Nunzio Pomara

Biosketch / Results /

Nunzio Pomara

Professor, Department of Psychiatry;Professor, Department of Pathology

Contact Info

1 Park Avenue
New York, NY 10016



1972-1976 — SUNY Downstate, Medical Education
1976-1977 — Metropolitan Hospital-New York Medical College, Internship
1977-1980 — Metropolitan Hospital-New York Medical College, Residency Training
1980-1982 — Wayne State University-Lafayette Clinic, Clinical Fellowships

Research Summary

A major focus of Dr. Pomara’s research has been to elucidate pharmacokinetic and pharmacodynamic factors that may contribute to individual vulnerability to drug induced cognitive and psychomotor toxicity in the elderly. He has shown that certain variants of the APOE and TOMM40 genes increase risk for drug-induced adverse events unrelated to pharmacokinetic factors and likely reflecting pharmacodynamic mechanisms.

Other important contributions include his early reports of increased activity in the HPA axis associated with both aging and AD, as determined by studies of baseline cortisol and dexamethasone response. These results led to the first pilot clinical trial that examined the cognitive effects of the glucocorticoid receptor antagonist, RU486, in AD. Dr. Pomara also provided the first report on an absence of a cortisol response to naltrexone and an elevation in CSF-glutamate in Alzheimer’s patients.

Dr. Pomara additionally presented the first evidence that late life depression, a condition associated with increased risk for Alzheimer’s disease (AD) or prodromal phase, may be accompanied by disturbances in central and peripheral metabolism of amyloid-beta, a peptide implicated in AD. More recently, he has been collaborating with the NYU Cohen Veterans Center to identify biomarkers for PTSD/TBI.

Research Interests

Pharmacogenetics, Alzheimer's Disease, drug-induced cognitive toxicity, late-life depression

The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals
Bruno, Davide; Grothe, Michel J; Nierenberg, Jay; Teipel, Stefan J; Zetterberg, Henrik; Blennow, Kaj; Pomara, Nunzio
2015-08-31; 2352-8729,Alzheimer's & dementia : diagnosis, assessment & disease monitoring - id: 1744712, year: 2015 JOURNAL ARTICLE

A study on the specificity of the association between hippocampal volume and delayed primacy performance in cognitively intact elderly individuals
Bruno, Davide; Grothe, Michel J; Nierenberg, Jay; Zetterberg, Henrik; Blennow, Kaj; Teipel, Stefan; Pomara, Nunzio
2015-01-26; 0028-3932,Neuropsychologia - id: 1440512, year: 2015 JOURNAL ARTICLE

Cognitive reserve and emotional stimuli in older individuals: level of education moderates the age-related positivity effect
Bruno, Davide; Brown, Adam D; Kapucu, Aycan; Marmar, Charles R; Pomara, Nunzio
2014-04-05; 0361-073x,Experimental aging research - id: 865662, year: 2014 Journal Article

Efficacy and safety of vilazodone in major depressive disorder: a randomized, double-blind, placebo-controlled trial
Croft, Harry A; Pomara, Nunzio; Gommoll, Carl; Chen, Dalei; Nunez, Rene; Mathews, Maju
2014-12-08; 0160-6689,Journal of clinical psychiatry - id: 1371092, year: 2014 Journal Article

Adverse performance effects of acute lorazepam administration in elderly long-term users: Pharmacokinetic and clinical predictors
Pomara, Nunzio; Lee, Sang Han; Bruno, Davide; Silber, Timothy; Greenblatt, David J; Petkova, Eva; Sidtis, John J
2014-09-11; 0278-5846,Progress in neuro-psychopharmacology & biological psychiatry - id: 1181302, year: 2014 JOURNAL ARTICLE