Miriam Keltz Pomeranz, M.D.

Physiologic changes and dermatoses of pregnancy
Geraghty, Laurel Naversen; Pomeranz, Miriam Keltz
2011 Jul;50(7):771-782, International journal of dermatology
Like all organ systems, the skin undergoes significant changes during pregnancy. The majority of physiologic skin conditions related to gestation resolve after childbirth. However, they may cause significant concern or cosmetic distress or be mistaken for one of the specific dermatoses of pregnancy. Dermatoses unique to pregnancy are rare but important to recognize because they may be intensely pruritic or painful to the mother, and they may pose significant risks to the patient, her fetus, or both. Clinicians familiar with the cutaneous manifestations of pregnancy can most effectively treat and counsel patients, guide expectations, and avoid unnecessary diagnostic tests and therapies. This review summarizes physiologic skin changes in the gravid patient and the specific dermatoses of pregnancy
— id: 134727, year: 2011, vol: 50, page: 771, stat: Journal Article,

Erythema multiforme-like drug reaction to sorafenib
Lewin, Jesse; Farley-Loftus, Rachel; Pomeranz, Miriam Keltz
2011 Dec;10(12):1462-1463, Journal of drugs in dermatology : JDD
The authors present a case of erythema multiforme-like drug reaction to the multikinase inhibitor sorafenib. While considered targeted therapy, multikinase inhibitors have been demonstrated to have various cutaneous effects. It is important to distinguish allergic reactions from adverse side effects as the latter may permit cautious re-challenge with medications that can potentially prolong survival in patients with advanced or metastatic disease
— id: 149801, year: 2011, vol: 10, page: 1462, stat: Journal Article,

A critical oversight An irksome ailment became life-threatening after misdiagnosis
Lewin, Jesse; Liang, Christine; Pomeranz, Miriam
2010 Aug;203(2):188.e1-188.e2, American journal of obstetrics & gynecology
— id: 111352, year: 2010, vol: 203, page: 188.e1, stat: Journal Article,

Alkaptonuria
Yancovitz, Molly; Anolik, Robert; Pomeranz, Miriam Keltz
2010 ;16(11):6-6, Dermatology online journal
A 69-year-old woman presented with a 30-year history of lower back and large joint pain of the hips and shoulders. On examination blue-grey, pigmented macules were present over the cartilaginous portions of the ears and on the sclera. Past medical history included aortic stenosis. Urine homogentisic acid level was elevated, which is diagnostic for alkaptonuria. Alkaptonuria is an autosomal recessive disorder that results in deficiency of homogentisic acid oxidase and in the accumulation of homogentisic acid in connective tissue. Disease can result in blue-grey pigmentation of the cartilage, sclerae, face, and hands as well as severe arthropathy and cardiac valve disease. Treatment is limited at this time. Promising early reports of the use of nitisinone have prompted ongoing trials of this therapeutic agent
— id: 115877, year: 2010, vol: 16, page: 6, stat: Journal Article,

Pityriasis rotunda
Batra, Priya; Cheung, Wang; Meehan, Shane A; Pomeranz, Miriam
2009 ;15(8):14-14, Dermatology online journal
A 42-year-old man presented with asymptomatic, sharply-demarcated, round, scaly lesions on his forearms that had been present for several months. A skin biopsy specimen was consistent with pityriasis rotunda. Pityriasis rotunda is a disorder of keratinization, which is thought to be a form of acquired ichthyosis, a delayed presentation of congenital ichthyosis, or a cutaneous manifestation of systemic disease. Patients with pityriasis rotunda may be classified into one of two groups, which are based on ethnicity, number of lesions, family history, and association with systemic diseases. Treatment is challenging, but the use of lactic acid lotion and oral vitamin A has shown some promise
— id: 115800, year: 2009, vol: 15, page: 14, stat: Journal Article,

Systemic drug-related intertriginous and flexural exanthema (SDRIFE)
Elmariah, Sarina B; Cheung, Wang; Wang, Nadia; Kamino, Hideko; Pomeranz, Miriam K
2009 ;15(8):3-3, Dermatology online journal
A 72-year-old man with a history of metastatic melanoma presented with a two-day history of erythematous and edematous plaques, with scattered bullae on the neck, chest, axillae, and inguinal and gluteal folds, which began five days after infusion of an experimental drug. The clinical and histopathologic findings were consistent with systemic drug-related intertriginous and flexural exanthema (SDRIFE), which is an uncommon drug reaction that results in symmetric erythema that affects the buttocks, groin, and/or thighs as well other flexural folds. The clinical manifestations of SDRIFE are highly characteristic and include distinctive primary cutaneous lesions with a specific distribution and course; however, heterogeneity exists with respect to histopathologic features, skin test results, and in vitro investigations. The exact mechanism of SDRIFE remains unknown but is thought to result from a type IV delayed hypersensitivity immune response. Treatment is symptomatic and includes topical or oral glucocorticoids
— id: 108280, year: 2009, vol: 15, page: 3, stat: Journal Article,

An unusual pruritic eruption of the feet. Churg-Strauss syndrome (CSS)(allergic granulomatosis)
Farley-Loftus, Rachel; Anandasabapathy, Niroshana; Bossenbroek, Nicole; Rosenman, Karla; Pomeranz, Miriam Keltz
2009 Jun;145(6):715-720, Archives of dermatology
— id: 100200, year: 2009, vol: 145, page: 715, stat: Journal Article,

Pustular psoriasis of pregnancy in a patient whose dermatosis showed features of acute generalized exanthematous pustulosis
Green, Michelle Goldberg; Bragg, Jennifer; Rosenman, Karla S; Pomeranz, Miriam Keltz
2009 Mar;48(3):299-303, International journal of dermatology
— id: 97043, year: 2009, vol: 48, page: 299, stat: Journal Article,

Extramammary Paget disease
Anolik, Robert; Liang, Christine; Wang, Nadia; Rosenman, Karla; Pomeranz, Miriam; Joe, Edwin
2008 ;14(10):15-15, Dermatology online journal
A 59-year-old man presented with a well-demarcated, tender ulcer at the base of the penile shaft that had been present for approximately five years. The ulcer had been responsive neither to topical antibacterials, antifungals, and glucocorticoids nor to oral acyclovir. A biopsy specimen showed an intra-epidermal neoplasm consistent with extramammary Paget disease (EMPD) based on light microscopy and immunohistochemistry. Patients with EMPD require extensive medical evaluation because of its association with adnexal carcinoma and visceral malignant conditions. Evaluation should include a full body skin and lymph node examination, colonscopy, cystoscopy, and sex-specific studies including pelvic and breast examinations, with imaging for women and prostate examination with prostate specific antigen levels for men. Close monitoring after treatment is important because of the recognized risk of recurrence and malignant conditions
— id: 115874, year: 2008, vol: 14, page: 15, stat: Journal Article,

X-Linked ocular albinism; Nettleship-Falls ocular albinism
Booth, Alexandria V; Soldano, Anthony C; Levine, Jonathan; Pomeranz, Miriam
2008 ;14(5):4-4, Dermatology online journal
A 39-year-old man with foveal hypoplasia, nystagmus, and decreased visual acuity was found to have multiple, cutaneous, hypopigmented macules. Macromelanosomes were demonstrated in normal skin on histopathologic examination. The patient's constellation of findings along with a strong X-linked inheritance pattern in family members led to the diagnosis of X-linked ocular albinism, which is an uncommon condition that is characterized by congenital nystagmus, iris translucency, hypopigmentation of the ocular fundus, strabismus, foveal hypoplasia, photophobia, and impaired vision
— id: 115871, year: 2008, vol: 14, page: 4, stat: Journal Article,

Epidermodysplasia verruciformis in the setting of HIV infection
Chen, Peter Jr; Kamino, Hideko; Walters, Ruth F; Rosenman, Karla; Pomeranz, Miriam K; Sanchez, Miguel
2008 ;14(10):1-1, Dermatology online journal
A 56-year-old man with human immunodeficiency virus infection presented with pink-to-hypopigmented, thin, flat-topped papules coalescent to plaques on the trunk and extremities for five years. The histopathologic findings were consistent with flat warts resembling epidermodysplasia verruciformis. Typically an inherited condition, this entity has also been observed in the setting of immunosuppression; the risk of developing non-melanoma skin cancers is of concern. Treatment options vary considerably, but often the lesions will recur upon cessation of therapy
— id: 95645, year: 2008, vol: 14, page: 1, stat: Journal Article,

Unilateral nevoid telangiectasia
Dadlani, Chicky; Kamino, Hideko; Walters, Ruth F; Rosenman, Karla; Pomeranz, Miriam K
2008 ;14(10):3-3, Dermatology online journal
A 30-year-old woman, who was six months pregnant, presented with multiple, blanching, asymptomatic telangiectasies on her right upper extremity for two years. At the onset of her pregnancy, her lesions increased in number and redness. Given the unilateral distribution and worsening during pregnancy, a diagnosis of unilateral nevoid telangiectasia was made. This condition is a rare entity that has been most commonly reported in association with puberty, pregnancy, the use of oral contraceptives, and alcoholic cirrhosis. However, there have been case reports in otherwise healthy individuals
— id: 95643, year: 2008, vol: 14, page: 3, stat: Journal Article,

Invasive squamous-cell carcinoma and arsenical keratoses
Elmariah, Sarina B; Anolik, Robert; Walters, Ruth F; Rosenman, Karla; Pomeranz, Miriam K; Sanchez, Miguel R
2008 ;14(10):24-24, Dermatology online journal
A 42-year-old man presented with a six-month history of a slowly-enlarging ulcer on his right sole, a 30-year history of altered pigmentation of the trunk and extremities, and hyperkeratotic papules of the palms and soles. Histopathologic examination showed an invasive squamous-cell carcinoma of the right sole and hyperkeratosis with keratinocyte atypia of the left finger and left lateral foot. The clinical and histopathologic findings are consistent with chronic arsenicism, which most commonly occurs in the setting of drinking contaminated water or after occupational exposure. Evaluation should include a physical examination, basic laboratory work-up, and measurement of a 24-hour urine arsenic concentration. Vigilant surveillance for the development of cutaneous malignancies is required. Oral retinoids may be helpful in reducing hyperkeratosis secondary to chronic arsenicism
— id: 107817, year: 2008, vol: 14, page: 24, stat: Journal Article,

Erythema elevatum diutinum
Farley-Loftus, Rachel; Dadlani, Chicky; Wang, Nadia; Rosenman, Karla; Kamino, Hideko; Prystowsky, Stephen; Franks, Andrew G Jr; Pomeranz, Miriam K
2008 ;14(10):13-13, Dermatology online journal
A 64-year-old woman presented with a one-and-one-half year history of an enlarging, red-brown, firm plaque on the left thigh, with numerous, scattered, indurated, hyperpigmented patches on the lower extremities. Histopathologic examination of the largest plaque confirmed the diagnosis of erythema elevatum diutinum, which is a rare form of leukocytoclastic vasculitis that is associated with many disease entities, which include human immunodeficiency virus infection, malignant conditions, hematologic abnormalities, chronic infection, and autoimmune and connective-tissue disorders. The treatment of choice is dapsone; however, several other treatment modalities have been reported to be of benefit
— id: 95639, year: 2008, vol: 14, page: 13, stat: Journal Article,

Palisaded neutrophilic and granulomatous dermatosis
Heidary, Noushin; Mengden, Stephanie; Pomeranz, Miriam K
2008 ;14(5):17-17, Dermatology online journal
A 22-year-old woman with mixed connective-tissue disease presented with a 5-month history of recurrent episodes of tender, erythematous papules, nodules, and edematous plaques on the upper extremities and thighs. Cutaneous lesions occurred in the setting of livedo reticularis. A biopsy specimen showed interstitial and perivascular inflammation with lymphocytes, macrophages, neutrophils, nuclear dust, collagen alteration, extravasated erythrocytes, and fibrin within small superficial blood vessels. These changes were consistent with a diagnosis of palisaded neutrophilic and granulomatous dermatosis, which is a rare entity that includes a combination of a neutrophilic infiltrate, abnormal or altered collagen, granuloma formation, and leukocytoclastic debris in the context of an immune-mediated collagen vascular or systemic disease. The underlying mechanism remains poorly understood. Treatment is limited, and resolution of lesions typically occurs within several months to years
— id: 115872, year: 2008, vol: 14, page: 17, stat: Journal Article,

Chronic cutaneous lupus erythematosus in vitiligo
Johnson, Hillary; Bossenbroek, Nicole M; Rosenman, Karla; Meehan, Shane A; Robles, Mirin; Pomeranz, Miriam K
2008 ;14(10):10-10, Dermatology online journal
A 49-year-old woman presented with a seven-year history of pruritic, erythematous, scaling plaques on sun-exposed skin that localized only to pre-existing depigmented patches. Histopathologic examination showed changes consistent with cutaneous lupus erythematosus with lichenoid features and confirmed contiguous vitiligo. Diagnosis of chronic cutaneous lupus erythematosus localized to areas of vitiligo was determined by clinicopathologic correlation and may reflect an autoimmune diathesis. Consequently, hydroxychloroquine and topical glucocorticoids therapy were initiated with reported improvement in pruritus, erythema, and scale. Clinical monitoring for development of squamous-cell carcinoma in areas of chronic inflammation and sun-exposure is imperative
— id: 95420, year: 2008, vol: 14, page: 10, stat: Journal Article,

Lichen planopilaris and psoriasis
Lane, Tameka K; Kamino, Hideko; Walters, Ruth F; Meehan, Shane; Pomeranz, Miriam K
2008 ;14(10):4-4, Dermatology online journal
A 34-year-old woman presented with large, scaly patches of alopecia with a peripheral rim of violaceous, folliculocentric papules and appreciable pruritus of one-year duration. Histopathologic examination showed changes consistent with lichen planopilaris and psoriasis, which was suggested by neutrophilic spongiosis. Consequently, cyclosporine and betamethasone valerate topical 0.12 percent foam twice daily were initiated. A short time after, there was clinical reduction of perifollicular erythema and attenuation of pruritus. However, there was no decrease of scale. Although LLP is classified in the lymphocytic group of cicatricial alopecias, this case demonstrates a clinical and histopathologic overlap with a psoriasiform dermatosis which may represent a collision of two diseases
— id: 95642, year: 2008, vol: 14, page: 4, stat: Journal Article,

Mastocytosis with urticaria pigmentosa and osteoporosis
Stein, Jennifer A; Kamino, Hideko; Walters, Ruth F; Pomeranz, Miriam K
2008 ;14(10):2-2, Dermatology online journal
A 76-year-old man with a 52-year history of urticaria pigmentosa was found to have an elevated serum tryptase level as well as osteoporosis. Histopathologic alterations of one his skin lesions showed an infiltrate of mast cells. Urticaria pigmentosa patients are at risk for osteoporosis because of elevated heparin and stem-cell factor levels. These patients should be screened with serum tryptase levels and bone density studies to detect osteoporosis, regardless of their age
— id: 95644, year: 2008, vol: 14, page: 2, stat: Journal Article,

Perforating collagenosis
Yancovitz, Molly; Johnson, Hillary; Wang, Nadia; Pomeranz, Miriam K
2008 ;14(10):14-14, Dermatology online journal
A 55-year-old man presented with a three-week history of pruritic, erythematous papules with hyperkeratotic dells on the dorsum of the left hand, which was preceded by swelling, redness and itching. Histopathologic examination showed an acanthotic epidermis with a central invagination filled with a plug composed of parakeratotic debris, collagen, and inflammatory cells. These findings are consistent with acquired reactive perforating collagenosis, which is most frequently reported in patients with pruritus and underlying diabetes mellitus or chronic renal insufficiency. Topical and oral retinoids and topical and intralesional glucocorticoids have been reported to be effective in some patients in case series
— id: 115873, year: 2008, vol: 14, page: 14, stat: Journal Article,

Papulopustular drug eruption due to an epidermal growth factor receptor inhibitors, erlotinib and cetuximab
Bragg, Jennifer; Pomeranz, Miriam Keltz
2007 ;13(1):1-1, Dermatology online journal
Two patients receiving epidermal growth factor receptor inhibitors for cancer treatment developed papulopustular eruptions a few days after starting treatment. One patient is a 56-year-old man with metastatic lung cancer treated with erlotinib. Bacterial cultures of the nares and a pustule showed no growth. The eruption improved with a lowered dose of erlotinib and the application of topical clindamycin solution and triamcinolone cream. The other patient is a 53-year-old man with metastatic rectal cancer treated with cetuximab. Bacterial culture of a pustule grew Staphylococcus aureus, and a skin biopsy specimen showed a suppurative folliculitis. The eruption improved with a two-week course of oral antibiotics and the application of topical clindamycin solution and triamcinolone cream. A papulopustular eruption occurs in up to 90% of patients treated with epidermal growth factor receptor blocking agents and may correlate with a positive response to chemotherapy. Treatment options are based on anecdotal evidence and may include topical antibiotics, topical glucocorticoids, and oral antibiotics for secondary infection
— id: 97044, year: 2007, vol: 13, page: 1, stat: Journal Article,

The "louse blouse" as a cause of erythroderma
Irizarry, Eddie; Brownell, Isaac; Pomeranz, Miriam Keltz
2007 May;143(5):682-682, Archives of dermatology
— id: 73295, year: 2007, vol: 143, page: 682, stat: Journal Article,

Images in clinical medicine. Phytophotodermatitis and limes
Pomeranz, Miriam Keltz; Karen, Julie K
2007 Jul 5;357(1):e1-e1, New England journal of medicine
— id: 73035, year: 2007, vol: 357, page: e1, stat: Journal Article,

Eumycetoma
Brownell, Isaac; Pomeranz, Miriam; Ma, Linglei
2005 ;11(4):10-10, Dermatology online journal
Eumycetoma is a localized, chronic fungal infection of skin and subcutaneous tissues. It is characterized by tumefaction, abscess formation, draining sinuses, and sclerotia (grains) within the abscesses and fistulae. Treatment of eumycetoma is a challenge. Relapse rates are high even when a combination of surgical and medical approaches is utilized. Here we report a case of eumycetoma due to Exophiala jeanselmei arising on the foot of a man from Trinidad, West Indies
— id: 66683, year: 2005, vol: 11, page: 10, stat: Journal Article,

Simultaneous acral nodular eruption and flagellate erythema caused by bleomycin
Mikhail, Maryann; Eichenbaum, Mark; Gerstenfeld, Eric; Duquette, Julie; Pomeranz, Miriam Keltz; Polsky, David
2005 Jan-Feb;4(1):81-84, Journal of drugs in dermatology : JDD
A 29-year-old male with AIDS was treated with bleomycin and vincristine for visceral Kaposi's sarcoma. Three days later, he developed two distinct eruptions simultaneously. One eruption was characterized by tender, erythematous, edematous plaques and nodules on the palmar and dorsal surfaces of the hands, forearms, and elbows. The other consisted of grouped, erythematous, hyperpigmented streaks on the trunk, buttocks, and extremities. The patient subsequently received a second treatment consisting of vincristine with adriamycin, without bleomycin, and no cutaneous effects were seen. Diagnoses of flagellate erythema and acral nodular eruption secondary to bleomycin were made and confirmed histopathologically. To our knowledge, this is the first report of two cutaneous side effects of bleomycin appearing simultaneously in a patient with AIDS
— id: 51785, year: 2005, vol: 4, page: 81, stat: Journal Article,

Mycobacteria and the skin
Burgin S; Pomeranz MK; Orbuch P; Shupack JL; Brand RS
Tuberculosis Philadelphia : Lippincott Williams & Wilkins, 2004,
— id: 3981, year: 2004, vol: , page: 593, stat: Chapter,

Lupus erythematosus and lichen planus overlap syndrome
Kim, Hanna; Pomeranz, Miriam K
2004 May-Jun;3(3):311-312, Journal of drugs in dermatology : JDD
A case of lupus erythematosus (LE) and lichen planus (LP) overlap syndrome in a 71-year-old woman is presented. This disease displays characteristics of both LE and LP. The clinical, histologic, and immunopathologic features of this disorder are reviewed
— id: 115869, year: 2004, vol: 3, page: 311, stat: Journal Article,

A case of livedoid vasculopathy in a 22-year-old man
Leonard, Aimee; Pomeranz, Miriam Keltz; Franks, Andrew G Jr
2004 Nov-Dec;3(6):678-679, Journal of drugs in dermatology : JDD
A 23-year-old man presented with a 3-year history of painful ulcerations and retiform scarring of his lower extremities. Skin biopsy revealed evidence of thrombotic vasculopathy. Livedoid vasculopathy is an uncommon condition presenting as painful lower extremity ulceration and scarring in the form of irregular, ivory-white, stellate plaques. Its pathogenesis is unclear, but it is thought to result from coagulation and fibrinolytic disorders causing occlusion of dermal vessels
— id: 48882, year: 2004, vol: 3, page: 678, stat: Journal Article,

Generalized pustules in a healthy woman
Arroyo, Martha P; Heller, Patricia; Pomeranz, Miriam Keltz
2002 Jul;1(1):63-65, Journal of drugs in dermatology : JDD
A healthy 47-year-old woman developed diffuse pustules and edema of the skin after exposure to diltiazem and cephalexin. Bacterial, fungal and viral cultures were sterile suggesting a noninfectious etiology. A skin biopsy showed spongiosis, subcorneal collections of neutrophils, papillary dermal edema and a superficial perivascular mixed cell infiltrate. The clinical and histopathologic findings were consistent with acute generalized exanthematous pustulosis (AGEP). The patient was treated with supportive care and the pustular dermatitis cleared. AGEP is a rare complication of drug therapy and should be considered in the differential diagnosis of patients presenting with acute onset pustular dermatitis. Drug reactions are an uncommon and unpredictable complication of medical therapy. Cutaneous drug reaction rates occur with a frequency of 1% to 8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug-hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthermatous pustulosis (AGEP) is a rare presentation of a drug reaction and can be difficult to distinguish from other pustular dermatoses. Herein we review a case of AGEP and include a discussion of salient clinical and histological features of AGEP
— id: 67098, year: 2002, vol: 1, page: 63, stat: Journal Article,

Dermatologic agents during pregnancy and lactation: an update and clinical review
Hale, Elizabeth K; Pomeranz, Miriam Keltz
2002 Apr;41(4):197-203, International journal of dermatology
— id: 32131, year: 2002, vol: 41, page: 197, stat: Journal Article,

Dermatoses of pregnancy
Baxt R; Pomeranz M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3691, year: 2001, vol: , page: 42, stat: Chapter,

Vulvar diseases
Baxt R; Pomeranz M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3768, year: 2001, vol: , page: 218, stat: Chapter,

Nonvascular skin ulcers
Kim L; Cohen M; Pomeranz M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3729, year: 2001, vol: , page: 130, stat: Chapter,

Pressure ulcers and mal perforans
Kim L; Pomeranz M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3748, year: 2001, vol: , page: 170, stat: Chapter,

Vascular ulcers and stasis dermatitis
Pomeranz M
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3765, year: 2001, vol: , page: 212, stat: Chapter,

Rediscovering mycophenolic acid: a review of its mechanism, side effects, and potential uses
Kitchin JE; Pomeranz MK; Pak G; Washenik K; Shupack JL
1997 Sep;37(3 Pt 1):445-449, Journal of the American Academy of Dermatology
Oral mycophenolic acid (MPA) therapy has been investigated in the treatment of moderate to severe psoriasis since the early 1970s and has been found to be both safe and effective. By inhibiting de novo purine biosynthesis, it functions as an antifungal, antibacterial, antiviral, and immunosuppressive agent. The recent availability of mycophenolate mofetil (MMF), a morpholinoester of MPA, has created renewed interest in the antipsoriatic properties of MPA. MMF is currently indicated for the prevention of organ rejection in transplant recipients and is used concomitantly with cyclosporine and corticosteroids. This review focuses on the pharmacology of MPA and MMF, studies of MPA in the treatment of psoriasis, and therapy with MMF. There is a potential application of MMF in the treatment of severe psoriasis and other inflammatory dermatoses, as well as topical MPA for the treatment of psoriasis
— id: 56960, year: 1997, vol: 37, page: 445, stat: Journal Article,

Mycobacteria and the skin
Pomeranz, Miriam Keltz; Orbuch, Philip; Shupack, Jerome; Brand, Rena
Tuberculosis Boston : Little Brown, 1996,
— id: 4968, year: 1996, vol: , page: ?, stat: Chapter,

Rediscovering thalidomide: a review of its mechanism of action, side effects, and potential uses
Tseng S; Pak G; Washenik K; Pomeranz MK; Shupack JL
1996 Dec;35(6):969-979, Journal of the American Academy of Dermatology
Thalidomide, a hypnosedative drug introduced in the 1950s, has been used in a variety of dermatologic conditions during the past few decades. Although originally withdrawn from the world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clinical uses of thalidomide in the treatment of dermatologic diseases was performed. Diseases for which thalidomide has been found effective include erythema nodosum leprosum, prurigo nodularis, actinic prurigo, discoid lupus erythematosus, aphthous stomatitis, Behcet's syndrome, and graft-versus-host disease. Side effects such as teratogenicity and peripheral neuropathy remain its limiting factor. Thalidomide is a useful addition to the therapeutic armamentarium for treatment-resistant dermatoses as long as proper vigilance for adverse effects is maintained
— id: 56915, year: 1996, vol: 35, page: 969, stat: Journal Article,