Mariano J. Rey, M.D.

Cardiovascular disorders
Mola, Ana; Whiteson, Jonathan H; Rey, Mariano J
Medical aspects of disability : a handbook for the rehabilitation professional New York : Springer, c2011,
— id: 5784, year: 2011, vol: , page: ?, stat: Chapter,

Moderate doses of hGH (0.64 mg/d) improve lipids but not cardiovascular function in GH-deficient adults with normal baseline cardiac function
Newman, Connie B; Frisch, Katalin A; Rosenzweig, Barry; Roubenoff, Ronenn; Rey, Mariano; Kidder, Teresa; Kong, Yuan; Pursnani, Amit; Sedlis, Steven P; Schwartzbard, Arthur; Kleinberg, David L
2011 Jan;96(1):122-132, Journal of clinical endocrinology & metabolism
CONTEXT: Data regarding effects of lower-dose GH on cardiopulmonary function in GH-deficient (GHD) adults are limited. OBJECTIVES: The objective was to assess effects of lower-dose GH on exercise capacity and echocardiographic parameters in GHD adults. DESIGN: The study was a 6-month double-blind, placebo-controlled randomized trial. SETTING: The study was conducted at the General Clinical Research Center. PARTICIPANTS: Thirty hypopituitary adults with GHD were studied. INTERVENTION: Subjects were randomized to recombinant human GH or placebo for 6 months, followed by open-label recombinant human GH for 12 months. MAIN OUTCOME MEASURES: Primary endpoints were exercise duration, maximal oxygen consumption, and left ventricular ejection fraction. Secondary endpoints were echocardiographic indices of systolic and diastolic function, left ventricular mass, lipids, and body composition. RESULTS: In the 6-month double-blind phase, mean GH dose was 0.64 mg/d. Mean IGF-I sd score increased from -4.5 to -1.0. Exercise duration, maximal oxygen consumption, left ventricular ejection fraction, and other echocardiographic parameters were normal at baseline and did not change. GH decreased total and low-density lipoprotein cholesterol by 7.5% (P = 0.016) and 14.7% (P = 0.002) (P = 0.04 vs. placebo). Mean lean body mass increased by 2.2 kg (P = 0.004), fat mass decreased by 1.7 kg (P = 0.21), and percent body fat decreased by 2.5% (P = 0.018), although between-group changes were not significant. CONCLUSIONS: Human GH did not improve exercise performance or echocardiographic parameters or decrease fat mass but significantly decreased total and low-density lipoprotein cholesterol, increased IGF-I, and increased lean body mass. These results indicate that responses to human GH are variable and should be assessed at baseline and during treatment
— id: 138237, year: 2011, vol: 96, page: 122, stat: Journal Article,

The asian american hepatitis B program: building a coalition to address hepatitis B health disparities
Trinh-Shevrin, Chau; Pollack, Henry J; Tsang, Thomas; Park, Jihyun; Ramos, Mary Ruchel; Islam, Nadia; Wang, Su; Chun, Kay; Sim, Shao-Chee; Pong, Perry; Rey, Mariano Jose; Kwon, Simona C
2011 Fall;5(3):261-271, Progress in community health partnerships : research, education, & action
Background: Community coalitions are increasingly recognized as important strategies for addressing health disparities. By providing the opportunity to pool resources, they provide a means to develop and sustain innovative approaches to affect community health. Objectives: This article describes the challenges and lessons learned in building the Asian American Hepatitis B Program (AAHBP) coalition to conduct a community-based participatory research (CBPR) initiative to address hepatitis B (HBV) among New York City Asian-American communities. Methods: Using the stages of coalition development as a framework, a comprehensive assessment of the process of developing and implementing the AAHBP coalition is presented. Lessons Learned: Findings highlight the importance of developing a sound infrastructure and set of processes to foster a greater sense of ownership, shared vision, and investment in the program. Conclusion: Grassroots community organizing and campus-community partnerships can be successfully leveraged to address and prevent a significant health disparity in an underserved and diverse community
— id: 143334, year: 2011, vol: 5, page: 261, stat: Journal Article,

Asian American communities and health : context, research, policy and action
Trihn-Shevrin, Chau; Islam, Nadia Shilpi; Rey, Mariano Jose
San Francisco CA : Jossey-Bass, 2009,
— id: 1794, year: 2009, vol: , page: , stat: ,

Promoting community-based participatory research at the institutional level
Trihn-Shevrin, Chau; Islam, Nadia Shilpi; Rey, Mariano Jose
Asian American communities and health : context, research, policy and action San Francisco CA : Jossey-Bass, 2009,
— id: 4972, year: 2009, vol: , page: ?, stat: Chapter,

Toward a contextual understanding of Asian American health
Trihn-Shevrin, Chau; Islam, Nadia Shilpi; Rey, Mariano Jose
Asian American communities and health : context, research, policy and action San Francisco CA : Jossey-Bass, 2009,
— id: 4971, year: 2009, vol: , page: ?, stat: Chapter,

A socioeconomic analysis of obesity and diabetes in New York City
Wallach, Jonathan B; Rey, Mariano J
2009 Jul;6(3):A108-A108, Preventing chronic disease
— id: 100195, year: 2009, vol: 6, page: A108, stat: Journal Article,

Hepatitis B knowledge, attitudes, and susceptibility in an immigrant Caribbean community
Francois, F; Frederick, J; Joseph, N; John, S; Elysee, G; Rey, M
2008 SEP ;103(9):S134-S134, American journal of gastroenterology
— id: 86596, year: 2008, vol: 103, page: S134, stat: Journal Article,

Using Community-Based Participatory Research as a Guiding Framework for Health Disparities Research Centers
Chau, Trinh-Shevrin; Islam, Nadia; Tandon, Darius; Ho-Asjoe, Henrietta; Rey, Mariano
2007 ;1(2):195-205, Progress in community health partnerships : research, education, & action
There has been growing interest in conducting community-based health research using a participatory approach that involves the active collaboration of academic and community partners to address community-level health concerns. Project EXPORT (Excellence in Partnerships, Outreach, Research, and Training) is a National Center for Minority Health and Health Disparities (NCMHD) initiative focused on understanding and eliminating health disparities for racial and ethnic minorities and medically underserved populations in the United States. The New York University (NYU) Center for the Study of Asian American Health (CSAAH) is 1 of 76 Project EXPORT sites. This paper describes how CSAAH developed partnerships with varied Asian American community stakeholders as a first step in establishing itself as a Project EXPORT center that uses community-based participatory research (CBPR) as its orienting framework. Three guiding principles were followed to develop community-academic partnerships: (1) creating and sustaining multiple partnerships; (2) promoting equity in partnerships; and (3) commitment to action and research. We discuss strategies and action steps taken to put each principle into practice, as well as the successes and challenges we faced in doing so. Developing community-academic partnerships has been essential in our ability to conduct health disparities research in Asian American communities. Approaches and lessons learned from our experience can be applied to other communities conducing health disparities research
— id: 95045, year: 2007, vol: 1, page: 195, stat: Journal Article,

Clinical characteristics of Asian Americans infected with hepatitis B diagnosed by community-based screenings in New York City
Pollack, H; Sherman, A; Tsang, T; Wan, K; Lupatkin, H; Villaneuva, G; Tso, A; Angela, T; Michael, P; Pearl, K; Ruchel, R; Rey, M; Tobias, H
2006 OCT ;44(4):568A-568A, Hepatology
— id: 70934, year: 2006, vol: 44, page: 568A, stat: Journal Article,

An epidemiologic study of hepatitis B virus infection among Asian Americans in New York City
Wan, K; Chen, Y; Tsang, T; Sherman, A; Tso, A; Korenblit, P; Son, S; Poon, E; Ramos, R; Tobias, H; Rey, M; Pollack, H
2006 JUN 1 ;163(11):S252-S252, American journal of epidemiology
— id: 68859, year: 2006, vol: 163, page: S252, stat: Journal Article,

Nomogram for exercise capacity in women
Haas, Francois; Byrne, Nuala M; Rey, Mariano
2005 Nov 24;353(21):2301-2303, New England journal of medicine
— id: 96580, year: 2005, vol: 353, page: 2301, stat: Journal Article,

The effectiveness of different combinations of pulmonary rehabilitation program components - A randomized controlled trial
Norweg, AM; Whiteson, J; Malgady, R; Mola, A; Rey, M
2005 AUG ;128(2):663-672, Chest
Study objectives: To study the short-term and long-term effects of combining activity training or lectures to exercise training on quality of life, functional status, and exercise tolerance. Design: Randomized clinical trial. Setting: Outpatient pulmonary rehabilitation center. Participants: Forty-three outpatients with COPD. Interventions: Patients were randomized to one of three treatment groups: exercise training alone, exercise training plus activity training, and exercise training plus a lecture series. The mean treatment period was 10 weeks. Measurement: The Chronic Respiratory Disease Questionnaire, the modified version of the Pulmonary Functional Status and Dyspnea Questionnaire, and the COPD Self-Efficacy Scale were administered at baseline, and 6, 12, 18, and 24 weeks from the beginning of the rehabilitation program. The 6-min walk test was used to measure exercise tolerance. Results: Benefits of activity training combined with exercise included less dyspnea (p <= 0.04) and fatigue (p <= 0.01), and increased activity involvement (p <= 0.02) and total functional status (p :5 0.02) in the short term compared to comparison treatment groups for comparatively older participants. Compared to the lecture series adjunct, the activity training adjunct resulted in significantly higher gains in total quality of life (p = 0.04) maintained at 24 weeks. Significantly worse emotional function and functional status resulted from the lecture series adjunct in the oldest participants (p <= 0.03). Treatment groups did not differ significantly on exercise tolerance or self-efficacy. Conclusions: Evidence for additional benefits of activity-specific training combined with exercise was found. A behavioral method emphasizing structured controlled breathing and supervised physical activity was statistically significantly more effective than didactic instruction in facilitating additional gains and meeting participants' learning needs
— id: 57687, year: 2005, vol: 128, page: 663, stat: Journal Article,

Cardiovascular Disorders
Rey, Mariano J
Medical aspects of disability : a handbook for the rehabilitation professional New York, NY, US: Springer Publishing Co, 2005,
This chapter provides a comprehensive review of the cardiovascular system and its diseases. For each disease, the author discusses function and disability, treatment and prognosis, and psychological and vocational implications. A list of recommended readings is provided.
— id: 4100, year: 2005, vol: , page: 179, stat: Chapter,

Effects of horticultural therapy on mood and heart rate in patients participating in an inpatient cardiopulmonary rehabilitation program
Wichrowski, Matthew; Whiteson, Jonathan; Haas, Francois; Mola, Ana; Rey, Mariano J
2005 Sep-Oct;25(5):270-274, Journal of cardiopulmonary rehabilitation
PURPOSE: To assess the effects of horticultural therapy (HT) on mood state and heart rate (HR) in patients participating in an inpatient cardiac rehabilitation program. METHODS: Cardiac rehabilitation inpatients (n = 107) participated in the study. The HT group consisted of 59 subjects (34 males, 25 females). The control group, which participated in patient education classes (PECs), consisted of 48 subjects (31 males, 17 females). Both HT sessions and PEC are components of the inpatient rehabilitation program. Each group was evaluated before and after a class in their respective modality. Evaluation consisted of the completion of a Profile of Mood States (POMS) inventory, and an HR obtained by pulse oximetry. RESULTS: Changes in the POMS total mood disturbance (TMD) score and HR between preintervention and postintervention were compared between groups. There was no presession difference in either TMD score (16 +/- 3.6 and 19.0 +/- 3.2, PEC and HT, respectively) or HR (73.5 +/- 2.5 and 79 +/- 1.8, PEC and HT, respectively). Immediately following the intervention, the HT TMD was significantly reduced (post-TMD = 1.6 +/- 3.2, P < .001), while PEC TMD was not significantly changed (TMD = 17.0 +/- 28.5). After intervention, HR fell in HT by 4 +/- 9.6 bpm (P < .001) but was unchanged in PEC. CONCLUSION: These findings indicate that HT improves mood state, suggesting that it may be a useful tool in reducing stress. Therefore, to the extent that stress contributes to coronary heart disease, these findings support the role of HT as an effective component of cardiac rehabilitation
— id: 61846, year: 2005, vol: 25, page: 270, stat: Journal Article,

Medical humanities at New York University School of Medicine: an array of rich programs in diverse settings
Krackov, Sharon K; Levin, Richard I; Catanese, Veronica; Rey, Mariano; Aull, Felice; Blagev, Denitza; Dreyer, Benard; Grieco, Anthony J; Hebert, Cristy; Kalet, Adina; Lipkin, Mack Jr; Lowenstein, Jerome; Ofri, Danielle; Stevens, David
2003 Oct;78(10):977-982, Academic medicine
The New York University School of Medicine has a rich tradition of cultivating programs in medical humanities and professionalism. They are drawn from the departments, centers, students, and faculty in the School of Medicine, have linkages throughout the university, and are interwoven into the fabric and culture of the institution. Some are centrally based in the School of Medicine's deans' office, and others are located in individual departments and receive support from the dean's office. This article describes representative programs for medical students and faculty. Curricular initiatives, the fundamental components of medical students' learning, include a course entitled 'The Physician, Patient, and Society,' a clerkship essay in the Medicine Clerkship, an opportunity for reflection during the medicine clerkship, and a medical humanities elective. In 2002, the Professionalism Initiative was launched to enhance and reflect the values of the medical profession. Its curriculum consists of a series of events that coordinate, particularly, with existing elements of the first-year curriculum (e.g., orientation week, a session during anatomy, a self-assessment workshop, and a peer-assessment workshop). The Master Scholars Program is a group of five, theme-based master societies consisting of faculty and students who share common interests around the society's themes. Programs developed for the societies include colloquia, faculty-led seminars, a mandatory student-mentoring program, and visiting scholars. Finally, the authors describe three high-quality literary publications created at New York University School of Medicine. Each of the initiatives undergoes regular critical examination and reflection that drive future planning
— id: 39038, year: 2003, vol: 78, page: 977, stat: Journal Article,

Mentoring for a new era
Kalet, Adina; Krackov, Sharon; Rey, Mariano
2002 Nov;77(11):1171-1172, Academic medicine
OBJECTIVE: Over the course of their education, medical students must develop an identity that involves a deep understanding of professional principles and the skills to apply these ideals. This task is so important that it cannot be left to informal means and should be cultivated by a structured system that is focused on professionalism. The overall goal of our student-mentoring program is to advance the professional development of our students during the first two years of medical school through regular group meetings with skilled, trained faculty facilitators. DESCRIPTION: We shaped the program to foster meaningful mentoring relationships among students and faculty, facilitate personal reflection, and encourage exploration of larger questions related to professional development. This program has evolved from a model of individual student-faculty pairings that resulted in uneven experiences. It is organized through a new 'Master Scholars Program' (MSP), inaugurated in 2001-2002. The MSP features five theme-based societies composed of students and faculty who share interests in the theme (e.g., bioethics/human rights, health policy/public health, arts/humanities in medicine, biomedical/health sciences, medical informatics/biotechnology). Approximately once per month, eight students and two faculty members from each society meet over lunch for student-led discussions on topics related to their own professional development. In the first session, structured exercises enable students to get to know one another and brainstorm a curriculum for the year. In subsequent sessions, student pairs lead discussions on topics of interest to the group ranging from 'the role of medical professionals in the aftermath of the World Trade Center attacks' to 'balancing careers in medicine with family.' A list of each group's discussion topics is posted on an electronic bulletin board to inform others. Two faculty mentors lead each group to ensure continuity and diversity over the two-year course of their meetings. A total of 57 out of 78 (73%) attended workshops to learn about the program and enhance their facilitation skills. Professional behaviors are explicitly emphasized in the materials outlining expectations of both students and faculty. Students are expected to attend, participate in and lead discussions, be constructive, respectful, and supportive, and accept/act on constructive feedback. Mentors are to facilitate the group's process, and provide feedback and guidance about the students' ideas and passions and the challenges they encounter. The faculty mentors will contribute descriptive material for the dean's letter on each student. We assessed student understanding of the definition of professionalism prior to the mentoring program and will follow up at regular intervals. Formative evaluation of the program includes surveys and focus groups with students and faculty to assess the effectiveness of the group process in accomplishing the stated goals of the program. DISCUSSION: Our medical school has committed resources, and our faculty and students have given thought, energy, and enthusiasm, to our mentoring program. This innovative new model has the potential to deepen and enrich the culture of medicine by providing a forum and skills for students to reflect on their own professional development and interact in a meaningful way with committed and skilled faculty who share similar interests
— id: 36046, year: 2002, vol: 77, page: 1171, stat: Journal Article,

T-Wave alternans during ventricular pacing
Fedor, MC; Chinitz, JS; Holmes, DS; Bernstein, NE; Ruffo, S; Manaris, A; Balch, LJ; Slater, W; Rey, M; Chinitz, LA
2000 FEB ;35(2):145A-145A, Journal of the American College of Cardiology
— id: 54748, year: 2000, vol: 35, page: 145A, stat: Journal Article,

Atrial natriuretic peptide antagonizes endothelin-induced calcium increase and cell contraction in cultured human hepatic stellate cells
Gorbig MN; Gines P; Bataller R; Nicolas JM; Garcia-Ramallo E; Tobias E; Titos E; Rey MJ; Claria J; Arroyo V; Rodes J
1999 Aug;30(2):501-509, Hepatology
Hepatic stellate cells (HSCs) participate in the regulation of hepatic microcirculation and have receptors for many vasoconstrictor factors. It is unknown whether HSCs have receptors for circulating vasodilators such as atrial natriuretic peptide (ANP). This study investigated the presence of ANP receptors in human HSCs and whether ANP antagonizes the effects of endothelin-1 in these cells. ANP receptors were assessed by binding and cross-linking studies, reverse-transcriptase polymerase chain reaction (PCR), and measuring intracellular cyclic guanosine monophosphate concentration. Intracellular calcium concentration ([Ca(2+)](i)) and cell contraction were measured in individual cells loaded with fura-2 using a morphometric method. Binding and cross-linking affinity experiments showed the existence of ANP receptors in human HSCs. PCR products with the expected length were obtained for guanylate cyclase A receptor, the physiological receptor of ANP, both in quiescent and activated human cells. ANP induced a dose-dependent increase in intracellular cyclic guanosine monophosphate concentration and blunted the increase in [Ca(2+)](i) elicited by endothelin-1. Most importantly, ANP markedly reduced cell contraction induced by endothelin-1. HSCs isolated from rats with carbon tetrachloride-induced cirrhosis showed a higher number of ANP receptors compared with HSCs isolated from normal rats, indicating that in vivo activation of HSCs is associated with an up-regulation of ANP receptors. These results indicate that human HSCs have receptors for ANP, the activation of which reduces the effects of endothelin-1 on [Ca(2+)](i) and cell contraction. ANP could participate in regulating the contractility of HSCs by antagonizing the effect of vasoconstrictors
— id: 20495, year: 1999, vol: 30, page: 501, stat: Journal Article,

Birth order is a risk factor for premature coronary events
Mann, DM; Fisher, DC; Chakka, MN; Rey, MJ
1998 MAR ;46(3):201A-201A, Journal of investigative medicine
— id: 53494, year: 1998, vol: 46, page: 201A, stat: Journal Article,

Mitral valve rupture following percutaneous mitral commissurotomy: existence of predictive factors
Le Feuvre C; Bonan R; Rey MJ; Serra A; Leung TK; Petitclerc R; Leclerc Y; Creepeau J; Dyrda I
1995 Jan;16(1):43-48, European heart journal
The purpose of this study was to describe the mechanism and determine predictive factors of mitral valve rupture requiring valve replacement following percutaneous mitral commissurotomy. Of the 350 consecutive patients treated by balloon mitral commissurotomy, the procedure was not completed in 16, and 11 developed acute severe mitral regurgitation requiring valve replacement: seven cases of anterior leaflet rupture, three cases of posterior leaflet rupture and one case of anterior chordal surface. These 27 group I patients were compared to the remaining 323 (group II) in whom the procedure was completed. The 11 excised valves were evaluated by an experienced pathologist. Eight of the 11 patients had an echocardiographic score < 8 (mean score 6.5 +/- 1), no valvular calcification at X-ray and double balloon percutaneous mitral commissurotomy. Microscopy in six patients showed focal fibrous thickening at the site of the rupture but no calcification. One patient developed severe mitral regurgitation due to chordal rupture with an Inoue balloon. The two remaining patients had an echo score of ten and valve calcification on X-ray. Microscopy revealed severe homogeneous chronic rheumatic mitral disease. In one of these two patients, leaflet rupture was related to an 'oversized balloon' (2 x 19 mm + 15 mm). Statistical analysis showed only echo score differences between the two groups (6.9 +/- 1.4 in group I vs 8.2 +/- 1.6 in group II, P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
— id: 20496, year: 1995, vol: 16, page: 43, stat: Journal Article,

CAN QUANTITATIVE STRESS TL-201 IMAGING PREDICT THE INFARCT VESSEL IN MULTIVESSEL CORONARY-ARTERY DISEASE
GLOTZER, TV; WALTUCH, J; SANGER, JJ; REY, M; SLATER, WR
1994 APR ;42(2):A191-A191, Clinical research
— id: 52493, year: 1994, vol: 42, page: A191, stat: Journal Article,

QUANTITATIVE-ANALYSIS OF TL-201 IMAGING PREDICTS RISK OF MYOCARDIAL-INFARCTION
WALTUCH, J; GLOTZER, TV; REY, M; SANGER, JJ; SLATER, WR
1994 APR ;42(2):A191-A191, Clinical research
— id: 52492, year: 1994, vol: 42, page: A191, stat: Journal Article,

Growth rate of primary left atrial myxoma
Rey MJ; Tamm C; Faidutti B; Luthy P; Unger PF
1993 Aug;14(8):1146-1147, European heart journal
— id: 20497, year: 1993, vol: 14, page: 1146, stat: Journal Article,

Echocardiographic diagnosis of left ventricular outflow tract obstruction after mitral valvuloplasty with a flexible Duran ring
Rey MJ; Mercier LA; Castonguay Y
1992 Jan-Feb;5(1):89-92, Journal of the American Society of Echocardiography
We report on a patient in whom left ventricular outflow obstruction developed after mitral valve repair with a flexible Duran ring. This complication has been reported in 4.5% to 21% of patients when a rigid Carpentier ring was used but was thought to be eliminated with the use of flexible rings
— id: 20498, year: 1992, vol: 5, page: 89, stat: Journal Article,

Silent maladie de Roger
Rosenzweig BP; Rey MJ; Williams LB; Kronzon I
1992 Jul;102(1):320-322, Chest
A patient with no cardiac murmur was found to have a ventricular septal defect by Doppler echocardiography yet no evidence of pulmonary or right ventricular hypertension. This array of findings is distinctly unusual and appears to be at odds with the clinical teachings concerning small ventricular septal defects
— id: 13525, year: 1992, vol: 102, page: 320, stat: Journal Article,

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer [published erratum appears in J Clin Oncol 1992 May;10(5):867]
Speyer JL; Green MD; Zeleniuch-Jacquotte A; Wernz JC; Rey M; Sanger J; Kramer E; Ferrans V; Hochster H; Meyers M; et al
1992 Jan;10(1):117-127, Journal of clinical oncology
PURPOSE: To test potential protection by ICRF-187 against cumulative doxorubicin-dose-related cardiac toxicity, we conducted a randomized clinical trial in 150 women with advanced breast cancer. PATIENTS AND METHODS: Patients received fluorouracil (5FU) 500 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2 every 21 days intravenously (IV) (control regimen, 74 patients), or the same regimen preceded by ICRF-187 1,000 mg/m2 IV (experimental regimen, 76 patients). RESULTS: We previously reported that ICRF-187 in this dose and schedule provides cardiac protection and does not substantially alter the noncardiac toxicity or antitumor efficacy of the control regimen. In this updated analysis of the entire patient cohort, we provide additional support for these findings and demonstrate that patients in the ICRF-187 group received more cycles (median, 11) and higher cumulative doses (median, 500 mg/m2) of doxorubicin than patients in the control group (median, nine cycles, P less than .01; and 441 mg/m2, P less than .05). Twenty-six patients in the ICRF-187 group received doxorubicin doses of at least 700 mg/m2, and among them, 11 patients received 1,000 mg/m2 or more. Only three patients in the control group received doxorubicin doses of 700 mg/m2; the maximum dose administered to one patient in this group was 950 mg/m2. ICRF-187 cardiac protection was demonstrated by difference in incidence of clinical congestive heart failure (CHF; two patients in the ICRF-187 group v 20 in the control group; P less than .0001) and by differences in resting left ventricular ejection fraction (LVEF) determined by multigated radionuclide (MUGA) scan from baselines and that required patient removal from study (five patients in the ICRF-187 group had a decrease in LVEF to less than 0.45 or a decrease from the baseline LVEF of 0.20 or more v 32 in the control group; P less than .000001). Among the 30 patients who had an assessable endomyocardial biopsy at cumulative doxorubicin 450 mg/m2, none of 16 in the ICRF-187 group and six of 14 in the control group had a score of 2 (P less than .05). ICRF-187 cardiac protection was observed in patients with and without prior chest-wall radiation or other risk factors for developing doxorubicin cardiac toxicity. CONCLUSION: By protecting against cumulative doxorubicin-induced cardiac toxicity, ICRF-187 permits significantly greater doses of doxorubicin to be administered to patients with greater safety
— id: 13730, year: 1992, vol: 10, page: 117, stat: Journal Article,

EFFECT OF COLLATERAL VESSELS ON EXERCISE TEST-PERFORMANCE IN SEVERE SINGLE VESSEL CORONARY-ARTERY DISEASE
Katz, E; Kaplan, B; Perez, J; Slater, J; Glassman, E; Rey, M; Slater, W
1990 Oct;38(3):A764-A764, Clinical research
— id: 31919, year: 1990, vol: 38, page: A764, stat: Journal Article,

A prospective randomized trial of ICRF-187 for prevention of cumulative doxorubicin-induced cardiac toxicity in women with breast cancer
Speyer JL; Green MD; Sanger J; Zeleniuch-Jacquotte A; Kramer E; Rey M; Wernz JC; Blum RH; Hochester H; Meyers M; et al
1990 Sep;17(2-3):161-163, Cancer treatment reviews
— id: 15688, year: 1990, vol: 17, page: 161, stat: Journal Article,

Late thrombolytic therapy preserves left ventricular function in patients with collateralized total coronary occlusion: primary end point findings of the Second Mount Sinai-New York University Reperfusion Trial
Rentrop KP; Feit F; Sherman W; Stecy P; Hosat S; Cohen M; Rey M; Ambrose J; Nachamie M; Schwartz W; et al.
1989 Jul;14(1):58-64, Journal of the American College of Cardiology
The change in left ventricular ejection fraction from preintervention to predischarge was prospectively assessed in 393 patients with acute myocardial infarction. Within 12 h of symptom onset (mean 6.3 +/- 2.7 h), patients were randomly assigned to a double-blind intracoronary infusion of streptokinase, nitroglycerin, both streptokinase and nitroglycerin or conventional therapy without acute cardiac catheterization. Treatment effects were also assessed in prospectively defined angiographic subsets. There was a significant interaction between streptokinase and nitroglycerin (p less than 0.01), resulting in an increase in ejection fraction of 3.9 percentage units in the combined treatment arm (p less than 0.001). Patients with collateral flow to a totally obstructed infarct-related artery showed a significant improvement over those without collateral flow in the streptokinase (5.4 +/- 2.5%) and streptokinase-nitroglycerin (10.6 +/- 2.7%) arms, but not in the nitroglycerin arm. Time to treatment did not influence the change in ejection fraction. In patients with initial subtotal occlusion, thrombolytic therapy was of no short-term benefit because ejection fraction increased by 6% in all three intervention arms. These findings indicate that relatively late thrombolytic therapy results in significant myocardial salvage in those patients with collateralized total coronary occlusion. This benefit is potentiated by concomitant nitroglycerin therapy
— id: 37091, year: 1989, vol: 14, page: 58, stat: Journal Article,

Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer
Speyer JL; Green MD; Kramer E; Rey M; Sanger J; Ward C; Dubin N; Ferrans V; Stecy P; Zeleniuch-Jacquotte A; et al.
1988 Sep 22;319(12):745-752, New England journal of medicine
Studies in animals suggest that the bispiperazinedione ICRF-187 can prevent the development of dose-related doxorubicin-induced cardiac toxicity. In a randomized trial in 92 women with advanced breast cancer, we compared treatment with fluorouracil, doxorubicin, and cyclophosphamide (FDC), given every 21 days, with the same regimen preceded by administration of ICRF-187 (FDC + ICRF-187). Patients were withdrawn from the study when cardiac toxicity developed or the cancer progressed. The mean cumulative dose of doxorubicin tolerated by patients withdrawn from study was 397.2 mg per square meter of body-surface area in the FDC group and 466.3 mg in the FDC + ICRF-187 group (no significant difference). Eleven patients on the FDC + ICRF-187 arm received cumulative doxorubicin doses above 600 mg per square meter, whereas one receiving FDC was able to remain in the study beyond this dose. Antitumor response rates were similar (FDC vs. FDC + ICRF-187, 3 vs. 4 complete responses; 17 vs. 17 partial responses; and 9.3 vs. 10.3 months to disease progression). Although myelosuppression was slightly greater in the FDC + ICRF-187 group, the incidence of fever, infections, alopecia, nausea and vomiting, or death due to toxicity did not differ between the groups. Cardiac toxicity was evaluated by clinical examination, determination of the left ventricular ejection fraction by multigated nuclear scans, and endomyocardial biopsy. In comparisons of the FDC group with the FDC + ICRF-187 group, clinical congestive heart failure was observed in 11 as compared with 2 patients; the mean decrease in the left ventricular ejection fraction was 7 vs. 1 percent when the cumulative dose of doxorubicin was 250 to 399 mg per square meter (P = 0.02), 16 vs. 1 percent at 400 to 499 mg (P = 0.001), and 16 vs. 3 percent at 500 to 599 mg (P = 0.003); and the Billingham biopsy score was 2 or more in 5 of 13 patients undergoing biopsy vs. none of 13 (P = 0.03). We conclude that ICRF-187 offers significant protection against cardiac toxicity caused by doxorubicin, without affecting the antitumor effect of doxorubicin or the incidence of noncardiac toxic reactions
— id: 34756, year: 1988, vol: 319, page: 745, stat: Journal Article,

ST SEGMENT DEPRESSION MANIFESTED ONLY IN THE POST EXERCISE PERIOD AS AN INDICATOR OF CORONARY-ARTERY DISEASE
Fox, SN; Reitano, JM; Rey, MJ; Goodfield, P; Feit, F; Stecy, PJ; Rubler, S
1987 Apr;35(3):A278-A278, Clinical research
— id: 31363, year: 1987, vol: 35, page: A278, stat: Journal Article,

A RANDOMIZED TRIAL OF ICRF-187 TO REDUCE DOXORUBICIN (DOX) CARDIOMYOPATHY - COMPARATIVE ACUTE TOXICITIES
Green, MD; Speyer, JL; Stecy, P; Rey, M; Kramer, E; Sanger, J; Ward, C; London, C; Blum, R; Wernz, J; Rohde, J; Muggia, FM
1987 May;5(1):117-117, Investigational new drugs
— id: 31182, year: 1987, vol: 5, page: 117, stat: Journal Article,

CORRELATION OF LEFT-VENTRICULAR FUNCTION AND ELECTROCARDIOGRAPHY AFTER MYOCARDIAL REPERFUSION
SHERMAN, W; REY, M; FEIT, F; STECY, P; SANGER, J; HOROWITZ, S; FAGERSTROM, R; HOLT, J; RENTROP, P
1986 OCT ;74(4):479-479, Circulation
— id: 41340, year: 1986, vol: 74, page: 479, stat: Journal Article,

A NEW TEST FOR THE EARLY DETECTION OF CARDIAC ABNORMALITIES IN BETA-THALASSEMIA MAJOR - THALLIUM SCINTIGRAPHY
Rey, M; Goodfield, P; Sanger, J; Rutkowski, M
1985 ;72(4):95-95, Circulation
— id: 30721, year: 1985, vol: 72, page: 95, stat: Journal Article,

Effects of intracoronary streptokinase and intracoronary nitroglycerin infusion on coronary angiographic patterns and mortality in patients with acute myocardial infarction
Rentrop KP; Feit F; Blanke H; Stecy P; Schneider R; Rey M; Horowitz S; Goldman M; Karsch K; Meilman H; Fox AC; et al.
1984 Dec 6;311(23):1457-1463, New England journal of medicine
We randomly assigned patients with a clinical diagnosis of acute myocardial infarction to one of four treatment groups: intracoronary streptokinase, intracoronary nitroglycerin, intracoronary streptokinase and intracoronary nitroglycerin, or conventional therapy without initial angiography. Of 124 patients 122 sustained acute myocardial infarction. Initial angiography revealed total occlusion of the coronary artery responsible for infarction in 67 per cent (61 of 91). Acute recanalization occurred in 74 per cent (32 of 43) of patients receiving streptokinase but in only 6 per cent (1 of 18) of patients treated with nitroglycerin alone (P less than 0.01). At angiography of all four groups on Day 10 to 14 the vessel responsible for acute myocardial infarction was patent in 77 per cent (71 of 92) of patients; there was no difference among groups, indicating gradual, endogenous thrombolysis in patients not treated with streptokinase. Patients with subtotal obstruction initially had significant improvement in left ventricular function, significantly lower peak creatine kinase levels, and a trend toward lower mortality than patients with total occlusion initially. Mortality at six months in patients receiving streptokinase (21 per cent, 13 of 62) did not differ significantly from that in patients not treated with streptokinase (10 per cent, 6 of 61). Additional studies will be necessary to assess treatment effects in the angiographic subsets identified by this trial
— id: 32402, year: 1984, vol: 311, page: 1457, stat: Journal Article,

Nucleotide sequence of the gene for heat-stable enterotoxin II of Escherichia coli
Picken, R N; Mazaitis, A J; Maas, W K; Rey, M; Heyneker, H
1983 Oct;42(1):269-275, Infection & immunity
Previously, the gene for heat-stable enterotoxin II (STII) has been mapped by transposon Tn5 insertion mutagenesis in the chimeric R-Ent plasmid pCG86 (Mazaitis, A. J., R. Maas, and W. K. Maas, J. Bacteriol. 145:97-105, 1981). DNA segments containing this gene were cloned from the wild-type and STII-insertion-mutant plasmid. The position of the Tn5 insertion was determined, and a 530-base-pair-long segment of the wild-type plasmid corresponding to the Tn5 insertion site was sequenced. An open reading frame for the STII gene was identified and is characterized by typical promoter and ribosome binding site sequences. The deduced STII structural gene codes for a protein 71 amino acids long, including a typical signal peptide of 23 amino acids and a mature protein of 48 amino acids. The size and overall structure of STII are similar to those of STI, but the amino acid compositions of the two heat-stable enterotoxins are completely different
— id: 77955, year: 1983, vol: 42, page: 269, stat: Journal Article,

LATE VENTRICULAR ECTOPY IN THE MT-SINAI-NYU MYOCARDIAL INFARCT REPERFUSION TRIAL
REY, M; SIEGEL, S; FEIT, F; NACHAMIE, M; EHRICH, M; STECY, P; BLANKE, H; SCHNEIDER, R; RENTROP, P
1983 ;68(4):410-410, Circulation
— id: 40627, year: 1983, vol: 68, page: 410, stat: Journal Article,