Dimitris George Placantonakis

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Dimitris George Placantonakis, M.D., Ph.D.

Assistant Professor; Dir Neurosurgical Laboratory for Stem Cell Resch
Department of Neurosurgery (Neurosurgery)

Clinical Addresses

530 FIRST AVENUE, SKIRBALL 8R
SILVERSTEIN ELEVATORS
NEW YORK, NY 10016
Hours: Thu. 2 - 6
Handicap Access: yes
Phone: 212-263-2441
Fax: 212-263-8042

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Medical Specialties

Neurosurgery

Medical Expertise

Meningioma, Pituitary Adenoma, Brain Tumors, Glioma

Clinical Responsibilities

Dr. Placantonakis obtained his MD and PhD degrees from NYU School of Medicine's MSTP Program. At NYU, he was elected to the Alpha Omega Alpha National Honor Medical Society and received the Alpha Omega Alpha award for the highest scholastic rating in his medical school class. He then moved to Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center for his neurosurgical residency training with Drs. Phil Stieg and Phil Gutin. Within his residency, he completed a 2-year postdoctoral research fellowship with Drs. Lorenz Studer and Viviane Tabar at Memorial Sloan-Kettering, studying human embryonic stem cell biology. He has received numerous awards for his work, including the Congress of Neurological Surgeons Resident Award, the Neurosurgery Research and Education Foundation Research Fellowship, the New York Society for Neurosurgery Resident Award, and the Distinguished Housestaff Award at Weill Cornell Medical College.

Dr. Placantonakis is interested in the management of brain tumors, including gliomas, pituitary adenomas, meningiomas and metastases. He has received extensive training in intraoperative functional mapping and transnasal endoscopic approaches. He is also the Director of the Neurosurgical Laboratory for Stem Cell Research that studies glioblastoma stem cell and human embryonic stem cell biology. In particular, Dr. Placantonakis' laboratory works on identifying distinct types of cancer stem cells in glioblastoma and modeling the origin of glioma using human embryonic stem cells. His laboratory is funded by the National Institutes of Health (NIH), NYULMC's Cancer Institute and NYULMC's Clinical and Translational Science Institute.

Languages

French, Greek

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, HOTEL TRADES, LOCAL 1199 PPO, MULTIPLAN/PHCS PPO, Medicare, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, Tricare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Education

1995-2003 — NYU School of Medicine, Medical Education
2003-2010 — Cornell University Medical College (Neurosurgery), Residency Training
2003-2010 — Cornell University Medical College (Neurosurgery), Internship
2003-2010 — Memorial Sloan-Kettering Cancer Center (Neurosurgery), Residency Training
2006-2008 — Memorial Sloan-Ketteriing Cancer Center ([None or N/A]), Clinical Fellowships

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Research Summary

Dr. Placantonakis obtained his MD/PhD degree in Neuroscience from NYU School of Medicine and completed a postdoctoral fellowship in human embryonic stem cell biology with Drs. Lorenz Studer and Viviane Tabar at Memorial Sloan-Kettering. He was also trained in Neurosurgery at Weill Cornell Medical College and Memorial Sloan-Kettering. At NYU, he is a tenure-track physician-scientist dividing his time between his neurosurgical practice and the laboratory. Dr. Placantonakis has an interest in the treatment of gliomas and brain tumors in general. The Neurosurgical Laboratory for Stem Cell Research, which is headed by Dr. Placantonakis, studies stem cell biology in the context of glioma, a malignant brain tumor. We adapt human embryonic stem cell and genetic technologies to model oncogenic processes, with the goal of understanding the early steps in glioma formation and developing translational applications, such as high-throughput drug screening and biomarker identification. Furthermore, we use genetic approaches and patients' tissue to generate models for high-grade gliomas, with emphasis on the role of stem cells in pathogenesis and new therapeutic approaches that directly target them. Our ultimate goal is to translate our laboratory findings to new therapies and diagnostic tests for patients with glioma.

Dr. Placantonakis' laboratory is funded by the National Institutes of Health (NIH), NYULMC's Cancer Institute and NYULMC's Clinical and Translational Science Institute.

Research Interests

Glioblastoma stem cells, human embryonic stem cells, glioma biology, gliomagenesis, glioma therapeutics

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature
Bassani, Luigi; Graffeo, Christopher S; Behrooz, Navid; Tyagi, Vineet; Wilson, Taylor; Penaranda, Saul; Zagzag, David; Rifkin, Daniel B; Barcellos-Hoff, Mary Helen; Fatterpekar, Girish; Placantonakis, Dimitris
2014 ;5:8-8, Surgical neurology international
— id: 820792, year: 2014, vol: 5, page: 8, stat: Journal Article,

Brain stem cells as the cell of origin in glioma
Modrek, Aram S; Bayin, N Sumru; Placantonakis, Dimitris G
2014 Jan;6(1):43-52, World journal of stem cells
— id: 820902, year: 2014, vol: 6, page: 43, stat: Journal Article,

A panoramic view of the skull base: systematic review of open and endoscopic endonasal approaches to four tumors
Graffeo, Christopher S; Dietrich, August R; Grobelny, Bartosz; Zhang, Meng; Goldberg, Judith D; Golfinos, John G; Lebowitz, Richard; Kleinberg, David; Placantonakis, Dimitris G
2013 Sep;:?-?, Pituitary
— id: 590322, year: 2013, vol: , page: ?, stat: Journal Article,

The transplanum transtuberculum approaches for suprasellar and sellar-suprasellar lesions. Avoidance of CSF leak and lessons learned
Mascarenhas, Lino; Moshel, Yaron A; Bayad, Fatema; Szentirmai, Oszkar; Salek, Al Amin; Leng, Lewis Z; Hofstetter, Christoph P; Placantonakis, Dimitris G; Tsiouris, Apostolos J; Anand, Vijay K; Schwartz, Theodore H
2013 Feb;:?-?, World neurosurgery
— id: 240312, year: 2013, vol: , page: ?, stat: Journal Article,

A NOVEL GENE THERAPY APPROACH IN GLIOBLASTOMA THAT TARGETS TUMOR STEM CELLS
Bayin, Nermin S.; Dietrich, August; Abel, Tobias; Chao, Moses V.; Song, Hae-Ri; Buchholz, Christian J.; Placantonakis, Dimitris
2012 OCT;14 6 6:148-148, Neuro-oncology
— id: 205002, year: 2012, vol: 14 6 6, page: 148, stat: Journal Article,

Neurosurgical management of symptomatic thoracic spinal ossification in a patient with fibrodysplasia ossificans progressiva
Grobelny, BT; Rubin, D; Fleischut, P; Rubens, E; Mack, PF; Fink, M; Placantonakis, DG; Elowitz, EH
2012 Mar;16(3):285-288, Journal of neurosurgery. Spine
— id: 155737, year: 2012, vol: 16, page: 285, stat: Journal Article,

ERG AS A RELIABLE MARKER OF VASCULAR CELLS IN BRAIN TUMORS
Iranmahboob, Amir; Haber, Matthew; Esencay, Mine; Fatterpekar, Girish; Raz, Eytan; Placantonakis, Dimitris; Zagzag, David
2012 OCT;14 6 6:3-3, Neuro-oncology
— id: 204932, year: 2012, vol: 14 6 6, page: 3, stat: Journal Article,

USE OF MULTIVOXEL DSC-MRI PERFUSION DATA IN STEREOTACTIC-GUIDED GLIOMA SURGERY AND CORRELATION WITH TUMOR PATHOLOGY
Parker, Erik; Fatterpekar, Girish; Raz, Eytan; Narayana, Ashwatha; Johnson, Glyn; Placantonakis, Dimitris; Zagzag, David
2012 OCT;14 6 6:125-125, Neuro-oncology
— id: 204992, year: 2012, vol: 14 6 6, page: 125, stat: Journal Article,

Transsphenoidal resection of sellar tumors using high-field intraoperative magnetic resonance imaging
Szerlip, Nicholas J; Zhang, Yi-Chen; Placantonakis, Dimitris G; Goldman, Marc; Colevas, Kara B; Rubin, David G; Kobylarz, Eric J; Karimi, Sasan; Girotra, Monica; Tabar, Viviane
2011 Jul;21(4):223-232, Skull base
— id: 240322, year: 2011, vol: 21, page: 223, stat: Journal Article,

Bilateral intracranial electrodes for lateralizing intractable epilepsy: efficacy, risk, and outcome
Placantonakis, Dimitris G; Shariff, Saadat; Lafaille, Fabien; Labar, Douglas; Harden, Cynthia; Hosain, Syed; Kandula, Padmaja; Schaul, Neil; Kolesnik, Dimitrius; Schwartz, Theodore H
2010 Feb;66(2):274-283, Neurosurgery
— id: 111489, year: 2010, vol: 66, page: 274, stat: Journal Article,

Intracranial and spinal metastases from eccrine mucinous carcinoma: case report
Sheth, Rishi N; Placantonakis, Dimitris G; Gutin, Philip H
2010 Sep;67(3):E861-E862, Neurosurgery
— id: 138207, year: 2010, vol: 67, page: E861, stat: Journal Article,

Localization in epilepsy
Placantonakis, Dimitris G; Schwartz, Theodore H
2009 Nov;27(4):1015-1030, Neurologic clinics
— id: 111490, year: 2009, vol: 27, page: 1015, stat: Journal Article,

Enriched motor neuron populations derived from bacterial artificial chromosome-transgenic human embryonic stem cells
Placantonakis, Dimitris G; Tomishima, Mark J; Lafaille, Fabien; Desbordes, Sabrina C; Jia, Fan; Socci, Nicholas D; Viale, Agnes; Lee, Hyojin; Harrison, Neil; Studer, Lorenz; Tabar, Viviane S
2009 ;56:125-132, Clinical neurosurgery
— id: 111491, year: 2009, vol: 56, page: 125, stat: Journal Article,

BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage
Placantonakis, Dimitris G; Tomishima, Mark J; Lafaille, Fabien; Desbordes, Sabrina C; Jia, Fan; Socci, Nicholas D; Viale, Agnes; Lee, Hyojin; Harrison, Neil; Tabar, Viviane; Studer, Lorenz
2009 Mar;27(3):521-532, Stem cells
— id: 111492, year: 2009, vol: 27, page: 521, stat: Journal Article,

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
Desbordes, Sabrina C; Placantonakis, Dimitris G; Ciro, Anthony; Socci, Nicholas D; Lee, Gabsang; Djaballah, Hakim; Studer, Lorenz
2008 Jun 5;2(6):602-612, Cell Stem Cell
— id: 111494, year: 2008, vol: 2, page: 602, stat: Journal Article,

Posterior stabilization strategies following resection of cervicothoracic junction tumors: review of 90 consecutive cases
Placantonakis, Dimitris G; Laufer, Ilya; Wang, Jeremy C; Beria, Jasmine S; Boland, Patrick; Bilsky, Mark
2008 Aug;9(2):111-119, Journal of neurosurgery. Spine
— id: 111493, year: 2008, vol: 9, page: 111, stat: Journal Article,

Safety of low-dose intrathecal fluorescein in endoscopic cranial base surgery
Placantonakis, Dimitris G; Tabaee, Abtin; Anand, Vijay K; Hiltzik, David; Schwartz, Theodore H
2007 Sep;61(3 Suppl):161-5; discussion 165, Neurosurgery
— id: 111495, year: 2007, vol: 61, page: 161, stat: Journal Article,

Intrathecal fluorescein in endoscopic skull base surgery
Tabaee, Abtin; Placantonakis, Dimitris G; Schwartz, Theodore H; Anand, Vijay K
2007 Aug;137(2):316-320, Otolaryngology, head & neck surgery
— id: 111496, year: 2007, vol: 137, page: 316, stat: Journal Article,

Continuous electrical oscillations emerge from a coupled network: a study of the inferior olive using lentiviral knockdown of connexin36
Placantonakis, Dimitris G; Bukovsky, Anatoly A; Aicher, Sue A; Kiem, Hans-Peter; Welsh, John P
2006 May 10;26(19):5008-5016, Journal of neuroscience
— id: 111498, year: 2006, vol: 26, page: 5008, stat: Journal Article,

Intradiploic cerebrospinal fluid fistulas of iatrogenic origin. Report of two cases
Placantonakis, Dimitris G; Lis, Eric; Souweidane, Mark M
2006 May;104(5 Suppl):356-359, Journal of neurosurgery
— id: 111497, year: 2006, vol: 104, page: 356, stat: Journal Article,

Neurosurgical management of medically intractable epilepsy associated with hypomelanosis of Ito
Placantonakis, Dimitris G; Ney, Gershon; Edgar, Mark; Souweidane, Mark; Hosain, Syed; Schwartz, Theodore H
2005 Feb;46(2):329-331, Epilepsia
— id: 111500, year: 2005, vol: 46, page: 329, stat: Journal Article,

Is autism due to brain desynchronization?
Welsh, John P; Ahn, Edward S; Placantonakis, Dimitris G
2005 Apr-May;23(2-3):253-263, International journal of developmental neuroscience
— id: 111499, year: 2005, vol: 23, page: 253, stat: Journal Article,

Fundamental role of inferior olive connexin 36 in muscle coherence during tremor
Placantonakis, Dimitris G; Bukovsky, Anatoly A; Zeng, Xiao-Hui; Kiem, Hans-Peter; Welsh, John P
2004 Jun 4;101(18):7164-7169, Proceedings of the National Academy of Sciences of the United States of America
— id: 46182, year: 2004, vol: 101, page: 7164, stat: Journal Article,

A dominant negative mutation of neuronal connexin 36 that blocks intercellular permeability
Placantonakis, Dimitris; Cicirata, Federico; Welsh, John P
2002 Jan 31;98(1-2):15-28, Brain research. Molecular brain research
— id: 39716, year: 2002, vol: 98, page: 15, stat: Journal Article,

The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity
Welsh, John P; Placantonakis, Dimitris G; Warsetsky, Sarah I; Marquez, Rolando G; Bernstein, Lana; Aicher, Sue A
2002 ;89:307-329, Advances in neurology
— id: 111502, year: 2002, vol: 89, page: 307, stat: Journal Article,

Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus
Welsh, John P; Yuen, Genevieve; Placantonakis, Dimitris G; Vu, Toan Q; Haiss, Florent; O'Hearn, Elizabeth; Molliver, Mark E; Aicher, Sue A
2002 ;89:331-359, Advances in neurology
— id: 111501, year: 2002, vol: 89, page: 331, stat: Journal Article,

Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive
Placantonakis D; Welsh J
2001 Jul 1;534(Pt 1):123-140, Journal of physiology
— id: 21156, year: 2001, vol: 534, page: 123, stat: Journal Article,

Serotonin suppresses subthreshold and suprathreshold oscillatory activity of rat inferior olivary neurones in vitro
Placantonakis DG; Schwarz C; Welsh JP
2000 May 1;524 Pt 3:833-851, Journal of physiology
— id: 11729, year: 2000, vol: 524 Pt 3, page: 833, stat: Journal Article,

NMDA receptor involvement in subthreshold oscillations of the inferior olive
Placantonakis, D G; Welsh, J P
1999 Oct 23-28;25(1-2):1560-1560, Abstracts (Society for Neuroscience)
— id: 15823, year: 1999, vol: 25, page: 1560, stat: Journal Article,

Serotonin suppresses subthreshold oscillations in the interior olive
Placantonakis, D G; Schwarz, C; Welsh, J P
1998 Nov 7-12;24(1-2):665-665, Abstracts (Society for Neuroscience)
— id: 15929, year: 1998, vol: 24, page: 665, stat: Journal Article,