Biosketch / Results /

Mark Reid Philips, M.D.

Professor; Director for Basic Research CI; Assoc Director for Basic Research CI
Departments of Medicine (Rheum Div), Cell Biology (Cell Biology) and Biochemistry and Molecular Pharmacology

Clinical Addresses

522 FIRST AVENUE
SMILOW RESEARCH BUILDING RM. 1205
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-7404
Fax: 212-263-9210

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Medical Specialties

Rheumatology, Internal Medicine

Dr. Philips is the Course Director for the Rheumatology Section of Second Year Medicine and is an Attending Physician in the Department of Medicine.

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Board Certification

1985 — Ab Internal Medicine - Internal Medicine
1988 — Ab Internal Medicine (Rheumatology)

Education

1982 — Columbia University College of Physicians & Surgeons, Medical Education
1982-1985 — NYU Medical Center (Internal Medicine), Residency Training
1985-1988 — NYU Medical Center (Rheumatology), Clinical Fellowships

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Research Summary

Our laboratory is primarily interested in the cell biology of GTPases. GTPases are ubiquitous elements of signaling pathways, including those regulating cell growth and differentiation. Virtually all cellular processes utilize GTPases as regulatory elements including processes that control the immune response. Thus, although our work has immediate relevance to cancer, insights from our studies may be relevant to a wide variety of human diseases including inflammatory and autoimmune disorders.<br><br>The protooncogene ras and closely related GTPases are among a class of proteins that are synthesized as soluble molecules in the cytosol and are then targeted to membranes by a series of posttranslational modifications of a C-terminal CAAX sequence that includes prenylation, proteolysis, and carboxyl methylation. Of these modifications, only carboxyl methylation is reversible and may therefore have a signaling function. We therefore focused on the enzyme that catalyzes this modification, prenylcysteine carboxyl methyltransferase, and recently cloned its gene.<br><br>Prenylcysteine carboxyl methyltransferase proved to be a multiple membrane spanning protein that is expressed in ER and Golgi but not plasma membrane (see figure). This observation was surprising since it implied that ras, synthesized in the cytosol and destined for the plasma membrane, must make a detour to the ER to complete processing. The ER processing of ras led us to hypothesize that ras is transported to plasma membrane via the vesicular transport system. Using green fluorescent protein-tagged ras proteins we showed that this model is correct. We also showed that carboxyl methylation is required for vesicular transport of ras. We hope to exploit this previously unappreciated aspect of ras biology to develop novel anticancer therapies.<br><br>In more recent work we have tested the hypothesis that intracellular ras can be activated and regulate signaling pathways and proved it correct. We accomplished this by developing a novel fluorescent probe that reports when and where Ras becomes activated in living cells. We consider our probe for activated ras a prototyped of a class of molecules that can serve as fluorescent reporters of signaling events in living cells and thereby elucidate many previously inaccessible aspects of signal transduction.

Research Interests

Processing and membrane targeting of GTPases.<br>

Research Keywords

Cancer, Signal Transduction, GTPases, Ras, Protein Prenylation, Protein Methylation.<br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Metabolic labeling of ras with tritiated palmitate to monitor palmitoylation and depalmitoylation
Tsai, Frederick D; Wynne, Joseph P; Ahearn, Ian M; Philips, Mark R
2014 ;1120:33-41, Methods in molecular biology
— id: 778262, year: 2014, vol: 1120, page: 33, stat: Journal Article,

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression
Court, Helen; Amoyel, Marc; Hackman, Michael; Lee, Kyoung Eun; Xu, Ruliang; Miller, George; Bar-Sagi, Dafna; Bach, Erika A; Bergo, Martin O; Philips, Mark R
2013 Oct;:182-192, Journal of clinical investigation
— id: 761382, year: 2013, vol: , page: 182, stat: Journal Article,

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors
Sung, Pamela J; Tsai, Frederick D; Vais, Horia; Court, Helen; Yang, Jun; Fehrenbacher, Nicole; Foskett, J Kevin; Philips, Mark R
2013 Dec;110(51):20593-20598, Proceedings of the National Academy of Sciences of the United States of America
— id: 712492, year: 2013, vol: 110, page: 20593, stat: Journal Article,

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression
Wang, Yufang; Velho, Sergia; Vakiani, Efsevia; Peng, Shouyong; Bass, Adam J; Chu, Gerald C; Gierut, Jessica; Bugni, James M; Der, Channing J; Philips, Mark; Solit, David B; Haigis, Kevin M
2013 Mar;3(3):294-307, Cancer discovery
— id: 334592, year: 2013, vol: 3, page: 294, stat: Journal Article,

The RA and PH domains of RIAM act as a proximity detector for Rap1 and PI(4,5)P-2
Wynne, J. ; Wu, J. ; Su, W. ; Hubbard, S. R. ; Philips, M. R.
2013 JUL;280 1 1(SI):400-400, FEBS journal
— id: 657892, year: 2013, vol: 280 1 1, page: 400, stat: Journal Article,

Regulating the regulator: post-translational modification of RAS
Ahearn, Ian M; Haigis, Kevin; Bar-Sagi, Dafna; Philips, Mark R
2012 Jan;13(1):39-51, Nature reviews. Molecular cell biology
— id: 147707, year: 2012, vol: 13, page: 39, stat: Journal Article,

Rac1 gets fattier
Tsai, Frederick D; Philips, Mark R
2012 Feb;31(3):517-518, EMBO journal
— id: 221132, year: 2012, vol: 31, page: 517, stat: Journal Article,

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
Wynne, Joseph P; Wu, Jinhua; Su, Wenjuan; Mor, Adam; Patsoukis, Nikolaos; Boussiotis, Vassiliki A; Hubbard, Stevan R; Philips, Mark R
2012 Oct;199(2):317-330, Journal of cell biology
— id: 180090, year: 2012, vol: 199, page: 317, stat: Journal Article,

Regulation of RAS oncogenicity by acetylation
Yang, Moon Hee; Nickerson, Seth; Kim, Eric T; Liot, Caroline; Laurent, Gaelle; Spang, Robert; Philips, Mark R; Shan, Yibing; Shaw, David E; Bar-Sagi, Dafna; Haigis, Marcia C; Haigis, Kevin M
2012 Jul;109(27):10843-10848, Proceedings of the National Academy of Sciences of the United States of America
— id: 173075, year: 2012, vol: 109, page: 10843, stat: Journal Article,

FKBP12 binds to acylated h-ras and promotes depalmitoylation
Ahearn, Ian M; Tsai, Frederick D; Court, Helen; Zhou, Mo; Jennings, Benjamin C; Ahmed, Mahiuddin; Fehrenbacher, Nicole; Linder, Maurine E; Philips, Mark R
2011 Jan 21;41(2):173-185, Molecular cell
— id: 121308, year: 2011, vol: 41, page: 173, stat: Journal Article,

Cytosolic ras supports eye development in Drosophila
Sung, Pamela J; Rodrigues, Aloma B; Kleinberger, Andrew; Quatela, Steven; Bach, Erika A; Philips, Mark R
2010 Dec;30(24):5649-5657, Molecular & cellular biology
— id: 114824, year: 2010, vol: 30, page: 5649, stat: Journal Article,

Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis
Botelho, Roberto J; Harrison, Rene E; Stone, James C; Hancock, John F; Philips, Mark R; Jongstra-Bilen, Jenny; Mason, David; Plumb, Jonathan; Gold, Michael R; Grinstein, Sergio
2009 Oct 16;284(42):28522-28532, Journal of biological chemistry
— id: 133732, year: 2009, vol: 284, page: 28522, stat: Journal Article,

Ras/MAPK signaling from endomembranes
Fehrenbacher, Nicole; Bar-Sagi, Dafna; Philips, Mark
2009 Aug;3(4):297-307, Molecular oncology
— id: 101955, year: 2009, vol: 3, page: 297, stat: Journal Article,

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation
Madigan, James P; Bodemann, Brian O; Brady, Donita C; Dewar, Brian J; Keller, Patricia J; Leitges, Michael; Philips, Mark R; Ridley, Anne J; Der, Channing J; Cox, Adrienne D
2009 Nov 15;424(1):153-161, Biochemical journal
— id: 150609, year: 2009, vol: 424, page: 153, stat: Journal Article,

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane
Mor, Adam; Wynne, Joseph P; Ahearn, Ian M; Dustin, Michael L; Du, Guangwei; Philips, Mark R
2009 Jun;29(12):3297-3306, Molecular & cellular biology
— id: 99231, year: 2009, vol: 29, page: 3297, stat: Journal Article,

Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe
Wright, Latasha P; Court, Helen; Mor, Adam; Ahearn, Ian M; Casey, Patrick J; Philips, Mark R
2009 Apr;29(7):1826-1833, Molecular & cellular biology
— id: 97752, year: 2009, vol: 29, page: 1826, stat: Journal Article,

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
Michaelson, David; Abidi, Wasif; Guardavaccaro, Daniele; Zhou, Mo; Ahearn, Ian; Pagano, Michele; Philips, Mark R
2008 May 5;181(3):485-496, Journal of cell biology
— id: 79148, year: 2008, vol: 181, page: 485, stat: Journal Article,

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis
Quatela, Steven E; Sung, Pamela J; Ahearn, Ian M; Bivona, Trever G; Philips, Mark R
2008 ;439:87-102, Methods in enzymology
— id: 79382, year: 2008, vol: 439, page: 87, stat: Journal Article,

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion
Quinlan, Margaret P; Quatela, Steven E; Philips, Mark R; Settleman, Jeffrey
2008 Apr;28(8):2659-2674, Molecular & cellular biology
— id: 133405, year: 2008, vol: 28, page: 2659, stat: Journal Article,

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans
Yun, Chi; Stanhill, Ariel; Yang, Yun; Zhang, Yuhong; Haynes, Cole M; Xu, Chong-Feng; Neubert, Thomas A; Mor, Adam; Philips, Mark R; Ron, David
2008 May 13;105(19):7094-7099, Proceedings of the National Academy of Sciences of the United States of America
— id: 94504, year: 2008, vol: 105, page: 7094, stat: Journal Article,

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
Mor, Adam; Campi, Gabriele; Du, Guangwei; Zheng, Yang; Foster, David A; Dustin, Michael L; Philips, Mark R
2007 Jun;9(6):713-719, Nature cell biology
— id: 73108, year: 2007, vol: 9, page: 713, stat: Journal Article,

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling
Mor, Adam; Dustin, Michael L; Philips, Mark R
2007 Aug;218:114-125, Immunological reviews
— id: 73951, year: 2007, vol: 218, page: 114, stat: Journal Article,

The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis
Mor, Adam; Philips, Mark R; Pillinger, Michael H
2007 Dec;125(3):215-223, Clinical immunology
— id: 75658, year: 2007, vol: 125, page: 215, stat: Journal Article,

Geranylgeranyltransferase I as a target for anti-cancer drugs
Philips, Mark R; Cox, Adrienne D
2007 May;117(5):1223-1225, Journal of clinical investigation
— id: 72874, year: 2007, vol: 117, page: 1223, stat: Journal Article,

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
Beigneux, Anne P; Vergnes, Laurent; Qiao, Xin; Quatela, Steven; Davis, Ryan; Watkins, Steven M; Coleman, Rosalind A; Walzem, Rosemary L; Philips, Mark; Reue, Karen; Young, Stephen G
2006 Apr;47(4):734-744, Journal of lipid research
— id: 150604, year: 2006, vol: 47, page: 734, stat: Journal Article,

Analysis of Ras activation in living cells with GFP-RBD
Bivona, TG; Quatela, S; Philips, MR
2006 MAY ;407(11):128-143, Methods in enzymology
— id: 98072, year: 2006, vol: 407, page: 128, stat: Journal Article,

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
Bivona, Trever G; Quatela, Steven E; Bodemann, Brian O; Ahearn, Ian M; Soskis, Michael J; Mor, Adam; Miura, John; Wiener, Heidi H; Wright, Latasha; Saba, Shahryar G; Yim, Duke; Fein, Adam; Perez de Castro, Ignacio; Li, Chi; Thompson, Craig B; Cox, Adrienne D; Philips, Mark R
2006 Feb 17;21(4):481-493, Molecular cell
— id: 64117, year: 2006, vol: 21, page: 481, stat: Journal Article,

Spatial segregation of Ras signaling: new evidence from fission yeast
Chang, Eric C; Philips, Mark R
2006 Sep;5(17):1936-1939, Cell cycle
— id: 150608, year: 2006, vol: 5, page: 1936, stat: Journal Article,

The use of GFP to localize Rho GTPases in living cells
Michaelson, David; Philips, Mark
2006 ;406:296-315, Methods in enzymology
— id: 150605, year: 2006, vol: 406, page: 296, stat: Journal Article,

Compartmentalized ras/mapk signaling
Mor, Adam; Philips, Mark R
2006 ;24:771-800, Annual review of immunology
— id: 64114, year: 2006, vol: 24, page: 771, stat: Journal Article,

Compartmentalized signaling of Ras in fission yeast
Onken, Brian; Wiener, Heidi; Philips, Mark R; Chang, Eric C
2006 Jun 13;103(24):9045-9050, Proceedings of the National Academy of Sciences of the United States of America
— id: 150606, year: 2006, vol: 103, page: 9045, stat: Journal Article,

Ras signaling on the Golgi
Quatela, Steven E; Philips, Mark R
2006 Apr;18(2):162-167, Current opinion in cell biology
— id: 64116, year: 2006, vol: 18, page: 162, stat: Journal Article,

Thematic review series: Lipid Posttranslational Modifications. CAAX modification and membrane targeting of Ras
Wright, Latasha P; Philips, Mark R
2006 May;47(5):883-891, Journal of lipid research
— id: 64115, year: 2006, vol: 47, page: 883, stat: Journal Article,

Receptor activation alters inner surface potential during phagocytosis
Yeung, Tony; Terebiznik, Mauricio; Yu, Liming; Silvius, John; Abidi, Wasif M; Philips, Mark; Levine, Tim; Kapus, Andras; Grinstein, Sergio
2006 Jul 21;313(5785):347-351, Science
— id: 150607, year: 2006, vol: 313, page: 347, stat: Journal Article,

Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains
Bivona, Trever G; Philips, Mark R
2005 Oct;37(2):138-145, Methods
— id: 61854, year: 2005, vol: 37, page: 138, stat: Journal Article,

Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion
Chan, Amanda Y; Coniglio, Salvatore J; Chuang, Ya-yu; Michaelson, David; Knaus, Ulla G; Philips, Mark R; Symons, Marc
2005 Nov 24;24(53):7821-7829, Oncogene
— id: 64120, year: 2005, vol: 24, page: 7821, stat: Journal Article,

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
Goodwin, J Shawn; Drake, Kimberly R; Rogers, Carl; Wright, Latasha; Lippincott-Schwartz, Jennifer; Philips, Mark R; Kenworthy, Anne K
2005 Jul 18;170(2):261-272, Journal of cell biology
— id: 64121, year: 2005, vol: 170, page: 261, stat: Journal Article,

Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII
Jordan, J Dedrick; He, John Cijiang; Eungdamrong, Narat J; Gomes, Ivone; Ali, Wasif; Nguyen, Tracy; Bivona, Trever G; Philips, Mark R; Devi, Lakshmi A; Iyengar, Ravi
2005 Mar 25;280(12):11413-11421, Journal of biological chemistry
— id: 64122, year: 2005, vol: 280, page: 11413, stat: Journal Article,

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases
Michaelson, David; Ali, Wasif; Chiu, Vi K; Bergo, Martin; Silletti, Joseph; Wright, Latasha; Young, Stephen G; Philips, Mark
2005 Apr;16(4):1606-1616, Molecular biology of the cell
— id: 57676, year: 2005, vol: 16, page: 1606, stat: Journal Article,

Compartmentalized signalling of Ras
Philips, M R
2005 Aug;33(Pt 4):657-661, Transactions (Biochemical Society (Great Britain))
— id: 64119, year: 2005, vol: 33, page: 657, stat: Journal Article,

Analysis of monomeric GTPases of the Ras and Rho families
Philips, Mark R
2005 Oct;37(2):129-130, Methods
— id: 64118, year: 2005, vol: 37, page: 129, stat: Journal Article,

Teaching resources. Imaging signal transduction in living cells with fluorescent proteins
Philips, Mark R
2005 Dec 13;2005(314):tr28-tr28, Science's STKE
— id: 62640, year: 2005, vol: 2005, page: tr28, stat: Journal Article,

Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
Bivona, Trever G; Wiener, Heidi H; Ahearn, Ian M; Silletti, Joseph; Chiu, Vi K; Philips, Mark R
2004 Mar 2;164(3):461-470, Journal of cell biology
— id: 46166, year: 2004, vol: 164, page: 461, stat: Journal Article,

Carboxyl methylation of Ras regulates membrane targeting and effector engagement
Chiu, Vi K; Silletti, Joseph; Dinsell, Victoria; Wiener, Heidi; Loukeris, Kristina; Ou, Guoming; Philips, Mark R; Pillinger, Michael H
2004 Mar 20;279(8):7346-7352, Journal of biological chemistry
— id: 46235, year: 2004, vol: 279, page: 7346, stat: Journal Article,

Membranes as messengers in T cell adhesion signaling
Dustin, Michael L; Bivona, Trever G; Philips, Mark R
2004 Apr;5(4):363-372, Nature immunology
— id: 44917, year: 2004, vol: 5, page: 363, stat: Journal Article,

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics
Lee, Mona D; She, Yuhong; Soskis, Michael J; Borella, Christopher P; Gardner, Jeffrey R; Hayes, Paula A; Dy, Benzon M; Heaney, Mark L; Philips, Mark R; Bornmann, William G; Sirotnak, Francis M; Scheinberg, David A
2004 Oct;114(8):1107-1116, Journal of clinical investigation
— id: 64123, year: 2004, vol: 114, page: 1107, stat: Journal Article,

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus
Perez de Castro, Ignacio; Bivona, Trever G; Philips, Mark R; Pellicer, Angel
2004 May;24(8):3485-3496, Molecular & cellular biology
— id: 46001, year: 2004, vol: 24, page: 3485, stat: Journal Article,

Differential spatio-temporal activation of Ras and Rap1 in living cells
Philips, M; Bivona, T
2004 MAY 14 ;18(8):C1-C1, FASEB journal
— id: 46553, year: 2004, vol: 18, page: C1, stat: Journal Article,

Methotrexate and Ras methylation: a new trick for an old drug?
Philips, Mark R
2004 Apr 23;2004(225):pe13-pe13, Science's STKE
— id: 46205, year: 2004, vol: 2004, page: pe13, stat: Journal Article,

Sef: a MEK/ERK catcher on the Golgi
Philips, Mark R
2004 Aug 23;15(2):168-169, Molecular cell
— id: 45970, year: 2004, vol: 15, page: 168, stat: Journal Article,

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations
Walker, Simon A; Kupzig, Sabine; Bouyoucef, Dalila; Davies, Louise C; Tsuboi, Takashi; Bivona, Trever G; Cozier, Gyles E; Lockyer, Peter J; Buckler, Alan; Rutter, Guy A; Allen, Maxine J; Philips, Mark R; Cullen, Peter J
2004 Apr 21;23(8):1749-1760, EMBO journal
— id: 64124, year: 2004, vol: 23, page: 1749, stat: Journal Article,

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
Zhang, Si Qing; Yang, Wentian; Kontaridis, Maria I; Bivona, Trever G; Wen, Gengyun; Araki, Toshiyuki; Luo, Jincai; Thompson, Julie A; Schraven, Burkhart L; Philips, Mark R; Neel, Benjamin G
2004 Feb 13;13(3):341-355, Molecular cell
— id: 64125, year: 2004, vol: 13, page: 341, stat: Journal Article,

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
Bivona, Trever G; Perez De Castro, Ignacio; Ahearn, Ian M; Grana, Theresa M; Chiu, Vi K; Lockyer, Peter J; Cullen, Peter J; Pellicer, Angel; Cox, Adrienne D; Philips, Mark R
2003 Aug 7;424(6949):694-698, Nature
— id: 39161, year: 2003, vol: 424, page: 694, stat: Journal Article,

Ras pathway signaling on endomembranes
Bivona, Trever G; Philips, Mark R
2003 Apr;15(2):136-142, Current opinion in cell biology
— id: 39266, year: 2003, vol: 15, page: 136, stat: Journal Article,

Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1
Cascone, Ilaria; Audero, Enrica; Giraudo, Enrico; Napione, Lucia; Maniero, Fabrizio; Philips, Mark R; Collard, John G; Serini, Guido; Bussolino, Federico
2003 Oct 1;102(7):2482-2490, Blood
— id: 64127, year: 2003, vol: 102, page: 2482, stat: Journal Article,

Immunotoxin resistance in multidrug resistant cells
McGrath, Melissa S; Rosenblum, Michael G; Philips, Mark R; Scheinberg, David A
2003 Jan 1;63(1):72-79, Cancer research
— id: 64128, year: 2003, vol: 63, page: 72, stat: Journal Article,

Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK
Mohney, Robert P; Das, Margaret; Bivona, Trever G; Hanes, Richard; Adams, Anthony G; Philips, Mark R; O'Bryan, John P
2003 Nov 21;278(47):47038-47045, Journal of biological chemistry
— id: 64126, year: 2003, vol: 278, page: 47038, stat: Journal Article,

Localized diacylglycerol-dependent activation of Ras during Fc gamma receptor-mediated phagocytosis
Botelho, RJ; Mojdami, D; Chiu, VK; Bivona, T; Philips, MR; Grinstein, S
2002 NOV ;13(4):225A-225A, Molecular biology of the cell
— id: 37187, year: 2002, vol: 13, page: 225A, stat: Journal Article,

Ras signalling on the endoplasmic reticulum and the Golgi
Chiu, Vi K; Bivona, Trever; Hach, Angela; Sajous, J Bernard; Silletti, Joseph; Wiener, Heidi; Johnson, Ronald L 2nd; Cox, Adrienne D; Philips, Mark R
2002 May;4(5):343-350, Nature cell biology
— id: 32483, year: 2002, vol: 4, page: 343, stat: Journal Article,

Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi
Michaelson, David; Ahearn, Ian; Bergo, Martin; Young, Stephen; Philips, Mark
2002 Sep;13(9):3294-3302, Molecular biology of the cell
— id: 47809, year: 2002, vol: 13, page: 3294, stat: Journal Article,

Activity of G gamma prenylcysteine carboxyl methyltransferase
Michaelson, David; Philips, Mark R
2002 ;344(10):234-245, Methods in enzymology
— id: 27263, year: 2002, vol: 344, page: 234, stat: Journal Article,

Green fluorescent protein-tagged Ras proteins for intracellular localization
Choy E; Philips M
2001 ;332(4):50-64, Methods in enzymology
— id: 21199, year: 2001, vol: 332, page: 50, stat: Journal Article,

Activity of G[gamma] prenylcysteine carboxyl methyltransferase
Michaelson D; Philips MR
2001 ;344:234-245, Methods in enzymology
— id: 26863, year: 2001, vol: 344, page: 234, stat: Journal Article,

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
Michaelson D; Silletti J; Murphy G; D'Eustachio P; Rush M; Philips MR
2001 Jan 8;152(1):111-126, Journal of cell biology
— id: 17229, year: 2001, vol: 152, page: 111, stat: Journal Article,

Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways
Murphy GA; Jillian SA; Michaelson D; Philips MR; D'Eustachio P; Rush MG
2001 Mar;12(3):157-167, Cell growth & differentiation
— id: 26749, year: 2001, vol: 12, page: 157, stat: Journal Article,

Expression and activity of human prenylcysteine-directed carboxyl methyltransferase
Choy, E; Philips, M
2000 ;325:101-114, Methods in enzymology
— id: 150603, year: 2000, vol: 325, page: 101, stat: Journal Article,

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi [see comments]
Choy E; Chiu VK; Silletti J; Feoktistov M; Morimoto T; Michaelson D; Ivanov IE; Philips MR
1999 Jul 9;98(1):69-80, Cell
— id: 8499, year: 1999, vol: 98, page: 69, stat: Journal Article,

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway
Capodici C; Pillinger MH; Han G; Philips MR; Weissmann G
1998 Jul 1;102(1):165-175, Journal of clinical investigation
— id: 7521, year: 1998, vol: 102, page: 165, stat: Journal Article,

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum
Dai Q; Choy E; Chiu V; Romano J; Slivka SR; Steitz SA; Michaelis S; Philips MR
1998 Jun 12;273(24):15030-15034, Journal of biological chemistry
— id: 7542, year: 1998, vol: 273, page: 15030, stat: Journal Article,

Brainstem origins of the n18 component of the somatosensory evoked response
Philips, M; Kotapka, M; Patterson, T; Bigelow, D C; Zager, E; Flamm, E S; Stecker, M
1998 ;8(3):133-140, Skull base surgery
— id: 123822, year: 1998, vol: 8, page: 133, stat: Journal Article,

Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion
Pillinger MH; Capodici C; Rosenthal P; Kheterpal N; Hanft S; Philips MR; Weissmann G
1998 Nov 24;95(24):14540-14545, Proceedings of the National Academy of Sciences of the United States of America
— id: 7745, year: 1998, vol: 95, page: 14540, stat: Journal Article,

Differential phosphorylation of the beta2 integrin CD11b/CD18 in the plasma and specific granule membranes of neutrophils
Buyon JP; Philips MR; Merrill JT; Slade SG; Leszczynska-Piziak J; Abramson SB
1997 Mar;61(3):313-321, Journal of leukocyte biology
— id: 9735, year: 1997, vol: 61, page: 313, stat: Journal Article,

Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex
Clancy RM; Rediske J; Tang X; Nijher N; Frenkel S; Philips M; Abramson SB
1997 Oct 1;100(7):1789-1796, Journal of clinical investigation
— id: 9733, year: 1997, vol: 100, page: 1789, stat: Journal Article,

Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: evidence for regulation of cell-cell adhesion
Pillinger MH; Feoktistov AS; Capodici C; Solitar B; Levy J; Oei TT; Philips MR
1996 May 17;271(20):12049-12056, Journal of biological chemistry
— id: 8311, year: 1996, vol: 271, page: 12049, stat: Journal Article,

Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity
Philips MR; Feoktistov A; Pillinger MH; Abramson SB
1995 May 12;270(19):11514-11521, Journal of biological chemistry
— id: 6712, year: 1995, vol: 270, page: 11514, stat: Journal Article,

Prenylcysteine-directed carboxyl methyltransferase activity in human neutrophil membranes
Philips MR; Pillinger MH
1995 ;256:49-63, Methods in enzymology
— id: 12854, year: 1995, vol: 256, page: 49, stat: Journal Article,

Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit
Philips MR; Staud R; Pillinger M; Feoktistov A; Volker C; Stock JB; Weissmann G
1995 Mar 14;92(6):2283-2287, Proceedings of the National Academy of Sciences of the United States of America
— id: 6713, year: 1995, vol: 92, page: 2283, stat: Journal Article,

CARBOXYL METHYLATION OF RHO-FAMILY RAS-RELATED PROTEINS IN HUMAN NEUTROPHILS IS ASSOCIATED WITH ACTIN POLYMERIZATION
PHILIPS, MR; FEOKTISTOV, AS; PILLINGER, MH
1995 SEP ;38(9):159-159, Arthritis & rheumatism
— id: 86687, year: 1995, vol: 38, page: 159, stat: Journal Article,

Crosstalk in signal transduction via EP receptors: prostaglandin E1 inhibits chemoattractant-induced mitogen-activated protein kinase activity in human neutrophils
Pillinger MH; Philips MR; Feoktistov A; Weissmann G
1995 ;23:311-316, Advances in prostaglandin thromboxane & leukotriene research
— id: 6714, year: 1995, vol: 23, page: 311, stat: Journal Article,

CROSSTALK IN SIGNAL-TRANSDUCTION VIA EP RECEPTORS - PROSTAGLANDIN E(1) INHIBITS CHEMOATTRACTANT-INDUCED MITOGEN-ACTIVATED PROTEIN-KINASE ACTIVITY IN HUMAN NEUTROPHILS
PILLINGER, MH; PHILIPS, MR; FEOKTISTOV, A; WEISSMANN, G
1995 FEB ;23(2):311-316, Advances in prostaglandin & thromboxane research
— id: 87404, year: 1995, vol: 23, page: 311, stat: Journal Article,

Prenylcysteine analogs to study function of carboxylmethylation in signal transduction
Volker C; Pillinger MH; Philips MR; Stock JB
1995 ;250(19):216-225, Methods in enzymology
— id: 23914, year: 1995, vol: 250, page: 216, stat: Journal Article,

Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): requirement for assembly of heterotrimeric G proteins in bilayer phospholipid
Abramson SB; Leszczynska-Piziak J; Clancy RM; Philips M; Weissmann G
1994 Feb 9;47(3):563-572, Biochemical pharmacology
— id: 6306, year: 1994, vol: 47, page: 563, stat: Journal Article,

Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils
Pillinger MH; Volker C; Stock JB; Weissmann G; Philips MR
1994 Jan 14;269(2):1486-1492, Journal of biological chemistry
— id: 6485, year: 1994, vol: 269, page: 1486, stat: Journal Article,

Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils
Philips MR; Pillinger MH; Staud R; Volker C; Rosenfeld MG; Weissmann G; Stock JB
1993 Feb 12;259(5097):977-980, Science
— id: 13250, year: 1993, vol: 259, page: 977, stat: Journal Article,

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors
Cronstein BN; Levin RI; Philips M; Hirschhorn R; Abramson SB; Weissmann G
1992 Apr 1;148(7):2201-2206, Journal of immunology (1950)
— id: 9751, year: 1992, vol: 148, page: 2201, stat: Journal Article,

LIGATION OF THE NEUTROPHIL FORMYL PEPTIDE RECEPTOR INDUCES CARBOXYL METHYLATION OF G-GAMMA
STAUD, R; PILLINGER, MH; WEISSMANN, G; PHILIPS, MR
1992 SEP ;35(9):S137-S137, Arthritis & rheumatism
— id: 74222, year: 1992, vol: 35, page: S137, stat: Journal Article,

Low molecular weight GTP-binding proteins in human neutrophil granule membranes
Philips MR; Abramson SB; Kolasinski SL; Haines KA; Weissmann G; Rosenfeld MG
1991 Jan 15;266(2):1289-1298, Journal of biological chemistry
— id: 8314, year: 1991, vol: 266, page: 1289, stat: Journal Article,

Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes
Abramson SB; Cherksey B; Gude D; Leszczynska-Piziak J; Philips MR; Blau L; Weissmann G
1990 Feb;14(1):11-30, Inflammation
— id: 9760, year: 1990, vol: 14, page: 11, stat: Journal Article,

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions
Buyon JP; Slade SG; Reibman J; Abramson SB; Philips MR; Weissmann G; Winchester R
1990 Jan 1;144(1):191-197, Journal of immunology (1950)
— id: 9762, year: 1990, vol: 144, page: 191, stat: Journal Article,

Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase
Haines KA; Reibman J; Callegari PE; Abramson SB; Philips MR; Weissmann G
1990 Jun 15;144(12):4757-4764, Journal of immunology (1950)
— id: 9758, year: 1990, vol: 144, page: 4757, stat: Journal Article,

Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation
Buyon JP; Abramson SB; Philips MR; Slade SG; Ross GD; Weissmann G; Winchester RJ
1988 May 1;140(9):3156-3160, Journal of immunology (1950)
— id: 9768, year: 1988, vol: 140, page: 3156, stat: Journal Article,

Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis
Hopkins P; Belmont HM; Buyon J; Philips M; Weissmann G; Abramson SB
1988 May;31(5):632-641, Arthritis & rheumatism
— id: 9769, year: 1988, vol: 31, page: 632, stat: Journal Article,

Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation
Philips MR; Buyon JP; Winchester R; Weissmann G; Abramson SB
1988 Aug;82(2):495-501, Journal of clinical investigation
— id: 9767, year: 1988, vol: 82, page: 495, stat: Journal Article,