Biosketch / Results /

Qingshan Qu

Research Associate Professor, Department of Environmental Medicine
Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845/731-3567
Qingshan.Qu@nyumc.org

Education

1969-1973 — Third Teaching Hospital of Beijing Medical College, Residency

Research Summary



Dr. Qu''s research interests have been mainly focused on: 1) biomarker application and risk assessment in human populations exposed to occupational or environmental pollutants; and 2) identification of genetic susceptibility factors in human diseases with environmental origins. Previous studies have shown that both urinary S-phenylmercapturic acid (S-PMA) and t,t-muconic acid, especially S-PMA, are the most sensitive and reliable exposure markers for low level benzene exposure in workers. In addition, the genotypes of CYP2E1, NQO1, MPO, and GSTT1 genes were identified in all recruited subjects, including both healthy benzene exposed and poisoned workers. The healthy exposed workers with NQO1 variant alleles showed significantly lower WBC and neutrophil counts than those who have homozygous wild type alleles, especially after adjusting for smoking, gender, and benzene exposure. Comparison between healthy exposed and poisoned workers further confirmed the finding that variant alleles of NQO1 gene may make people more susceptible to benzene-associated hematotoxicity. One of the ongoing projects has been conducted in a Chinese occupational population to validate the biomarkers of polycyclic aromatic hydrocarbons (PAHs) exposure, including 1-hydroxypyrene (1-OH-P) in urine, DNA adducts, DNA damage detected by comet assay in lymphocytes, albumin adducts of PAHs metabolites, and identification of polymorphisms of metabolic genes, such as CYP1A1, GSTM1, microsomal epoxide hydrolase (mEH). Another newly funded project focuses on the biomarker applications and risk assessment for Cr(VI) in humans with broad range of exposures to chromium. In this study, The Cr levels in erythrocytes, lymphocytes, DNA-protein crosslinks, DNA damage detected by comet assay in lymphocytes, and 8-hydroxy-2!?-deoxyguanosine are being measured and evaluated as both exposure and biological effect markers.











Representative

Research Interests

Pulmonary toxicology; Biomarker application and risk assessment

The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells
Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan; Chen, Lung Chi
2014-09-01; 0895-8378,Inhalation toxicology - id: 1161512, year: 2014 Journal Article

Regulation of microRNA expression in the lungs by exposure to air pollution & antigen
Lucas, B; Chen, W -C; Bleck, B; Reibman, J; Rom, W; Narayanan, N; Qu, Q; Park, S -H; Grunig, G
2014-07-02; 0022-1767,Journal of immunology (1950) - id: 1058342, year: 2014

The Environment and Children's Health Care in Northwest China
Trasande, Leonardo; Niu, Jingping; Li, Juansheng; Liu, Xingrong; Zhang, Benzhong; Li, Zhilan; Ding, Guowu; Sun, Yingbiao; Chen, Meichi; Hu, Xiaobin; Chen, Lung-Chi; Mendelsohn, Alan; Chen, Yu; Qu, Qingshan
2014-04-07; 1471-2431,BMC pediatrics - id: 867162, year: 2014 Journal Article; Research Support, N.I.H., Extramural

Gene expression profiles in peripheral blood mononuclear cells of chinese nickel refinery workers with high exposures to nickel and control subjects
Arita, Adriana; Munoz, Alexandra; Chervona, Yana; Niu, Jingping; Qu, Qingshan; Zhao, Najuan; Ruan, Ye; Kiok, Kathrin; Kluz, Thomas; Sun, Hong; Clancy, Hailey A; Shamy, Magdy; Costa, Max
2013-02-11; 1055-9965,Cancer epidemiology biomarkers & prevention - id: 217832, year: 2013 Journal Article

The Role of Metal Components in the Cardiovascular Effects of PM2.5
Niu, Jingping; Liberda, Eric N; Qu, Song; Guo, Xinbiao; Li, Xiaomei; Zhang, Jingjing; Meng, Junliang; Yan, Bing; Li, Nairong; Zhong, Mianhua; Ito, Kazuhiko; Wildman, Rachel; Liu, Hong; Chen, Lung Chi; Qu, Qingshan
2014-01-20; 1932-6203,PLoS one - id: 741052, year: 2013 Journal Article