Biosketch / Results /
Ruth NussenzweigResearch Professor, Department of Pathology;Professor Emerita of Microbiology and Pathology, Department of Microbiology
Education— M.D. University of Sao Paulo, School of Medicine, Sao Paulo, Brazil, Medical Education
Research SummaryWe seek to elucidate the molecular basis of the immunological effector mechanisms of acquired malaria resistance in experimental animal models, individuals living in malaria endemic areas, and vaccinated human volunteers. We study both humoral and cellular protective mechanisms, including the relative role and mode of action of antibodies, cytotoxic T cells, and interferon and other cytokines on the distinct developmental stages of malarial parasites.
Most recently our research has been focused on a recombinant of the Yellow Fever vaccine expressing "foreign" microbial sequences.
This novel experimental approach has the advantage of requiring a single immunizing dose and eliciting a long lasting protection (> 4 months in mice).
Research InterestsDevelopment of Experimental Basis for Malaria Vaccine; Immunoparasitology; Mechanisms of Protection
Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria
Huang, Jing; Li, Xiangming; Coelho-Dos-Reis, Jordana G A; Zhang, Min; Mitchell, Robert; Nogueira, Raquel Tayar; Tsao, Tiffany; Noe, Amy R; Ayala, Ramses; Sahi, Vincent; Gutierrez, Gabriel M; Nussenzweig, Victor; Wilson, James M; Nardin, Elizabeth H; Nussenzweig, Ruth S; Tsuji, Moriya
2015-10-04; 1872-7905,Journal of immunological methods - id: 1789642, year: 2015 JOURNAL ARTICLE
Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents
Teixeira, Lais H; Tararam, Cibele A; Lasaro, Marcio O; Camacho, Ariane G A; Ersching, Jonatan; Leal, Monica T; Herrera, Socrates; Bruna-Romero, Oscar; Soares, Irene S; Nussenzweig, Ruth S; Ertl, Hildegund C J; Nussenzweig, Victor; Rodrigues, Mauricio M
2014-02-27; 0019-9567,Infection & immunity - id: 816532, year: 2014 Journal Article
Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity
Mishra, Satish; Nussenzweig, Ruth S; Nussenzweig, Victor
2012-03-23; 0022-1759,Journal of immunological methods - id: 161567, year: 2012 Journal Article
TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
Camacho, Ariane Guglielmi Ariza; Teixeira, Lais Helena; Bargieri, Daniel Youssef; Boscardin, Silvia Beatriz; Soares, Irene da Silva; Nussenzweig, Ruth Sonntag; Nussenzweig, Victor; Rodrigues, Mauricio Martins
2012-02-05; 1678-8060,Memorias do Instituto Oswaldo Cruz - id: 138010, year: 2011
Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites
Mishra, Satish; Rai, Urvashi; Shiratsuchi, Takayuki; Li, Xiangming; Vanloubbeeck, Yannick; Cohen, Joe; Nussenzweig, Ruth S; Winzeler, Elizabeth A; Tsuji, Moriya; Nussenzweig, Victor
2012-02-05; 1873-2518,Vaccine - id: 138108, year: 2011