Home
Joel D Oppenheim

You are about to go to a non-NYULMC website.

Biosketch / Results /

Joel D Oppenheim, Ph.D.

Professor; Senior Associate Dean for Biomedical Sciences; Dir Skler Inst Grad Biomedical Sci
Departments of Microbiology (Microbiology ) and Administration

Contact Info

Address
550 First Ave
Dean's Office Floor G Room N-06-6
Schwartz Lecture Hall
New York, NY 10016

Phone: 212-263-8001
Fax: 212-263-7600,
Email: Joel.Oppenheim@nyumc.org

« Back to Results

Education

1970 — Dr. Oppenheim received his Ph.D. degree in Medical Microbiology from Loyola University Medical Center, Chicago, IL, Graduate Education
1971-1972 — Dr. Oppenheim was a Postdoctoral Fellow in the Department of Microbiology at New York University School of Medicine, New York, NY, PostDoctoral Training

« Back to Results

Research Summary

In collaboration with NYU School of Medicine colleague Dr. G.J. Thorbecke, our group seeks to elucidate the function of IgD, an immunoglobulin that, while in trace amounts in serum (less than 1% of total), is present on the surface of most B lymphocytes. Although IgD's precise biological function has not been defined, considerable evidence indicates its role in humoral immunoaugmentation. In vivo and in vitro murine studies suggest that IgD's augmentation involvement applies to primary and secondary antibody responses, with helper T cells acting as mediators of the effect. This augmentation appears to result from direct contact between IgD and a specific class of T cells expressing IgD receptors on their cell surface (T-delta cells). Such contact causes up-regulation of the IgD receptors on these T cells, allowing them to bind more strongly to B cells and facilitating B-cell activation and proliferation. In microdissection studies of purified murine and human IgD to determine the minimum molecular entity that can induce IgD receptor up-regulation on T cells, we showed that IgD immune augmentation resides solely in the carbohydrate moieties on the molecule and, in murine IgD, specifically in N-linked sequences. Continuing studies examine 1) the precise oligosaccharide sequence(s) responsible for this IgD biological activity, 2) the synthesis of such sequences, 3) the nature and specificity of the IgD receptor, and 4) the use of purified IgD, or carbohydrate sequences therefrom, to stimulate various immune responses.

Our group also develops unique protocols and techniques for purifying biologically and immunologically active proteins.

Research Interests

Structure and Function of IgD Domains

Research Keywords

B-cell activation, immunoaugmentation, immunoglobin D, immunoglobulin D receptor, protein purification

« Back to Results

All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search#about

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing
Ren M; Villamarin A; Shih A; Coutavas E; Moore MS; LoCurcio M; Clarke V; Oppenheim JD; D'Eustachio P; Rush MG
1995 Apr;15(4):2117-2124, Molecular & cellular biology
— id: 6723, year: 1995, vol: 15, page: 2117, stat: Journal Article,

THE IGD RECEPTOR (IGD-R) ON HUMAN T-CELLS IS A LECTIN THAT BINDS TO A CARBOHYDRATE SEQUENCE COMMON TO IGD AND IGA1
AMIN, AR; SWENSON, CD; WEI, CF; TAMMA, SML; OPPENHEIM, JD; PATEL, T; COICO, RF; PAREKH, RB; THORBECKE, GJ
1994 MAR 18 ;8(5):A749-A749, FASEB journal
— id: 52519, year: 1994, vol: 8, page: A749, stat: Journal Article,

Explanation for different types of regulation of arginine biosynthesis in Escherichia coli B and Escherichia coli K12 caused by a difference between their arginine repressors
Tian G; Lim D; Oppenheim JD; Maas WK
1994 Jan 7;235(1):221-230, Journal of molecular biology
— id: 6537, year: 1994, vol: 235, page: 221, stat: Journal Article,

TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor
Wisniewski HG; Burgess WH; Oppenheim JD; Vilcek J
1994 Jun 14;33(23):7423-7429, Biochemistry
— id: 6555, year: 1994, vol: 33, page: 7423, stat: Journal Article,

TSG-6, AN ARTHRITIS-ASSOCIATED HYALURONAN-BINDING PROTEIN, FORMS A STABLE COMPLEX WITH INTER-ALPHA-INHIBITOR VIA A GLYCOSAMINOGLYCAN CROSS-LINK
WISNIEWSKI, HG; BURGESS, WH; OPPENHEIM, JD; VILCEK, J
1994 JAN 4 ;269(6):338-338, Journal of cellular biochemistry
— id: 52588, year: 1994, vol: 269, page: 338, stat: Journal Article,

The immunoaugmenting properties of murine IgD reside in its C delta 1 and C delta 3 regions: potential role for IgD-associated glycans
Amin AR; Tamma SM; Swenson CD; Kieda CC; Oppenheim JD; Finkelman FD; Coico RF
1993 Jun;5(6):607-614, International immunology
— id: 13148, year: 1993, vol: 5, page: 607, stat: Journal Article,

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4
Coutavas E; Ren M; Oppenheim JD; D'Eustachio P; Rush MG
1993 Dec 9;366(6455):585-587, Nature
— id: 6344, year: 1993, vol: 366, page: 585, stat: Journal Article,

WHILE OLIGOMERIC IGD AUGMENTS, MONOMERIC IGD INHIBITS THE GENERATION OF IGG MEMORY IN THE ANTIBODY-RESPONSE IN PARALLEL WITH IGD RECEPTOR EXPRESSION ON T-CELLS
SWENSON, CD; AMIN, AR; RIZINASHVILI, E; OPPENHEIM, JD; THORBECKE, GJ
1993 APR 15 ;150(8):A276-A276, Journal of immunology
— id: 54232, year: 1993, vol: 150, page: A276, stat: Journal Article,

Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring
Viitanen PV; Lorimer GH; Seetharam R; Gupta RS; Oppenheim J; Thomas JO; Cowan NJ
1992 Jan 15;267(2):695-698, Journal of biological chemistry
— id: 8274, year: 1992, vol: 267, page: 695, stat: Journal Article,

Specificity of the murine IgD receptor on T cells is for N-linked glycans on IgD molecules
Amin AR; Tamma SM; Oppenheim JD; Finkelman FD; Kieda C; Coico RF; Thorbecke GJ
1991 Oct 15;88(20):9238-9242, Proceedings of the National Academy of Sciences of the United States of America
— id: 57447, year: 1991, vol: 88, page: 9238, stat: Journal Article,

The Bacillus subtilis sin gene, a regulator of alternate developmental processes, codes for a DNA-binding protein
Gaur, N K; Oppenheim, J; Smith, I
1991 Jan;173(2):678-686, Journal of bacteriology
— id: 138918, year: 1991, vol: 173, page: 678, stat: Journal Article,

Isolation and properties of the RepA1 protein of the IncFII replicon, RepFIC [published erratum appears in Mol Microbiol 1991 Dec;5(12):3089]
Maas R; Oppenheim J; Saadi S; Fuchs T; Maas WK
1991 Apr;5(4):927-932, Molecular microbiology
— id: 14084, year: 1991, vol: 5, page: 927, stat: Journal Article,

Seasonally occurring lectins from the bryozoan Bugula neritina
Colon-Urban, R; Oppenheim, J D
1990 May;254(2):138-143, Journal of experimental zoology
— id: 141122, year: 1990, vol: 254, page: 138, stat: Journal Article,

Biochemical characterization of Plasmodium falciparum hemozoin
Goldie P; Roth EF Jr; Oppenheim J; Vanderberg JP
1990 Dec;43(6):584-596, American journal of tropical medicine & hygiene
— id: 14250, year: 1990, vol: 43, page: 584, stat: Journal Article,

Expression of the cloned gene for enterotoxin STb of Escherichia coli
Lawrence, R M; Huang, P T; Glick, J; Oppenheim, J D; Maas, W K
1990 Apr;58(4):970-977, Infection & immunity
— id: 67823, year: 1990, vol: 58, page: 970, stat: Journal Article,

A rapid one step purification procedure for murine IgD based on the specific affinity of Bandeiraea (Griffonia) simplicifolia-1 for N-linked carbohydrates on IgD
Oppenheim JD; Amin AR; Thorbecke GJ
1990 Jul 3;130(2):243-250, Journal of immunological methods
— id: 8754, year: 1990, vol: 130, page: 243, stat: Journal Article,

Immunocytochemical localization of the [3H]estradiol-binding protein in rat pancreatic acinar cells
Grossman A; Oppenheim J; Grondin G; St. Jean P; Beaudoin AR
1989 Jun;124(6):2857-2866, Endocrinology
— id: 10614, year: 1989, vol: 124, page: 2857, stat: Journal Article,

Isolation of a hemolysin from a spore-crystal mixture of Bacillus thuringiensis israelensis (serotype H-14)
Weinstein SA; Bernheimer AW; Oppenheim JD
1988 ;26(8):733-746, Toxicon
— id: 11252, year: 1988, vol: 26, page: 733, stat: Journal Article,

Kinetics of hemolysis induced by a toxin from Bacillus thuringiensis israelensis
Weinstein SA; Bernheimer AW; Oppenheim JD
1988 ;26(12):1177-1185, Toxicon
— id: 11240, year: 1988, vol: 26, page: 1177, stat: Journal Article,

Some properties of flammutoxin from the edible mushroom Flammulina velutipes
Bernheimer AW; Oppenheim JD
1987 ;25(11):1145-1152, Toxicon
— id: 11414, year: 1987, vol: 25, page: 1145, stat: Journal Article,

LECTIN-LIKE BINDING-PROTEINS FROM THE BRYOZOAN BUGULA-NERITINA
COLONURBAN, R; OPPENHEIM, J
1987 FEB ;27(4):A37-A37, American zoologist
— id: 41831, year: 1987, vol: 27, page: A37, stat: Journal Article,

Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor
Lim DB; Oppenheim JD; Eckhardt T; Maas WK
1987 Oct;84(19):6697-6701, Proceedings of the National Academy of Sciences of the United States of America
— id: 11360, year: 1987, vol: 84, page: 6697, stat: Journal Article,

RAPID PURIFICATION OF ANTI-I AND ANTI-I COLD ANTIBODIES BY AFFINITY-CHROMATOGRAPHY
GLICK, J; OPPENHEIM, JD
1985 ;49(1):49-57, Vox sanguinis
— id: 41220, year: 1985, vol: 49, page: 49, stat: Journal Article,

Lack of inhibitory effects of alpha 1-acid glycoprotein (orosomucoid) on Plasmodium falciparum invasion of human erythrocytes
Gupta SK; Oppenheim JD; Glick J; Schulman S; Vanderberg JP
1985 Sep;34(5):441-446, American journal of tropical medicine & hygiene
— id: 29364, year: 1985, vol: 34, page: 441, stat: Journal Article,

Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin
Kelker HC; Oppenheim JD; Stone-Wolff D; Henriksen-DeStefano D; Aggarwal BB; Stevenson HC; Vilcek J
1985 Jul 15;36(1):69-73, International journal of cancer
— id: 15035, year: 1985, vol: 36, page: 69, stat: Journal Article,

Role of the carbohydrate domains of glycophorins as erythrocyte receptors for invasion by Plasmodium falciparum merozoites
Vanderberg JP; Gupta SK; Schulman S; Oppenheim JD; Furthmayr H
1985 Jan;47(1):201-210, Infection & immunity
— id: 29367, year: 1985, vol: 47, page: 201, stat: Journal Article,

THE DISTRIBUTION OF AND THE BIOCHEMICAL AND SEROLOGICAL RELATIONSHIPS BETWEEN THE I/I AND ABH BLOOD-GROUP ANTIGENS OF THE HUMAN-ERYTHROCYTE MEMBRANE AS DETERMINED BY IMMUNOELECTROPHORETIC TECHNIQUES
Oppenheim, JD; Nachbar, MS; Blank, M
1983 ;4(1):53-62, Electrophoresis
— id: 30672, year: 1983, vol: 4, page: 53, stat: Journal Article,

Assay of erythrocyte components as inhibitors of Plasmodium falciparum merozoite invasion of erythrocytes
Schulman S; Oppenheim JD; Vanderberg JP
1983 Jul;32(4):666-670, American journal of tropical medicine & hygiene
— id: 29370, year: 1983, vol: 32, page: 666, stat: Journal Article,

Tomato (Lycopersicon esculentum) lectin
Nachbar MS; Oppenheim JD
1982 ;83(9):363-368, Methods in enzymology
— id: 18944, year: 1982, vol: 83, page: 363, stat: Journal Article,

MITOGENIC AND ADJUVANT PROPERTIES OF THE LPS-LIKE COMPONENT OF LISTERIA-MONOCYTOGENES
Oppenheim, JD; Nachbar, MS; Bhardwaj, N; Wexler, H
1981 ;10(1):25-28, FEMS microbiology letters
— id: 30224, year: 1981, vol: 10, page: 25, stat: Journal Article,

Plasmodium falciparum: assay in vitro for inhibitors of merozoite penetration of erythrocytes
Weiss MM; Oppenheim JD; Vanderberg JP
1981 Jun;51(3):400-407, Experimental parasitology
— id: 29375, year: 1981, vol: 51, page: 400, stat: Journal Article,

Stimulation of human gamma interferon production by diterpene esters
Yip YK; Pang RH; Oppenheim JD; Nachbar MS; Henriksen D; Zerebeckyj-Eckhardt I; Vilcek J
1981 Oct;34(1):131-139, Infection & immunity
— id: 15601, year: 1981, vol: 34, page: 131, stat: Journal Article,

Lectins in the United States diet: a survey of lectins in commonly consumed foods and a review of the literature
Nachbar MS; Oppenheim JD
1980 Nov;33(11):2338-2345, American journal of clinical nutrition
— id: 18945, year: 1980, vol: 33, page: 2338, stat: Journal Article,

Lectins in the U.S. Diet. Isolation and characterization of a lectin from the tomato (Lycopersicon esculentum)
Nachbar MS; Oppenheim JD; Thomas JO
1980 Mar 10;255(5):2056-2061, Journal of biological chemistry
— id: 18946, year: 1980, vol: 255, page: 2056, stat: Journal Article,

Plasmodium berghei and Plasmodium knowlesi: serum binding to sporozoites
Schulman S; Oppenheim JD; Vanderberg JP
1980 Jun;49(3):420-429, Experimental parasitology
— id: 29377, year: 1980, vol: 49, page: 420, stat: Journal Article,

ISOLATION, CHARACTERIZATION, AND BIOLOGICAL PROPERTIES OF AN ENDOTOXIN-LIKE MATERIAL FROM THE GRAM-POSITIVE ORGANISM LISTERIA-MONOCYTOGENES
Wexler, H; Oppenheim, JD
1979 ;23(3):845-857, Infection & immunity
— id: 29989, year: 1979, vol: 23, page: 845, stat: Journal Article,

Chloride self exchange in Ehrlich ascites cells. Inhibition by furosemide and 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid
Aull F; Nachbar MS; Oppenheim JD
1977 Dec 15;471(3):341-347, Biochimica & biophysica acta
— id: 18947, year: 1977, vol: 471, page: 341, stat: Journal Article,

Nature of lectin-induced alteration of potassium transfer in Ehrlich ascites tumor cells
Aull F; Nachbar MS; Oppenheim JD
1977 Jan;90(1):9-14, Journal of cellular physiology
— id: 18951, year: 1977, vol: 90, page: 9, stat: Journal Article,

CHLORIDE EXCHANGE AND EFFECT OF SITS IN EHRLICH ASCITES TUMOR- CELLS
Aull, F; Nachbar, MS; Oppenheim, JD
1977 ;297(2):163-163, Journal of supramolecular structure
— id: 29576, year: 1977, vol: 297, page: 163, stat: Journal Article,

The use of lectins in the quantitation and analysis of macromolecules by affinoelectrophoresis
Owen P; Oppenheim JD; Nachbar MS; Kessler RE
1977 Jun;80(2):446-457, Analytical biochemistry
— id: 18949, year: 1977, vol: 80, page: 446, stat: Journal Article,

MECHANISM OF LECTIN INDUCED CHANGES IN POTASSIUM-TRANSPORT OF EHRLICH ASCITES TUMOR-CELLS
Aull, F; Nachbar, MS; Oppenheim, JD
1976 ;35(3):605-605, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 29495, year: 1976, vol: 35, page: 605, stat: Journal Article,

Interactions of lectins with plasma membrane glycoproteins of the Ehrlich ascites carcinoma cell
Nachbar MS; Oppenheim JD; Aull F
1976 Feb 6;419(3):512-529, Biochimica & biophysica acta
— id: 18952, year: 1976, vol: 419, page: 512, stat: Journal Article,

Multiple specificities of mammalian blood group substances comparatively studied with human isoagglutinins and fractionated anti-H lectins
Chuba JV; Kuhns WJ; Oppenheim JD; Nachbar MS; Nigrelli RF
1975 Jul;29(1):17-30, Immunology
— id: 18953, year: 1975, vol: 29, page: 17, stat: Journal Article,

Cell surface contributions to the malignant process
Nachbar MS; Oppenheim JD; Aull F
1974 Sep;268(3):122-138, American journal of the medical sciences
— id: 18954, year: 1974, vol: 268, page: 122, stat: Journal Article,

Purification of a hemagglutinin from Limulus polyphemus by affinity chromatography
Oppenheim JD; Nachbar MS; Salton MR; Aull F
1974 Jun 18;58(4):1127-1134, Biochemical & biophysical research communications
— id: 18955, year: 1974, vol: 58, page: 1127, stat: Journal Article,

Labile inhibitor of lymphocyte transformation in plasma from a patient and subacute sclerosing panencephalitis
Allen J; Oppenheim J; Brody JA; Miller J
1973 Jul;8(1):80-82, Infection & immunity
— id: 57743, year: 1973, vol: 8, page: 80, stat: Journal Article,

The production and purification of specific anti-soybean agglutinin antibody by affinity chromatography
Nachbar MS; Oppenheim JD
1973 Sep 14;320(2):494-502, Biochimica & biophysica acta
— id: 18957, year: 1973, vol: 320, page: 494, stat: Journal Article,

Localization and distribution of Micrococcus lysodeikticus membrane ATPase determined by ferritin labeling
Oppenheim, J D; Salton, M R
1973 Mar 16;298(2):297-322, Biochimica & biophysica acta
— id: 76897, year: 1973, vol: 298, page: 297, stat: Journal Article,