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Fabio PonzoAssistant Professor, Department of Radiology
NYU Radiology Associates
Research SummaryFluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) is an established imaging technique widely used to differentiate between malignant and benign lesions based on the increased metabolic activity of most tumor cells. FDG-uptake is not a tumor specific process and multiple inflammatory diseases have been reported to give a positive signal.
At present, literature on the evaluation of sarcoidosis using FDG PET has been mostly anecdotal. FDG-PET has been evaluated in patients with sarcoidosis. It has been showed that FDG uptake is increased in areas of ongoing inflammation and it has been suggested that FDG-PET may be of significant clinical use in the assessment and management of sarcoidosis. However, only two small series of patients have been evaluated to present.
It has been also suggested that the degree of active ongoing inflammation may be a predictor for response to therapy. However, currently there are no diagnostic tools to determine the degree of inflammatory activity except for surgical lung biopsy.
PET scanning may be useful to determine disease activity and may be useful as a guide for lung biopsy. PET scanning may also give a quantitative measure of the degree of inflammation in the rest of the body and may be useful to predict and assess therapy response.
Research InterestsPET imaging in oncology and inflammatory condition (with focus on lung inflammations). PET imaging for cardiac function and viability
Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
Golden, Encouse B; Chhabra, Arpit; Chachoua, Abraham; Adams, Sylvia; Donach, Martin; Fenton-Kerimian, Maria; Friedman, Kent; Ponzo, Fabio; Babb, James S; Goldberg, Judith; Demaria, Sandra; Formenti, Silvia C
2015-06-28; 1474-5488,Lancet oncology - id: 1640742, year: 2015 JOURNAL ARTICLE
PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations
Heacock, Laura; Weissbrot, Joseph; Raad, Roy; Campbell, Naomi; Friedman, Kent P; Ponzo, Fabio; Chandarana, Hersh
2015-03-23; 0361-803x,American journal of roentgenology (1976) - id: 1506542, year: 2015 Journal Article
Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: Current Status, Future Aspects
Rakheja, Rajan; Chandarana, Hersh; Ponzo, Fabio; Seltzer, Alexandra L; Beltran, Luis S; Geppert, Christian; Friedman, Kent P
2014-07-25; 1556-8598,PET clinics - id: 1075192, year: 2014 REVIEW
Role of fusion of prone FDG-PET and magnetic resonance imaging of the breasts in the evaluation of breast cancer
Moy, Linda; Noz, Marilyn E; Maguire, Gerald Q Jr; Melsaether, Amy; Deans, Abby E; Murphy-Walcott, Antoinette D; Ponzo, Fabio
2012-02-05; 1524-4741,Breast journal - id: 111347, year: 2010 Journal Article
Prone breast dual-time-point PET/CT compared with MRI for determining breast cancer
Maguire, Gerald Q Jr; Noz, Marilyn E; Ponzo, Fabio
2012-03-08; 0361-803X,American journal of roentgenology (1976) - id: 159167, year: 2009 Comment; Letter