Biosketch / Results /
Philip J Miller, M.D.
Clinical Assistant Professor;Department of Otolaryngology (Otolaryngology)
Clinical Addresses
60 E. 56TH STREET, 3RD FLOORNEW YORK, NY 10022
Hours: Mon. 8:30 - 12; Tue. 8:30 - 12; Thu. 12:30 - 5
Phone: 212-750-7100
Fax: 212-750-7101
Medical Specialties
Otolaryngology, EntMedical Expertise
Endoscopic Sinus Surgery, Cosmetic/Reconstructive Surg., Laser Surgery, Head & Neck Surgery, RhinoplastyInsurance
MedicareInsurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.
Board Certification
2000 — OtolaryngologyEducation
1989 — Univ. of Massachusetts Medical School, Medical Education1989-1991 — NYU Medical Center (Surgery), Internship
1991-1995 — NYU Medical Center (Otolarnygology), Residency Training
1995-1996 — Oregon Health Sciences University (Plastic Surgery), Clinical Fellowships
All data from NYU Health Sciences Library Faculty Bibliography — -
Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search#about
Outcomes of direct facial-to-hypoglossal neurorrhaphy with parotid release
Jacobson J.; Rihani J.; Lin K.; Miller P.J.; Roland J.T.
2011 ;21(1):7-12, Skull base
Lesions of the temporal bone and cerebellopontine angle and their management can result in facial nerve paralysis. When the nerve deficit is not amenable to primary end-to-end repair or interpositional grafting, nerve transposition can be used to accomplish the goals of restoring facial tone, symmetry, and voluntary movement. The most widely used nerve transposition is the hypoglossal-facial nerve anastamosis, of which there are several technical variations. Previously we described a technique of single end-to-side anastamosis using intratemporal facial nerve mobilization and parotid release. This study further characterizes the results of this technique with a larger patient cohort and longer-term follow-up. The design of this study is a retrospective chart review and the setting is an academic tertiary care referral center. Twenty-one patients with facial nerve paralysis from proximal nerve injury at the cerebellopontine angle underwent facial-hypoglossal neurorraphy with parotid release. Outcomes were assessed using the Repaired Facial Nerve Recovery Scale, questionnaires, and patient photographs. Of the 21 patients, 18 were successfully reinnervated to a score of a B or C on the recovery scale, which equates to good oral and ocular sphincter closure with minimal mass movement. The mean duration of paralysis between injury and repair was 12.1 months (range 0 to 36 months) with a mean follow-up of 55 months. There were no cases of hemiglossal atrophy, paralysis, or subjective dysfunction. Direct facial-hypoglossal neurorrhaphy with parotid release achieved a functional reinnervation and good clinical outcome in the majority of patients, with minimal lingual morbidity. This technique is a viable option for facial reanimation and should be strongly considered as a surgical option for the paralyzed face.
—
id: 121345,
year: 2011,
vol: 21,
page: 7,
stat: Journal Article,
Biomechanical analysis of anchoring points in rhytidectomy
Carron, Michael A; Zoumalan, Richard A; Miller, Philip J; Shah, Anil R
2010 Jan-Feb;12(1):37-39, Archives of facial plastic surgery
OBJECTIVE: To quantify tissue tearing force at various anchoring points on the face. METHODS: This is a prospective anatomic study using 4 fresh cadavers of persons aged 60 to 70 years at the time of death, for a total of 8 sides. Standardized 1-cm distances were measured at the various anchor points, and a single 0 Prolene suture loop was tied at each standardized anchoring point. Steady force was applied perpendicular to the plane of the face with a digital hanging scale. The scale was pulled until the suture ruptured the tissue at the anchoring point. The values at which the tissue ruptured were recorded, averaged, and compared. RESULTS: The average tissue force was 7.01 kg for the root of the zygoma vs 3.44 kg for the temporalis fascia (P < .05). The average tissue force was 5.50 kg for infralobular tissue vs 4.09 kg for tissue of the superficial musculoaponeurotic system located 1 cm anterior to the infralobular tissue (P < .05). The force for the fascia of the sternocleidomastoid was 3.89 kg vs 5.57 kg for the mastoid fascia (P < .05). There was a statistically significant difference between vertical bites of the temporalis fascia at 1.90 kg vs horizontal bites of the temporalis at 5.01 kg (P < .05). CONCLUSION: The tissue tearing force varies by location on the face as well as suture orientation
—
id: 129087,
year: 2010,
vol: 12,
page: 37,
stat: Journal Article,
The bow-tie mattress suture for the correction of nasal cartilage convexities and concavities
Miller, Philip J; Dayan, Steven H
2010 Sep-Oct;12(5):354-356, Archives of facial plastic surgery
—
id: 141870,
year: 2010,
vol: 12,
page: 354,
stat: Journal Article,
Treatment of dorsal deviation
Zoumalan, Richard A; Carron, Michael A; Tajudeen, Bobby A; Miller, Philip J
2009 Jun;42(3):579-586, Otolaryngologic clinics of North America
The deviated nasal dorsum is a complex problem with a variety of proposed solutions. Straightening the deviated nose should be focused on maximizing cosmetic outcome while preserving or improving nasal function. Deviations can occur in one or a combination of the nasal thirds. A simple approach to treatment is to develop a strategy for each third of the nose. Tailoring maneuvers to alleviate problems in each specific third helps the surgeon deal with deviations in an effective and straightforward manner
—
id: 99245,
year: 2009,
vol: 42,
page: 579,
stat: Journal Article,
The evolving surgeon: how, when, and why change is for the better
Miller, Philip J
2007 Feb;23(1):3-6, Facial plastic surgery
Change is an inevitable part of a surgeon's practice. There are several positive and negative forces encouraging a surgeon to change. Whether a surgeon should modify and how to do it are the focus of this article
—
id: 71865,
year: 2007,
vol: 23,
page: 3,
stat: Journal Article,
The subzygomatic fossa: a practical landmark in identifying the zygomaticus major muscle
Miller, Philip J; Smith, Sarah; Shah, Anil
2007 Jul-Aug;9(4):271-274, Archives of facial plastic surgery
OBJECTIVE: To test the validity of the subzygomatic fossa as a possible landmark in identifying the origin of the zygomaticus major muscle (ZMM). METHODS: Twenty-three fresh cadaver facial halves were dissected. Four references points were identified in each cadaver head: the zygomatic arch, the malar eminence, the modiolus, and the ZMM insertion notch. The ZMM insertion notch is a palpable landmark that is typically identified midway between the zygomatic arch and the malar eminience. A straight line was drawn from the ZMM insertion notch to the modiolus. An additional line was drawn from the malar eminence to the modiolus. An incision was made along the each line to the depth of the facial muscles. The presence or absence of the ZMM was recorded, and the location of the ZMM insertion notch was characterized in each cadaver. RESULTS: The ZMM insertion notch was palpated and identified in 23 of 23 facial halves. It was accurate in identifying the course of the ZMM in all 23 facial halves. The line created by the malar eminence to the modiolus was inaccurate in all 23 facial halves. CONCLUSION: The ZMM insertion notch is a reliable landmark for identification of the ZMM
—
id: 73809,
year: 2007,
vol: 9,
page: 271,
stat: Journal Article,
Direct Facial-to-Hypoglossal Neurorrhaphy with Parotid Release
Roland, J Thomas Jr; Lin, Karen; Klausner, Lee M; Miller, Philip J
2006 May;16(2):101-108, Skull base
Objective: Facial nerve paralysis or compromise can be caused by lesions of the temporal bone and cerebellopontine angle and their treatment. When the facial nerve is transected or severely compromised and primary end-to-end repair is not possible, hypoglossal-facial nerve anastomosis remains the most popular method for accomplishing three main goals: restoring facial tone, restoring facial symmetry, and facilitating return of voluntary facial movement. Our objectives are to evaluate the surgical feasibility and long-term outcomes of our technique of direct facial-to-hypoglossal neurorrhaphy with a parotid-release maneuver. Design: Prospective cohort. Setting: Academic tertiary care referral center. Patients: Ten patients with facial paralysis from proximal nerve injury underwent the facial-hypoglossal neurorrhaphy with a parotid-release maneuver. Main outcome measures: The Repaired Facial Nerve Recovery Scale, questionnaires, and photographs. Results: Facial-hypoglossal neurorrhaphy with parotid release was technically feasible in all cases, and anastomosis was performed distal to the origin of the ansa hypoglossi. All patients had good return of facial nerve function. Nine patients had scores of C or better, indicating strong eyelid and oral sphincter closure and mass motion. There was no hemilingual atrophy and no subjective tongue dysfunction. Conclusions: The parotid-release maneuver mobilizes additional length to the facial nerve, facilitating a tensionless communication distal to the ansa hypoglossi. The technique is a viable option for facial reanimation, and our patients achieved good clinical outcomes with continual improvement
—
id: 105544,
year: 2006,
vol: 16,
page: 101,
stat: Journal Article,
Structural approach to endonasal rhinoplasty
Shah, Anil R; Miller, Philip J
2006 Feb;22(1):55-60, Facial plastic surgery
The marriage of endonasal rhinoplasty with structural grafting has resulted in more consistent rhinoplasty results. The nasal base can be stabilized by tongue-in-groove techniques, a columellar strut, or extended columellar strut. The middle vault can be addressed with spreader grafts or butterfly grafts. Lower lateral cartilage weakness can be supported with alar batten grafts or repositioning of the lower lateral cartilages
—
id: 64792,
year: 2006,
vol: 22,
page: 55,
stat: Journal Article,
Computerized plastic surgery office
Miller, Philip J
2004 Aug;12(4):357-361, Current opinion in otolaryngology & head & neck surgery
PURPOSE OF REVIEW: Technology in general and computer capabilities in particular are growing at an exponential rate. Keeping current with the latest technological capacities and means of incorporating this technology into the facial plastic surgeon's office poses a significant challenge. This review will document the most appropriate method of incorporation and the latest available technological tools. RECENT FINDINGS: Recent developments in wireless networking, systems integration, digital photography and video, powerful inexpensive computer systems, and the growth of personal digital assistant integration have all contributed to a surge in technological advances. Implementing any or all can significantly benefit the busy facial plastic surgery office. SUMMARY: Keeping abreast of technological advances is a daunting task. Adaptation of these advances into the office can at times be overwhelming. This review will assist the practicing physician in incorporating selective technological tools to streamline his or her systems and increase efficiency
—
id: 47853,
year: 2004,
vol: 12,
page: 357,
stat: Journal Article,
Expanded polytetrafluoroethylene implants in rhinoplasty: literature review, operative techniques, and outcome
Ham, Jongwook; Miller, Philip J
2003 Dec;19(4):331-339, Facial plastic surgery
Gore-Tex, a form of expanded polytetrafluoroethylene (ePTFE), over the past 30 years has attracted much attention as an alloplast for use in rhinoplasty, both from advocates and opponents of its use. It has many desirable traits as an alloplast implant, but many surgeons harbor hesitation and reluctance for alloplast use in rhinoplasty based on historical data of previous nasal implants. Only when objective data from large series of patients with long-term follow-up become available will such skepticism be resolved. Large series of patients with Gore-Tex implant placement during rhinoplasty are beginning to emerge in the literature. The purpose of this article is twofold. The first is to provide the reader with an up-to-date review of the literature on the host response to polymer implants and, second, of the current indications and operative techniques for use and outcomes of Gore-Tex implants in rhinoplasty
—
id: 46278,
year: 2003,
vol: 19,
page: 331,
stat: Journal Article,
A simple and reliable method of patient evaluation in the surgical treatment of nasal obstruction
Constantinides, Minas; Galli, Suzanne K Doud; Miller, Philip J
2002 Oct;81(10):734-737, Ear, nose & throat journal
We have developed a simple method of evaluating nasal obstruction both before and after corrective surgery. With our system, patients self-rate their nasal patency on a 10-point visual analog scale under different conditions. After a baseline self-assessment, patients rate their breathing while the examiner lifts the lower lateral nasal cartilage with an ear curette and again during lifting of the upper lateral cartilage. Separate assessments during cartilage support are made before and after the patient has received nasal decongestion therapy. The results of these manipulations help identify the specific structural abnormality and its anatomic site, thereby serving as a reliable aid to planning surgery (i.e., open septorhinoplasty, turbinoplasty, external valve surgery with alar batten grafts, and/or internal valve surgery with spreader grafts with or without composite skin/cartilage grafts). We tested our method in preoperative evaluation and surgical planning on 19 patients with nasal obstructions. Our method was just as useful in making postoperative assessments, and it allowed us to judge the effectiveness of specific procedures in restoring nasal patency. Of the 19 patients, 18 (94.7%) reported that their nasal breathing had improved following surgery
—
id: 39573,
year: 2002,
vol: 81,
page: 734,
stat: Journal Article,
Complications of static facial suspensions with expanded polytetrafluoroethylene (ePTFE)
Constantinides M; Galli SK; Miller PJ
2001 Dec;111(12):2114-2121, Laryngoscope
BACKGROUND: Expanded polytetrafluoroethylene (ePTFE) is a synthetic porous material that has been used for static suspension in facial paralysis. It is manufactured in thin (1-mm or 2-mm) sheets that can be cut into strips and implanted through keyhole facial incisions. Regional deformities are addressed by multiple suspensions that provide cosmetic and functional therapy. The use of ePTFE eliminates donor site morbidity associated with the traditional harvest of fascia from either the temporal area or fascia lata. However, properties unique to this alloplast contribute to the complications that have occurred after its use in facial reanimation. OBJECTIVE: To describe complications with the use of ePTFE for facial suspension. SETTING: Academic medical center. METHOD: Retrospective chart review and review of literature. RESULTS: Six patients with facial paralysis who were treated with the ePTFE sling procedure had complications. Five slings failed because of stretch despite prestretching at implantation. One patient developed a late wound infection requiring removal of the sling. CONCLUSION: An ePTFE facial sling is an option for static facial suspension that can be therapeutic for patients with seventh nerve damage. There is a high rate of complications leading to revision surgery. Future studies are needed to evaluate alloplastic alternatives to ePTFE
—
id: 25993,
year: 2001,
vol: 111,
page: 2114,
stat: Journal Article,
Vertical lobule division in rhinoplasty: maintaining an intact strip
Constantinides M; Liu ES; Miller PJ; Adamson PA
2001 Oct-Dec;3(4):258-263, Archives of facial plastic surgery
OBJECTIVE: To review the indications for, surgical techniques of, and results of vertical lobule division (VLD) of the alar cartilages. DESIGN: Prospective study of patients assigned to undergo variations of VLD of the lower lateral cartilages. SETTING: Private facial plastic surgery practice in a major university teaching hospital. PATIENTS: Twenty-four patients who underwent variations of VLD of the lower lateral cartilages with re-creation of an intact strip, including 4 patients undergoing revision. MAIN OUTCOME MEASURES: Postoperative photographs were reviewed for tip projection and rotation, tip symmetry, bossae, knuckles, columellar position and length, and alar retraction. Patients were polled about their overall satisfaction with nasal aesthetics and degree of subjective nasal obstruction preoperatively and postoperatively. RESULTS: Vertical lobule division decreased projection in 22 of 22 patients, increased rotation in 12 of 12 patients, decreased rotation in 1 of 2 patients, corrected tip asymmetry in 3 of 4 patients, and shortened a long infratip lobule in 1 patient. Postoperatively, bossae and knuckling developed in 1 patient, and 2 patients demonstrated alar retraction that did not exist preoperatively. One patient undergoing revision noted worsened nasal obstruction not related to VLD. CONCLUSIONS: Vertical lobule division is a reliable, safe technique with predictable outcomes in tip repositioning. It allows for preservation of a strong tip complex while adding versatility to tip refinement
—
id: 25994,
year: 2001,
vol: 3,
page: 258,
stat: Journal Article,
Midfacial effects of the deep-plane facelift
Miller PJ; Constantinides M; Galli SK
2001 Feb;17(1):49-56, Facial plastic surgery
Rejuvenation of the midface is a challenge in facial plastic surgery. To this end, several techniques have been developed to address the changes seen in the midface with aging. Specifically, ptosis of the malar fat pad and deepening of the nasolabial fold contribute to the aesthetic changes that characterize midfacial aging. The history of modern facelifts and deep-plane facelift techniques to correct the nasolabial fold are presented
—
id: 25995,
year: 2001,
vol: 17,
page: 49,
stat: Journal Article,
Malar, submalar, and midfacial implants
Constantinides MS; Galli SK; Miller PJ; Adamson PA
2000 ;16(1):35-44, Facial plastic surgery
A resurgence of malar augmentation using alloplastic implants can be attributed to the safety, simplicity of technique, and reliable good results of these implants. As the more sculpted face becomes a common aesthetic goal, malar augmentation plays an increased role in facial plastic surgery practices. It provides a natural, 'unoperated' look that is preferred by most patients today. The history of our current aesthetic and how new alloplasts have contributed is reviewed. The development of simpler techniques of malar analysis will also be reviewed. An indepth look at aesthetic analysis, implant choice, surgical approach, postoperative results, and possible complications will provide a thorough review of current malar implantation
—
id: 25991,
year: 2000,
vol: 16,
page: 35,
stat: Journal Article,
Softform for facial rejuvenation: historical review, operative techniques, and recent advances
Miller PJ; Levine J; Ahn MS; Maas CS; Constantinides M
2000 ;16(1):23-28, Facial plastic surgery
The deep nasolabial fold and other facial furrows and wrinkles have challenged the facial plastic surgeon. A variety of techniques have been used in the past to correct these troublesome defects. Advances in the last five years in new materials and design have created a subcutaneous implant that has excellent properties. This article reviews the development and use of Softform facial implant
—
id: 25992,
year: 2000,
vol: 16,
page: 23,
stat: Journal Article,
Grafting for nasal valve collapse
Miller PJ; Constantinides M
1999 ;10(3):238-242, Operative techniques in otolaryngology, head & neck surgery
—
id: 26023,
year: 1999,
vol: 10,
page: 238,
stat: Journal Article,
Midline cleft. Treatment of the bifid nose
Miller PJ; Grinberg D; Wang TD
1999 Jul-Sep;1(3):200-203, Archives of facial plastic surgery
BACKGROUND: Midline facial clefts are rare deformities with a wide range of clinical findings from a simple midline vermillion notch to major skeletal malformations, including orbital hypertelorism. The bifid nose is a relatively uncommon malformation that is frequently associated with hypertelorbitism and midline clefts of the lip. The presentation of a bifid nose ranges from a minimally noticeable midline nasal tip central groove to a complete clefting of the osteocartilaginous framework, resulting in 2 complete half noses. We describe our experience with 2 patients with midface clefts who presented with bifid noses and a variety of other congenital abnormalities. The anatomy, extensive treatment, and complications of the bifid nose are discussed. DESIGN: Retrospective case review and literature review. RESULTS: Successful creation of an aesthetic nasal contour and normal nasal function was achieved without complication via extensive skin, bony, and cartilaginous resection. CONCLUSIONS: The bifid nose challenges the rhinoplasty surgeon. A successful outcome is dependent on a thorough understanding of the bifid nasal anatomy, proper patient evaluation, careful preoperative planning, and meticulous surgical technique
—
id: 11557,
year: 1999,
vol: 1,
page: 200,
stat: Journal Article,
Extended applications for endoscopic forehead surgery
Miller PJ; Grinberg D; Zimbler M
1999 Oct-Dec;1(4):316-319, Archives of facial plastic surgery
Endoscopic equipment and specially designed elevators and dissecting instruments provide access to the forehead and scalp region through minimal incisions. This technique is now widely accepted for aesthetic forehead and browlifts. To our knowledge, however, it has not previously been used in reconstructive forehead and scalp surgery. We carried out a retrospective review of 5 cases involving patients who underwent reconstructive scalp and frontal bone defect surgery: 2 patients had frontal defects that were contoured with expanded polytetrafluoroethylene (Gore-Tex; WL Gore & Assoc, Phoenix, Ariz) inserted endoscopically; 2 patients had scalp soft tissue defects that were treated with wide subgaleal undermining and endoscopically guided galeotomies that resulted in primary closure; and 1 patient was treated for facial paralysis to improve the aesthetic result. We conclude that aesthetic endoscopic surgical techniques and equipment can be used in reconstructive therapy for patients with bony and soft tissue defects of the scalp and forehead
—
id: 11556,
year: 1999,
vol: 1,
page: 316,
stat: Journal Article,
A comparison of digital cameras
Miller PJ; Light J
1999 ;15(2):111-117, Facial plastic surgery
Digital photography is becoming an increasingly popular alternative to traditional 35-mm photography. Clearly, the efficiency and versatility of digital cameras will have a major impact on the future of clinical photodocumentation in facial plastic surgery. However, most physicians who are interested in incorporating digital photography into their clinical practice have limited experience with this new technology. This article reviews the difference between traditional and digital cameras, compares various commercially available products, and discusses several features unique to digital cameras
—
id: 39444,
year: 1999,
vol: 15,
page: 111,
stat: Journal Article,
New developments in nasal valve analysis and functional nasal surgery
Constantinides M; Miller PJ
1998 ;6(4):238-245, Current opinion in otolaryngology & head & neck surgery
The nasal valve is the most important region responsible for air flow and nasal resistance. In the past five years, numerous advances have been made in nasal valve analysis and surgery. The discovery that the valve consists of two distinct regions, the external and internal valves, has led to tailored surgical techniques to improve each site independently. Improved objective tests using rhinomanometry, acoustic rhinometry, and magnetic resonance imaging have proven that certain surgical techniques will improve nasal valve function. The roles of septoplasty, inferior turbinate surgery, and cartilage grafting have been objectively analyzed and methodically delineated. The nasal valve is now a prominent factor in planning cosmetic and functional rhinoplasty. This review examines the recent developments in nasal valve surgery and fits them into historical perspective with the evolution of our understanding of the nasal valve
—
id: 15967,
year: 1998,
vol: 6,
page: 238,
stat: Journal Article,
Simple and serial excisions
Miller PJ; Constantinides M
1998 ;6(2):141-147, Facial plastic surgery clinics of North America
—
id: 26022,
year: 1998,
vol: 6,
page: 141,
stat: Journal Article,
Replantation of the amputated nose
Miller PJ; Hertler C; Alexiades G; Cook TA
1998 Aug;124(8):907-910, Archives of otolaryngology, head & neck surgery
OBJECTIVE: To assess the effectiveness of replantation in the treatment of nasal amputations. DESIGN: Retrospective chart review. SETTING: A university medical center. RESULTS: In no case did the replant survive completely, and in all cases revision surgery was required. However, in all cases, the resulting deformity was less than the original defect. In our pediatric patients, reconstruction with cartilage grafting and a midline forehead flap was successful and demonstrated proportionate and appropriate growth. CONCLUSIONS: It is our belief that replantation serves many therapeutic functions. At the very least, there is the psychological/emotional factor that is involved in attempting to replace a native body part that has been severed. Also, it is difficult to persuade parents and patients that the amputated tissue that has been handled with kid gloves by paramedics, maintaining its pink 'alive' color, is ultimately doomed to failure. Forehead flaps and conchal cartilage grafts are more willingly accepted after a 'failed' replantation than as primary reconstructions. In every instance, we believe, the ultimate defect will be smaller than the original deformity. Certainly, the need for vestibular lining reconstruction is far less. Thus, the ultimate healed defect from the replantation greatly facilitates final nasal reconstruction
—
id: 12082,
year: 1998,
vol: 124,
page: 907,
stat: Journal Article,
Coronoid osteochondroma of the mandible: transzygomatic access and autogenous bony reconstruction
Constantinides M; Lagmay V; Miller P
1997 Dec;117(6):S86-S91, Otolaryngology, head & neck surgery
—
id: 12186,
year: 1997,
vol: 117,
page: S86,
stat: Journal Article,
Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation
Muggia, F M; Hainsworth, J D; Jeffers, S; Miller, P; Groshen, S; Tan, M; Roman, L; Uziely, B; Muderspach, L; Garcia, A; Burnett, A; Greco, F A; Morrow, C P; Paradiso, L J; Liang, L J
1997 Mar;15(3):987-993, Journal of clinical oncology
PURPOSE: A phase II study of liposomal doxorubicin was conducted in patients with ovarian cancer who failed to respond to platinum- and paclitaxel-based regimens. Liposomal doxorubicin was selected as a result of its superior activity against ovarian cancer xenografts relative to free doxorubicin and activity in refractory ovarian cancer patients that was noted during the phase I study. PATIENTS AND METHODS: Thirty-five consecutive patients were accrued in two institutions (22 in one and 13 in the other). All had progressive disease after either cisplatin or carboplatin and paclitaxel, or at least one platinum-based and one paclitaxel-based regimen. Patients received intravenous (I.V.) liposomal doxorubicin 50 mg/m2 every 3 weeks with a dose reduction to 40 mg/m2 in the event of grade 3 or 4 toxicities, or a lengthening of the interval to 4 weeks (and occasionally to 5 weeks) with persistence of grade 1 or 2 toxicities beyond 3 weeks. RESULTS: Nine clinical responses (one complete response [CR], eight partial responses [PRs]) were observed in 35 patients (25.7%), with seven of these having been confirmed by two consecutive computed tomographic (CT) measurements. The median progression-free survival was 5.7 months with an overall survival of 1.5 to 24+ months (median, 11 months). Although 13 patients experienced grade 3 or 4 nonhematologic skin and mucosal toxicities (either hand-foot syndrome or stomatitis), with dose modifications, the treatment was very well tolerated. Nausea that was clearly attributable to the drug, hair loss, extravasation necrosis, or decreases in ejection fraction did not occur. CONCLUSION: Liposomal doxorubicin has substantial activity against ovarian cancer refractory to platinum and paclitaxel. The responses achieved with liposomal doxorubicin were durable and maintained with minimal toxicity. This liposomal formulation should be evaluated further in combination with other drugs in less refractory patients
—
id: 111689,
year: 1997,
vol: 15,
page: 987,
stat: Journal Article,
Intracranial inverting papilloma
Miller PJ; Jacobs J; Roland JT Jr; Cooper J; Mizrachi HH
1996 Sep-Oct;18(5):450-453, Head & neck
BACKGROUND: Inverting papillomas usually originate from the lateral wall of the nose and sporadically from the ethmoid, maxillary, sphenoid, or frontal sinuses. Intracranial extension and dural penetration is rare and often associated with recurrent disease that has degenerated into squamous cell carcinoma. A case of inverting papilloma with dural penetration in the absence of malignant degeneration has prompted an investigation into the incidence and treatment of dural invasion by benign inverting papilloma. METHODS: A literature search revealed 1468 cases of inverting papilloma. A detailed analysis was performed to obtain data on the incidence of intracranial invasion. RESULTS: Of the 1468 cases, 5 were noted to be associated with intracranial extension without histologic evidence of malignancy (0.34%). Treatment consisted of surgery alone in 3, radiotherapy in 1, and combined therapy in the last patient. Dural invasion was documented histopathologically in one case. CONCLUSION: Intracranial extension and dural penetration of benign inverting papilloma is extremely rare, and a uniform treatment plan has not been established. Further investigation is necessary in the pathophysiology and management of intracranial inverting papilloma
—
id: 12554,
year: 1996,
vol: 18,
page: 450,
stat: Journal Article,
Rejuvenation of the aging forehead and brow
Miller PJ; Wang TD; Cook TA
1996 Apr;12(2):147-155, Facial plastic surgery
Rejuvenation of the aging upper face can transform tired and angry features into youthful-appearing ones. This article presents the principles for analyzing and treating the aging forehead and brow. The esthetic dimensions and proportions of the brow and forehead are discussed, in context with the corresponding surgical anatomy. The goals of facial rejuvenation surgery as it relates to the upper third of the face are addressed. Various approaches, including their advantages and disadvantages, are presented. The appropriate approach is selected to eliminate unsightly features that are in need of correction while minimizing hairline shifts and forehead scarring and anesthesia. Following the principles and techniques illustrated in this article, the facial plastic surgeon may confidently treat the signs and complaints of the aging upper face
—
id: 7220,
year: 1996,
vol: 12,
page: 147,
stat: Journal Article,
Retrofacial approach to the hypotympanum
Roland JT Jr; Hoffman RA; Miller PJ; Cohen NL
1995 Feb;121(2):233-236, Archives of otolaryngology, head & neck surgery
Otologic disease often extends into the hypotympanum, posterior mesotympanum, and infralabyrinthine compartments. Surgical access to these areas can be difficult because of the proximity of the facial nerve. In patients with a normal bone anatomy, these regions can be accessed by a retrofacial approach, which spares the posterior canal wall and avoids transposition of the facial nerve. The anatomy of the hypotympanum, posterior mesotympanum, and infralabyrinthine compartments will be reviewed emphasizing gross anatomic documentation. We will detail the surgical approach to these areas along the retrofacial air cell tract, and will present an appropriate case history
—
id: 12806,
year: 1995,
vol: 121,
page: 233,
stat: Journal Article,
Intradiploic epidermoid of the temporal bone: case history and literature review
Miller PJ; Hoffman R; Holliday R
1994 Dec;111(6):827-831, Otolaryngology, head & neck surgery
—
id: 12856,
year: 1994,
vol: 111,
page: 827,
stat: Journal Article,
Madelung's disease: case reports and literature review
Kohan D; Miller PJ; Rothstein SG; Kaufman D
1993 Feb;108(2):156-159, Otolaryngology, head & neck surgery
—
id: 13257,
year: 1993,
vol: 108,
page: 156,
stat: Journal Article,


