Jennifer A. Philips

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Jennifer Philips

Assistant Professor, Department of Medicine;Assistant Professor, Department of Microbiology;Assistant Professor, Department of Pathology

Contact Info

522 First Avenue
New York, NY 10016


Research Summary

The Philips lab is interested in how mycobacteria survive in macrophages. One third of the world population is infected with Mycobacterium tuberculosis (M.tb), and it causes 2-3 million deaths yearly. The enormous worldwide burden of disease underscores the proficiency by which M.tb is able to evade eradication by the host, subverting innate and adaptive defenses. M.tb targets evolutionarily conserved molecules to survive within macrophages, cells that normally eradicate bacteria. We have employed genome-wide, high throughput strategies to identify both bacterial effectors and host factors that influence the outcome of infection in both model systems and mammalian macrophages.

The goal of the lab is to characterize the role of such factors during infection. Insight into M.tb-host interactions is sure to broaden our understanding of bacterial pathogenesis as well as eukaryotic cell biology and may ultimately translate into effective therapeutics more quickly than traditional strategies targeting bacterial factors.

Post-doctoral Positions Available: interested individuals should contact

Jennifer Philips, MD, lab website: Jennifer Philips Research

Research Interests

Tuberculosis, Host Pathogen Interactions, Innate Immunity, Bacterial Pathogenesis

Autophagy meets phagocytosis
Cadwell, Ken; Philips, Jennifer A
2013-09-30; 1074-7613,Immunity - id: 542812, year: 2013 Journal Article

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
Mehra, Alka; Zahra, Aleena; Thompson, Victor; Sirisaengtaksin, Natalie; Wells, Ashley; Porto, Maura; Koster, Stefan; Penberthy, Kristen; Kubota, Yoshihisha; Dricot, Amelie; Rogan, Daniel; Vidal, Marc; Hill, David E; Bean, Andrew J; Philips, Jennifer A
2013-11-18; 1553-7366,PLoS pathogens - id: 626852, year: 2013 Journal Article

Tuberculosis Pathogenesis and Immunity
Philips JA; Ernst JD
2012-02-05; 1553-4014,Annual review of pathology - id: 145546, year: 2012

Directly observing therapy: a new view of drug tolerance in tuberculosis
Philips, Jennifer A; Ernst, Joel D
2012-02-05; 1097-4172,Cell - id: 130308, year: 2011

Mycobacterial manipulation of vacuolar sorting
Philips, Jennifer A
2012-02-05; 1462-5822,Cellular microbiology - id: 91720, year: 2008 Journal Article; Review