Anna Nolan

Biosketch / Results /

Anna Nolan

Assistant Professor, Department of Medicine
Assistant Professor, Department of Environmental Medicine

Research Subject Safety Officer - GCRC

Contact Info

Address
462 First Avenue
New York, NY 10016

212/562-8242
Anna.Nolan@nyumc.org


Education

1992-1996 — SUNY HSC @ Brooklyn, Medical Education
1996-2000 — St. Luke's Roosevelt, Residency Training
2000-2003 — New York University, Clinical Fellowships

Research Summary

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

Research Interests

Environmental Exposures Particulate Matter Induced Lung Injury Sepsis Innate Immunity Acute Lung Injury Chronic Obstructive Lung Disease Biomarkers

Research Keywords

Inflammation, Particulate matter, Lung Injury, Obstructive Airways Disease, World Trade Center, Sepsis

Lung Function Trajectories in World Trade Center-Exposed New York City Firefighters Over 13 Years: The Roles of Smoking and Smoking Cessation
Aldrich, Thomas K; Vossbrinck, Madeline; Zeig-Owens, Rachel; Hall, Charles B; Schwartz, Theresa M; Moir, William; Webber, Mayris P; Cohen, Hillel W; Nolan, Anna; Weiden, Michael D; Christodoulou, Vasilios; Kelly, Kerry J; Prezant, David J. Lung Function Trajectories in World Trade Center-Exposed New York City Firefighters Over 13 Years: The Roles of Smoking and Smoking Cessation. Chest. 2016 Jun;149(6):1419-1427 (2143002)

"I Can't Walk" : An Unusual Presentation of Burkitt's Lymphoma
Andriotis, A; Ahmed, A; Nolan, Anna. "I Can't Walk" : An Unusual Presentation of Burkitt's Lymphoma [Meeting Abstract]. Chest. 2016 ;150(4 Suppl):248A-248A (2279612)

A Case of a Rare and Devastating Consequence of Childhood Measles
Andriotis, A; Ahmed, N; Nolan, Anna. A Case of a Rare and Devastating Consequence of Childhood Measles [Meeting Abstract]. Chest. 2016 ;150(Suppl 4):259A-259A (2279622)

The Misadventures of Air: Colitis Versus Barotrauma
Doo, Kathleen; Ahuja, Shilpi B; Nolan, Anna. The Misadventures of Air: Colitis Versus Barotrauma [Meeting Abstract]. American journal of respiratory & critical care medicine. 2016 ;193(Online Abstracts):?-? #A5330 (2097732)

Biomarkers of GERD and Barrett's Esophagus in World Trade Center-Exposed Fire Department of New York City Rescue Workers: The Aerodigestive Continuum
Haider, Syed Hissam; Kwon, Sophia; Caraher, Erin J; Lee, Audrey K; Schwartz, Theresa; Zeig-Owens, Rachel; Webber, Myris P; Prezant, David J; Nolan, Anna. Biomarkers of GERD and Barrett's Esophagus in World Trade Center-Exposed Fire Department of New York City Rescue Workers: The Aerodigestive Continuum [Meeting Abstract]. American journal of respiratory & critical care medicine. 2016 ;193(Online Abstracts):?-? #A5444 (2097692)