Biosketch / Results /
William RomSol and Judith Bergstein Professor of Medicine, Department of Medicine;Professor, Department of Environmental Medicine
462 First Avenue
New York, NY 10016
In the lower respiratory tract, alveolar macrophages (AMs) phagocytose inorganic particles and microorganisms, thus playing an important role in host defense. AMs have a complex array of intracellular machinery to respond and direct inflammatory and fibrotic processes. Through releasing peptide growth factors such as platelet-derived growth factor and insulin-like growth factor-I, they stimulate fibroblast proliferation and contribute to fibrosis. Through releasing interleukin-8 (IL-8), they attract neutrophils and lymphocytes by chemotaxis to participate in immune-effector functions. The macrophage processes antigen and presents it to naive T lymphocytes, activating them in immune or cytotoxic responses. AMs are a major source of cytokines IL-b, TNF-a, and IL-6, all of which participate in granulomatous lung inflammation. AMs can phagocytose apoptotic neutrophils and lymphocytes participating in programmed cell death.
We also analyze BAL cells, bronchial brush, and microdissected samples from lung resections to search for tumor suppressor gene mutations and gene expression changes that will help us identify workers exposed to asbestos and cigarette smoke making them at high risk for lung cancer.
In tuberculosis studies, we investigate IL-8, TNF-a, IL-1b, and IL-6 roles in the granulomatous response. Regarding the transcriptional regulation of these genes, we identified NF-IL6 enhancer site(s) that respond to Mycobacterium tuberculosis or cytokines stimulated by the mycobacterium. Interferon-g activates AM to enhance M. tuberculosis killing and IL-12 promotes the TH1 cytokine response; we evaluate how these cytokines alter the immune response in vivo by BAL. Also, we study the interaction of NF-IL6 with the natural resistance in the AM (Nramp) gene to dissect the genetic control of AM activation.
Research InterestsHuman Alveolar Macrophage Function in Health and Disease; Molecular Mechanisms of Lung Cancer; Molecular Host Response to M tuberculosis; Environmental Health Policy; Asbestos-related diseases
Environmental lung diseases-2015
Rom, William N; Reibman, Joan
2015-06-08; 1098-9048,Seminars in respiratory & critical care medicine - id: 1616472, year: 2015 Journal Article
Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma
Tsay, Jun-Chieh J; Li, Zhiguo; Yie, Ting-An; Wu, Feng; Segal, Leopoldo; Greenberg, Alissa K; Leibert, Eric; Weiden, Michael D; Pass, Harvey; Munger, John; Statnikov, Alexander; Tchou-Wong, Kam-Meng; Rom, William N
2015-03-01; 1932-6203,PLoS one - id: 1473472, year: 2015 Journal Article
Validation of a multiprotein plasma classifier to identify benign lung nodules
Vachani, Anil; Pass, Harvey I; Rom, William N; Midthun, David E; Edell, Eric S; Laviolette, Michel; Li, Xiao-Jun; Fong, Pui-Yee; Hunsucker, Stephen W; Hayward, Clive; Mazzone, Peter J; Madtes, David K; Miller, York E; Walker, Michael G; Shi, Jing; Kearney, Paul; Fang, Kenneth C; Massion, Pierre P
2015-04-23; 1556-1380,Journal of thoracic oncology - id: 1539382, year: 2015 Journal Article
Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of Distal Airway and Blood Biomarkers that Predict FEV1 Decline
Weiden, Michael D; Kwon, Sophia; Caraher, Erin; Berger, Kenneth I; Reibman, Joan; Rom, William N; Prezant, David J; Nolan, Anna
2015-06-01; 1098-9048,Seminars in respiratory & critical care medicine - id: 1603792, year: 2015 Journal Article
Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma
Wikoff, William R; Grapov, Dmitry; Fahrmann, Johannes F; DeFelice, Brian; Rom, William N; Pass, Harvey I; Kim, Kyoungmi; Nguyen, UyenThao; Taylor, Sandra L; Gandara, David R; Kelly, Karen; Fiehn, Oliver; Miyamoto, Suzanne
2015-05-11; 1940-6215,Cancer prevention research (Philadelphia, Pa.) - id: 1568502, year: 2015 Journal Article