Michael H Pillinger

Biosketch / Results /

Michael Pillinger

Professor, Department of Medicine
Professor, Department of Biochemistry and Molecular Pharmacology

Dir Rheumatology FlwpPgm Chr/Dir Rheumatology VA

Contact Info

Address
227 East 30th Street
New York, NY 10016

646/501-2722
Michael.Pillinger@nyumc.org

Education

1987 — NYU School of Medicine, Medical Education
1987-1990 — A Einstein College of Medicine (Bronx Municipal Hospital Center), Residency Training
1990-1993 — NYU Medical Center (Rheumatology), Clinical Fellowships

Research Summary

In rheumatoid arthritis (RA) the tissues of the involved joints assume inflammatory, autoimmune and pseudoneoplastic features. The cells contributing to these phenotypes include neutrophils, which accumulate in the RA joint space, and synovial fibroblasts (SFs), which proliferate in great numbers in the RA synovium (pannus) and secrete matrix metalloproteinases (MMPs) that participate in the destruction of cartilage.
The mitogen-activated protein kinases (MAPKs) include the Erks, Jnks and p38. Our laboratory is interested in the role of MAPKs on neutrophils and SF regulation. We are especially interested in the role of Erks. We have observed that, in neutrophils, Erk is rapidly activated in response to chemoattractants and regulates neutrophil adhesion, a critical early step in the acute inflammation. In SFs we have shown that Erk regulates proliferation, but also the release of some (MMP-1,3,9) but not other (MMP-13) metalloproteinases. Interestingly, high-dose salicylates (doses achievable in patients but in excess of those needed to inhibit cyclooxygenase) inhibit Erk in both neutrophils and SFs, and concordantly inhibit neutrophil adhesion and SF MMP release. Non-salicylate nonsteroidals also inhibit cyclooxygenase but do not reproduce these effects. Indeed, COX inhibition actually leads to enhancement of MMP release from synovial fibroblasts.
Our present aims are threefold: 1) to understand the mechanisms through which Erk positively regulates neutrophil adhesion; 2) to understand the cross talk between prostaglandin production and Erk activation in SF responses; 3) to understand the mechanisms through which salicylates inhibit Erk, as a clue into how Erk, and other signaling pathways, may be pharmacologically targeted. A better understanding of these phenomena may lead to new approaches, and new agents, for the treatment of RA.}

Research Interests

Signal transduction and the regulation of cells involved in inflammation and rheumatoid arthritis

Cardiovascular Disease Prevalence in Patients with Osteoarthritis, Gout, or Both
Bang, Daisy; Xu, Jinfeng; Keenan, Robert; Pike, Virginia; Lehmann, Robert; Tenner, Craig; Crittenden, Daria; Pillinger, Michael; Krasnokutsky, Svetlana. Cardiovascular Disease Prevalence in Patients with Osteoarthritis, Gout, or Both. Bulletin of the Hospital for Joint Diseases (2013). 2016 Jun ;74(2):113-118 (2170062)

Pegloticase failure and a possible solution: Immunosuppression to prevent intolerance and inefficacy in patients with gout
Berhanu, Adey A; Krasnokutsky, Svetlana; Keenan, Robert T; Pillinger, Michael H. Pegloticase failure and a possible solution: Immunosuppression to prevent intolerance and inefficacy in patients with gout. Seminars in arthritis & rheumatism. 2016 Sep 20;:?-? (2280192)

Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education
Berman, J R; O'Rourke, K S; Kolasinski, S L; Aizer, J; Wheatley, M J; Battistone, M J; Siaton, B C; Criscione-Schreiber, L; Pillinger, M H; Lazaro, D M. Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education. Arthritis care & research (2010). 2016 2016;(no(pagination):- (2301522)

The Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education
Berman, Jessica R; O'Rourke, Kenneth S; Kolasinski, Sharon L; Aizer, Juliet; Wheatley, Mary; Battistone, Michael J; Siaton, Bernadette C; Criscione-Schreiber, Lisa; Pillinger, Michael H; Lazaro, Deana M. The Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education. Arthritis care & research (2010). 2016 Oct 1;68(11):1591-1597 (2009132)

Association Between Gout and Aortic Stenosis
Chang, Kevin; Yokose, Chio; Tenner, Craig; Oh, Cheongeun; Donnino, Robert; Choy-Shan, Alana; Pike, Virginia C; Shah, Binita D; Lorin, Jeffrey D; Krasnokutsky, Svetlana; Sedlis, Steven P; Pillinger, Michael H. Association Between Gout and Aortic Stenosis. American journal of medicine. 2016 Oct 6;:?-? (2278232)