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Seth J. Orlow

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Seth J. Orlow, M.D., Ph.D.

Professor; Samuel Weinberg Professor of Pediatric Dermatology; Derm Dir Pgrm Cutaneous Bio NYU Cancer Skn; Chair Ronald O Perelman Derm
Departments of Dermatology (Chair), Cell Biology (Cell Biology) and Pediatrics (Administration)
NYU Dermatologic Associates

Clinical Addresses

530 FIRST AVENUE, SUITE 7R
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-5889
Fax: 212-263-7680

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Medical Specialties

Pediatric Dermatology, Dermatology

Medical Expertise

Pediatric Dermatology, Skin Malignancies/Hemangiomas, Genetic Skin Diseases

Languages

French

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Board Certification

1990 — Dermatology
2004 — Pediatric Dermatology (Derm)

Education

1986 — Albert Einstein College of Medicine, Medical Education
1986-1987 — Mount Sinai Medical Center (Pediatrics), Internship
1987-1989 — Yale - New Haven Medical Center (Dermatology), Residency Training
1989-1990 — Yale - New Haven Medical Center (Pediatric Dermatolog), Clinical Fellowships

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Research Summary

1. Development of novel therapeutics for the treatment of a number of cancers including melanoma and multiple myeloma, as well as unraveling pathways underlying chemoresistance in these tumors. To do so, we utilize small molecule screening of already-approved drugs ("drug repositioning") and of natural products combined with molecular and cellular techniques. 2. Understanding the cell biology of melanin synthesis and deposition in the skin, hair and eyes, including the processing and trafficking of tyrosinase, the rate-limiting enzyme in melanin production, as well as the pathogenesis of various forms of oculocutaneous albinism that diminish pigmentation. 3. Elucidating the pathogenesis of vitiligo, in which melanocytes in the skin are destroyed, including the role of endoplasmic reticulum stress and the unfolded protein response.

Research Interests

Development of Novel Targeted Therapeies in Melanoma and other Cancers; Molecular and Cellular Basis of Pigmentation

Research Keywords

eye color, genetics, melanosomes, membrane glycoproteins, pigmentation