Biosketch / Results /

Qingshan Qu, M.D.

Research Associate Professor;
Department of Environmental Medicine

Contact Info

Address
57 Old Forge Road
Floor 2 Room 273A
Sterling Forest
Tuxedo, NY 10987

845-731-3567
845-351-5472
Qingshan.Qu@nyumc.org

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Education

1969-1973 — Third Teaching Hospital of Beijing Medical College, Residency

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Research Summary

<br><P><br>Dr. Qu''s research interests have been mainly focused on: 1) biomarker application and risk assessment in human populations exposed to occupational or environmental pollutants; and 2) identification of genetic susceptibility factors in human diseases with environmental origins. Previous studies have shown that both urinary S-phenylmercapturic acid (S-PMA) and t,t-muconic acid, especially S-PMA, are the most sensitive and reliable exposure markers for low level benzene exposure in workers. In addition, the genotypes of CYP2E1, NQO1, MPO, and GSTT1 genes were identified in all recruited subjects, including both healthy benzene exposed and poisoned workers. The healthy exposed workers with NQO1 variant alleles showed significantly lower WBC and neutrophil counts than those who have homozygous wild type alleles, especially after adjusting for smoking, gender, and benzene exposure. Comparison between healthy exposed and poisoned workers further confirmed the finding that variant alleles of NQO1 gene may make people more susceptible to benzene-associated hematotoxicity. One of the ongoing projects has been conducted in a Chinese occupational population to validate the biomarkers of polycyclic aromatic hydrocarbons (PAHs) exposure, including 1-hydroxypyrene (1-OH-P) in urine, DNA adducts, DNA damage detected by comet assay in lymphocytes, albumin adducts of PAHs metabolites, and identification of polymorphisms of metabolic genes, such as CYP1A1, GSTM1, microsomal epoxide hydrolase (mEH). Another newly funded project focuses on the biomarker applications and risk assessment for Cr(VI) in humans with broad range of exposures to chromium. In this study, The Cr levels in erythrocytes, lymphocytes, DNA-protein crosslinks, DNA damage detected by comet assay in lymphocytes, and 8-hydroxy-2!?-deoxyguanosine are being measured and evaluated as both exposure and biological effect markers.<br><P><br><br><br><br><P><br><br><br><br><br><br>Representative <br>

Research Interests

Pulmonary toxicology; Biomarker application and risk assessment<br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells
Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan; Chen, Lung Chi
2014 Aug;26(10):588-597, Inhalation toxicology
— id: 1161512, year: 2014, vol: 26, page: 588, stat: Journal Article,

Regulation of microRNA expression in the lungs by exposure to air pollution & antigen
Lucas, B; Chen, W -C; Bleck, B; Reibman, J; Rom, W; Narayanan, N; Qu, Q; Park, S -H; Grunig, G
2014 01 May 2014;192(1):-, Journal of immunology (1950)
— id: 1058342, year: 2014, vol: 192, page: , stat: Journal Article,

The Environment and Children's Health Care in Northwest China
Trasande, Leonardo; Niu, Jingping; Li, Juansheng; Liu, Xingrong; Zhang, Benzhong; Li, Zhilan; Ding, Guowu; Sun, Yingbiao; Chen, Meichi; Hu, Xiaobin; Chen, Lung-Chi; Mendelsohn, Alan; Chen, Yu; Qu, Qingshan
2014 ;14:82-82, BMC pediatrics
— id: 867162, year: 2014, vol: 14, page: 82, stat: Journal Article,

Gene expression profiles in peripheral blood mononuclear cells of chinese nickel refinery workers with high exposures to nickel and control subjects
Arita, Adriana; Munoz, Alexandra; Chervona, Yana; Niu, Jingping; Qu, Qingshan; Zhao, Najuan; Ruan, Ye; Kiok, Kathrin; Kluz, Thomas; Sun, Hong; Clancy, Hailey A; Shamy, Magdy; Costa, Max
2013 Feb;22(2):261-269, Cancer epidemiology biomarkers & prevention
— id: 217832, year: 2013, vol: 22, page: 261, stat: Journal Article,

The Role of Metal Components in the Cardiovascular Effects of PM2.5
Niu, Jingping; Liberda, Eric N; Qu, Song; Guo, Xinbiao; Li, Xiaomei; Zhang, Jingjing; Meng, Junliang; Yan, Bing; Li, Nairong; Zhong, Mianhua; Ito, Kazuhiko; Wildman, Rachel; Liu, Hong; Chen, Lung Chi; Qu, Qingshan
2013 ;8(12):e83782-e83782 e83782, PLoS one
— id: 741052, year: 2013, vol: 8, page: e83782, stat: Journal Article,

Plasma Anti-Glycan Antibody Profiles Associated with Nickel level in Urine
Vuskovic, Marko; Barbuti, Anna-Maria; Goldsmith-Rooney, Emma; Glassman, Laura; Bovin, Nicolai; Pass, Harvey; Tchou-Wong, Kam-Meng; Chen, Meichi; Yan, Bing; Niu, Jingping; Qu, Qingshan; Costa, Max; Huflejt, Margaret
2013 Dec;6(12):302-312, Journal of proteomics & bioinformatics
— id: 899372, year: 2013, vol: 6, page: 302, stat: Journal Article,

Global Levels of Histone Modifications in Peripheral Blood Mononuclear Cells of Subjects with Exposure to Nickel
Arita A; Niu J; Qu Q; Zhao N; Ruan Y; Nadas A; Chervona Y; Wu F; Sun H; Hayes RB; Costa M
2012 Feb;120(2):198-203, Environmental health perspectives
— id: 141421, year: 2012, vol: 120, page: 198, stat: Journal Article,

The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects
Arita, Adriana; Shamy, Magdy Y; Chervona, Yana; Clancy, Harriet A; Sun, Hong; Hall, Megan N; Qu, Qingshan; Gamble, Mary V; Costa, Max
2012 Jun;26(2-3):174-178, Journal of trace elements in medicine & biology
— id: 169480, year: 2012, vol: 26, page: 174, stat: Journal Article,

Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008
Xu, Xiaohua; Deng, Furong; Guo, Xinbiao; Lv, Peng; Zhong, Mianhua; Liu, Cuiqing; Wang, Aixia; Tzan, Kevin; Jiang, Silis Y; Lippmann, Morton; Rajagopalan, Sanjay; Qu, Qingshan; Chen, Lung-Chi; Sun, Qinghua
2012 Jul;212(2):147-156, Toxicology letters
— id: 173080, year: 2012, vol: 212, page: 147, stat: Journal Article,

Nickel and Disrupted Endothelial Integrity: Implications to PM2.5-associated Cardiovascular Disorders
Niu, Jingping; Qu, Song; Guo, Xinbiao; Li, Xiaomei; Luo, Bin; Zhang, Liying; Ito, Kazuhiko; Wildman, Rachel; Chen, Lung-Chi; Qu, Qingshan
2011 JAN ;22(1):S79-S79, Epidemiology
— id: 124131, year: 2011, vol: 22, page: S79, stat: Journal Article,

Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells
Liberda, Eric N; Cuevas, Azita K; Gillespie, Patricia A; Grunig, Gabriele; Qu, Qingshan; Chen, Lung Chi
2010 Dec;22 Suppl 2:95-99, Inhalation toxicology
— id: 138256, year: 2010, vol: 22 Suppl 2, page: 95, stat: Journal Article,

In vitro assessment of the inflammatory response of respiratory endothelial cells exposed to particulate matter
Qu, Song; Liberda, Eric N; Qu, Qingshan; Chen, Lung-Chi
2010 Jan;73(16):1113-1121, Journal of toxicology & environmental health. Pt. A
— id: 111619, year: 2010, vol: 73, page: 1113, stat: Journal Article,

210Pb: A Predictive Biomarker of Retrospective Cigarette Smoke Exposure
Schayer, Stephen R; Qu, Qingshan; Wang, Yanling; Cohen, Beverly S
2010 Feb;19(2):338-350, Cancer epidemiology biomarkers & prevention
— id: 106598, year: 2010, vol: 19, page: 338, stat: Journal Article,

Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust
Wang, Shang; Prophete, Colette; Soukup, Joleen M; Chen, Lung-Chi; Costa, Max; Ghio, Andrew; Qu, Qingshan; Cohen, Mitchell D; Chen, Haobin
2010 Oct-Dec;7(4):298-307, Journal of immunotoxicology
— id: 138258, year: 2010, vol: 7, page: 298, stat: Journal Article,

210Po and 210Pb activity in Chinese cigarettes
Schayer, Stephen; Nowak, Barbara; Wang, Yanling; Qu, Qingshan; Cohen, Beverly
2009 May;96(5):543-549, Health physics
— id: 97961, year: 2009, vol: 96, page: 543, stat: Journal Article,

PAH-DNA adducts in a Chinese population: relationship to PAH exposure, smoking and polymorphisms of metabolic and DNA repair genes
Hu, Yu; Li, Gang; Xue, Xiaonan; Zhou, Zongcan; Li, Xiaomei; Fu, Juanling; Cohen, Beverly; Roy, Nirmal; Li, Donghui; Sun, Jianya; Nan, Peihong; Tang, Moon-Shong; Qu, Qingshan
2008 Feb;13(1):27-40, Biomarkers
— id: 79241, year: 2008, vol: 13, page: 27, stat: Journal Article,

CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins
Qu, Qingshan; Li, Xiaomei; An, Feiyun; Jia, Guang; Liu, Lanzeng; Watanabe-Meserve, Hiroko; Koenig, Karen; Cohen, Beverly; Costa, Max; Roy, Nirmal; Zhong, Mianhua; Chen, Lung Chi; Liu, Suhua; Yan, Lei
2008 Aug;13(5):467-477, Biomarkers
— id: 93384, year: 2008, vol: 13, page: 467, stat: Journal Article,

Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells
Ouyang, Weiming; Hu, Yu; Li, Jingxia; Ding, Min; Lu, Yongju; Zhang, Dongyun; Yan, Yan; Song, Lun; Qu, Qingshan; Desai, Dhimant; Amin, Shantu; Huang, Chuanshu
2007 Oct;28(10):2218-2226, Carcinogenesis
— id: 75360, year: 2007, vol: 28, page: 2218, stat: Journal Article,

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure
Hu, Y; Zhou, Z; Xue, X; Li, X; Fu, J; Cohen, B; Melikian, A A; Desai, M; Tang, M -S; Huang, X; Roy, N; Sun, J; Nan, P; Qu, Q
2006 Jul-Aug;11(4):306-318, Biomarkers
— id: 68305, year: 2006, vol: 11, page: 306, stat: Journal Article,

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells
Yan, Yan; Li, Jingxia; Ouyang, Weiming; Ma, Qian; Hu, Yu; Zhang, Dongyun; Ding, Jin; Qu, Qingshan; Subbaramaiah, Kotha; Huang, Chuanshu
2006 Jul 15;119(Pt 14):2985-2994, Journal of cell science
— id: 110428, year: 2006, vol: 119, page: 2985, stat: Journal Article,

Biomarkers of benzene: Urinary metabolites in relation to individual genotype and personal exposure
Qu, Qingshan; Shore, Roy; Li, Guilan; Su, Lin; Jin, Ximei; Melikian, Asseih A; Roy, Nirmal; Chen, Lung Chi; Wirgin, Isaac; Cohen, Beverly; Yin, Songnian; Li, Yuying; Mu, Ruidong
2005 May 30;153-154:85-95, Chemico-biological interactions
— id: 56002, year: 2005, vol: 153-154, page: 85, stat: Journal Article,

Protein adducts as biomarkers of human benzene metabolism
Rappaport, Stephen M; Waidyanatha, Suramya; Yeowell-O'Connell, Karen; Rothman, Nathaniel; Smith, Martyn T; Zhang, Luoping; Qu, Qingshan; Shore, Roy; Li, Guilan; Yin, Songnian
2005 May 30;153-154:103-109, Chemico-biological interactions
— id: 72193, year: 2005, vol: 153-154, page: 103, stat: Journal Article,

Validation of biomarkers in humans exposed to PAHs
Qu, Q; Hu, Y; Xue, X; Zhou, Z; Li, X; Fu, J; Cohen, B; Tang, E; Roy, N; Melikian, AA; Li, D
2004 JUN 15 ;197(3):187-188, Toxicology & applied pharmacology
— id: 46527, year: 2004, vol: 197, page: 187, stat: Journal Article,

Benzene exposure measurement in shoe and glue manufacturing: a study to validate biomarkers
Qu, Qingshan; Cohen, Beverly S; Shore, Roy; Chen, Lung Chi; Li, Guilan; Jin, Ximei; Melikian, Assieh A; Yin, Songnian; Yan, Huifang; Xu, Bohong; Li, Yuying; Mu, Ruidong; Zhang, Xiaoling; Li, Keqi
2003 Dec;18(12):988-998, Applied occupational & environmental hygiene
— id: 38997, year: 2003, vol: 18, page: 988, stat: Journal Article,

Validation and evaluation of biomarkers in workers exposed to benzene in China
Qu, Qingshan; Shore, Roy; Li, Guilan; Jin, Ximei; Chen, Lung Chi; Cohen, Beverly; Melikian, Assieh A; Eastmond, David; Rappaport, Stephen; Li, Heyi; Rupa, Doppalapudi; Waidyanatha, Suramya; Yin, Songnian; Yan, Huifang; Meng, Min; Winnik, Witold; Kwok, Eric S C; Li, Yuying; Mu, Ruidong; Xu, Bohong; Zhang, Xiaoling; Li, Keqi
2003 Jun;23(115):1-72; discussion 73, Research report (Health Effects Institute)
— id: 39100, year: 2003, vol: 23, page: 1, stat: Journal Article,

Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid
Melikian, Assieh A; Qu, Qingshan; Shore, Roy; Li, Guilan; Li, Heyi; Jin, Ximei; Cohen, Beverly; Chen, Lungchi; Li, Yuying; Yin, Songnian; Mu, Reidong; Zhang, Xiaoling; Wang, Yuanxiang
2002 Oct 5;778(1-2):211-221, Journal of chromatography. B. Analytical technologies in the biomedical & life sciences
— id: 34386, year: 2002, vol: 778, page: 211, stat: Journal Article,

Hematological changes among Chinese workers with a broad range of benzene exposures
Qu, Qingshan; Shore, Roy; Li, Guilan; Jin, Ximei; Chen, Lung Chi; Cohen, Beverly; Melikian, Assieh A; Eastmond, David; Rappaport, Stephen M; Yin, Songnian; Li, Heyi; Waidyanatha, Suramya; Li, Yuying; Mu, Ruidong; Zhang, Xiaoling; Li, Keqi
2002 Oct;42(4):275-285, American journal of industrial medicine
— id: 34387, year: 2002, vol: 42, page: 275, stat: Journal Article,

Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism
Rappaport, Stephen M; Waidyanatha, Suramya; Qu, Qingshan; Shore, Roy; Jin, Ximei; Cohen, Beverly; Chen, Lung-Chi; Melikian, Assieh A; Li, Guilan; Yin, Songnian; Yan, Huifang; Xu, Bohong; Mu, Ruidong; Li, Yuying; Zhang, Xiaoling; Li, Keqi
2002 Mar 1;62(5):1330-1337, Cancer research
— id: 34388, year: 2002, vol: 62, page: 1330, stat: Journal Article,

Validation of biomarkers in humans exposed to benzene: urine metabolites
Qu Q; Melikian AA; Li G; Shore R; Chen L; Cohen B; Yin S; Kagan MR; Li H; Meng M; Jin X; Winnik W; Li Y; Mu R; Li K
2000 May;37:522-531, American journal of industrial medicine
— id: 10349, year: 2000, vol: 37, page: 522, stat: Journal Article,

Ozone inactivates cyclooxygenase in human tracheal epithelial cells without altering PGHS-2 mRNA or protein
Alpert, S E; Walenga, R W; Jaspers, I; Qu, Q; Chen, L C
1997 May;272(5 Pt 1):L879-L887, American journal of physiology
— id: 72461, year: 1997, vol: 272, page: L879, stat: Journal Article,

Formation of intracellular free radicals in guinea pig airway epithelium during in vitro exposure to ozone
Chen LC; Qu Q
1997 Mar;143(1):96-101, Toxicology & applied pharmacology
— id: 12371, year: 1997, vol: 143, page: 96, stat: Journal Article,

The role of ferrous sulfate in coal dust induced lung injury
Chen LC; Huang X; Wu CY; Zalma R; Perzerat H; Qu QS
1996 ;11:973-979, Applied occupational & environmental hygiene
— id: 72668, year: 1996, vol: 11, page: 973, stat: Journal Article,

Respiratory effects of kerosene space heater emissions
Chen, LC; Qu, QS; Gordon, T
1996 JAN ;8(1):49-64, Inhalation toxicology
— id: 53093, year: 1996, vol: 8, page: 49, stat: Journal Article,

Vanadium affects macrophage interferon-gamma-binding and -inducible responses
Cohen MD; McManus TP; Yang Z; Qu Q; Schlesinger RB; Zelikoff JT
1996 May;138(1):110-120, Toxicology & applied pharmacology
— id: 6988, year: 1996, vol: 138, page: 110, stat: Journal Article,

Effects of ozone upon macrophage-interferon interactions
Cohen MD; Zelikoff JT; Qu Q; Schlesinger RB
1996 Dec 18;114(3):243-252, Toxicology
— id: 10366, year: 1996, vol: 114, page: 243, stat: Journal Article,

Alteration of pulmonary macrophage intracellular pH following inhalation exposure to sulfuric acid/ozone mixtures
Chen LC; Qu Q; Amdur MO; Schlesinger RB
1995 Jan-Feb;21(1):113-128, Experimental lung research
— id: 6593, year: 1995, vol: 21, page: 113, stat: Journal Article,

NUMBER CONCENTRATION AND MASS CONCENTRATION AS DETERMINANTS OF BIOLOGICAL RESPONSE TO INHALED IRRITANT PARTICLES
CHEN, LC; WU, CY; QU, QS; SCHLESINGER, RB
1995 JUL ;7(5):577-588, Inhalation toxicology
— id: 87250, year: 1995, vol: 7, page: 577, stat: Journal Article,

Modulation of Ca2+ influx by a mediator released from human tracheal epithelial cells exposed to ozone in vitro
Qu QS; Chen LC
1995 Apr;268(4 Pt 1):L558-L564, American journal of physiology. Lung cellular & molecular physiology
— id: 6719, year: 1995, vol: 268, page: L558, stat: Journal Article,

Exposure of workers to a mixture of toluene and xylenes. I. Metabolism
Huang, M Y; Jin, C; Liu, Y T; Li, B H; Qu, Q S; Uchida, Y; Inoue, O; Nakatsuka, H; Watanabe, T; Ikeda, M
1994 Jan;51(1):42-46, Occupational & environmental medicine
— id: 105307, year: 1994, vol: 51, page: 42, stat: Journal Article,

EFFECT OF IN-VITRO OZONE EXPOSURE ON INTRACELLULAR PH AND FREE CA2+ IN HUMAN TRACHEAL EPITHELIAL-CELLS
QU, QS; CHEN, LC
1994 MAR 18 ;8(5):A897-A897, FASEB journal
— id: 52521, year: 1994, vol: 8, page: A897, stat: Journal Article,

A novel system for the in vitro exposure of pulmonary cells to acid sulfate aerosols
Chen LC; Fang CP; Qu QS; Fine JM; Schlesinger RB
1993 Feb;20(2):170-176, Fundamental & applied toxicology
— id: 8209, year: 1993, vol: 20, page: 170, stat: Journal Article,

Excretion of methylhippuric acids in urine of workers exposed to a xylene mixture: comparison among three xylene isomers and toluene
Inoue, O; Seiji, K; Kawai, T; Watanabe, T; Jin, C; Cai, S X; Chen, Z; Qu, Q S; Zhang, T; Ikeda, M
1993 ;64(7):533-539, International archives of occupational & environmental health
— id: 109034, year: 1993, vol: 64, page: 533, stat: Journal Article,