Ruth S Nussenzweig

Biosketch / Results /

Ruth Nussenzweig

Research Professor, Department of Pathology
Professor Emerita of Microbiology and Pathology, Department of Microbiology


Contact Info

212/263-6800
Ruth.Nussenzweig@nyumc.org


Education

— M.D. University of Sao Paulo, School of Medicine, Sao Paulo, Brazil, Medical Education

Research Summary

We seek to elucidate the molecular basis of the immunological effector mechanisms of acquired malaria resistance in experimental animal models, individuals living in malaria endemic areas, and vaccinated human volunteers. We study both humoral and cellular protective mechanisms, including the relative role and mode of action of antibodies, cytotoxic T cells, and interferon and other cytokines on the distinct developmental stages of malarial parasites.

Most recently our research has been focused on a recombinant of the Yellow Fever vaccine expressing "foreign" microbial sequences.

This novel experimental approach has the advantage of requiring a single immunizing dose and eliciting a long lasting protection (> 4 months in mice).

Research Interests

Development of Experimental Basis for Malaria Vaccine; Immunoparasitology; Mechanisms of Protection

Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria
Huang, Jing; Li, Xiangming; Coelho-Dos-Reis, Jordana G A; Zhang, Min; Mitchell, Robert; Nogueira, Raquel Tayar; Tsao, Tiffany; Noe, Amy R; Ayala, Ramses; Sahi, Vincent; Gutierrez, Gabriel M; Nussenzweig, Victor; Wilson, James M; Nardin, Elizabeth H; Nussenzweig, Ruth S; Tsuji, Moriya. Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria. Journal of immunological methods. 2015 Sep 26;427:42-50 (1789642)

Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents
Teixeira, Lais H; Tararam, Cibele A; Lasaro, Marcio O; Camacho, Ariane G A; Ersching, Jonatan; Leal, Monica T; Herrera, Socrates; Bruna-Romero, Oscar; Soares, Irene S; Nussenzweig, Ruth S; Ertl, Hildegund C J; Nussenzweig, Victor; Rodrigues, Mauricio M. Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents. Infection & immunity. 2013 Dec 9;82(2):793-807 (816532)

Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity
Mishra, Satish; Nussenzweig, Ruth S; Nussenzweig, Victor. Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity. Journal of immunological methods. 2012 Jan 28;377(1-2):47-52 (161567)

TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
Camacho, Ariane Guglielmi Ariza; Teixeira, Lais Helena; Bargieri, Daniel Youssef; Boscardin, Silvia Beatriz; Soares, Irene da Silva; Nussenzweig, Ruth Sonntag; Nussenzweig, Victor; Rodrigues, Mauricio Martins. TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium. Memorias do Instituto Oswaldo Cruz. 2011 Aug ;106 Suppl 1:167-171 (138010)

Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites
Mishra, Satish; Rai, Urvashi; Shiratsuchi, Takayuki; Li, Xiangming; Vanloubbeeck, Yannick; Cohen, Joe; Nussenzweig, Ruth S; Winzeler, Elizabeth A; Tsuji, Moriya; Nussenzweig, Victor. Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine. 2011 Jul 30;29(43):7335-7342 (138108)