Jennifer A. Philips

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Jennifer A. Philips, M.D., Ph.D.

Assistant Professor;
Departments of Medicine (ID&Immun Div), Pathology (Pathology) and Microbiology (Microbiology )

Clinical Addresses

550 FIRST AVENUE
NEW YORK, NY 10016
Phone: 212-263-9181

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Medical Specialties

Infectious Diseases

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Board Certification

2004 — Ab Internal Medicine - Internal Medicine
2005 — Ab Internal Medicine (Infectious Disease)

Education

1991-2000 — University of California - San Francisco, Medical Education
2000-2002 — Brigham and Women's Hospital (Internal Medicine), Internship
2000-2002 — Brigham and Women's Hospital (Internal Medicine), Residency Training
2002-2006 — Massachusetts General Hospital (Infectious Diseases), Clinical Fellowships

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Research Summary

The Philips lab is interested in how mycobacteria survive in macrophages. One third of the world population is infected with Mycobacterium tuberculosis (M.tb), and it causes 2-3 million deaths yearly. The enormous worldwide burden of disease underscores the proficiency by which M.tb is able to evade eradication by the host, subverting innate and adaptive defenses. M.tb targets evolutionarily conserved molecules to survive within macrophages, cells that normally eradicate bacteria. We have employed genome-wide, high throughput strategies to identify both bacterial effectors and host factors that influence the outcome of infection in both model systems and mammalian macrophages.

The goal of the lab is to characterize the role of such factors during infection. Insight into M.tb-host interactions is sure to broaden our understanding of bacterial pathogenesis as well as eukaryotic cell biology and may ultimately translate into effective therapeutics more quickly than traditional strategies targeting bacterial factors.

Post-doctoral Positions Available: interested individuals should contact Jennifer.Philips@nyumc.org

Jennifer Philips, MD, lab website: Jennifer Philips Research

Research Interests

Tuberculosis, Host Pathogen Interactions, Innate Immunity, Bacterial Pathogenesis

Research Keywords

Tuberculosis, host-pathogen interactions, Type VII secretion, ESCRT, phagosome maturation, autophagy