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Jennifer A. Philips

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Jennifer A. Philips, M.D., Ph.D.

Assistant Professor;
Departments of Medicine (ID&Immun Div), Pathology (Pathology) and Microbiology (Microbiology )

Clinical Addresses

550 FIRST AVENUE
NEW YORK, NY 10016
Phone: 212-263-9181

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Medical Specialties

Infectious Diseases

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Board Certification

2004 — Ab Internal Medicine - Internal Medicine
2005 — Ab Internal Medicine (Infectious Disease)

Education

1991-2000 — University of California - San Francisco, Medical Education
2000-2002 — Brigham and Women's Hospital (Internal Medicine), Internship
2000-2002 — Brigham and Women's Hospital (Internal Medicine), Residency Training
2002-2006 — Massachusetts General Hospital (Infectious Diseases), Clinical Fellowships

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Research Summary

The Philips lab is interested in how mycobacteria survive in macrophages. One third of the world population is infected with Mycobacterium tuberculosis (M.tb), and it causes 2-3 million deaths yearly. The enormous worldwide burden of disease underscores the proficiency by which M.tb is able to evade eradication by the host, subverting innate and adaptive defenses. M.tb targets evolutionarily conserved molecules to survive within macrophages, cells that normally eradicate bacteria. Using RNAi, we have employed genome-wide, high throughput strategies to identify host factors that influence the outcome of infection in both model systems and mammalian macrophages. This work lead to the identification of numerous host cell factors that alter infection, and one goal of the lab is to characterize the role of such factors during infection. For example, we found that endosomal sorting complex required for transport (ESCRT) machinery plays a role in mycobacterial phagosome maturation in addition to its known functions in receptor trafficking and viral budding. Ongoing work involves elucidating the mechanism by which the ESCRT machinery restricts bacterial growth, as well as evaluating whether Mycobacterium tuberculosis targets ESCRT activity in order to promote survival within macrophages. In the future, we will combine such functional genomics approaches with systems-based strategies to identify molecular interactions between the bacterial secretome and host cell targets. Insight into M.tb-host interactions is sure to broaden our understanding of bacterial pathogenesis as well as eukaryotic cell biology and may ultimately translate into effective therapeutics more quickly than traditional strategies targeting bacterial factors.

Post-doctoral Positions Available: interested individuals should contact Jennifer.Philips@nyumc.org

Research Interests

Tuberculosis, Host Pathogen Interactions, Innate Immunity, Bacterial Pathogenesis

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Tuberculosis Pathogenesis and Immunity
Philips JA; Ernst JD
2012 Feb;7:353-384, Annual review of pathology
— id: 145546, year: 2012, vol: 7, page: 353, stat: Journal Article,

Directly observing therapy: a new view of drug tolerance in tuberculosis
Philips, Jennifer A; Ernst, Joel D
2011 Apr 1;145(1):13-14, Cell
— id: 130308, year: 2011, vol: 145, page: 13, stat: Journal Article,

Mycobacterial manipulation of vacuolar sorting
Philips, Jennifer A
2008 Dec;10(12):2408-2415, Cellular microbiology
— id: 91720, year: 2008, vol: 10, page: 2408, stat: Journal Article,

ESCRT factors restrict mycobacterial growth
Philips, Jennifer A; Porto, Maura C; Wang, Hui; Rubin, Eric J; Perrimon, Norbert
2008 Feb 26;105(8):3070-3075, Proceedings of the National Academy of Sciences of the United States of America
— id: 91700, year: 2008, vol: 105, page: 3070, stat: Journal Article,

Torsades de pointes associated with voriconazole use
Philips, J A; Marty, F M; Stone, R M; Koplan, B A; Katz, J T; Baden, L R
2007 Mar;9(1):33-36, Transplant infectious disease
— id: 92781, year: 2007, vol: 9, page: 33, stat: Journal Article,

Genome-wide RNAi screen for host factors required for intracellular bacterial infection
Agaisse, Herve; Burrack, Laura S; Philips, Jennifer A; Rubin, Eric J; Perrimon, Norbert; Higgins, Darren E
2005 Aug 19;309(5738):1248-1251, Science
— id: 91618, year: 2005, vol: 309, page: 1248, stat: Journal Article,

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection
Philips, Jennifer A; Rubin, Eric J; Perrimon, Norbert
2005 Aug 19;309(5738):1251-1253, Science
— id: 91619, year: 2005, vol: 309, page: 1251, stat: Journal Article,

Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae
Philips, J; Herskowitz, I
1998 Oct 19;143(2):375-389, Journal of cell biology
— id: 92779, year: 1998, vol: 143, page: 375, stat: Journal Article,

Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
Philips, J; Herskowitz, I
1997 Sep 8;138(5):961-974, Journal of cell biology
— id: 92780, year: 1997, vol: 138, page: 961, stat: Journal Article,

Perturbation of nuclear architecture by long-distance chromosome interactions
Dernburg, A F; Broman, K W; Fung, J C; Marshall, W F; Philips, J; Agard, D A; Sedat, J W
1996 May 31;85(5):745-759, Cell
— id: 92778, year: 1996, vol: 85, page: 745, stat: Journal Article,

Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo
Wasilewski, M M; Lim, K C; Phillips, J; McKerrow, J H
1996 Oct 30;81(2):179-189, Molecular & biochemical parasitology
— id: 92782, year: 1996, vol: 81, page: 179, stat: Journal Article,

Comparison of the expression of the seven ribosomal RNA operons in Escherichia coli
Condon, C; Philips, J; Fu, Z Y; Squires, C; Squires, C L
1992 Nov;11(11):4175-4185, EMBO journal
— id: 92777, year: 1992, vol: 11, page: 4175, stat: Journal Article,