Michele Pagano

Biosketch / Results /

Michele Pagano, M.D.

May Ellen and Gerald Jay Ritter Professor of Oncology;
Department of Pathology (Pathology)

Contact Info

Address

522 First Avenue Floor 11th Room 1103
Smilow Research Building
New York, NY 10016

212-263-5129, 212-263-5332
212-263-5107
Michele.Pagano@nyumc.org


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Education

— Dr. Pagano was a post-doctoral fellow at EMBL, Heidelberg, Germany (August 1990-October 1992), before following his mentor to Mitotix Inc, Cambridge, MA (November 1992-August 1996), PostDoctoral Training
— First Medical School University of Naples, Italy, Medical Education

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Research Summary

Our laboratory explores the roles that the ubiquitin system plays in fundamental cellualr processes, such as cell growth, proliferation, and the DNA damage response. His group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. .

Research Interests

Cell Cycle Control and Ubiquitin-mediated degradation<br>

Research Keywords

Cell cycle, cancer, cyclin-dependent-kinases, cyclins, Cdk-inhibitors, tumor suppressors, F-box proteins, SCF ligase, protein degradation, ubiquitin.


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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival
Chen, X; Sahasrabuddhe, A A; Szankasi, P; Chung, F; Basrur, V; Rangnekar, V M; Pagano, M; Lim, M S; Elenitoba-Johnson, K S J
2014 Oct;21(10):1535-1545, Cell death & differentiation
— id: 1186632, year: 2014, vol: 21, page: 1535, stat: Journal Article,

Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
Choi, B H; Pagano, M; Da, W
2014 16 May 2014;289(20):14066-14074, Journal of biological chemistry
— id: 1058172, year: 2014, vol: 289, page: 14066, stat: Journal Article,

Cdh1, a substrate recruiting component of APC/C ubiquitin E3 ligase, specifically interacts with PTEN and promotes its removal from chromatin
Choi, Byeong Hyeok; Pagano, Michele; Huang, Chuanshu; Dai, Wei
2014 May;:17951-17959, Journal of biological chemistry
— id: 988602, year: 2014, vol: , page: 17951, stat: Journal Article,

Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle
Choi, Byeong; Pagano, Michele; Dai, Wei
2014 Apr;:14066-14074, Journal of biological chemistry
— id: 988612, year: 2014, vol: , page: 14066, stat: Journal Article,

DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation
Horn, Moritz; Geisen, Christoph; Cermak, Lukas; Becker, Ben; Nakamura, Shuhei; Klein, Corinna; Pagano, Michele; Antebi, Adam
2014 Mar;28(6):697-710, Developmental cell
— id: 883552, year: 2014, vol: 28, page: 697, stat: Journal Article,

Critical role for IL-1beta in DNA damage-induced mucositis
Kanarek, Naama; Grivennikov, Sergei I; Leshets, Michael; Lasry, Audrey; Alkalay, Irit; Horwitz, Elad; Shaul, Yoav D; Stachler, Matthew; Voronov, Elena; Apte, Ron N; Pagano, Michele; Pikarsky, Eli; Karin, Michael; Ghosh, Sankar; Ben-Neriah, Yinon
2014 Feb;111(6):E702-E711, Proceedings of the National Academy of Sciences of the United States of America
— id: 836712, year: 2014, vol: 111, page: E702, stat: Journal Article,

SCF ubiquitin ligase-targeted therapies
Skaar, Jeffrey R; Pagan, Julia K; Pagano, Michele
2014 Dec;13(12):889-903, Nature reviews. Drug discovery
— id: 1369022, year: 2014, vol: 13, page: 889, stat: Journal Article,

The ubiquitin proteasome system - Implications for cell cycle control and the targeted treatment of cancer
Bassermann, Florian; Eichner, Ruth; Pagano, Michele
2013 Mar;:150-162, Biochimica & biophysica acta
— id: 539812, year: 2013, vol: , page: 150, stat: Journal Article,

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis
D'Angiolella, Vincenzo; Esencay, Mine; Pagano, Michele
2013 Mar;23(3):135-140, Trends in cell biology
— id: 248122, year: 2013, vol: 23, page: 135, stat: Journal Article,

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
Fernandez-Saiz, Vanesa; Targosz, Bianca-Sabrina; Lemeer, Simone; Eichner, Ruth; Langer, Christian; Bullinger, Lars; Reiter, Clemens; Slotta-Huspenina, Julia; Schroeder, Sonja; Knorn, Anna-Maria; Kurutz, Julia; Peschel, Christian; Pagano, Michele; Kuster, Bernhard; Bassermann, Florian
2013 Jan;15(1):72-81, Nature cell biology
— id: 539822, year: 2013, vol: 15, page: 72, stat: Journal Article,

FBH1 protects melanocytes from transformation and is deregulated in melanomas
Jeong, Yeon-Tae; Cermak, Lukas; Guijarro, Maria V; Hernando, Eva; Pagano, Michele
2013 Apr;12(7):1128-1132, Cell cycle
— id: 287222, year: 2013, vol: 12, page: 1128, stat: Journal Article,

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Jeong, Yeon-Tae; Rossi, Mario; Cermak, Lukas; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Sung, Patrick; Schildkraut, Carl; Pagano, Michele
2013 Jan;200(2):141-149, Journal of cell biology
— id: 213662, year: 2013, vol: 200, page: 141, stat: Journal Article,

FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade
Kuchay, Shafi; Duan, Shanshan; Schenkein, Emily; Peschiaroli, Angelo; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele
2013 May;15(5):472-480, Nature cell biology
— id: 316032, year: 2013, vol: 15, page: 472, stat: Journal Article,

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
Li, Ji; D'Angiolella, Vincenzo; Seeley, E Scott; Kim, Sehyun; Kobayashi, Tetsuo; Fu, Wenxiang; Campos, Eric I; Pagano, Michele; Dynlacht, Brian David
2013 Mar;495(7440):255-259, Nature
— id: 242352, year: 2013, vol: 495, page: 255, stat: Journal Article,

Protein degradation regulates centriole disengagement in mitosis
Pagan, J K; Jones, M; Marzio, A; Pagano, M
2013 15 Dec 2013;24(24):-, Molecular biology of the cell
— id: 884372, year: 2013, vol: 24, page: , stat: Journal Article,

Role of the ubiquitin proteasome system in the heart
Pagan, Julia; Seto, Tiffany; Pagano, Michele; Cittadini, Antonio
2013 Mar;112(7):1046-1058, Circulation research
— id: 306262, year: 2013, vol: 112, page: 1046, stat: Journal Article,

Regulation of the CRL4(Cdt2) Ubiquitin Ligase and Cell-Cycle Exit by the SCF(Fbxo11) Ubiquitin Ligase
Rossi, Mario; Duan, Shanshan; Jeong, Yeon-Tae; Horn, Moritz; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Antebi, Adam; Pagano, Michele
2013 Mar;49(6):1159-1166, Molecular cell
— id: 271332, year: 2013, vol: 49, page: 1159, stat: Journal Article,

Mechanisms and function of substrate recruitment by F-box proteins
Skaar, Jeffrey R; Pagan, Julia K; Pagano, Michele
2013 Jun;14(6):369-381, Nature reviews. Molecular cell biology
— id: 353272, year: 2013, vol: 14, page: 369, stat: Journal Article,

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis
Tsunematsu, Takaaki; Takihara, Yoshihiro; Ishimaru, Naozumi; Pagano, Michele; Takata, Takashi; Kudo, Yasusei
2013 ;4:1885-1885, Nature communications
— id: 394762, year: 2013, vol: 4, page: 1885, stat: Journal Article,

SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket
Xing, Weiman; Busino, Luca; Hinds, Thomas R; Marionni, Samuel T; Saifee, Nabiha H; Bush, Matthew F; Pagano, Michele; Zheng, Ning
2013 Apr;496(7443):64-68, Nature
— id: 306182, year: 2013, vol: 496, page: 64, stat: Journal Article,

SCF-Mediated Degradation of p100 (NF-kappaB2): Mechanisms and Relevance in Multiple Myeloma
Busino, Luca; Millman, Scott E; Pagano, Michele
2012 ;5(253):pt14-pt14 pt14, Science signaling
— id: 197502, year: 2012, vol: 5, page: pt14, stat: Journal Article,

Fbxw7alpha- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
Busino, Luca; Millman, Scott E; Scotto, Luigi; Kyratsous, Christos A; Basrur, Venkatesha; O'Connor, Owen; Hoffmann, Alexander; Elenitoba-Johnson, Kojo S; Pagano, Michele
2012 Apr;14(4):375-385, Nature cell biology
— id: 163573, year: 2012, vol: 14, page: 375, stat: Journal Article,

SCFFbxo45 controls cytokinesis through ubiquitin-mediated proteolysis of GEF-H1
Chen, X; Ahn, J -Y; Szankasi, P; Chung, F; Basrur, E; Lim, M S; Miller, A L; Pagano, M; Elenitoba-Johnson, K S J
2012 April, 2012;26:-, FASEB journal
— id: 178106, year: 2012, vol: 26, page: , stat: Journal Article,

Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry
Chow, C; Wong, N; Pagano, M; Lun, S W-M; Nakayama, K-I; Nakayama, K; Lo, K-W
2012 Apr;31(15):1975-1987, Oncogene
— id: 165670, year: 2012, vol: 31, page: 1975, stat: Journal Article,

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair
D'Angiolella, Vincenzo; Donato, Valerio; Forrester, Frances M; Jeong, Yeon-Tae; Pellacani, Claudia; Kudo, Yasusei; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Pagano, Michele
2012 May;149(5):1023-1034, Cell
— id: 167802, year: 2012, vol: 149, page: 1023, stat: Journal Article,

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
Duan, S; Cermak, L; Pagan, J K; Rossi, M; Martinengo, C; Francia, Di Celle P; Chapuy, B; Shipp, M; Chiarle, R; Pagano, M
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884402, year: 2012, vol: 23, page: , stat: Journal Article,

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
Duan, Shanshan; Cermak, Lukas; Pagan, Julia K; Rossi, Mario; Martinengo, Cinzia; di Celle, Paola Francia; Chapuy, Bjoern; Shipp, Margaret; Chiarle, Roberto; Pagano, Michele
2012 Jan 5;481(7379):90-93, Nature
— id: 149798, year: 2012, vol: 481, page: 90, stat: Journal Article,

Fbw7gamma-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes
Kim, Dong Seok; Zhang, Wei; Millman, Scott E; Hwang, Byung Joon; Kwon, Seok Joo; Clayberger, Carol; Pagano, Michele; Krensky, Alan M
2012 Aug;120(8):1658-1667, Blood
— id: 177229, year: 2012, vol: 120, page: 1658, stat: Journal Article,

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress
Kruiswijk, Flore; Yuniati, Laurensia; Magliozzi, Roberto; Low, Teck Yew; Lim, Ratna; Bolder, Renske; Mohammed, Shabaz; Proud, Christopher G; Heck, Albert J R; Pagano, Michele; Guardavaccaro, Daniele
2012 Jun;5(227):ra40-ra40 ra40, Science signaling
— id: 539832, year: 2012, vol: 5, page: ra40, stat: Journal Article,

Centrosome homeostasis is controlled by ubiquitylation and deubiquitylation cycles
Li, J; D'Angiolella, V; Seeley, E; Kobayashi, T; Kim, S; Pagano, M; Dynlacht, B
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884432, year: 2012, vol: 23, page: , stat: Journal Article,

APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit
Ping, Zhen; Lim, Ratna; Bashir, Tarig; Pagano, Michele; Guardavaccaro, Daniele
2012 May;11(10):1999-2005, Cell cycle
— id: 169025, year: 2012, vol: 11, page: 1999, stat: Journal Article,

SCF ubiquitin ligases in the maintenance of genome stability
Silverman, Joshua S; Skaar, Jeffrey R; Pagano, Michele
2012 Feb;37(2):66-73, Trends in biochemical sciences
— id: 155863, year: 2012, vol: 37, page: 66, stat: Journal Article,

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation
Wu, Lily; Grigoryan, Arsen V; Li, Yunfeng; Hao, Bing; Pagano, Michele; Cardozo, Timothy J
2012 Dec;19(12):1515-1524, Chemistry & biology
— id: 207422, year: 2012, vol: 19, page: 1515, stat: Journal Article,

BubR1 Is Modified by Sumoylation during Mitotic Progression
Yang, Feikun; Hu, Liyan; Chen, Cheng; Yu, Jianxiu; O'Connell, Christopher B; Khodjakov, Alexey; Pagano, Michele; Dai, Wei
2012 Feb;287(7):4875-4882, Journal of biological chemistry
— id: 157470, year: 2012, vol: 287, page: 4875, stat: Journal Article,

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
Cotto-Rios, Xiomaris M; Jones, Mathew J K; Busino, Luca; Pagano, Michele; Huang, Tony T
2011 Jul 25;194(2):177-186, Journal of cell biology
— id: 135576, year: 2011, vol: 194, page: 177, stat: Journal Article,

Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFbetaTrCP ubiquitin ligases
Duan, Shanshan; Pagano, Michele
2011 Dec 27;108(52):20857-20858, Proceedings of the National Academy of Sciences of the United States of America
— id: 149805, year: 2011, vol: 108, page: 20857, stat: Journal Article,

mTOR Generates an Auto-Amplification Loop by Triggering the betaTrCP- and CK1alpha-Dependent Degradation of DEPTOR
Duan, Shanshan; Skaar, Jeffrey R; Kuchay, Shafi; Toschi, Alfredo; Kanarek, Naama; Ben-Neriah, Yinon; Pagano, Michele
2011 Oct 21;44(2):317-324, Molecular cell
— id: 139744, year: 2011, vol: 44, page: 317, stat: Journal Article,

MCL1 meets its end during mitotic arrest
Millman, Scott E; Pagano, Michele
2011 May 1;12(5):384-385, EMBO reports
— id: 131815, year: 2011, vol: 12, page: 384, stat: Journal Article,

Loss of p27KIP1 Expression in Fully-staged Node-negative Breast Cancer: Association with Lack of Hormone Receptors in T1a/b, but not T1c Infiltrative Ductal Carcinoma
Mirchandani, Deepu; Roses, Daniel F; Inghirami, Giorgio; Zeleniuch-Jacquotte, Anne; Cangiarella, Joan; Guth, Amber; Safyan, Rachael Ann; Formenti, Silvia C; Pagano, Michele; Muggia, Franco
2011 Dec;31(12):4401-4405, Anticancer research
— id: 149934, year: 2011, vol: 31, page: 4401, stat: Journal Article,

The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
Nguyen, Paul L; Lin, Douglas I; Lei, Junyi; Fiorentino, Michelangelo; Mueller, Elke; Weinstein, Michael H; Pagano, Michele; Loda, Massimo
2011 May-Jun;29(3):302-308, Urologic oncology
— id: 539932, year: 2011, vol: 29, page: 302, stat: Journal Article,

FBXW5 controls centrosome number
Pagan, Julia; Pagano, Michele
2011 ;13(8):888-890, Nature cell biology
— id: 135567, year: 2011, vol: 13, page: 888, stat: Journal Article,

Clinical relevance of SKP2 alterations in metastatic melanoma
Rose, Amy E; Wang, Guimin; Hanniford, Douglas; Monni, Stefano; Tu, Ting; Shapiro, Richard L; Berman, Russell S; Pavlick, Anna C; Pagano, Michele; Darvishian, Farbod; Mazumdar, Madhu; Hernando, Eva; Osman, Iman
2011 Feb;24(1):197-206, Pigment cell & melanoma research
— id: 138133, year: 2011, vol: 24, page: 197, stat: Journal Article,

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization
Bashir, Tarig; Pagan, Julia K; Busino, Luca; Pagano, Michele
2010 Mar;9(5):971-974, Cell cycle
— id: 109207, year: 2010, vol: 9, page: 971, stat: Journal Article,

Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
Bassermann, F; Pagano, M
2010 Jan;17(1):78-85, Cell death & differentiation
— id: 136505, year: 2010, vol: 17, page: 78, stat: Journal Article,

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
D'Angiolella, Vincenzo; Donato, Valerio; Vijayakumar, Sangeetha; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Dynlacht, Brian; Pagano, Michele
2010 Jul 1;466(7302):138-142, Nature
— id: 110690, year: 2010, vol: 466, page: 138, stat: Journal Article,

Tumor Suppressor Function of Androgen Receptor Coactivator ARA70{alpha} in Prostate Cancer
Ligr, Martin; Li, Yirong; Zou, Xuanyi; Daniels, Garrett; Melamed, Jonathan; Peng, Yi; Wang, Wei; Wang, Jinhua; Ostrer, Harry; Pagano, Michele; Wang, Zhengxin; Garabedian, Michael J; Lee, Peng
2010 Apr;176(4):1891-1900, American journal of pathology
— id: 107298, year: 2010, vol: 176, page: 1891, stat: Journal Article,

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival
Peschiaroli, A; Skaar, J R; Pagano, M; Melino, G
2010 Mar;29(9):1384-1393, Oncogene
— id: 539842, year: 2010, vol: 29, page: 1384, stat: Journal Article,

Spindle assembly checkpoint inactivation: a new role for phosphatases
Skaar, Jeffrey R; Pagano, Michele
2010 Feb;9(4):644-645, Cell cycle
— id: 539852, year: 2010, vol: 9, page: 644, stat: Journal Article,

Cdc25 phosphatases: differential regulation by ubiquitin-mediated proteolysis
Young, Lauren M; Pagano, Michele
2010 Dec;9(23):4613-4614, Cell cycle
— id: 539862, year: 2010, vol: 9, page: 4613, stat: Journal Article,

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
Dehan, Elinor; Bassermann, Florian; Guardavaccaro, Daniele; Vasiliver-Shamis, Gaia; Cohen, Michael; Lowes, Kym N; Dustin, Michael; Huang, David C S; Taunton, Jack; Pagano, Michele
2009 Jan 16;33(1):109-116, Molecular cell
— id: 92189, year: 2009, vol: 33, page: 109, stat: Journal Article,

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation
Ge, Sheng; Skaar, Jeffrey R; Pagano, Michele
2009 Jan 1;8(1):167-171, Cell cycle
— id: 93223, year: 2009, vol: 8, page: 167, stat: Journal Article,

Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222
Hu, Liang; Ibrahim, Sherif; Liu, Cynthia; Skaar, Jeffrey; Pagano, Michele; Karpatkin, Simon
2009 Apr 15;69(8):3374-3381, Cancer research
— id: 98895, year: 2009, vol: 69, page: 3374, stat: Journal Article,

Wnt signaling in mitosis
Kaldis, Philipp; Pagano, Michele
2009 Dec;17(6):749-750, Developmental cell
— id: 539872, year: 2009, vol: 17, page: 749, stat: Journal Article,

Degradation of cyclin A is regulated by acetylation
Mateo, F; Vidal-Laliena, M; Canela, N; Busino, L; Martinez-Balbas, M A; Pagano, M; Agell, N; Bachs, O
2009 Jul;28(29):2654-2666, Oncogene
— id: 539882, year: 2009, vol: 28, page: 2654, stat: Journal Article,

Hypertension and diabetes mellitus are associated with cardiovascular events in the elderly without cardiovascular disease. Results of a 15-year follow-up in a Mediterranean population
Noto, D; Cefalu, A B; Barbagallo, C M; Sapienza, M; Cavera, G; Nardi, I; Pagano, M; Vivona, N; Notarbartolo, A; Averna, M R
2009 Jun;19(5):321-326, Nutrition, metabolism, & cardiovascular diseases : NMCD
— id: 79362, year: 2009, vol: 19, page: 321, stat: Journal Article,

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
Peschiaroli, A; Scialpi, F; Bernassola, F; Pagano, M; Melino, G
2009 Sep;28(35):3157-3166, Oncogene
— id: 539892, year: 2009, vol: 28, page: 3157, stat: Journal Article,

SnapShot: F Box Proteins II
Skaar, Jeffrey R; D'Angiolella, Vincenzo; Pagan, Julia K; Pagano, Michele
2009 Jun 26;137(7):1181-1183, Cell
— id: 100622, year: 2009, vol: 137, page: 1181, stat: Journal Article,

SnapShot: F box proteins I
Skaar, Jeffrey R; Pagan, Julia K; Pagano, Michele
2009 Jun 12;137(6):1160-1160.e1, Cell
— id: 100193, year: 2009, vol: 137, page: 1160, stat: Journal Article,

Control of cell growth by the SCF and APC/C ubiquitin ligases
Skaar, Jeffrey R; Pagano, Michele
2009 Dec;21(6):816-824, Current opinion in cell biology
— id: 105497, year: 2009, vol: 21, page: 816, stat: Journal Article,

INTS3 controls the hSSB1-mediated DNA damage response
Skaar, Jeffrey R; Richard, Derek J; Saraf, Anita; Toschi, Alfredo; Bolderson, Emma; Florens, Laurence; Washburn, Michael P; Khanna, Kum Kum; Pagano, Michele
2009 Oct 5;187(1):25-32, Journal of cell biology
— id: 103155, year: 2009, vol: 187, page: 25, stat: Journal Article,

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
Abbas, Tarek; Sivaprasad, Uma; Terai, Kenta; Amador, Virginia; Pagano, Michele; Dutta, Anindya
2008 Sep 15;22(18):2496-2506, Genes & development
— id: 96958, year: 2008, vol: 22, page: 2496, stat: Journal Article,

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
Bassermann, Florian; Frescas, David; Guardavaccaro, Daniele; Busino, Luca; Peschiaroli, Angelo; Pagano, Michele
2008 Jul 25;134(2):256-267, Cell
— id: 80620, year: 2008, vol: 134, page: 256, stat: Journal Article,

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state
Frescas, David; Guardavaccaro, Daniele; Kuchay, Shafi M; Kato, Hiroyuki; Poleshko, Andrey; Basrur, Venkatesha; Elenitoba-Johnson, Kojo S; Katz, Richard A; Pagano, Michele
2008 Nov 15;7(22):3539-3547, Cell cycle
— id: 91978, year: 2008, vol: 7, page: 3539, stat: Journal Article,

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
Frescas, David; Pagano, Michele
2008 Jun;8(6):438-449, Nature reviews. Cancer
— id: 79246, year: 2008, vol: 8, page: 438, stat: Journal Article,

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
Guardavaccaro, Daniele; Frescas, David; Dorrello, N Valerio; Peschiaroli, Angelo; Multani, Asha S; Cardozo, Timothy; Lasorella, Anna; Iavarone, Antonio; Chang, Sandy; Hernando, Eva; Pagano, Michele
2008 Mar 20;452(7185):365-369, Nature
— id: 78365, year: 2008, vol: 452, page: 365, stat: Journal Article,

Thrombin Enhances Spontaneous Tumor Growth and Cell Cycle Activation by Downregulation of p27(Kipl) and Upregulation of Skp2 and MiR-222
Hu, L; Ibrahim, S; Liu, C; Skaar, J; Pagano, M; Karpatkin, S
2008 NOV 16 ;112(11):152-152, Blood
— id: 93282, year: 2008, vol: 112, page: 152, stat: Journal Article,

APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation
Merluzzi, Sonia; Gri, Giorgia; Gattei, Valter; Pagano, Michele; Pucillo, Carlo
2008 Aug;45(14):3731-3739, Molecular immunology
— id: 96959, year: 2008, vol: 45, page: 3731, stat: Journal Article,

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
Michaelson, David; Abidi, Wasif; Guardavaccaro, Daniele; Zhou, Mo; Ahearn, Ian; Pagano, Michele; Philips, Mark R
2008 May 5;181(3):485-496, Journal of cell biology
— id: 79148, year: 2008, vol: 181, page: 485, stat: Journal Article,

The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: results of a 15 years follow-up in a Mediterranean population
Noto, Davide; Barbagallo, Carlo Maria; Cefalu, Angelo Baldassare; Falletta, Angelo; Sapienza, Michelangelo; Cavera, Giovanni; Amato, Salvatore; Pagano, Michele; Maggiore, Maria; Carroccio, Antonio; Notarbartolo, Alberto; Averna, Maurizio R
2008 Mar;197(1):147-153, Atherosclerosis
— id: 79364, year: 2008, vol: 197, page: 147, stat: Journal Article,

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70
Peng, Yi; Li, Caihong X; Chen, Fei; Wang, Zhengxin; Ligr, Martin; Melamed, Jonathan; Wei, Jianjun; Gerald, William; Pagano, Michele; Garabedian, Michael J; Lee, Peng
2008 Jan;172(1):225-235, American journal of pathology
— id: 76451, year: 2008, vol: 172, page: 225, stat: Journal Article,

Cdh1: a master G0/G1 regulator
Skaar, Jeffrey R; Pagano, Michele
2008 Jul;10(7):755-757, Nature cell biology
— id: 80618, year: 2008, vol: 10, page: 755, stat: Journal Article,

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Zhao, Xudong; Heng, Julian Ik-Tsen; Guardavaccaro, Daniele; Jiang, Richeng; Pagano, Michele; Guillemot, Francois; Iavarone, Antonio; Lasorella, Anna
2008 Jun;10(6):643-653, Nature cell biology
— id: 79363, year: 2008, vol: 10, page: 643, stat: Journal Article,

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
Amador, Virginia; Ge, Sheng; Santamaria, Patricia G; Guardavaccaro, Daniele; Pagano, Michele
2007 Aug 3;27(3):462-473, Molecular cell
— id: 73589, year: 2007, vol: 27, page: 462, stat: Journal Article,

Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1
Bassermann, Florian; von Klitzing, Christine; Illert, Anna Lena; Munch, Silvia; Morris, Stephan W; Pagano, Michele; Peschel, Christian; Duyster, Justus
2007 Jun;282(22):15965-15972, Journal of biological chemistry
— id: 159217, year: 2007, vol: 282, page: 15965, stat: Journal Article,

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
Busino, Luca; Bassermann, Florian; Maiolica, Alessio; Lee, Choogon; Nolan, Patrick M; Godinho, Sofia I H; Draetta, Giulio F; Pagano, Michele
2007 May 11;316(5826):900-904, Science
— id: 72420, year: 2007, vol: 316, page: 900, stat: Journal Article,

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
Cardozo, Timothy; Pagano, Michele
2007 ;8 Suppl 1:S9-S9, BMC biochemistry
— id: 75675, year: 2007, vol: 8 Suppl 1, page: S9, stat: Journal Article,

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age
Fielenbach, Nicole; Guardavaccaro, Daniele; Neubert, Kerstin; Chan, Tammy; Li, Dongling; Feng, Qin; Hutter, Harald; Pagano, Michele; Antebi, Adam
2007 Mar;12(3):443-455, Developmental cell
— id: 79365, year: 2007, vol: 12, page: 443, stat: Journal Article,

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
Frescas, David; Guardavaccaro, Daniele; Bassermann, Florian; Koyama-Nasu, Ryo; Pagano, Michele
2007 Nov 8;450(7167):309-313, Nature
— id: 75415, year: 2007, vol: 450, page: 309, stat: Journal Article,

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
Godinho, Sofia I H; Maywood, Elizabeth S; Shaw, Linda; Tucci, Valter; Barnard, Alun R; Busino, Luca; Pagano, Michele; Kendall, Rachel; Quwailid, Mohamed M; Romero, M Rosario; O'neill, John; Chesham, Johanna E; Brooker, Debra; Lalanne, Zuzanna; Hastings, Michael H; Nolan, Patrick M
2007 May 11;316(5826):897-900, Science
— id: 72419, year: 2007, vol: 316, page: 897, stat: Journal Article,

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer
Kitajima, Shojiro; Kudo, Yasusei; Ogawa, Ikuko; Tatsuka, Masaaki; Kawai, Hidehiko; Pagano, Michele; Takata, Takashi
2007 ;2(9):e944-e944, PLoS one
— id: 79130, year: 2007, vol: 2, page: e944, stat: Journal Article,

The pRb-Cdh1-p27 autoamplifying network
Santamaria, Patricia G; Pagano, Michele
2007 Feb;9(2):137-138, Nature cell biology
— id: 72423, year: 2007, vol: 9, page: 137, stat: Journal Article,

Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan; Abbasian, Mahan; Patel, Palka; Jensen-Pergakes, Kristen; Lombardo, Christian R; Cathers, Brian E; Xie, Weilin; Mercurio, Frank; Pagano, Michele; Giegel, David; Cox, Sarah
2007 May 25;282(21):15462-15470, Journal of biological chemistry
— id: 72421, year: 2007, vol: 282, page: 15462, stat: Journal Article,

APC/CCDC20 controls the ubiquitin-mediated degradation of p21 during early mitosis
Amador, V; Gonzalez-Santamaria, P; Pagano, M
2006 JUN ;273(11):136-136, FEBS journal
— id: 69260, year: 2006, vol: 273, page: 136, stat: Journal Article,

Modification of Cul1 regulates its association with proteasomal subunits
Bloom, Joanna; Peschiaroli, Angelo; Demartino, George; Pagano, Michele
2006 ;1:5-5, Cell division
— id: 72425, year: 2006, vol: 1, page: 5, stat: Journal Article,

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
Dorrello, N Valerio; Peschiaroli, Angelo; Guardavaccaro, Daniele; Colburn, Nancy H; Sherman, Nicholas E; Pagano, Michele
2006 Oct 20;314(5798):467-471, Science
— id: 69030, year: 2006, vol: 314, page: 467, stat: Journal Article,

Stabilizers and destabilizers controlling cell cycle oscillators
Guardavaccaro, Daniele; Pagano, Michele
2006 Apr 7;22(1):1-4, Molecular cell
— id: 64207, year: 2006, vol: 22, page: 1, stat: Journal Article,

Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27Kip1
Ji, Peng; Goldin, Luba; Ren, Hao; Sun, Daqian; Guardavaccaro, Daniele; Pagano, Michele; Zhu, Liang
2006 Aug 18;281(33):24058-24069, Journal of biological chemistry
— id: 66921, year: 2006, vol: 281, page: 24058, stat: Journal Article,

Cell Division, a new open access online forum for and from the cell cycle community
Kaldis, Philipp; Pagano, Michele
2006 ;1(1):1-1, Cell division
— id: 66922, year: 2006, vol: 1, page: 1, stat: Journal Article,

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Lasorella, Anna; Stegmuller, Judith; Guardavaccaro, Daniele; Liu, Guangchao; Carro, Maria S; Rothschild, Gerson; de la Torre-Ubieta, Luis; Pagano, Michele; Bonni, Azad; Iavarone, Antonio
2006 Jul 27;442(7101):471-474, Nature
— id: 66920, year: 2006, vol: 442, page: 471, stat: Journal Article,

Response: More money, and less time!
Pagano, M
2006 NOV 17 ;127(4):664-665, Cell
— id: 69456, year: 2006, vol: 127, page: 664, stat: Journal Article,

American Idol and NIH Grant Review
Pagano, Michele
2006 Aug 25;126(4):637-638, Cell
— id: 72424, year: 2006, vol: 126, page: 637, stat: Journal Article,

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
Peschiaroli, Angelo; Dorrello, N Valerio; Guardavaccaro, Daniele; Venere, Monica; Halazonetis, Thanos; Sherman, Nicholas E; Pagano, Michele
2006 Aug 4;23(3):319-329, Molecular cell
— id: 66918, year: 2006, vol: 23, page: 319, stat: Journal Article,

A peptidomimetic siRNA transfection reagent for highly effective gene silencing
Utku, Yeliz; Dehan, Elinor; Ouerfelli, Ouathek; Piano, Fabio; Zuckermann, Ronald N; Pagano, Michele; Kirshenbaum, Kent
2006 Jun;2(6-7):312-317, Molecular bioSystems
— id: 66919, year: 2006, vol: 2, page: 312, stat: Journal Article,

Cdk1: the dominant sibling of Cdk2
Bashir, Tarig; Pagano, Michele
2005 Aug;7(8):779-781, Nature cell biology
— id: 64218, year: 2005, vol: 7, page: 779, stat: Journal Article,

Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
Benmaamar, Ramla; Pagano, Michele
2005 Sep;4(9):1230-1232, Cell cycle
— id: 64217, year: 2005, vol: 4, page: 1230, stat: Journal Article,

The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain
Block, Karen; Appikonda, Srikanth; Lin, Horng-Ru; Bloom, Joanna; Pagano, Michele; Yew, P Renee
2005 Oct;4(10):1421-1427, Cell cycle
— id: 64216, year: 2005, vol: 4, page: 1421, stat: Journal Article,

Experimental tests to definitively determine ubiquitylation of a substrate
Bloom, Joanna; Pagano, Michele
2005 ;399:249-266, Methods in enzymology
— id: 64215, year: 2005, vol: 399, page: 249, stat: Journal Article,

Skp2, the FoxO1 hunter
Dehan, Elinor; Pagano, Michele
2005 Mar;7(3):209-210, Cancer cell
— id: 51787, year: 2005, vol: 7, page: 209, stat: Journal Article,

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
Hao, Bing; Zheng, Ning; Schulman, Brenda A; Wu, Geng; Miller, Julie J; Pagano, Michele; Pavletich, Nikola P
2005 Oct 7;20(1):9-19, Molecular cell
— id: 64214, year: 2005, vol: 20, page: 9, stat: Journal Article,

Previous preterm cesarean delivery: identification of a new risk factor for uterine rupture in VBAC candidates
Rochelson, Burton; Pagano, Michelle; Conetta, Laurie; Goldman, Benjamin; Vohra, Nidhi; Frey, Michael; Day, Catherine
2005 Nov;18(5):339-342, Journal of maternal-fetal & neonatal medicine
— id: 62636, year: 2005, vol: 18, page: 339, stat: Journal Article,

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
Bashir, Tarig; Dorrello, N Valerio; Amador, Virginia; Guardavaccaro, Daniele; Pagano, Michele
2004 Mar 11;428(6979):190-193, Nature
— id: 42119, year: 2004, vol: 428, page: 190, stat: Journal Article,

Don't skip the G(1) phase: How APC/C(Cdh1) Keeps SCF(Skp2) in Check
Bashir, Tarig; Pagano, Michele
2004 Jul 14;3(7):850-852, Cell cycle
— id: 44902, year: 2004, vol: 3, page: 850, stat: Journal Article,

Varshavsky's contributions
Baumeister, Wolfgang; Bachmair, Andreas; Chau, Vincent; Cohen, Robert; Coffino, Phil; Demartino, George; Deshaies, Raymond; Dohmen, Juergen; Emr, Scott; Finley, Daniel; Hampton, Randy; Hill, Christopher; Hochstrasser, Mark; Huber, Robert; Jackson, Peter; Jentsch, Stefan; Johnson, Erica; Kwon, Yong Tae; Pagano, Michele; Pickart, Cecile; Rechsteiner, Martin; Scheffner, Martin; Sommer, Thomas; Tansey, William; Tyers, Mike; Vierstra, Richard; Weissman, Allan; Wilkinson, Keith D; Wolf, Dieter
2004 Nov 19;306(5700):1290-1292, Science
— id: 64220, year: 2004, vol: 306, page: 1290, stat: Journal Article,

Ubiquitin-dependent degradation of p73 is inhibited by PML
Bernassola, Francesca; Salomoni, Paolo; Oberst, Andrew; Di Como, Charles J; Pagano, Michele; Melino, Gerry; Pandolfi, Pier Paolo
2004 Jun 7;199(11):1545-1557, Journal of experimental medicine
— id: 45027, year: 2004, vol: 199, page: 1545, stat: Journal Article,

To be or not to be ubiquitinated?
Bloom, Joanna; Pagano, Michele
2004 Mar-Apr;3(2):138-140, Cell cycle
— id: 42120, year: 2004, vol: 3, page: 138, stat: Journal Article,

The SCF ubiquitin ligase: insights into a molecular machine
Cardozo, Timothy; Pagano, Michele
2004 Sep;5(9):739-751, Nature reviews. Molecular cell biology
— id: 45024, year: 2004, vol: 5, page: 739, stat: Journal Article,

Oncogenic aberrations of cullin-dependent ubiquitin ligases
Guardavaccaro, Daniele; Pagano, Michele
2004 Mar 15;23(11):2037-2049, Oncogene
— id: 42579, year: 2004, vol: 23, page: 2037, stat: Journal Article,

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
Ji, Peng; Jiang, Hong; Rekhtman, Katya; Bloom, Joanna; Ichetovkin, Marina; Pagano, Michele; Zhu, Liang
2004 Oct 8;16(1):47-58, Molecular cell
— id: 64223, year: 2004, vol: 16, page: 47, stat: Journal Article,

Systematic analysis and nomenclature of mammalian F-box proteins
Jin, Jianping; Cardozo, Timothy; Lovering, Ruth C; Elledge, Stephen J; Pagano, Michele; Harper, J Wade
2004 Nov 1;18(21):2573-2580, Genes & development
— id: 64222, year: 2004, vol: 18, page: 2573, stat: Journal Article,

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation
Kitajima, Shojiro; Kudo, Yasusei; Ogawa, Ikuko; Bashir, Tarig; Kitagawa, Masae; Miyauchi, Mutsumi; Pagano, Michele; Takata, Takashi
2004 Dec;165(6):2147-2155, American journal of pathology
— id: 64219, year: 2004, vol: 165, page: 2147, stat: Journal Article,

Role of F-Box Protein betaTrcp1 in mammary gland development and tumorigenesis
Kudo, Yasusei; Guardavaccaro, Daniele; Santamaria, Patricia G; Koyama-Nasu, Ryo; Latres, Esther; Bronson, Roderick; Yamasaki, Lili; Pagano, Michele
2004 Sep;24(18):8184-8194, Molecular & cellular biology
— id: 45025, year: 2004, vol: 24, page: 8184, stat: Journal Article,

Fenton's pre-treatment of mature landfill leachate
Lopez, Antonio; Pagano, Michele; Volpe, Angela; Di Pinto, Appio Claudio
2004 Feb;54(7):1005-1010, Chemosphere
— id: 64226, year: 2004, vol: 54, page: 1005, stat: Journal Article,

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
Moshe, Yakir; Boulaire, Jerome; Pagano, Michele; Hershko, Avram
2004 May 25;101(21):7937-7942, Proceedings of the National Academy of Sciences of the United States of America
— id: 64224, year: 2004, vol: 101, page: 7937, stat: Journal Article,

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis
Pagano, Michele
2004 May 21;14(4):414-416, Molecular cell
— id: 45028, year: 2004, vol: 14, page: 414, stat: Journal Article,

Wagging the dogma; tissue-specific cell cycle control in the mouse embryo
Pagano, Michele; Jackson, Peter K
2004 Sep 3;118(5):535-538, Cell
— id: 45026, year: 2004, vol: 118, page: 535, stat: Journal Article,

Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma
Shapira, Ma'anit; Ben-Izhak, Ofer; Bishara, Bishara; Futerman, Boris; Minkov, Ira; Krausz, Michael M; Pagano, Michele; Hershko, Dan D
2004 Apr 15;100(8):1615-1621, Cancer
— id: 64225, year: 2004, vol: 100, page: 1615, stat: Journal Article,

Cell cycle, proteolysis and cancer
Yamasaki, Lili; Pagano, Michele
2004 Dec;16(6):623-628, Current opinion in cell biology
— id: 64221, year: 2004, vol: 16, page: 623, stat: Journal Article,

Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis
Bashir, Tarig; Pagano, Michele
2003 ;88(Pt 1):101-144, Advances in cancer research
— id: 39260, year: 2003, vol: 88, page: 101, stat: Journal Article,

Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation
Bloom, Joanna; Amador, Virginia; Bartolini, Francesca; DeMartino, George; Pagano, Michele
2003 Oct 3;115(1):71-82, Cell
— id: 38122, year: 2003, vol: 115, page: 71, stat: Journal Article,

Deregulated degradation of the cdk inhibitor p27 and malignant transformation
Bloom, Joanna; Pagano, Michele
2003 Feb;13(1):41-47, Seminars in cancer biology
— id: 39340, year: 2003, vol: 13, page: 41, stat: Journal Article,

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
Bornstein, Gil; Bloom, Joanna; Sitry-Shevah, Danielle; Nakayama, Keiko; Pagano, Michele; Hershko, Avram
2003 Jul 11;278(28):25752-25757, Journal of biological chemistry
— id: 64228, year: 2003, vol: 278, page: 25752, stat: Journal Article,

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
Busino, Luca; Donzelli, Maddalena; Chiesa, Massimo; Guardavaccaro, Daniele; Ganoth, Dvora; Dorrello, N Valerio; Hershko, Avram; Pagano, Michele; Draetta, Giulio F
2003 Nov 6;426(6962):87-91, Nature
— id: 42121, year: 2003, vol: 426, page: 87, stat: Journal Article,

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients
Drobnjak, Marija; Melamed, Jonathan; Taneja, Samir; Melzer, Kate; Wieczorek, Rosemary; Levinson, Benjamin; Zeleniuch-Jacquotte, Anne; Polsky, David; Ferrara, Jay; Perez-Soler, Roman; Cordon-Cardo, Carlos; Pagano, Michele; Osman, Iman
2003 Jul;9(7):2613-2619, Clinical cancer research
— id: 38153, year: 2003, vol: 9, page: 2613, stat: Journal Article,

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo
Guardavaccaro, Daniele; Kudo, Yasusei; Boulaire, Jerome; Barchi, Marco; Busino, Luca; Donzelli, Maddalena; Margottin-Goguet, Florence; Jackson, Peter K; Yamasaki, Lili; Pagano, Michele
2003 Jun;4(6):799-812, Developmental cell
— id: 39205, year: 2003, vol: 4, page: 799, stat: Journal Article,

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
McAllister, Sandra S; Becker-Hapak, Michelle; Pintucci, Giuseppe; Pagano, Michele; Dowdy, Steven F
2003 Jan;23(1):216-228, Molecular & cellular biology
— id: 64229, year: 2003, vol: 23, page: 216, stat: Journal Article,

When protein destruction runs amok, malignancy is on the loose
Pagano, Michele; Benmaamar, Ramla
2003 Oct;4(4):251-256, Cancer cell
— id: 38583, year: 2003, vol: 4, page: 251, stat: Journal Article,

Low prepregnancy ideal weight:height ratio in women with hyperemesis gravidarum
Rochelson, Burton; Vohra, Nidhi; Darvishzadeh, J; Pagano, Michelle
2003 Jun;48(6):422-424, Journal of reproductive medicine
— id: 94035, year: 2003, vol: 48, page: 422, stat: Journal Article,

Olive husk: an alternative sorbent for removing heavy metals from aqueous streams
Volpe, Angela; Lopez, Antonio; Pagano, Michele
2003 Sep;110(3):137-149, Applied biochemistry & biotechnology
— id: 64227, year: 2003, vol: 110, page: 137, stat: Journal Article,

Nutritional characteristics of a rural Southern Italy population: the Ventimiglia di Sicilia Project
Barbagallo, Carlo M; Cavera, Giovanni; Sapienza, Michelangelo; Noto, Davide; Cefalu, Angelo B; Polizzi, Francesco; Onorato, Francesco; Rini, GiovanBattista; Di Fede, Gaetana; Pagano, Michele; Montalto, Giuseppe; Rizzo, Manfredi; Descovich, GianCarlo; Notarbartolo, Alberto; Averna, Maurizio R
2002 Dec;21(6):523-529, Journal of the American College of Nutrition
— id: 64230, year: 2002, vol: 21, page: 523, stat: Journal Article,

Butyrolactone: more than a kinase inhibitor?
Bloom, Joanna; Pagano, Michele
2002 Mar-Apr;1(2):117-118, Cell cycle
— id: 39371, year: 2002, vol: 1, page: 117, stat: Journal Article,

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase
Chiarle, Roberto; Fan, Yan; Piva, Roberto; Boggino, Hugo; Skolnik, Jeffrey; Novero, Domenico; Palestro, Giorgio; De Wolf-Peeters, Chris; Chilosi, Marco; Pagano, Michele; Inghirami, Giorgio
2002 Apr;160(4):1457-1466, American journal of pathology
— id: 39682, year: 2002, vol: 160, page: 1457, stat: Journal Article,

Dual mode of degradation of Cdc25 A phosphatase
Donzelli, Maddalena; Squatrito, Massimo; Ganoth, Dvora; Hershko, Avram; Pagano, Michele; Draetta, Giulio F
2002 Sep 16;21(18):4875-4884, EMBO journal
— id: 64231, year: 2002, vol: 21, page: 4875, stat: Journal Article,

CDC25 phosphatases and checkpoint controls
Draetta, G; Donzelli, M; Squatrito, M; Ganoth, D; Hershko, A; Pagano, M
2002 NOV abstract #386;38(5):S116-S116, European journal of cancer (1990)
— id: 36591, year: 2002, vol: 38, page: S116, stat: Journal Article,

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation
Piva, Roberto; Liu, Jian; Chiarle, Roberto; Podda, Antonello; Pagano, Michele; Inghirami, Giorgio
2002 Dec;22(23):8375-8387, Molecular & cellular biology
— id: 39375, year: 2002, vol: 22, page: 8375, stat: Journal Article,

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Signoretti, Sabina; Di Marcotullio, Lucia; Richardson, Andrea; Ramaswamy, Sridhar; Isaac, Beth; Rue, Montserrat; Monti, Franco; Loda, Massimo; Pagano, Michele
2002 Sep;110(5):633-641, Journal of clinical investigation
— id: 64232, year: 2002, vol: 110, page: 633, stat: Journal Article,

Three different binding sites of Cks1 are required for p27-ubiquitin ligation
Sitry, Danielle; Seeliger, Markus A; Ko, Tun K; Ganoth, Dvora; Breward, Sadie E; Itzhaki, Laura S; Pagano, Michele; Hershko, Avram
2002 Nov 1;277(44):42233-42240, Journal of biological chemistry
— id: 64234, year: 2002, vol: 277, page: 42233, stat: Journal Article,

Lead removal and recovery from battery industry wastewaters by soluble starch xanthate
Tiravanti, Giovanni; Marani, Dario; Pagano, Michele; Presicce, Dominique Sara; Passino, Roberto
2002 Jul-Aug;92(7-8):677-688, Annali di chimica
— id: 64233, year: 2002, vol: 92, page: 677, stat: Journal Article,

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
Zheng, Ning; Schulman, Brenda A; Song, Langzhou; Miller, Julie J; Jeffrey, Philip D; Wang, Ping; Chu, Claire; Koepp, Deanna M; Elledge, Stephen J; Pagano, Michele; Conaway, Ronald C; Conaway, Joan W; Harper, J Wade; Pavletich, Nikola P
2002 Apr 18;416(6882):703-709, Nature
— id: 64235, year: 2002, vol: 416, page: 703, stat: Journal Article,

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression
Carrano AC; Pagano M
2001 Jun 25;153(7):1381-1390, Journal of cell biology
— id: 21089, year: 2001, vol: 153, page: 1381, stat: Journal Article,

Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70
Cheng H; Cenciarelli C; Shao Z; Vidal M; Parks WP; Pagano M; Cheng-Mayer C
2001 Nov 13;11(22):1771-1775, Current biology. CB
— id: 39468, year: 2001, vol: 11, page: 1771, stat: Journal Article,

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
Chiarle R; Pagano M; Inghirami G
2001 ;3(2):91-94, Breast cancer research
— id: 21234, year: 2001, vol: 3, page: 91, stat: Journal Article,

The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein
DeSalle LM; Latres E; Lin D; Graner E; Montagnoli A; Baker RT; Pagano M; Loda M
2001 Sep 6;20(39):5538-5542, Oncogene
— id: 26666, year: 2001, vol: 20, page: 5538, stat: Journal Article,

Regulation of the G1 to S transition by the ubiquitin pathway
DeSalle LM; Pagano M
2001 Feb 16;490(3):179-189, FEBS letters
— id: 21094, year: 2001, vol: 490, page: 179, stat: Journal Article,

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27
Ganoth D; Bornstein G; Ko TK; Larsen B; Tyers M; Pagano M; Hershko A
2001 Mar;3(3):321-324, Nature cell biology
— id: 21092, year: 2001, vol: 3, page: 321, stat: Journal Article,

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas
Hershko D; Bornstein G; Ben-Izhak O; Carrano A; Pagano M; Krausz MM; Hershko A
2001 May 1;91(9):1745-1751, Cancer
— id: 21091, year: 2001, vol: 91, page: 1745, stat: Journal Article,

Role of the F-box protein Skp2 in lymphomagenesis
Latres E; Chiarle R; Schulman BA; Pavletich NP; Pellicer A; Inghirami G; Pagano M
2001 Feb 27;98(5):2515-2520, Proceedings of the National Academy of Sciences of the United States of America
— id: 21093, year: 2001, vol: 98, page: 2515, stat: Journal Article,

Cul1 and Skp1 complexes inactivation leads to defective chromosome segregation, genetic instability and neoplastic transformation
Liu, J; Piva, R; Chiarle, R; Podda, A; Pagano, M; Inghirami, G
2001 OCT ;69(4):338-338, American journal of human genetics
— id: 54822, year: 2001, vol: 69, page: 338, stat: Journal Article,

Beware the baited hook of publicity
Pagano, M
2001 Dec;414(6866):843-843, Nature
— id: 539922, year: 2001, vol: 414, page: 843, stat: Journal Article,

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
Rodier, G; Montagnoli, A; Di Marcotullio, L; Coulombe, P; Draetta, G F; Pagano, M; Meloche, S
2001 Dec;20(23):6672-6682, EMBO journal
— id: 539902, year: 2001, vol: 20, page: 6672, stat: Journal Article,

Induction of beta -Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-kappa B
Spiegelman VS; Stavropoulos P; Latres E; Pagano M; Ronai Z; Slaga TJ; Fuchs SY
2001 Jul 20;276(29):27152-27158, Journal of biological chemistry
— id: 21090, year: 2001, vol: 276, page: 27152, stat: Journal Article,

Role of the Cdc25A phosphatase in human breast cancer
Cangi MG; Cukor B; Soung P; Signoretti S; Moreira G Jr; Ranashinge M; Cady B; Pagano M; Loda M
2000 Sep;106(6):753-761, Journal of clinical investigation
— id: 21097, year: 2000, vol: 106, page: 753, stat: Journal Article,

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
Chiarle R; Budel LM; Skolnik J; Frizzera G; Chilosi M; Corato A; Pizzolo G; Magidson J; Montagnoli A; Pagano M; Maes B; De Wolf-Peeters C; Inghirami G
2000 Jan 15;95(2):619-626, Blood
— id: 11873, year: 2000, vol: 95, page: 619, stat: Journal Article,

Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors
Chiaur DS; Murthy S; Cenciarelli C; Parks W; Loda M; Inghirami G; Demetrick D; Pagano M
2000 ;88(3-4):255-258, Cytogenetics & cell genetics
— id: 11681, year: 2000, vol: 88, page: 255, stat: Journal Article,

Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia [In Process Citation]
Chilosi M; Chiarle R; Lestani M; Menestrina F; Montagna L; Ambrosetti A; Prolla G; Pizzolo G; Doglioni C; Piva R; Pagano M; Inghirami G
2000 Oct;111(1):263-271, British journal of haematology
— id: 14849, year: 2000, vol: 111, page: 263, stat: Journal Article,

The F-box protein family
Kipreos ET; Pagano M
2000 ;1(5):REVIEWS3002-REVIEWS3002, Genome biology
— id: 21095, year: 2000, vol: 1, page: REVIEWS3002, stat: Journal Article,

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex
Schulman BA; Carrano AC; Jeffrey PD; Bowen Z; Kinnucan ER; Finnin MS; Elledge SJ; Harper JW; Pagano M; Pavletich NP
2000 Nov 16;408(6810):381-386, Nature
— id: 21098, year: 2000, vol: 408, page: 381, stat: Journal Article,

Regulation of the cdk inhibitor p27 and its deregulation in cancer
Slingerland J; Pagano M
2000 Apr;183(1):10-17, Journal of cellular physiology
— id: 8530, year: 2000, vol: 183, page: 10, stat: Journal Article,

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor
Spiegelman VS; Slaga TJ; Pagano M; Minamoto T; Ronai Z; Fuchs SY
2000 May;5(5):877-882, Molecular cell
— id: 21096, year: 2000, vol: 5, page: 877, stat: Journal Article,

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Carrano AC; Eytan E; Hershko A; Pagano M
1999 Aug;1(4):193-199, Nature cell biology
— id: 6242, year: 1999, vol: 1, page: 193, stat: Journal Article,

Identification of a family of human F-box proteins
Cenciarelli C; Chiaur DS; Guardavaccaro D; Parks W; Vidal M; Pagano M
1999 Oct 21;9(20):1177-1179, Current biology. CB
— id: 6225, year: 1999, vol: 9, page: 1177, stat: Journal Article,

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
Gonen, H; Bercovich, B; Orian, A; Carrano, A; Takizawa, C; Yamanaka, K; Pagano, M; Iwai, K; Ciechanover, A
1999 May;274(21):14823-14830, Journal of biological chemistry
— id: 163495, year: 1999, vol: 274, page: 14823, stat: Journal Article,

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
Latres E; Chiaur DS; Pagano M
1999 Jan 28;18(4):849-854, Oncogene
— id: 7381, year: 1999, vol: 18, page: 849, stat: Journal Article,

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
Montagnoli A; Fiore F; Eytan E; Carrano AC; Draetta GF; Hershko A; Pagano M
1999 May 1;13(9):1181-1189, Genes & development
— id: 6113, year: 1999, vol: 13, page: 1181, stat: Journal Article,

The cell cycle inhibitor p27 as a prognostic marker in human tumors and a novel target for therapeutic intervention
Pagano, Michele; Ravid, Katya
Signaling networks and cell cycles control: The molecual basis of cancer and other diseases Totowa, NJ : Humana Press,
— id: 2554, year: 1999, vol: , page: 545, stat: Chapter,

Activation of protein kinase C triggers its ubiquitination and degradation
Lu Z; Liu D; Hornia A; Devonish W; Pagano M; Foster DA
1998 Feb;18(2):839-845, Molecular & cellular biology
— id: 30817, year: 1998, vol: 18, page: 839, stat: Journal Article,

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
Singh SP; Lipman J; Goldman H; Ellis FH Jr; Aizenman L; Cangi MG; Signoretti S; Chiaur DS; Pagano M; Loda M
1998 Apr 15;58(8):1730-1735, Cancer research
— id: 7795, year: 1998, vol: 58, page: 1730, stat: Journal Article,

Regulation of the cell cycle by the ubiquitin pathway
Slingerland J; Pagano M
1998 ;22:133-147, Results & problems in cell differentation
— id: 12092, year: 1998, vol: 22, page: 133, stat: Journal Article,

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases
Thomas GV; Szigeti K; Murphy M; Draetta G; Pagano M; Loda M
1998 Sep;153(3):681-687, American journal of pathology
— id: 7821, year: 1998, vol: 153, page: 681, stat: Journal Article,

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes
Zhang Y; Wang Z; Liu DX; Pagano M; Ravid K
1998 Jan 16;273(3):1387-1392, Journal of biological chemistry
— id: 7867, year: 1998, vol: 273, page: 1387, stat: Journal Article,

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation
Alessandrini, A; Chiaur, D S; Pagano, M
1997 Mar;11(3):342-345, Leukemia
— id: 539912, year: 1997, vol: 11, page: 342, stat: Journal Article,

Mechanism of p53 degradation
Brown JP; Pagano M
1997 Apr 18;1332(2):O1-O6, Biochimica & biophysica acta
— id: 12325, year: 1997, vol: 1332, page: O1, stat: Journal Article,

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
Esposito, V; Baldi, A; De Luca, A; Groger, A M; Loda, M; Giordano, G G; Caputi, M; Baldi, F; Pagano, M; Giordano, A
1997 Aug;57(16):3381-3385, Cancer research
— id: 539942, year: 1997, vol: 57, page: 3381, stat: Journal Article,

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas [see comments]
Loda M; Cukor B; Tam SW; Lavin P; Fiorentino M; Draetta GF; Jessup JM; Pagano M
1997 Feb;3(2):231-234, Nature medicine
— id: 8310, year: 1997, vol: 3, page: 231, stat: Journal Article,

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest
Millard, S S; Yan, J S; Nguyen, H; Pagano, M; Kiyokawa, H; Koff, A
1997 Mar;272(11):7093-7098, Journal of biological chemistry
— id: 163492, year: 1997, vol: 272, page: 7093, stat: Journal Article,

Cell cycle regulation by the ubiquitin pathway
Pagano M
1997 Nov;11(13):1067-1075, FASEB journal
— id: 12224, year: 1997, vol: 11, page: 1067, stat: Journal Article,

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
Tan, P; Cady, B; Wanner, M; Worland, P; Cukor, B; Magi-Galluzzi, C; Lavin, P; Draetta, G; Pagano, M; Loda, M
1997 Apr;57(7):1259-1263, Cancer research
— id: 539952, year: 1997, vol: 57, page: 1259, stat: Journal Article,

Ubiquitin-dependent degradation of cyclin B is accelerated during an endomitotic cell cycle
Zhang, Y; Wang, Z; Pagano, M; Ravid, K
1997 JUL 31 ;11(9):A1217-A1217, FASEB journal
— id: 53457, year: 1997, vol: 11, page: A1217, stat: Journal Article,

Ubiqfitin-dependent degradation of cyclin b is accelerated during an endomitotic cell cycle
Zhanj, V; Wang, Z; Pagano, M; Rawid, K
1997 ;11(9):-, FASEB journal
— id: 589812, year: 1997, vol: 11, page: , stat: Journal Article,

Cell cycle and cancer: critical events at the G1 restriction point
DelSal, G; Loda, M; Pagano, M
1996 ;7(1-2):127-142, Critical reviews in oncogenesis
— id: 539962, year: 1996, vol: 7, page: 127, stat: Journal Article,

Cell cycle control and cancer
Draetta, G; Pagano, M
1996 DEC ;31(4):241-248, Annual reports in medicinal chemistry
— id: 98376, year: 1996, vol: 31, page: 241, stat: Journal Article,

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
Ohtsubo M; Theodoras AM; Schumacher J; Roberts JM; Pagano M
1995 May;15(5):2612-2624, Molecular & cellular biology
— id: 21100, year: 1995, vol: 15, page: 2612, stat: Journal Article,

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
Pagano M; Tam SW; Theodoras AM; Beer-Romero P; Del Sal G; Chau V; Yew PR; Draetta GF; Rolfe M
1995 Aug 4;269(5224):682-685, Science
— id: 21099, year: 1995, vol: 269, page: 682, stat: Journal Article,

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)
Rolfe, M; Beer-Romero, P; Glass, S; Eckstein, J; Berdo, I; Theodoras, A; Pagano, M; Draetta, G
1995 Apr;92(8):3264-3268, Proceedings of the National Academy of Sciences of the United States of America
— id: 539972, year: 1995, vol: 92, page: 3264, stat: Journal Article,

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
Lukas, J; Pagano, M; Staskova, Z; Draetta, G; Bartek, J
1994 Mar;9(3):707-718, Oncogene
— id: 539982, year: 1994, vol: 9, page: 707, stat: Journal Article,

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
Pagano M; Theodoras AM; Tam SW; Draetta GF
1994 Jul 15;8(14):1627-1639, Genes & development
— id: 21103, year: 1994, vol: 8, page: 1627, stat: Journal Article,

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4
Tam SW; Shay JW; Pagano M
1994 Nov 15;54(22):5816-5820, Cancer research
— id: 21101, year: 1994, vol: 54, page: 5816, stat: Journal Article,

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression
Tam SW; Theodoras AM; Shay JW; Draetta GF; Pagano M
1994 Sep;9(9):2663-2674, Oncogene
— id: 21102, year: 1994, vol: 9, page: 2663, stat: Journal Article,

Cyclin D1 is a nuclear protein required for cell cycle progression in G1
Baldin, V; Lukas, J; Marcote, M J; Pagano, M; Draetta, G
1993 May;7(5):812-821, Genes & development
— id: 539992, year: 1993, vol: 7, page: 812, stat: Journal Article,

Differential modulation of cyclin gene expression by MYC
Jansen-Durr, P; Meichle, A; Steiner, P; Pagano, M; Finke, K; Botz, J; Wessbecher, J; Draetta, G; Eilers, M
1993 Apr;90(8):3685-3689, Proceedings of the National Academy of Sciences of the United States of America
— id: 540012, year: 1993, vol: 90, page: 3685, stat: Journal Article,

G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently
O'Connor, P M; Ferris, D K; Pagano, M; Draetta, G; Pines, J; Hunter, T; Longo, D L; Kohn, K W
1993 Apr;268(11):8298-8308, Journal of biological chemistry
— id: 540002, year: 1993, vol: 268, page: 8298, stat: Journal Article,

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
Pagano M; Pepperkok R; Lukas J; Baldin V; Ansorge W; Bartek J; Draetta G
1993 Apr;121(1):101-111, Journal of cell biology
— id: 21104, year: 1993, vol: 121, page: 101, stat: Journal Article,

Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line
Landesman, Y; Pagano, M; Draetta, G; Rotter, V; Fusenig, N E; Kimchi, A
1992 Aug;7(8):1661-1665, Oncogene
— id: 540032, year: 1992, vol: 7, page: 1661, stat: Journal Article,

cdc2 protein kinase: structure-function relationships
Marcote, M J; Pagano, M; Draetta, G
1992 ;170:30-41; discussion 41, CIBA Foundation symposium
— id: 540052, year: 1992, vol: 170, page: 30, stat: Journal Article,

Association of cdk2 kinase with the transcription factor E2F during S phase
Pagano M; Draetta G; Jansen-Durr P
1992 Feb 28;255(5048):1144-1147, Science
— id: 21105, year: 1992, vol: 255, page: 1144, stat: Journal Article,

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells
Pagano, M; Durst, M; Joswig, S; Draetta, G; Jansen-Durr, P
1992 Sep;7(9):1681-1686, Oncogene
— id: 540022, year: 1992, vol: 7, page: 1681, stat: Journal Article,

Cyclin A is required at two points in the human cell cycle
Pagano, M; Pepperkok, R; Verde, F; Ansorge, W; Draetta, G
1992 Mar;11(3):961-971, EMBO journal
— id: 540042, year: 1992, vol: 11, page: 961, stat: Journal Article,

Cyclin A, cell cycle control and oncogenesis
Pagano, M; Draetta, G
1991 ;3(4):267-277, Progress in growth factor research
— id: 540062, year: 1991, vol: 3, page: 267, stat: Journal Article,