Biosketch / Results /
Nunzio PomaraProfessor, Department of Psychiatry
Professor, Department of Pathology
1 Park Avenue
New York, NY 10016
Education1972-1976 — SUNY Downstate, Medical Education
1976-1977 — Metropolitan Hospital-New York Medical College, Internship
1977-1980 — Metropolitan Hospital-New York Medical College, Residency Training
1980-1982 — Wayne State University-Lafayette Clinic, Clinical Fellowships
A major focus of Dr. Pomara’s research has been to elucidate pharmacokinetic and pharmacodynamic factors that may contribute to individual vulnerability to drug induced cognitive and psychomotor toxicity in the elderly. He has shown that certain variants of the APOE and TOMM40 genes increase risk for drug-induced adverse events unrelated to pharmacokinetic factors and likely reflecting pharmacodynamic mechanisms.
Other important contributions include his early reports of increased activity in the HPA axis associated with both aging and AD, as determined by studies of baseline cortisol and dexamethasone response. These results led to the first pilot clinical trial that examined the cognitive effects of the glucocorticoid receptor antagonist, RU486, in AD. Dr. Pomara also provided the first report on an absence of a cortisol response to naltrexone and an elevation in CSF-glutamate in Alzheimer’s patients.
Dr. Pomara additionally presented the first evidence that late life depression, a condition associated with increased risk for Alzheimer’s disease (AD) or prodromal phase, may be accompanied by disturbances in central and peripheral metabolism of amyloid-beta, a peptide implicated in AD. More recently, he has been collaborating with the NYU Cohen Veterans Center to identify biomarkers for PTSD/TBI.
Research InterestsPharmacogenetics, Alzheimer's Disease, drug-induced cognitive toxicity, late-life depression
The Primacy Effect in Amnestic Mild Cognitive Impairment: Associations with Hippocampal Functional Connectivity
Brueggen, Katharina; Kasper, Elisabeth; Dyrba, Martin; Bruno, Davide; Pomara, Nunzio; Ewers, Michael; Duering, Marco; Burger, Katharina; Teipel, Stefan J. The Primacy Effect in Amnestic Mild Cognitive Impairment: Associations with Hippocampal Functional Connectivity. Frontiers in aging neuroscience. 2016 ;8:244-244 (2312392)
Hippocampal volume and integrity as predictors of cognitive decline in intact elderly
Bruno, Davide; Ciarleglio, Adam; Grothe, Michel J; Nierenberg, Jay; Bachman, Alvin H; Teipel, Stefan J; Petkova, Eva; Ardekani, Babak A; Pomara, Nunzio. Hippocampal volume and integrity as predictors of cognitive decline in intact elderly. Neuroreport. 2016 Aug;27(11):869-873 (2196282)
The recency ratio as an index of cognitive performance and decline in elderly individuals
Bruno, Davide; Reichert, Chelsea; Pomara, Nunzio. The recency ratio as an index of cognitive performance and decline in elderly individuals. Journal of clinical & experimental neuropsychology. 2016 Nov;38(9):967-973 (2236382)
Abnormality in glutamine-glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study
Hashimoto, K; Bruno, D; Nierenberg, J; Marmar, C R; Zetterberg, H; Blennow, K; Pomara, N. Abnormality in glutamine-glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study. Translational psychiatry. 2016 Mar 1;6:e744-e744 e744 (2006272)
Neuronal correlates of serial position performance in amnestic mild cognitive impairment
Kasper, Elisabeth; Brueggen, Katharina; Grothe, Michel J; Bruno, Davide; Pomara, Nunzio; Unterauer, Elisabeth; Duering, Marco; Ewers, Michael; Teipel, Stefan; Buerger, Katharina. Neuronal correlates of serial position performance in amnestic mild cognitive impairment. Neuropsychology. 2016 Nov;30(8):906-914 (2312402)