Michele Pagano

Biosketch / Results /

Michele Pagano, M.D.

May Ellen and Gerald Jay Ritter Professor of Oncology;
Department of Pathology (Pathology)

Contact Info


522 First Avenue Floor 11th Room 1103
Smilow Research Building
New York, NY 10016

212-263-5129, 212-263-5332

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— Dr. Pagano was a post-doctoral fellow at EMBL, Heidelberg, Germany (August 1990-October 1992), before following his mentor to Mitotix Inc, Cambridge, MA (November 1992-August 1996), PostDoctoral Training
— First Medical School University of Naples, Italy, Medical Education

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All data from NYU Health Sciences Library Faculty Bibliography — -


Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival
Chen, X; Sahasrabuddhe, A A; Szankasi, P; Chung, F; Basrur, V; Rangnekar, V M; Pagano, M; Lim, M S; Elenitoba-Johnson, K S J
2014 Oct;21(10):1535-1545, Cell death & differentiation
— id: 1186632, year: 2014, vol: 21, page: 1535, stat: Journal Article,

Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
Choi, B H; Pagano, M; Da, W
2014 16 May 2014;289(20):14066-14074, Journal of biological chemistry
— id: 1058172, year: 2014, vol: 289, page: 14066, stat: Journal Article,

Cdh1, a substrate recruiting component of APC/C ubiquitin E3 ligase, specifically interacts with PTEN and promotes its removal from chromatin
Choi, Byeong Hyeok; Pagano, Michele; Huang, Chuanshu; Dai, Wei
2014 May;:17951-17959, Journal of biological chemistry
— id: 988602, year: 2014, vol: , page: 17951, stat: Journal Article,

Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle
Choi, Byeong; Pagano, Michele; Dai, Wei
2014 Apr;:14066-14074, Journal of biological chemistry
— id: 988612, year: 2014, vol: , page: 14066, stat: Journal Article,

DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation
Horn, Moritz; Geisen, Christoph; Cermak, Lukas; Becker, Ben; Nakamura, Shuhei; Klein, Corinna; Pagano, Michele; Antebi, Adam
2014 Mar;28(6):697-710, Developmental cell
— id: 883552, year: 2014, vol: 28, page: 697, stat: Journal Article,

Critical role for IL-1beta in DNA damage-induced mucositis
Kanarek, Naama; Grivennikov, Sergei I; Leshets, Michael; Lasry, Audrey; Alkalay, Irit; Horwitz, Elad; Shaul, Yoav D; Stachler, Matthew; Voronov, Elena; Apte, Ron N; Pagano, Michele; Pikarsky, Eli; Karin, Michael; Ghosh, Sankar; Ben-Neriah, Yinon
2014 Feb;111(6):E702-E711, Proceedings of the National Academy of Sciences of the United States of America
— id: 836712, year: 2014, vol: 111, page: E702, stat: Journal Article,

The ubiquitin proteasome system - Implications for cell cycle control and the targeted treatment of cancer
Bassermann, Florian; Eichner, Ruth; Pagano, Michele
2013 Mar;:150-162, Biochimica & biophysica acta
— id: 539812, year: 2013, vol: , page: 150, stat: Journal Article,

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis
D'Angiolella, Vincenzo; Esencay, Mine; Pagano, Michele
2013 Mar;23(3):135-140, Trends in cell biology
— id: 248122, year: 2013, vol: 23, page: 135, stat: Journal Article,

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
Fernandez-Saiz, Vanesa; Targosz, Bianca-Sabrina; Lemeer, Simone; Eichner, Ruth; Langer, Christian; Bullinger, Lars; Reiter, Clemens; Slotta-Huspenina, Julia; Schroeder, Sonja; Knorn, Anna-Maria; Kurutz, Julia; Peschel, Christian; Pagano, Michele; Kuster, Bernhard; Bassermann, Florian
2013 Jan;15(1):72-81, Nature cell biology
— id: 539822, year: 2013, vol: 15, page: 72, stat: Journal Article,

FBH1 protects melanocytes from transformation and is deregulated in melanomas
Jeong, Yeon-Tae; Cermak, Lukas; Guijarro, Maria V; Hernando, Eva; Pagano, Michele
2013 Apr;12(7):1128-1132, Cell cycle
— id: 287222, year: 2013, vol: 12, page: 1128, stat: Journal Article,

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Jeong, Yeon-Tae; Rossi, Mario; Cermak, Lukas; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Sung, Patrick; Schildkraut, Carl; Pagano, Michele
2013 Jan;200(2):141-149, Journal of cell biology
— id: 213662, year: 2013, vol: 200, page: 141, stat: Journal Article,

FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade
Kuchay, Shafi; Duan, Shanshan; Schenkein, Emily; Peschiaroli, Angelo; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele
2013 May;15(5):472-480, Nature cell biology
— id: 316032, year: 2013, vol: 15, page: 472, stat: Journal Article,

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
Li, Ji; D'Angiolella, Vincenzo; Seeley, E Scott; Kim, Sehyun; Kobayashi, Tetsuo; Fu, Wenxiang; Campos, Eric I; Pagano, Michele; Dynlacht, Brian David
2013 Mar;495(7440):255-259, Nature
— id: 242352, year: 2013, vol: 495, page: 255, stat: Journal Article,

Protein degradation regulates centriole disengagement in mitosis
Pagan, J K; Jones, M; Marzio, A; Pagano, M
2013 15 Dec 2013;24(24):-, Molecular biology of the cell
— id: 884372, year: 2013, vol: 24, page: , stat: Journal Article,

Role of the ubiquitin proteasome system in the heart
Pagan, Julia; Seto, Tiffany; Pagano, Michele; Cittadini, Antonio
2013 Mar;112(7):1046-1058, Circulation research
— id: 306262, year: 2013, vol: 112, page: 1046, stat: Journal Article,

Regulation of the CRL4(Cdt2) Ubiquitin Ligase and Cell-Cycle Exit by the SCF(Fbxo11) Ubiquitin Ligase
Rossi, Mario; Duan, Shanshan; Jeong, Yeon-Tae; Horn, Moritz; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Antebi, Adam; Pagano, Michele
2013 Mar;49(6):1159-1166, Molecular cell
— id: 271332, year: 2013, vol: 49, page: 1159, stat: Journal Article,

Mechanisms and function of substrate recruitment by F-box proteins
Skaar, Jeffrey R; Pagan, Julia K; Pagano, Michele
2013 Jun;14(6):369-381, Nature reviews. Molecular cell biology
— id: 353272, year: 2013, vol: 14, page: 369, stat: Journal Article,

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis
Tsunematsu, Takaaki; Takihara, Yoshihiro; Ishimaru, Naozumi; Pagano, Michele; Takata, Takashi; Kudo, Yasusei
2013 ;4:1885-1885, Nature communications
— id: 394762, year: 2013, vol: 4, page: 1885, stat: Journal Article,

SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket
Xing, Weiman; Busino, Luca; Hinds, Thomas R; Marionni, Samuel T; Saifee, Nabiha H; Bush, Matthew F; Pagano, Michele; Zheng, Ning
2013 Apr;496(7443):64-68, Nature
— id: 306182, year: 2013, vol: 496, page: 64, stat: Journal Article,

SCF-Mediated Degradation of p100 (NF-kappaB2): Mechanisms and Relevance in Multiple Myeloma
Busino, Luca; Millman, Scott E; Pagano, Michele
2012 ;5(253):pt14-pt14 pt14, Science signaling
— id: 197502, year: 2012, vol: 5, page: pt14, stat: Journal Article,

Fbxw7alpha- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
Busino, Luca; Millman, Scott E; Scotto, Luigi; Kyratsous, Christos A; Basrur, Venkatesha; O'Connor, Owen; Hoffmann, Alexander; Elenitoba-Johnson, Kojo S; Pagano, Michele
2012 Apr;14(4):375-385, Nature cell biology
— id: 163573, year: 2012, vol: 14, page: 375, stat: Journal Article,

SCFFbxo45 controls cytokinesis through ubiquitin-mediated proteolysis of GEF-H1
Chen, X; Ahn, J -Y; Szankasi, P; Chung, F; Basrur, E; Lim, M S; Miller, A L; Pagano, M; Elenitoba-Johnson, K S J
2012 April, 2012;26:-, FASEB journal
— id: 178106, year: 2012, vol: 26, page: , stat: Journal Article,

Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry
Chow, C; Wong, N; Pagano, M; Lun, S W-M; Nakayama, K-I; Nakayama, K; Lo, K-W
2012 Apr;31(15):1975-1987, Oncogene
— id: 165670, year: 2012, vol: 31, page: 1975, stat: Journal Article,

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair
D'Angiolella, Vincenzo; Donato, Valerio; Forrester, Frances M; Jeong, Yeon-Tae; Pellacani, Claudia; Kudo, Yasusei; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele
2012 May;149(5):1023-1034, Cell
— id: 167802, year: 2012, vol: 149, page: 1023, stat: Journal Article,

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
Duan, S; Cermak, L; Pagan, J K; Rossi, M; Martinengo, C; Francia, Di Celle P; Chapuy, B; Shipp, M; Chiarle, R; Pagano, M
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884402, year: 2012, vol: 23, page: , stat: Journal Article,

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
Duan, Shanshan; Cermak, Lukas; Pagan, Julia K; Rossi, Mario; Martinengo, Cinzia; di Celle, Paola Francia; Chapuy, Bjoern; Shipp, Margaret; Chiarle, Roberto; Pagano, Michele
2012 Jan 5;481(7379):90-93, Nature
— id: 149798, year: 2012, vol: 481, page: 90, stat: Journal Article,

Fbw7gamma-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes
Kim, Dong Seok; Zhang, Wei; Millman, Scott E; Hwang, Byung Joon; Kwon, Seok Joo; Clayberger, Carol; Pagano, Michele; Krensky, Alan M
2012 Aug;120(8):1658-1667, Blood
— id: 177229, year: 2012, vol: 120, page: 1658, stat: Journal Article,

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress
Kruiswijk, Flore; Yuniati, Laurensia; Magliozzi, Roberto; Low, Teck Yew; Lim, Ratna; Bolder, Renske; Mohammed, Shabaz; Proud, Christopher G; Heck, Albert J R; Pagano, Michele; Guardavaccaro, Daniele
2012 Jun;5(227):ra40-ra40 ra40, Science signaling
— id: 539832, year: 2012, vol: 5, page: ra40, stat: Journal Article,

Centrosome homeostasis is controlled by ubiquitylation and deubiquitylation cycles
Li, J; D'Angiolella, V; Seeley, E; Kobayashi, T; Kim, S; Pagano, M; Dynlacht, B
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884432, year: 2012, vol: 23, page: , stat: Journal Article,

APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit
Ping, Zhen; Lim, Ratna; Bashir, Tarig; Pagano, Michele; Guardavaccaro, Daniele
2012 May;11(10):1999-2005, Cell cycle
— id: 169025, year: 2012, vol: 11, page: 1999, stat: Journal Article,

SCF ubiquitin ligases in the maintenance of genome stability
Silverman, Joshua S; Skaar, Jeffrey R; Pagano, Michele
2012 Feb;37(2):66-73, Trends in biochemical sciences
— id: 155863, year: 2012, vol: 37, page: 66, stat: Journal Article,

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation
Wu, Lily; Grigoryan, Arsen V; Li, Yunfeng; Hao, Bing; Pagano, Michele; Cardozo, Timothy J
2012 Dec;19(12):1515-1524, Chemistry & biology
— id: 207422, year: 2012, vol: 19, page: 1515, stat: Journal Article,

BubR1 Is Modified by Sumoylation during Mitotic Progression
Yang, Feikun; Hu, Liyan; Chen, Cheng; Yu, Jianxiu; O'Connell, Christopher B; Khodjakov, Alexey; Pagano, Michele; Dai, Wei
2012 Feb;287(7):4875-4882, Journal of biological chemistry
— id: 157470, year: 2012, vol: 287, page: 4875, stat: Journal Article,

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
Cotto-Rios, Xiomaris M; Jones, Mathew J K; Busino, Luca; Pagano, Michele; Huang, Tony T
2011 Jul 25;194(2):177-186, Journal of cell biology
— id: 135576, year: 2011, vol: 194, page: 177, stat: Journal Article,

Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFbetaTrCP ubiquitin ligases
Duan, Shanshan; Pagano, Michele
2011 Dec 27;108(52):20857-20858, Proceedings of the National Academy of Sciences of the United States of America
— id: 149805, year: 2011, vol: 108, page: 20857, stat: Journal Article,

mTOR Generates an Auto-Amplification Loop by Triggering the betaTrCP- and CK1alpha-Dependent Degradation of DEPTOR
Duan, Shanshan; Skaar, Jeffrey R; Kuchay, Shafi; Toschi, Alfredo; Kanarek, Naama; Ben-Neriah, Yinon; Pagano, Michele
2011 Oct 21;44(2):317-324, Molecular cell
— id: 139744, year: 2011, vol: 44, page: 317, stat: Journal Article,

MCL1 meets its end during mitotic arrest
Millman, Scott E; Pagano, Michele
2011 May 1;12(5):384-385, EMBO reports
— id: 131815, year: 2011, vol: 12, page: 384, stat: Journal Article,

Loss of p27KIP1 Expression in Fully-staged Node-negative Breast Cancer: Association with Lack of Hormone Receptors in T1a/b, but not T1c Infiltrative Ductal Carcinoma
Mirchandani, Deepu; Roses, Daniel F; Inghirami, Giorgio; Zeleniuch-Jacquotte, Anne; Cangiarella, Joan; Guth, Amber; Safyan, Rachael Ann; Formenti, Silvia C; Pagano, Michele; Muggia, Franco
2011 Dec;31(12):4401-4405, Anticancer research
— id: 149934, year: 2011, vol: 31, page: 4401, stat: Journal Article,

The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
Nguyen, Paul L; Lin, Douglas I; Lei, Junyi; Fiorentino, Michelangelo; Mueller, Elke; Weinstein, Michael H; Pagano, Michele; Loda, Massimo
2011 May-Jun;29(3):302-308, Urologic oncology
— id: 539932, year: 2011, vol: 29, page: 302, stat: Journal Article,

FBXW5 controls centrosome number
Pagan, Julia; Pagano, Michele
2011 ;13(8):888-890, Nature cell biology
— id: 135567, year: 2011, vol: 13, page: 888, stat: Journal Article,

Clinical relevance of SKP2 alterations in metastatic melanoma
Rose, Amy E; Wang, Guimin; Hanniford, Douglas; Monni, Stefano; Tu, Ting; Shapiro, Richard L; Berman, Russell S; Pavlick, Anna C; Pagano, Michele; Darvishian, Farbod; Mazumdar, Madhu; Hernando, Eva; Osman, Iman
2011 Feb;24(1):197-206, Pigment cell & melanoma research
— id: 138133, year: 2011, vol: 24, page: 197, stat: Journal Article,

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization
Bashir, Tarig; Pagan, Julia K; Busino, Luca; Pagano, Michele
2010 Mar;9(5):971-974, Cell cycle
— id: 109207, year: 2010, vol: 9, page: 971, stat: Journal Article,

Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
Bassermann, F; Pagano, M
2010 Jan;17(1):78-85, Cell death & differentiation
— id: 136505, year: 2010, vol: 17, page: 78, stat: Journal Article,

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
D'Angiolella, Vincenzo; Donato, Valerio; Vijayakumar, Sangeetha; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Dynlacht, Brian; Pagano, Michele
2010 Jul 1;466(7302):138-142, Nature
— id: 110690, year: 2010, vol: 466, page: 138, stat: Journal Article,

Tumor Suppressor Function of Androgen Receptor Coactivator ARA70{alpha} in Prostate Cancer
Ligr, Martin; Li, Yirong; Zou, Xuanyi; Daniels, Garrett; Melamed, Jonathan; Peng, Yi; Wang, Wei; Wang, Jinhua; Ostrer, Harry; Pagano, Michele; Wang, Zhengxin; Garabedian, Michael J; Lee, Peng
2010 Apr;176(4):1891-1900, American journal of pathology
— id: 107298, year: 2010, vol: 176, page: 1891, stat: Journal Article,

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival
Peschiaroli, A; Skaar, J R; Pagano, M; Melino, G
2010 Mar;29(9):1384-1393, Oncogene
— id: 539842, year: 2010, vol: 29, page: 1384, stat: Journal Article,

Spindle assembly checkpoint inactivation: a new role for phosphatases
Skaar, Jeffrey R; Pagano, Michele
2010 Feb;9(4):644-645, Cell cycle
— id: 539852, year: 2010, vol: 9, page: 644, stat: Journal Article,

Cdc25 phosphatases: differential regulation by ubiquitin-mediated proteolysis
Young, Lauren M; Pagano, Michele
2010 Dec;9(23):4613-4614, Cell cycle
— id: 539862, year: 2010, vol: 9, page: 4613, stat: Journal Article,

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
Dehan, Elinor; Bassermann, Florian; Guardavaccaro, Daniele; Vasiliver-Shamis, Gaia; Cohen, Michael; Lowes, Kym N; Dustin, Michael; Huang, David C S; Taunton, Jack; Pagano, Michele
2009 Jan 16;33(1):109-116, Molecular cell
— id: 92189, year: 2009, vol: 33, page: 109, stat: Journal Article,

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation
Ge, Sheng; Skaar, Jeffrey R; Pagano, Michele
2009 Jan 1;8(1):167-171, Cell cycle
— id: 93223, year: 2009, vol: 8, page: 167, stat: Journal Article,

Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222
Hu, Liang; Ibrahim, Sherif; Liu, Cynthia; Skaar, Jeffrey; Pagano, Michele; Karpatkin, Simon
2009 Apr 15;69(8):3374-3381, Cancer research
— id: 98895, year: 2009, vol: 69, page: 3374, stat: Journal Article,

Wnt signaling in mitosis
Kaldis, Philipp; Pagano, Michele
2009 Dec;17(6):749-750, Developmental cell
— id: 539872, year: 2009, vol: 17, page: 749, stat: Journal Article,

Degradation of cyclin A is regulated by acetylation
Mateo, F; Vidal-Laliena, M; Canela, N; Busino, L; Martinez-Balbas, M A; Pagano, M; Agell, N; Bachs, O
2009 Jul;28(29):2654-2666, Oncogene
— id: 539882, year: 2009, vol: 28, page: 2654, stat: Journal Article,

Hypertension and diabetes mellitus are associated with cardiovascular events in the elderly without cardiovascular disease. Results of a 15-year follow-up in a Mediterranean population
Noto, D; Cefalu, A B; Barbagallo, C M; Sapienza, M; Cavera, G; Nardi, I; Pagano, M; Vivona, N; Notarbartolo, A; Averna, M R
2009 Jun;19(5):321-326, Nutrition, metabolism, & cardiovascular diseases : NMCD
— id: 79362, year: 2009, vol: 19, page: 321, stat: Journal Article,

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
Peschiaroli, A; Scialpi, F; Bernassola, F; Pagano, M; Melino, G
2009 Sep;28(35):3157-3166, Oncogene
— id: 539892, year: 2009, vol: 28, page: 3157, stat: Journal Article,

SnapShot: F Box Proteins II
Skaar, Jeffrey R; D'Angiolella, Vincenzo; Pagan, Julia K; Pagano, Michele
2009 Jun 26;137(7):1181-1183, Cell
— id: 100622, year: 2009, vol: 137, page: 1181, stat: Journal Article,

SnapShot: F box proteins I
Skaar, Jeffrey R; Pagan, Julia K; Pagano, Michele
2009 Jun 12;137(6):1160-1160.e1, Cell
— id: 100193, year: 2009, vol: 137, page: 1160, stat: Journal Article,

Control of cell growth by the SCF and APC/C ubiquitin ligases
Skaar, Jeffrey R; Pagano, Michele
2009 Dec;21(6):816-824, Current opinion in cell biology
— id: 105497, year: 2009, vol: 21, page: 816, stat: Journal Article,

INTS3 controls the hSSB1-mediated DNA damage response
Skaar, Jeffrey R; Richard, Derek J; Saraf, Anita; Toschi, Alfredo; Bolderson, Emma; Florens, Laurence; Washburn, Michael P; Khanna, Kum Kum; Pagano, Michele
2009 Oct 5;187(1):25-32, Journal of cell biology
— id: 103155, year: 2009, vol: 187, page: 25, stat: Journal Article,

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
Abbas, Tarek; Sivaprasad, Uma; Terai, Kenta; Amador, Virginia; Pagano, Michele; Dutta, Anindya
2008 Sep 15;22(18):2496-2506, Genes & development
— id: 96958, year: 2008, vol: 22, page: 2496, stat: Journal Article,

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
Bassermann, Florian; Frescas, David; Guardavaccaro, Daniele; Busino, Luca; Peschiaroli, Angelo; Pagano, Michele
2008 Jul 25;134(2):256-267, Cell
— id: 80620, year: 2008, vol: 134, page: 256, stat: Journal Article,

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state
Frescas, David; Guardavaccaro, Daniele; Kuchay, Shafi M; Kato, Hiroyuki; Poleshko, Andrey; Basrur, Venkatesha; Elenitoba-Johnson, Kojo S; Katz, Richard A; Pagano, Michele
2008 Nov 15;7(22):3539-3547, Cell cycle
— id: 91978, year: 2008, vol: 7, page: 3539, stat: Journal Article,

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
Frescas, David; Pagano, Michele
2008 Jun;8(6):438-449, Nature reviews. Cancer
— id: 79246, year: 2008, vol: 8, page: 438, stat: Journal Article,

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
Guardavaccaro, Daniele; Frescas, David; Dorrello, N Valerio; Peschiaroli, Angelo; Multani, Asha S; Cardozo, Timothy; Lasorella, Anna; Iavarone, Antonio; Chang, Sandy; Hernando, Eva; Pagano, Michele
2008 Mar 20;452(7185):365-369, Nature
— id: 78365, year: 2008, vol: 452, page: 365, stat: Journal Article,

Thrombin Enhances Spontaneous Tumor Growth and Cell Cycle Activation by Downregulation of p27(Kipl) and Upregulation of Skp2 and MiR-222
Hu, L; Ibrahim, S; Liu, C; Skaar, J; Pagano, M; Karpatkin, S
2008 NOV 16 ;112(11):152-152, Blood
— id: 93282, year: 2008, vol: 112, page: 152, stat: Journal Article,

APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation
Merluzzi, Sonia; Gri, Giorgia; Gattei, Valter; Pagano, Michele; Pucillo, Carlo
2008 Aug;45(14):3731-3739, Molecular immunology
— id: 96959, year: 2008, vol: 45, page: 3731, stat: Journal Article,

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
Michaelson, David; Abidi, Wasif; Guardavaccaro, Daniele; Zhou, Mo; Ahearn, Ian; Pagano, Michele; Philips, Mark R
2008 May 5;181(3):485-496, Journal of cell biology
— id: 79148, year: 2008, vol: 181, page: 485, stat: Journal Article,

The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: results of a 15 years follow-up in a Mediterranean population
Noto, Davide; Barbagallo, Carlo Maria; Cefalu, Angelo Baldassare; Falletta, Angelo; Sapienza, Michelangelo; Cavera, Giovanni; Amato, Salvatore; Pagano, Michele; Maggiore, Maria; Carroccio, Antonio; Notarbartolo, Alberto; Averna, Maurizio R
2008 Mar;197(1):147-153, Atherosclerosis
— id: 79364, year: 2008, vol: 197, page: 147, stat: Journal Article,

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70
Peng, Yi; Li, Caihong X; Chen, Fei; Wang, Zhengxin; Ligr, Martin; Melamed, Jonathan; Wei, Jianjun; Gerald, William; Pagano, Michele; Garabedian, Michael J; Lee, Peng
2008 Jan;172(1):225-235, American journal of pathology
— id: 76451, year: 2008, vol: 172, page: 225, stat: Journal Article,

Cdh1: a master G0/G1 regulator
Skaar, Jeffrey R; Pagano, Michele
2008 Jul;10(7):755-757, Nature cell biology
— id: 80618, year: 2008, vol: 10, page: 755, stat: Journal Article,

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Zhao, Xudong; Heng, Julian Ik-Tsen; Guardavaccaro, Daniele; Jiang, Richeng; Pagano, Michele; Guillemot, Francois; Iavarone, Antonio; Lasorella, Anna
2008 Jun;10(6):643-653, Nature cell biology
— id: 79363, year: 2008, vol: 10, page: 643, stat: Journal Article,

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
Amador, Virginia; Ge, Sheng; Santamaria, Patricia G; Guardavaccaro, Daniele; Pagano, Michele
2007 Aug 3;27(3):462-473, Molecular cell
— id: 73589, year: 2007, vol: 27, page: 462, stat: Journal Article,

Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1
Bassermann, Florian; von Klitzing, Christine; Illert, Anna Lena; Munch, Silvia; Morris, Stephan W; Pagano, Michele; Peschel, Christian; Duyster, Justus
2007 Jun;282(22):15965-15972, Journal of biological chemistry
— id: 159217, year: 2007, vol: 282, page: 15965, stat: Journal Article,

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
Busino, Luca; Bassermann, Florian; Maiolica, Alessio; Lee, Choogon; Nolan, Patrick M; Godinho, Sofia I H; Draetta, Giulio F; Pagano, Michele
2007 May 11;316(5826):900-904, Science
— id: 72420, year: 2007, vol: 316, page: 900, stat: Journal Article,

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
Cardozo, Timothy; Pagano, Michele
2007 ;8 Suppl 1:S9-S9, BMC biochemistry
— id: 75675, year: 2007, vol: 8 Suppl 1, page: S9, stat: Journal Article,

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age
Fielenbach, Nicole; Guardavaccaro, Daniele; Neubert, Kerstin; Chan, Tammy; Li, Dongling; Feng, Qin; Hutter, Harald; Pagano, Michele; Antebi, Adam
2007 Mar;12(3):443-455, Developmental cell
— id: 79365, year: 2007, vol: 12, page: 443, stat: Journal Article,

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
Frescas, David; Guardavaccaro, Daniele; Bassermann, Florian; Koyama-Nasu, Ryo; Pagano, Michele
2007 Nov 8;450(7167):309-313, Nature
— id: 75415, year: 2007, vol: 450, page: 309, stat: Journal Article,

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
Godinho, Sofia I H; Maywood, Elizabeth S; Shaw, Linda; Tucci, Valter; Barnard, Alun R; Busino, Luca; Pagano, Michele; Kendall, Rachel; Quwailid, Mohamed M; Romero, M Rosario; O'neill, John; Chesham, Johanna E; Brooker, Debra; Lalanne, Zuzanna; Hastings, Michael H; Nolan, Patrick M
2007 May 11;316(5826):897-900, Science
— id: 72419, year: 2007, vol: 316, page: 897, stat: Journal Article,

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer
Kitajima, Shojiro; Kudo, Yasusei; Ogawa, Ikuko; Tatsuka, Masaaki; Kawai, Hidehiko; Pagano, Michele; Takata, Takashi
2007 ;2(9):e944-e944, PLoS one
— id: 79130, year: 2007, vol: 2, page: e944, stat: Journal Article,

The pRb-Cdh1-p27 autoamplifying network
Santamaria, Patricia G; Pagano, Michele
2007 Feb;9(2):137-138, Nature cell biology
— id: 72423, year: 2007, vol: 9, page: 137, stat: Journal Article,

Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan; Abbasian, Mahan; Patel, Palka; Jensen-Pergakes, Kristen; Lombardo, Christian R; Cathers, Brian E; Xie, Weilin; Mercurio, Frank; Pagano, Michele; Giegel, David; Cox, Sarah
2007 May 25;282(21):15462-15470, Journal of biological chemistry
— id: 72421, year: 2007, vol: 282, page: 15462, stat: Journal Article,

APC/CCDC20 controls the ubiquitin-mediated degradation of p21 during early mitosis
Amador, V; Gonzalez-Santamaria, P; Pagano, M
2006 JUN ;273(11):136-136, FEBS journal
— id: 69260, year: 2006, vol: 273, page: 136, stat: Journal Article,

Modification of Cul1 regulates its association with proteasomal subunits
Bloom, Joanna; Peschiaroli, Angelo; Demartino, George; Pagano, Michele
2006 ;1:5-5, Cell division
— id: 72425, year: 2006, vol: 1, page: 5, stat: Journal Article,

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
Dorrello, N Valerio; Peschiaroli, Angelo; Guardavaccaro, Daniele; Colburn, Nancy H; Sherman, Nicholas E; Pagano, Michele
2006 Oct 20;314(5798):467-471, Science
— id: 69030, year: 2006, vol: 314, page: 467, stat: Journal Article,

Stabilizers and destabilizers controlling cell cycle oscillators
Guardavaccaro, Daniele; Pagano, Michele
2006 Apr 7;22(1):1-4, Molecular cell
— id: 64207, year: 2006, vol: 22, page: 1, stat: Journal Article,

Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27Kip1
Ji, Peng; Goldin, Luba; Ren, Hao; Sun, Daqian; Guardavaccaro, Daniele; Pagano, Michele; Zhu, Liang
2006 Aug 18;281(33):24058-24069, Journal of biological chemistry
— id: 66921, year: 2006, vol: 281, page: 24058, stat: Journal Article,

Cell Division, a new open access online forum for and from the cell cycle community
Kaldis, Philipp; Pagano, Michele
2006 ;1(1):1-1, Cell division
— id: 66922, year: 2006, vol: 1, page: 1, stat: Journal Article,

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Lasorella, Anna; Stegmuller, Judith; Guardavaccaro, Daniele; Liu, Guangchao; Carro, Maria S; Rothschild, Gerson; de la Torre-Ubieta, Luis; Pagano, Michele; Bonni, Azad; Iavarone, Antonio
2006 Jul 27;442(7101):471-474, Nature
— id: 66920, year: 2006, vol: 442, page: 471, stat: Journal Article,

Response: More money, and less time!
Pagano, M
2006 NOV 17 ;127(4):664-665, Cell
— id: 69456, year: 2006, vol: 127, page: 664, stat: Journal Article,

American Idol and NIH Grant Review
Pagano, Michele
2006 Aug 25;126(4):637-638, Cell
— id: 72424, year: 2006, vol: 126, page: 637, stat: Journal Article,

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
Peschiaroli, Angelo; Dorrello, N Valerio; Guardavaccaro, Daniele; Venere, Monica; Halazonetis, Thanos; Sherman, Nicholas E; Pagano, Michele
2006 Aug 4;23(3):319-329, Molecular cell
— id: 66918, year: 2006, vol: 23, page: 319, stat: Journal Article,

A peptidomimetic siRNA transfection reagent for highly effective gene silencing
Utku, Yeliz; Dehan, Elinor; Ouerfelli, Ouathek; Piano, Fabio; Zuckermann, Ronald N; Pagano, Michele; Kirshenbaum, Kent
2006 Jun;2(6-7):312-317, Molecular bioSystems
— id: 66919, year: 2006, vol: 2, page: 312, stat: Journal Article,

Cdk1: the dominant sibling of Cdk2
Bashir, Tarig; Pagano, Michele
2005 Aug;7(8):779-781, Nature cell biology
— id: 64218, year: 2005, vol: 7, page: 779, stat: Journal Article,

Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
Benmaamar, Ramla; Pagano, Michele
2005 Sep;4(9):1230-1232, Cell cycle
— id: 64217, year: 2005, vol: 4, page: 1230, stat: Journal Article,

The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain
Block, Karen; Appikonda, Srikanth; Lin, Horng-Ru; Bloom, Joanna; Pagano, Michele; Yew, P Renee
2005 Oct;4(10):1421-1427, Cell cycle
— id: 64216, year: 2005, vol: 4, page: 1421, stat: Journal Article,

Experimental tests to definitively determine ubiquitylation of a substrate
Bloom, Joanna; Pagano, Michele
2005 ;399:249-266, Methods in enzymology
— id: 64215, year: 2005, vol: 399, page: 249, stat: Journal Article,

Skp2, the FoxO1 hunter
Dehan, Elinor; Pagano, Michele
2005 Mar;7(3):209-210, Cancer cell
— id: 51787, year: 2005, vol: 7, page: 209, stat: Journal Article,

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
Hao, Bing; Zheng, Ning; Schulman, Brenda A; Wu, Geng; Miller, Julie J; Pagano, Michele; Pavletich, Nikola P
2005 Oct 7;20(1):9-19, Molecular cell
— id: 64214, year: 2005, vol: 20, page: 9, stat: Journal Article,

Previous preterm cesarean delivery: identification of a new risk factor for uterine rupture in VBAC candidates
Rochelson, Burton; Pagano, Michelle; Conetta, Laurie; Goldman, Benjamin; Vohra, Nidhi; Frey, Michael; Day, Catherine
2005 Nov;18(5):339-342, Journal of maternal-fetal & neonatal medicine
— id: 62636, year: 2005, vol: 18, page: 339, stat: Journal Article,

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
Bashir, Tarig; Dorrello, N Valerio; Amador, Virginia; Guardavaccaro, Daniele; Pagano, Michele
2004 Mar 11;428(6979):190-193, Nature
— id: 42119, year: 2004, vol: 428, page: 190, stat: Journal Article,

Don't skip the G(1) phase: How APC/C(Cdh1) Keeps SCF(Skp2) in Check
Bashir, Tarig; Pagano, Michele
2004 Jul 14;3(7):850-852, Cell cycle
— id: 44902, year: 2004, vol: 3, page: 850, stat: Journal Article,

Varshavsky's contributions
Baumeister, Wolfgang; Bachmair, Andreas; Chau, Vincent; Cohen, Robert; Coffino, Phil; Demartino, George; Deshaies, Raymond; Dohmen, Juergen; Emr, Scott; Finley, Daniel; Hampton, Randy; Hill, Christopher; Hochstrasser, Mark; Huber, Robert; Jackson, Peter; Jentsch, Stefan; Johnson, Erica; Kwon, Yong Tae; Pagano, Michele; Pickart, Cecile; Rechsteiner, Martin; Scheffner, Martin; Sommer, Thomas; Tansey, William; Tyers, Mike; Vierstra, Richard; Weissman, Allan; Wilkinson, Keith D; Wolf, Dieter
2004 Nov 19;306(5700):1290-1292, Science
— id: 64220, year: 2004, vol: 306, page: 1290, stat: Journal Article,

Ubiquitin-dependent degradation of p73 is inhibited by PML
Bernassola, Francesca; Salomoni, Paolo; Oberst, Andrew; Di Como, Charles J; Pagano, Michele; Melino, Gerry; Pandolfi, Pier Paolo
2004 Jun 7;199(11):1545-1557, Journal of experimental medicine
— id: 45027, year: 2004, vol: 199, page: 1545, stat: Journal Article,

To be or not to be ubiquitinated?
Bloom, Joanna; Pagano, Michele
2004 Mar-Apr;3(2):138-140, Cell cycle
— id: 42120, year: 2004, vol: 3, page: 138, stat: Journal Article,

The SCF ubiquitin ligase: insights into a molecular machine
Cardozo, Timothy; Pagano, Michele
2004 Sep;5(9):739-751, Nature reviews. Molecular cell biology
— id: 45024, year: 2004, vol: 5, page: 739, stat: Journal Article,

Oncogenic aberrations of cullin-dependent ubiquitin ligases
Guardavaccaro, Daniele; Pagano, Michele
2004 Mar 15;23(11):2037-2049, Oncogene
— id: 42579, year: 2004, vol: 23, page: 2037, stat: Journal Article,

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
Ji, Peng; Jiang, Hong; Rekhtman, Katya; Bloom, Joanna; Ichetovkin, Marina; Pagano, Michele; Zhu, Liang
2004 Oct 8;16(1):47-58, Molecular cell
— id: 64223, year: 2004, vol: 16, page: 47, stat: Journal Article,

Systematic analysis and nomenclature of mammalian F-box proteins
Jin, Jianping; Cardozo, Timothy; Lovering, Ruth C; Elledge, Stephen J; Pagano, Michele; Harper, J Wade
2004 Nov 1;18(21):2573-2580, Genes & development
— id: 64222, year: 2004, vol: 18, page: 2573, stat: Journal Article,

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation
Kitajima, Shojiro; Kudo, Yasusei; Ogawa, Ikuko; Bashir, Tarig; Kitagawa, Masae; Miyauchi, Mutsumi; Pagano, Michele; Takata, Takashi
2004 Dec;165(6):2147-2155, American journal of pathology
— id: 64219, year: 2004, vol: 165, page: 2147, stat: Journal Article,

Role of F-Box Protein betaTrcp1 in mammary gland development and tumorigenesis
Kudo, Yasusei; Guardavaccaro, Daniele; Santamaria, Patricia G; Koyama-Nasu, Ryo; Latres, Esther; Bronson, Roderick; Yamasaki, Lili; Pagano, Michele
2004 Sep;24(18):8184-8194, Molecular & cellular biology
— id: 45025, year: 2004, vol: 24, page: 8184, stat: Journal Article,

Fenton's pre-treatment of mature landfill leachate
Lopez, Antonio; Pagano, Michele; Volpe, Angela; Di Pinto, Appio Claudio
2004 Feb;54(7):1005-1010, Chemosphere
— id: 64226, year: 2004, vol: 54, page: 1005, stat: Journal Article,

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
Moshe, Yakir; Boulaire, Jerome; Pagano, Michele; Hershko, Avram
2004 May 25;101(21):7937-7942, Proceedings of the National Academy of Sciences of the United States of America
— id: 64224, year: 2004, vol: 101, page: 7937, stat: Journal Article,

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis
Pagano, Michele
2004 May 21;14(4):414-416, Molecular cell
— id: 45028, year: 2004, vol: 14, page: 414, stat: Journal Article,

Wagging the dogma; tissue-specific cell cycle control in the mouse embryo
Pagano, Michele; Jackson, Peter K
2004 Sep 3;118(5):535-538, Cell
— id: 45026, year: 2004, vol: 118, page: 535, stat: Journal Article,

Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma
Shapira, Ma'anit; Ben-Izhak, Ofer; Bishara, Bishara; Futerman, Boris; Minkov, Ira; Krausz, Michael M; Pagano, Michele; Hershko, Dan D
2004 Apr 15;100(8):1615-1621, Cancer
— id: 64225, year: 2004, vol: 100, page: 1615, stat: Journal Article,

Cell cycle, proteolysis and cancer
Yamasaki, Lili; Pagano, Michele
2004 Dec;16(6):623-628, Current opinion in cell biology
— id: 64221, year: 2004, vol: 16, page: 623, stat: Journal Article,

Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis
Bashir, Tarig; Pagano, Michele
2003 ;88(Pt 1):101-144, Advances in cancer research
— id: 39260, year: 2003, vol: 88, page: 101, stat: Journal Article,

Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation
Bloom, Joanna; Amador, Virginia; Bartolini, Francesca; DeMartino, George; Pagano, Michele
2003 Oct 3;115(1):71-82, Cell
— id: 38122, year: 2003, vol: 115, page: 71, stat: Journal Article,

Deregulated degradation of the cdk inhibitor p27 and malignant transformation
Bloom, Joanna; Pagano, Michele
2003 Feb;13(1):41-47, Seminars in cancer biology
— id: 39340, year: 2003, vol: 13, page: 41, stat: Journal Article,

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
Bornstein, Gil; Bloom, Joanna; Sitry-Shevah, Danielle; Nakayama, Keiko; Pagano, Michele; Hershko, Avram
2003 Jul 11;278(28):25752-25757, Journal of biological chemistry
— id: 64228, year: 2003, vol: 278, page: 25752, stat: Journal Article,

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
Busino, Luca; Donzelli, Maddalena; Chiesa, Massimo; Guardavaccaro, Daniele; Ganoth, Dvora; Dorrello, N Valerio; Hershko, Avram; Pagano, Michele; Draetta, Giulio F
2003 Nov 6;426(6962):87-91, Nature
— id: 42121, year: 2003, vol: 426, page: 87, stat: Journal Article,

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients
Drobnjak, Marija; Melamed, Jonathan; Taneja, Samir; Melzer, Kate; Wieczorek, Rosemary; Levinson, Benjamin; Zeleniuch-Jacquotte, Anne; Polsky, David; Ferrara, Jay; Perez-Soler, Roman; Cordon-Cardo, Carlos; Pagano, Michele; Osman, Iman
2003 Jul;9(7):2613-2619, Clinical cancer research
— id: 38153, year: 2003, vol: 9, page: 2613, stat: Journal Article,

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo
Guardavaccaro, Daniele; Kudo, Yasusei; Boulaire, Jerome; Barchi, Marco; Busino, Luca; Donzelli, Maddalena; Margottin-Goguet, Florence; Jackson, Peter K; Yamasaki, Lili; Pagano, Michele
2003 Jun;4(6):799-812, Developmental cell
— id: 39205, year: 2003, vol: 4, page: 799, stat: Journal Article,

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
McAllister, Sandra S; Becker-Hapak, Michelle; Pintucci, Giuseppe; Pagano, Michele; Dowdy, Steven F
2003 Jan;23(1):216-228, Molecular & cellular biology
— id: 64229, year: 2003, vol: 23, page: 216, stat: Journal Article,

When protein destruction runs amok, malignancy is on the loose
Pagano, Michele; Benmaamar, Ramla
2003 Oct;4(4):251-256, Cancer cell
— id: 38583, year: 2003, vol: 4, page: 251, stat: Journal Article,

Low prepregnancy ideal weight:height ratio in women with hyperemesis gravidarum
Rochelson, Burton; Vohra, Nidhi; Darvishzadeh, J; Pagano, Michelle
2003 Jun;48(6):422-424, Journal of reproductive medicine
— id: 94035, year: 2003, vol: 48, page: 422, stat: Journal Article,

Olive husk: an alternative sorbent for removing heavy metals from aqueous streams
Volpe, Angela; Lopez, Antonio; Pagano, Michele
2003 Sep;110(3):137-149, Applied biochemistry & biotechnology
— id: 64227, year: 2003, vol: 110, page: 137, stat: Journal Article,

Nutritional characteristics of a rural Southern Italy population: the Ventimiglia di Sicilia Project
Barbagallo, Carlo M; Cavera, Giovanni; Sapienza, Michelangelo; Noto, Davide; Cefalu, Angelo B; Polizzi, Francesco; Onorato, Francesco; Rini, GiovanBattista; Di Fede, Gaetana; Pagano, Michele; Montalto, Giuseppe; Rizzo, Manfredi; Descovich, GianCarlo; Notarbartolo, Alberto; Averna, Maurizio R
2002 Dec;21(6):523-529, Journal of the American College of Nutrition
— id: 64230, year: 2002, vol: 21, page: 523, stat: Journal Article,

Butyrolactone: more than a kinase inhibitor?
Bloom, Joanna; Pagano, Michele
2002 Mar-Apr;1(2):117-118, Cell cycle
— id: 39371, year: 2002, vol: 1, page: 117, stat: Journal Article,

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase
Chiarle, Roberto; Fan, Yan; Piva, Roberto; Boggino, Hugo; Skolnik, Jeffrey; Novero, Domenico; Palestro, Giorgio; De Wolf-Peeters, Chris; Chilosi, Marco; Pagano, Michele; Inghirami, Giorgio
2002 Apr;160(4):1457-1466, American journal of pathology
— id: 39682, year: 2002, vol: 160, page: 1457, stat: Journal Article,

Dual mode of degradation of Cdc25 A phosphatase
Donzelli, Maddalena; Squatrito, Massimo; Ganoth, Dvora; Hershko, Avram; Pagano, Michele; Draetta, Giulio F
2002 Sep 16;21(18):4875-4884, EMBO journal
— id: 64231, year: 2002, vol: 21, page: 4875, stat: Journal Article,

CDC25 phosphatases and checkpoint controls
Draetta, G; Donzelli, M; Squatrito, M; Ganoth, D; Hershko, A; Pagano, M
2002 NOV abstract #386;38(5):S116-S116, European journal of cancer (1990)
— id: 36591, year: 2002, vol: 38, page: S116, stat: Journal Article,

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation
Piva, Roberto; Liu, Jian; Chiarle, Roberto; Podda, Antonello; Pagano, Michele; Inghirami, Giorgio
2002 Dec;22(23):8375-8387, Molecular & cellular biology
— id: 39375, year: 2002, vol: 22, page: 8375, stat: Journal Article,

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Signoretti, Sabina; Di Marcotullio, Lucia; Richardson, Andrea; Ramaswamy, Sridhar; Isaac, Beth; Rue, Montserrat; Monti, Franco; Loda, Massimo; Pagano, Michele
2002 Sep;110(5):633-641, Journal of clinical investigation
— id: 64232, year: 2002, vol: 110, page: 633, stat: Journal Article,

Three different binding sites of Cks1 are required for p27-ubiquitin ligation
Sitry, Danielle; Seeliger, Markus A; Ko, Tun K; Ganoth, Dvora; Breward, Sadie E; Itzhaki, Laura S; Pagano, Michele; Hershko, Avram
2002 Nov 1;277(44):42233-42240, Journal of biological chemistry
— id: 64234, year: 2002, vol: 277, page: 42233, stat: Journal Article,

Lead removal and recovery from battery industry wastewaters by soluble starch xanthate
Tiravanti, Giovanni; Marani, Dario; Pagano, Michele; Presicce, Dominique Sara; Passino, Roberto
2002 Jul-Aug;92(7-8):677-688, Annali di chimica
— id: 64233, year: 2002, vol: 92, page: 677, stat: Journal Article,

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
Zheng, Ning; Schulman, Brenda A; Song, Langzhou; Miller, Julie J; Jeffrey, Philip D; Wang, Ping; Chu, Claire; Koepp, Deanna M; Elledge, Stephen J; Pagano, Michele; Conaway, Ronald C; Conaway, Joan W; Harper, J Wade; Pavletich, Nikola P
2002 Apr 18;416(6882):703-709, Nature
— id: 64235, year: 2002, vol: 416, page: 703, stat: Journal Article,

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression
Carrano AC; Pagano M
2001 Jun 25;153(7):1381-1390, Journal of cell biology
— id: 21089, year: 2001, vol: 153, page: 1381, stat: Journal Article,

Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70
Cheng H; Cenciarelli C; Shao Z; Vidal M; Parks WP; Pagano M; Cheng-Mayer C
2001 Nov 13;11(22):1771-1775, Current biology. CB
— id: 39468, year: 2001, vol: 11, page: 1771, stat: Journal Article,

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
Chiarle R; Pagano M; Inghirami G
2001 ;3(2):91-94, Breast cancer research
— id: 21234, year: 2001, vol: 3, page: 91, stat: Journal Article,

The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein
DeSalle LM; Latres E; Lin D; Graner E; Montagnoli A; Baker RT; Pagano M; Loda M
2001 Sep 6;20(39):5538-5542, Oncogene
— id: 26666, year: 2001, vol: 20, page: 5538, stat: Journal Article,

Regulation of the G1 to S transition by the ubiquitin pathway
DeSalle LM; Pagano M
2001 Feb 16;490(3):179-189, FEBS letters
— id: 21094, year: 2001, vol: 490, page: 179, stat: Journal Article,

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27
Ganoth D; Bornstein G; Ko TK; Larsen B; Tyers M; Pagano M; Hershko A
2001 Mar;3(3):321-324, Nature cell biology
— id: 21092, year: 2001, vol: 3, page: 321, stat: Journal Article,

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas
Hershko D; Bornstein G; Ben-Izhak O; Carrano A; Pagano M; Krausz MM; Hershko A
2001 May 1;91(9):1745-1751, Cancer
— id: 21091, year: 2001, vol: 91, page: 1745, stat: Journal Article,

Role of the F-box protein Skp2 in lymphomagenesis
Latres E; Chiarle R; Schulman BA; Pavletich NP; Pellicer A; Inghirami G; Pagano M
2001 Feb 27;98(5):2515-2520, Proceedings of the National Academy of Sciences of the United States of America
— id: 21093, year: 2001, vol: 98, page: 2515, stat: Journal Article,

Cul1 and Skp1 complexes inactivation leads to defective chromosome segregation, genetic instability and neoplastic transformation
Liu, J; Piva, R; Chiarle, R; Podda, A; Pagano, M; Inghirami, G
2001 OCT ;69(4):338-338, American journal of human genetics
— id: 54822, year: 2001, vol: 69, page: 338, stat: Journal Article,

Beware the baited hook of publicity
Pagano, M
2001 Dec;414(6866):843-843, Nature
— id: 539922, year: 2001, vol: 414, page: 843, stat: Journal Article,

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
Rodier, G; Montagnoli, A; Di Marcotullio, L; Coulombe, P; Draetta, G F; Pagano, M; Meloche, S
2001 Dec;20(23):6672-6682, EMBO journal
— id: 539902, year: 2001, vol: 20, page: 6672, stat: Journal Article,

Induction of beta -Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-kappa B
Spiegelman VS; Stavropoulos P; Latres E; Pagano M; Ronai Z; Slaga TJ; Fuchs SY
2001 Jul 20;276(29):27152-27158, Journal of biological chemistry
— id: 21090, year: 2001, vol: 276, page: 27152, stat: Journal Article,

Role of the Cdc25A phosphatase in human breast cancer
Cangi MG; Cukor B; Soung P; Signoretti S; Moreira G Jr; Ranashinge M; Cady B; Pagano M; Loda M
2000 Sep;106(6):753-761, Journal of clinical investigation
— id: 21097, year: 2000, vol: 106, page: 753, stat: Journal Article,

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
Chiarle R; Budel LM; Skolnik J; Frizzera G; Chilosi M; Corato A; Pizzolo G; Magidson J; Montagnoli A; Pagano M; Maes B; De Wolf-Peeters C; Inghirami G
2000 Jan 15;95(2):619-626, Blood
— id: 11873, year: 2000, vol: 95, page: 619, stat: Journal Article,

Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors
Chiaur DS; Murthy S; Cenciarelli C; Parks W; Loda M; Inghirami G; Demetrick D; Pagano M
2000 ;88(3-4):255-258, Cytogenetics & cell genetics
— id: 11681, year: 2000, vol: 88, page: 255, stat: Journal Article,

Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia [In Process Citation]
Chilosi M; Chiarle R; Lestani M; Menestrina F; Montagna L; Ambrosetti A; Prolla G; Pizzolo G; Doglioni C; Piva R; Pagano M; Inghirami G
2000 Oct;111(1):263-271, British journal of haematology
— id: 14849, year: 2000, vol: 111, page: 263, stat: Journal Article,

The F-box protein family
Kipreos ET; Pagano M
2000 ;1(5):REVIEWS3002-REVIEWS3002, Genome biology
— id: 21095, year: 2000, vol: 1, page: REVIEWS3002, stat: Journal Article,

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex
Schulman BA; Carrano AC; Jeffrey PD; Bowen Z; Kinnucan ER; Finnin MS; Elledge SJ; Harper JW; Pagano M; Pavletich NP
2000 Nov 16;408(6810):381-386, Nature
— id: 21098, year: 2000, vol: 408, page: 381, stat: Journal Article,

Regulation of the cdk inhibitor p27 and its deregulation in cancer
Slingerland J; Pagano M
2000 Apr;183(1):10-17, Journal of cellular physiology
— id: 8530, year: 2000, vol: 183, page: 10, stat: Journal Article,

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor
Spiegelman VS; Slaga TJ; Pagano M; Minamoto T; Ronai Z; Fuchs SY
2000 May;5(5):877-882, Molecular cell
— id: 21096, year: 2000, vol: 5, page: 877, stat: Journal Article,

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Carrano AC; Eytan E; Hershko A; Pagano M
1999 Aug;1(4):193-199, Nature cell biology
— id: 6242, year: 1999, vol: 1, page: 193, stat: Journal Article,

Identification of a family of human F-box proteins
Cenciarelli C; Chiaur DS; Guardavaccaro D; Parks W; Vidal M; Pagano M
1999 Oct 21;9(20):1177-1179, Current biology. CB
— id: 6225, year: 1999, vol: 9, page: 1177, stat: Journal Article,

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
Gonen, H; Bercovich, B; Orian, A; Carrano, A; Takizawa, C; Yamanaka, K; Pagano, M; Iwai, K; Ciechanover, A
1999 May;274(21):14823-14830, Journal of biological chemistry
— id: 163495, year: 1999, vol: 274, page: 14823, stat: Journal Article,

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
Latres E; Chiaur DS; Pagano M
1999 Jan 28;18(4):849-854, Oncogene
— id: 7381, year: 1999, vol: 18, page: 849, stat: Journal Article,

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
Montagnoli A; Fiore F; Eytan E; Carrano AC; Draetta GF; Hershko A; Pagano M
1999 May 1;13(9):1181-1189, Genes & development
— id: 6113, year: 1999, vol: 13, page: 1181, stat: Journal Article,

The cell cycle inhibitor p27 as a prognostic marker in human tumors and a novel target for therapeutic intervention
Pagano, Michele; Ravid, Katya
Signaling networks and cell cycles control: The molecual basis of cancer and other diseases Totowa, NJ : Humana Press,
— id: 2554, year: 1999, vol: , page: 545, stat: Chapter,

Activation of protein kinase C triggers its ubiquitination and degradation
Lu Z; Liu D; Hornia A; Devonish W; Pagano M; Foster DA
1998 Feb;18(2):839-845, Molecular & cellular biology
— id: 30817, year: 1998, vol: 18, page: 839, stat: Journal Article,

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
Singh SP; Lipman J; Goldman H; Ellis FH Jr; Aizenman L; Cangi MG; Signoretti S; Chiaur DS; Pagano M; Loda M
1998 Apr 15;58(8):1730-1735, Cancer research
— id: 7795, year: 1998, vol: 58, page: 1730, stat: Journal Article,

Regulation of the cell cycle by the ubiquitin pathway
Slingerland J; Pagano M
1998 ;22:133-147, Results & problems in cell differentation
— id: 12092, year: 1998, vol: 22, page: 133, stat: Journal Article,

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases
Thomas GV; Szigeti K; Murphy M; Draetta G; Pagano M; Loda M
1998 Sep;153(3):681-687, American journal of pathology
— id: 7821, year: 1998, vol: 153, page: 681, stat: Journal Article,

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes
Zhang Y; Wang Z; Liu DX; Pagano M; Ravid K
1998 Jan 16;273(3):1387-1392, Journal of biological chemistry
— id: 7867, year: 1998, vol: 273, page: 1387, stat: Journal Article,

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation
Alessandrini, A; Chiaur, D S; Pagano, M
1997 Mar;11(3):342-345, Leukemia
— id: 539912, year: 1997, vol: 11, page: 342, stat: Journal Article,

Mechanism of p53 degradation
Brown JP; Pagano M
1997 Apr 18;1332(2):O1-O6, Biochimica & biophysica acta
— id: 12325, year: 1997, vol: 1332, page: O1, stat: Journal Article,

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
Esposito, V; Baldi, A; De Luca, A; Groger, A M; Loda, M; Giordano, G G; Caputi, M; Baldi, F; Pagano, M; Giordano, A
1997 Aug;57(16):3381-3385, Cancer research
— id: 539942, year: 1997, vol: 57, page: 3381, stat: Journal Article,

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas [see comments]
Loda M; Cukor B; Tam SW; Lavin P; Fiorentino M; Draetta GF; Jessup JM; Pagano M
1997 Feb;3(2):231-234, Nature medicine
— id: 8310, year: 1997, vol: 3, page: 231, stat: Journal Article,

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest
Millard, S S; Yan, J S; Nguyen, H; Pagano, M; Kiyokawa, H; Koff, A
1997 Mar;272(11):7093-7098, Journal of biological chemistry
— id: 163492, year: 1997, vol: 272, page: 7093, stat: Journal Article,

Cell cycle regulation by the ubiquitin pathway
Pagano M
1997 Nov;11(13):1067-1075, FASEB journal
— id: 12224, year: 1997, vol: 11, page: 1067, stat: Journal Article,

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
Tan, P; Cady, B; Wanner, M; Worland, P; Cukor, B; Magi-Galluzzi, C; Lavin, P; Draetta, G; Pagano, M; Loda, M
1997 Apr;57(7):1259-1263, Cancer research
— id: 539952, year: 1997, vol: 57, page: 1259, stat: Journal Article,

Ubiquitin-dependent degradation of cyclin B is accelerated during an endomitotic cell cycle
Zhang, Y; Wang, Z; Pagano, M; Ravid, K
1997 JUL 31 ;11(9):A1217-A1217, FASEB journal
— id: 53457, year: 1997, vol: 11, page: A1217, stat: Journal Article,

Ubiqfitin-dependent degradation of cyclin b is accelerated during an endomitotic cell cycle
Zhanj, V; Wang, Z; Pagano, M; Rawid, K
1997 ;11(9):-, FASEB journal
— id: 589812, year: 1997, vol: 11, page: , stat: Journal Article,

Cell cycle and cancer: critical events at the G1 restriction point
DelSal, G; Loda, M; Pagano, M
1996 ;7(1-2):127-142, Critical reviews in oncogenesis
— id: 539962, year: 1996, vol: 7, page: 127, stat: Journal Article,

Cell cycle control and cancer
Draetta, G; Pagano, M
1996 DEC ;31(4):241-248, Annual reports in medicinal chemistry
— id: 98376, year: 1996, vol: 31, page: 241, stat: Journal Article,

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
Ohtsubo M; Theodoras AM; Schumacher J; Roberts JM; Pagano M
1995 May;15(5):2612-2624, Molecular & cellular biology
— id: 21100, year: 1995, vol: 15, page: 2612, stat: Journal Article,

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
Pagano M; Tam SW; Theodoras AM; Beer-Romero P; Del Sal G; Chau V; Yew PR; Draetta GF; Rolfe M
1995 Aug 4;269(5224):682-685, Science
— id: 21099, year: 1995, vol: 269, page: 682, stat: Journal Article,

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)
Rolfe, M; Beer-Romero, P; Glass, S; Eckstein, J; Berdo, I; Theodoras, A; Pagano, M; Draetta, G
1995 Apr;92(8):3264-3268, Proceedings of the National Academy of Sciences of the United States of America
— id: 539972, year: 1995, vol: 92, page: 3264, stat: Journal Article,

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
Lukas, J; Pagano, M; Staskova, Z; Draetta, G; Bartek, J
1994 Mar;9(3):707-718, Oncogene
— id: 539982, year: 1994, vol: 9, page: 707, stat: Journal Article,

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
Pagano M; Theodoras AM; Tam SW; Draetta GF
1994 Jul 15;8(14):1627-1639, Genes & development
— id: 21103, year: 1994, vol: 8, page: 1627, stat: Journal Article,

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4
Tam SW; Shay JW; Pagano M
1994 Nov 15;54(22):5816-5820, Cancer research
— id: 21101, year: 1994, vol: 54, page: 5816, stat: Journal Article,

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression
Tam SW; Theodoras AM; Shay JW; Draetta GF; Pagano M
1994 Sep;9(9):2663-2674, Oncogene
— id: 21102, year: 1994, vol: 9, page: 2663, stat: Journal Article,

Cyclin D1 is a nuclear protein required for cell cycle progression in G1
Baldin, V; Lukas, J; Marcote, M J; Pagano, M; Draetta, G
1993 May;7(5):812-821, Genes & development
— id: 539992, year: 1993, vol: 7, page: 812, stat: Journal Article,

Differential modulation of cyclin gene expression by MYC
Jansen-Durr, P; Meichle, A; Steiner, P; Pagano, M; Finke, K; Botz, J; Wessbecher, J; Draetta, G; Eilers, M
1993 Apr;90(8):3685-3689, Proceedings of the National Academy of Sciences of the United States of America
— id: 540012, year: 1993, vol: 90, page: 3685, stat: Journal Article,

G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently
O'Connor, P M; Ferris, D K; Pagano, M; Draetta, G; Pines, J; Hunter, T; Longo, D L; Kohn, K W
1993 Apr;268(11):8298-8308, Journal of biological chemistry
— id: 540002, year: 1993, vol: 268, page: 8298, stat: Journal Article,

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
Pagano M; Pepperkok R; Lukas J; Baldin V; Ansorge W; Bartek J; Draetta G
1993 Apr;121(1):101-111, Journal of cell biology
— id: 21104, year: 1993, vol: 121, page: 101, stat: Journal Article,

Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line
Landesman, Y; Pagano, M; Draetta, G; Rotter, V; Fusenig, N E; Kimchi, A
1992 Aug;7(8):1661-1665, Oncogene
— id: 540032, year: 1992, vol: 7, page: 1661, stat: Journal Article,

cdc2 protein kinase: structure-function relationships
Marcote, M J; Pagano, M; Draetta, G
1992 ;170:30-41; discussion 41, CIBA Foundation symposium
— id: 540052, year: 1992, vol: 170, page: 30, stat: Journal Article,

Association of cdk2 kinase with the transcription factor E2F during S phase
Pagano M; Draetta G; Jansen-Durr P
1992 Feb 28;255(5048):1144-1147, Science
— id: 21105, year: 1992, vol: 255, page: 1144, stat: Journal Article,

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells
Pagano, M; Durst, M; Joswig, S; Draetta, G; Jansen-Durr, P
1992 Sep;7(9):1681-1686, Oncogene
— id: 540022, year: 1992, vol: 7, page: 1681,