Biosketch / Results /
Fabio PonzoAssistant Professor, Department of Radiology
NYU Radiology Associates
Education— Univ Di Roma La Sapienza|, Residency Training
— Graduate Hospital, Internship
— University of Pennsylvania, Residency Training
— Univ Di Roma La Sapienza, Medical Education
Research SummaryFluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) is an established imaging technique widely used to differentiate between malignant and benign lesions based on the increased metabolic activity of most tumor cells. FDG-uptake is not a tumor specific process and multiple inflammatory diseases have been reported to give a positive signal.
At present, literature on the evaluation of sarcoidosis using FDG PET has been mostly anecdotal. FDG-PET has been evaluated in patients with sarcoidosis. It has been showed that FDG uptake is increased in areas of ongoing inflammation and it has been suggested that FDG-PET may be of significant clinical use in the assessment and management of sarcoidosis. However, only two small series of patients have been evaluated to present.
It has been also suggested that the degree of active ongoing inflammation may be a predictor for response to therapy. However, currently there are no diagnostic tools to determine the degree of inflammatory activity except for surgical lung biopsy.
PET scanning may be useful to determine disease activity and may be useful as a guide for lung biopsy. PET scanning may also give a quantitative measure of the degree of inflammation in the rest of the body and may be useful to predict and assess therapy response.
Research InterestsPET imaging in oncology and inflammatory condition (with focus on lung inflammations). PET imaging for cardiac function and viability
Utility of whole body PET-MRI using FDG, NAF and DWI in evaluating metastatic and primary bone malignancies
Beltran, L; Ponzo, F. Utility of whole body PET-MRI using FDG, NAF and DWI in evaluating metastatic and primary bone malignancies [Meeting Abstract]. Skeletal radiology. 2016 August 2016;45(8):1158-1159 (2204902)
Standardized Uptake Values from PET/MRI in Metastatic Breast Cancer: An Organ-based Comparison With PET/CT
Pujara, Akshat C; Raad, Roy A; Ponzo, Fabio; Wassong, Carolyn; Babb, James S; Moy, Linda; Melsaether, Amy N. Standardized Uptake Values from PET/MRI in Metastatic Breast Cancer: An Organ-based Comparison With PET/CT. Breast journal. 2016 Feb 4;22(3):264-273 (1933142)
Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
Golden, Encouse B; Chhabra, Arpit; Chachoua, Abraham; Adams, Sylvia; Donach, Martin; Fenton-Kerimian, Maria; Friedman, Kent; Ponzo, Fabio; Babb, James S; Goldberg, Judith; Demaria, Sandra; Formenti, Silvia C. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet oncology. 2015 Jun 18;16(7):795-803 (1640742)
PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations
Heacock, Laura; Weissbrot, Joseph; Raad, Roy; Campbell, Naomi; Friedman, Kent P; Ponzo, Fabio; Chandarana, Hersh. PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations. American journal of roentgenology (1976). 2015 Apr ;204(4):842-848 (1506542)
Outcome of small lung nodules missed on hybrid PET/MRI in patients with primary malignancy
Raad, Roy A; Friedman, Kent P; Heacock, Laura; Ponzo, Fabio; Melsaether, Amy; Chandarana, Hersh. Outcome of small lung nodules missed on hybrid PET/MRI in patients with primary malignancy. Journal of magnetic resonance imaging. 2015 Jul 20;43(2):504-511 (1683732)