Anthony J. Orsini, D.O.

The effect of a low discharge hematocrit on apnea and bradycardia during the first month at home
Parvez, N; Orsini, A; Hendricks-Munoz, K
2000 MAR ;48(2):213A-213A, Journal of investigative medicine
— id: 54585, year: 2000, vol: 48, page: 213A, stat: Journal Article,

The effect of education, race and socioeconomic status on parental compliance and parental perception of documented home apnea monitors
Javed, F; Orsini, AJ; Carseni, L; Bank, S; Hendricks-Munoz, KD
1999 APR ;45(4):246A-246A, Pediatric research
— id: 54068, year: 1999, vol: 45, page: 246A, stat: Journal Article,

Heliox improves pulmonary mechanics in a pediatric porcine model of induced severe bronchospasm and independent lung mechanical ventilation
Orsini AJ; Stefano JL; Leef KH; Jasani M; Ginn A; Tice L; Nadkarni VM
1999 ;3(2):65-70, Critical care
BACKGROUND: A helium-oxygen gas mixture (heliox) has low gas density and low turbulence and resistance through narrowed airways. The effects of heliox on pulmonary mechanics following severe methacholine-induced bronchospasm were investigated and compared to those of a nitrogen-oxygen gas mixture (nitrox) in an innovative pediatric porcine, independent lung, mechanical ventilation model. RESULTS: All of the lungs showed evidence of severe bronchospasm after methacholine challenge. Prospective definition of 'heliox response' was a 15% or greater improvement in lung function in the lung receiving heliox compared with the matched lung receiving nitrox. Seven out of 10 pigs responded to heliox therapy with respect to resistance and eight out of 10 pigs responded to heliox therapy with respect to compliance and tidal volume (P < 0.03). After crossover from nitrox to heliox, eight out of eight lungs significantly improved with respect to tidal volume, resistance and compliance (P < 0.001). After crossover from heliox to nitrox all eight lungs showed a significant increase in resistance and a significant decrease in tidal volume (P < 0.001). CONCLUSIONS: In a pediatric porcine model of acute, severe methacholine-induced bronchospasm and independent lung mechanical ventilation, administration of heliox improves pulmonary mechanics, gas flow, and ventilation. Administration of heliox should be considered for support of pediatric patients with acute, severe bronchospasm requiring mechanical ventilation through small artificial airways
— id: 27872, year: 1999, vol: 3, page: 65, stat: Journal Article,

The incidence of apnea after discharge in infants less than 34 weeks gestation with normal pre-discharge pneumocardiograms
Orsini, AJ; Pohl, CA; Gibson, E; Epstein, ML; Carseni, L; Hendricks-Munoz, KD
1999 APR ;45(4):252A-252A, Pediatric research
— id: 54070, year: 1999, vol: 45, page: 252A, stat: Journal Article,

Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome
Orsini AJ; Leef KH; Costarino A; Dettorre MD; Stefano JL
1996 Jul;129(1):140-145, Journal of pediatrics
OBJECTIVE: To determine whether fentanyl infusions given to premature infants with respiratory distress syndrome reduce stress and improve long- and short-term outcome. METHODS: Twenty premature infants undergoing mechanical ventilation for respiratory distress syndrome were randomly assigned, in a double-blind fashion, to receive fentanyl by continuous infusion or a volume-matched placebo infusion. A behavioral state score was used to assess the infants' behavior. Cortisol and 11-deoxycortisol levels were measured as physiologic markers of stress. Urinary 3-methyl histidine/creatinine molar ratio was determined and the fractional excretion of urea was measured to assess catabolic state. Ventilatory indexes were recorded for each infant. RESULTS: Infants receiving fentanyl showed significantly lower behavioral state scores (p < 0.04) and lower heart rates (p < 0.001) than those receiving placebo. 11-Deoxycortisol levels were lower in the fentanyl group on days 3, 4, and 5 of the study (p < 0.003). 3-Methyl histidine/creatinine ratios and fractional excretion of urea were not significantly different between the two groups. On the third day of the study, infants receiving fentanyl required a higher ventilator rate (p < 0.01), higher peak inspiratory pressures (p < 0.001), and higher positive end-expiratory pressure (p < 0.0001) than those receiving placebo. There was no difference in long-term outcome with respect to the incidence of bronchopulmonary dysplasia, intraventricular hemorrhage, or sepsis or with respect to the duration of ventilator use. CONCLUSIONS: Although there was a reduction in stress markers in the infants receiving fentanyl, we were unable to demonstrate an improvement in catabolic state or long-term outcome. In addition, the infants receiving fentanyl required higher ventilatory support in the early phase of respiratory distress syndrome than did those receiving placebo
— id: 32391, year: 1996, vol: 129, page: 140, stat: Journal Article,

The neutrophil response to polystyrene microspheres bearing defined surface functional groups
Orsini AJ; Ingenito AC; Needle MA; DeBari VA
1987 Feb;10(1):33-43, Cell biophysics
Luminol-induced chemiluminescence (CL) and phagocytosis by human neutrophils was studied using polystyrene microsphere latices as particulate stimuli. Chemiluminescence and phagocytosis parameters were measured for particles bearing carboxyl, hydroxyl, and amino groups, as well as for the underivatized microspheres. The kinetic curves of CL were bimodal, and curve parameters were evaluated for both the early- and late-phase responses. Significant differences were found among the particle surfaces studied. Underivatized particles elicited the greatest response, particles with the amino group stimulated PMN the least, carboxyl- and hydroxyl-group-bearing particles elicited intermediate magnitudes of response. Phagocytosis data were in good agreement with that obtained from CL measurements. These data provide further evidence in favor of the hypothesis that, in protein-free systems, hydrophobic particles are more readily phagocytosed. Additionally they demonstrate that electrostatic interactions are not a significant factor for neutrophil-particle contact
— id: 32392, year: 1987, vol: 10, page: 33, stat: Journal Article,

Neutrophil stimulation by lipid A and lipopolysaccharides from Salmonella minnesota
DeBari VA; Uychich PM; Orsini AJ; Ingenito AC; Needle MA
1986 Jul-Sep;32(1):597-600, ASAIO transactions (American Society of Artificial Internal Organs)
— id: 32393, year: 1986, vol: 32, page: 597, stat: Journal Article,

Chemiluminescence response of the human polymorphonuclear neutrophil to lipopolysaccharides
Nicotra J; Orsini AJ; DeBari VA
1985 Dec;7(4):283-291, Cell biophysics
Polymorphonuclear neutrophils (PMN) respond to a variety of stimuli with a sequence of reactions that lead to the production of 'active oxygen' species, including H2O2, free radicals, such as superoxide (O2-.) and hydroxyl (HO.), and singlet molecular oxygen (1O2). Some of these can oxidize (5-amino-2,3-dihydrophthalazine 1,4-dione) (luminol) to the ground state aminophthalate ion; this reaction sequence is accompanied by the generation of a photon and forms the basis for the chemiluminescence (CL) response. In this work we used a dedicated photon counting instrument to record CL from PMN incubated with bacterial lipopolysaccharide (LPS). We have studied the CL response to the LPS from Escherichia coli strains 026:B6 and 055:B5, as well as Salmonella minnesota RE 595 and have determined that CL requires heat-labile serum factors, these most likely being intact components of the complement system
— id: 32394, year: 1985, vol: 7, page: 283, stat: Journal Article,