in UV-irradiated cells inhibits translation
Deng, J; Harding, HP; Raught, B; Gingras, AC; Berlanga, JJ; Scheuner, D; Kaufman, RJ; Ron, D; Sonenberg, N
2002 Aug 6;12(15):1279-1286, Current biology. CB
— id: 32380, year: 2002, vol: 12, page: 1279, stat: Journal Article,

Transcriptional and translational control in the Mammalian unfolded protein response
Harding, Heather P; Calfon, Marcella; Urano, Fumihiko; Novoa, Isabel; Ron, David
2002 ;18(3):575-599, Annual review of cell & developmental biology
— id: 39419, year: 2002, vol: 18, page: 575, stat: Journal Article,

Endoplasmic reticulum stress and the development of diabetes: a review
Harding, Heather P; Ron, David
2002 Dec;51 Suppl 3(12):S455-S461, Diabetes
— id: 39351, year: 2002, vol: 51 Suppl 3, page: S455, stat: Journal Article,

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease
Hori, O; Ichinoda, F; Tamatani, T; Yamaguchi, A; Sato, N; Ozawa, K; Kitao, Y; Miyazaki, M; Harding, HP; Ron, D; Tohyama, M; Stern, DM; Ogawa, S
2002 Jun 24;157(7):1151-1160, Journal of cell biology
— id: 30699, year: 2002, vol: 157, page: 1151, stat: Journal Article,

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
Marcu, Monica G; Doyle, Melissa; Bertolotti, Anne; Ron, David; Hendershot, Linda; Neckers, Len
2002 Dec;22(24):8506-8513, Molecular & cellular biology
— id: 38133, year: 2002, vol: 22, page: 8506, stat: Journal Article,

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse
Ron, David
2002 Feb;109(4):443-445, Journal of clinical investigation
— id: 39707, year: 2002, vol: 109, page: 443, stat: Journal Article,

Translational control in the endoplasmic reticulum stress response
Ron, David
2002 Nov;110(10):1383-1388, Journal of clinical investigation
— id: 111718, year: 2002, vol: 110, page: 1383, stat: Journal Article,

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease
Ryu, Elizabeth J; Harding, Heather P; Angelastro, James M; Vitolo, Ottavio V; Ron, David; Greene, Lloyd A
2002 Dec;22(24):10690-10698, Journal of neuroscience
— id: 596312, year: 2002, vol: 22, page: 10690, stat: Journal Article,

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response
Urano, Fumihiko; Calfon, Marcella; Yoneda, Takunari; Yun, Chi; Kiraly, Moni; Clark, Scott G; Ron, David
2002 Aug 19;158(4):639-646, Journal of cell biology
— id: 38132, year: 2002, vol: 158, page: 639, stat: Journal Article,

Control of PERK eIF2 alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58(IPK)
Yan, W; Frank, CL; Korth, MJ; Sopher, BL; Novoa, I; Ron, D; Katze, MG
2002 DEC 10 ;99(25):15920-15925, Proceedings of the National Academy of Sciences of the United States of America
— id: 33276, year: 2002, vol: 99, page: 15920, stat: Journal Article,

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK
Yan, Wei; Frank, Christopher L; Korth, Marcus J; Sopher, Bryce L; Novoa, Isabel; Ron, David; Katze, Michael G
2002 Dec;99(25):15920-15925, Proceedings of the National Academy of Sciences of the United States of America
— id: 163355, year: 2002, vol: 99, page: 15920, stat: Journal Article,

Transmission of proteotoxicity across cellular compartments
Yoneda, Takunari; Urano, Fumihiko; Ron, David
2002 Jun 1;16(11):1307-1313, Genes & development
— id: 39635, year: 2002, vol: 16, page: 1307, stat: Journal Article,

Alterations in an IRE1-RNA complex in the mammalian unfolded protein response
Bertolotti A; Ron D
2001 Sep;114(Pt 17):3207-3212, Journal of cell science
— id: 26554, year: 2001, vol: 114, page: 3207, stat: Journal Article,

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice
Bertolotti A; Wang X; Novoa I; Jungreis R; Schlessinger K; Cho JH; West AB; Ron D
2001 Mar;107(5):585-593, Journal of clinical investigation
— id: 26774, year: 2001, vol: 107, page: 585, stat: Journal Article,

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
Harding HP; Zeng H; Zhang Y; Jungries R; Chung P; Plesken H; Sabatini DD; Ron D
2001 Jun;7(6):1153-1163, Molecular cell
— id: 21161, year: 2001, vol: 7, page: 1153, stat: Journal Article,

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK
Kumar R; Azam S; Sullivan JM; Owen C; Cavener DR; Zhang P; Ron D; Harding HP; Chen JJ; Han A; White BC; Krause GS; DeGracia DJ
2001 Jun;77(5):1418-1421, Journal of neurochemistry
— id: 27773, year: 2001, vol: 77, page: 1418, stat: Journal Article,

Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry
Ma Y; Lu Y; Zeng H; Ron D; Mo W; Neubert TA
2001 ;15(18):1693-1700, Rapid communications in mass spectrometry
— id: 23927, year: 2001, vol: 15, page: 1693, stat: Journal Article,

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
Novoa I; Zeng H; Harding HP; Ron D
2001 May 28;153(5):1011-1022, Journal of cell biology
— id: 21193, year: 2001, vol: 153, page: 1011, stat: Journal Article,

Hyperhomocysteinemia and function of the endoplasmic reticulum
Ron D
2001 May;107(10):1221-1222, Journal of clinical investigation
— id: 20643, year: 2001, vol: 107, page: 1221, stat: Journal Article,

Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity
Sok J; Calfon M; Lu J; Lichtlen P; Clark SG; Ron D
2001 Jan;6(1):6-15, Cell stress chaperones
— id: 26694, year: 2001, vol: 6, page: 6, stat: Journal Article,

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Bertolotti A; Zhang Y; Hendershot LM; Harding HP; Ron D
2000 Jun;2(6):326-332, Nature cell biology
— id: 11648, year: 2000, vol: 2, page: 326, stat: Journal Article,

Regulated translation initiation controls stress-induced gene expression in mammalian cells
Harding HP; Novoa I; Zhang Y; Zeng H; Wek R; Schapira M; Ron D
2000 Nov;6(5):1099-1108, Molecular cell
— id: 27774, year: 2000, vol: 6, page: 1099, stat: Journal Article,

Perk is essential for translational regulation and cell survival during the unfolded protein response
Harding HP; Zhang Y; Bertolotti A; Zeng H; Ron D
2000 May;5(5):897-904, Molecular cell
— id: 11620, year: 2000, vol: 5, page: 897, stat: Journal Article,

Male sterility and enhanced radiation sensitivity in TLS(-/-) mice
Kuroda M; Sok J; Webb L; Baechtold H; Urano F; Yin Y; Chung P; de Rooij DG; Akhmedov A; Ashley T; Ron D
2000 Feb 1;19(3):453-462, EMBO journal
— id: 8559, year: 2000, vol: 19, page: 453, stat: Journal Article,

PERK and translational control by stress in the endoplasmic reticulum
Ron, David; Harding, Heather P
Translation control of gene expression Plainview, NY : Cold Spring Harbor Laboratory Press ,
— id: 2555, year: 2000, vol: , page: 547, stat: Chapter,

IRE1 and efferent signaling from the endoplasmic reticulum
Urano F; Bertolotti A; Ron D
2000 Nov;113 Pt 21(4):3697-3702, Journal of cell science
— id: 39536, year: 2000, vol: 113 Pt 21, page: 3697, stat: Journal Article,

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
Urano F; Wang X; Bertolotti A; Zhang Y; Chung P; Harding HP; Ron D
2000 Jan 28;287(5453):664-666, Science
— id: 8577, year: 2000, vol: 287, page: 664, stat: Journal Article,

Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation
Baechtold, H; Kuroda, M; Sok, J; Ron, D; Lopez, B S; Akhmedov, A T
1999 Nov;274(48):34337-34342, Journal of biological chemistry
— id: 163494, year: 1999, vol: 274, page: 34337, stat: Journal Article,

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]
Harding HP; Zhang Y; Ron D
1999 Jan 21;397(6716):271-274, Nature
— id: 7985, year: 1999, vol: 397, page: 271, stat: Journal Article,

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
Jousse C; Bruhat A; Harding HP; Ferrara M; Ron D; Fafournoux P
1999 Apr 9;448(2-3):211-216, FEBS letters
— id: 27775, year: 1999, vol: 448, page: 211, stat: Journal Article,

Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation
Kanoe H; Nakayama T; Hosaka T; Murakami H; Yamamoto H; Nakashima Y; Tsuboyama T; Nakamura T; Ron D; Sasaki MS; Toguchida J
1999 Jan 21;18(3):721-729, Oncogene
— id: 7359, year: 1999, vol: 18, page: 721, stat: Journal Article,

Induction of a secreted protein by the myxoid liposarcoma oncogene
Kuroda M; Wang X; Sok J; Yin Y; Chung P; Giannotti JW; Jacobs KA; Fitz LJ; Murtha-Riel P; Turner KJ; Ron D
1999 Apr 27;96(9):5025-5030, Proceedings of the National Academy of Sciences of the United States of America
— id: 6104, year: 1999, vol: 96, page: 5025, stat: Journal Article,

Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
Ron, D; Napolitano, E W; Voronova, A; Vasquez, N J; Roberts, D N; Calio, B L; Caothien, R H; Pettiford, S M; Wellik, S; Mandac, J B; Kauvar, L M
1999 Jul 2;274(27):19003-19010, Journal of biological chemistry
— id: 127133, year: 1999, vol: 274, page: 19003, stat: Journal Article,

CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI
Sok J; Wang XZ; Batchvarova N; Kuroda M; Harding H; Ron D
1999 Jan;19(1):495-504, Molecular & cellular biology
— id: 7451, year: 1999, vol: 19, page: 495, stat: Journal Article,

gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line
Wang XZ; Jolicoeur EM; Conte N; Chaffanet M; Zhang Y; Mozziconacci MJ; Feiner H; Birnbaum D; Pebusque MJ; Ron D
1999 Oct 7;18(41):5718-5721, Oncogene
— id: 6220, year: 1999, vol: 18, page: 5718, stat: Journal Article,

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
Powers CA; Mathur M; Raaka BM; Ron D; Samuels HH
1998 Jan;12(1):4-18, Molecular endocrinology
— id: 7748, year: 1998, vol: 12, page: 4, stat: Journal Article,

Cloning of mammalian Ire1 reveals diversity in the ER stress responses
Wang XZ; Harding HP; Zhang Y; Jolicoeur EM; Kuroda M; Ron D
1998 Oct 1;17(19):5708-5717, EMBO journal
— id: 7841, year: 1998, vol: 17, page: 5708, stat: Journal Article,

Identification of novel stress-induced genes downstream of chop
Wang XZ; Kuroda M; Sok J; Batchvarova N; Kimmel R; Chung P; Zinszner H; Ron D
1998 Jul 1;17(13):3619-3630, EMBO journal
— id: 7842, year: 1998, vol: 17, page: 3619, stat: Journal Article,

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
Zinszner H; Kuroda M; Wang X; Batchvarova N; Lightfoot RT; Remotti H; Stevens JL; Ron D
1998 Apr 1;12(7):982-995, Genes & development
— id: 7873, year: 1998, vol: 12, page: 982, stat: Journal Article,

TLS-CHOP and the role of RNA-binding proteins in oncogenic transformation
Ron D
1997 ;220:131-142, Current topics in microbiology & immunology
— id: 7090, year: 1997, vol: 220, page: 131, stat: Journal Article,

A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited
Zinszner H; Immanuel D; Yin Y; Liang FX; Ron D
1997 Jan 30;14(4):451-461, Oncogene
— id: 12399, year: 1997, vol: 14, page: 451, stat: Journal Article,

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling
Zinszner H; Sok J; Immanuel D; Yin Y; Ron D
1997 Aug;110(Pt 15):1741-1750, Journal of cell science
— id: 7293, year: 1997, vol: 110, page: 1741, stat: Journal Article,

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
Wang XZ; Lawson B; Brewer JW; Zinszner H; Sanjay A; Mi LJ; Boorstein R; Kreibich G; Hendershot LM; Ron D
1996 Aug;16(8):4273-4280, Molecular & cellular biology
— id: 12576, year: 1996, vol: 16, page: 4273, stat: Journal Article,

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
Wang XZ; Ron D
1996 May 31;272(5266):1347-1349, Science
— id: 12602, year: 1996, vol: 272, page: 1347, stat: Journal Article,

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153)
Batchvarova N; Wang XZ; Ron D
1995 Oct 2;14(19):4654-4661, EMBO journal
— id: 6805, year: 1995, vol: 14, page: 4654, stat: Journal Article,

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II
Immanuel D; Zinszner H; Ron D
1995 Aug;15(8):4562-4571, Molecular & cellular biology
— id: 6834, year: 1995, vol: 15, page: 4562, stat: Journal Article,

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest
Barone, M V; Crozat, A; Tabaee, A; Philipson, L; Ron, D
1994 Feb 15;8(4):453-464, Genes & development
— id: 134698, year: 1994, vol: 8, page: 453, stat: Journal Article,

Inducible growth arrest: new mechanistic insights
Ron D
1994 Mar 15;91(6):1985-1986, Proceedings of the National Academy of Sciences of the United States of America
— id: 6500, year: 1994, vol: 91, page: 1985, stat: Journal Article,

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP
Zinszner H; Albalat R; Ron D
1994 Nov 1;8(21):2513-2526, Genes & development
— id: 6798, year: 1994, vol: 8, page: 2513, stat: Journal Article,

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
Crozat A; Aman P; Mandahl N; Ron D
1993 Jun 17;363(6430):640-644, Nature
— id: 6347, year: 1993, vol: 363, page: 640, stat: Journal Article,