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Anna Nolan

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Anna Nolan, M.D.

Assistant Professor; Research Subject Safety Officer - GCRC
Departments of Medicine (Pulmy&CCM Div) and Environmental Medicine

Contact Info

Address
550 First Avenue
Floor 7N Room 24
New Bellevue
New York, NY 10016-6481

Phone: 212-562-8242
Phone: 212-562-8242
Email: Anna.Nolan@nyumc.org

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Education

1992-1996 — SUNY HSC @ Brooklyn, Medical Education
1996-2000 — St. Luke's Roosevelt, Residency
2005-2007 — New York University-Masters of Science Clinical Investigation, Graduate Education
— New York University, Clinical Fellowships

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Research Summary

Sepsis (systemic inflammatory response to infection) is the leading cause of death in critically ill patients. In spite of significant investigation, treatment of sepsis remains largely supportive. Improved understanding of the mechanisms underlying inflammation in sepsis and preclinical investigation of interventions designed to reduce sepsis related mortality is our goal. Preliminary studies show that the costimulatory molecules, CD80 and CD86 and their ligand CD28 mediate a part of the innate immune response to sepsis. CD80/86-/- and CD28-/- mice have improved survival after polymicrobial sepsis produced by cecal ligation and puncture (CLP). Antibodies to CD80/86 also improve survival after CLP. Deletion of costmulatory molecules leads to reduced inflammatory cytokine production and less NF-kappaB activation after CLP. An in vitro model using neutrophil (PMN)/macrophage co-culture leads to macrophage activation by a CD80/86 dependent pathway. We have initiated a sepsis blood repository to collect serum and cells from patients with sepsis and have observed that monocyte surface expression of CD80 and CD86 is induced during sepsis and soluble CD28 levels are elevated in lethal sepsis. In the small group studied to date, elevated sCD28 is a better predictor of mortality than other well validated models such as APACHEII.

Research Interests

Sepsis Acute Lung Injury

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search#about

Metabolic Syndrome Biomarkers Predict Lung Function Impairment: A Nested Case-Control Study
Naveed B; Weiden MD; Kwon S; Gracely EJ; Comfort AL; Ferrier N; Kasturiarachchi KJ; Cohen HW; Aldrich TK; Rom WN; Kelly K; Prezant DJ; Nolan A
2012 Feb;185(4):392-399, American journal of respiratory & critical care medicine
— id: 149814, year: 2012, vol: 185, page: 392, stat: Journal Article,

Pulmonary Disability Evaluations In Fdny Rescue Workers Exposed To Wtc Particulates: A Pilot Study
Comfort AL; Weiden M; Naveed B; Ferrier N; Webber MP; Berger KI; Rom WN; Prezant DJ; Nolan A
2011 ;183:?-? #A4799, American journal of respiratory & critical care medicine
— id: 137900, year: 2011, vol: 183, page: ?, stat: Journal Article,

Low Serum Iga And Igg4 Levels Predict Accelerated Decline In Lung Function Of WTC Dust Exposed Firefighters
Ferrier NV; Nolan A; Naveed B; Rom WN; Comfort AL; Prezant DJ; Weiden MD
2011 ;183:?-? #A4773, American journal of respiratory & critical care medicine
— id: 137903, year: 2011, vol: 183, page: ?, stat: Journal Article,

Neutrophils Activate Alveolar Macrophages by Producing Caspase-6-Mediated Cleavage of IL-1 Receptor-Associated Kinase-M
Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Hoshino, Yoshihiko; Segal, Leopoldo N; Fujita, Yoko; Rom, William N; Weiden, Michael D
2011 Jan 1;186(1):403-410, Journal of immunology
— id: 116209, year: 2011, vol: 186, page: 403, stat: Journal Article,

Biomarkers of metabolic syndrome predict accelerated decline of lung function in NYC firefighters that were exposed to world trade center particulates
Naveed B.; Comfort A.; Ferrier N.; Kwon S.; Rom W.N.; Prezant D.J.; Weiden M.D.; Nolan A.
2011 ;4(2):99-99, Clinical & Translational Science
— id: 142066, year: 2011, vol: 4, page: 99, stat: Journal Article,

Biomarkers Of Metabolic Syndrome Predict Accelerated Decline Of Lung Function In NYC Firefighters That Were Exposed To Wtc Particulates
Naveed B; Comfort AL; Ferrier N; Kasturiarachchi KJ; Rom WN; Prezant DJ; Weiden MD; Nolan A
2011 ;183:?-? #A4795, American journal of respiratory & critical care medicine
— id: 137902, year: 2011, vol: 183, page: ?, stat: Journal Article,

WTC Dust Induces Gm-Csf In Serum Of Fdny Rescue Workers With Accelerated Decline Of Lung Function And In Cultured Alveolar Macrophages
Naveed B; Comfort AL; Ferrier N; Segal LN; Kasturiarachchi KJ; Kwon S; Chen LC; Gordon T; Cohen MD; Prophete C; Rom WN; Prezant DJ; Nolan A; Weiden M
2011 ;183:?-? #A4770, American journal of respiratory & critical care medicine
— id: 137901, year: 2011, vol: 183, page: ?, stat: Journal Article,

Inflammatory Biomarkers Predict Airflow Obstruction After Exposure to World Trade Center Dust
Nolan A; Naveed B; Comfort AL; Ferrier N; Hall CB; Kwon S; Kasturiarachchi KJ; Cohen HW; Zeig-Owens R; Glaser MS; Webber MP; Aldrich TK; Rom WN; Kelly K; Prezant DJ; Weiden MD
2011 Oct 13;:?-? #, Chest
— id: 138730, year: 2011, vol: , page: ?, stat: Journal Article,

Regulatory t cells and th17 cells in bronchoalveolar lavage
Segal L; Kulkarni R; Nolan A; Weiden MD; Tse DB; Rom WN
2011 ;183:?-? #A4799, American journal of respiratory & critical care medicine
— id: 137898, year: 2011, vol: 183, page: ?, stat: Journal Article,

HIV-1 and Bacterial Pneumonia in the Era of Antiretroviral Therapy
Segal, Leopoldo N; Methe, Barbara A; Nolan, Anna; Hoshino, Yoshihiko; Rom, William N; Dawson, Rod; Bateman, Eric; Weiden, Michael D
2011 Jun;8(3):282-287, Proceedings of the American Thoracic Society
— id: 134318, year: 2011, vol: 8, page: 282, stat: Journal Article,

Azithromycin suppresses inflammatory cytokines and induces inhibatory transcription factors in alveolar macrophages
Segal, Leopoldo; Kulkarni, Rohan; Fujita, Yoko; Nolan, Anna; Rom, William N; Weiden, Michael
2011 ;183:?-? #A2853, American journal of respiratory & critical care medicine
— id: 137899, year: 2011, vol: 183, page: ?, stat: Journal Article,

Physician-Diagnosed Respiratory Conditions and Mental Health Symptoms Seven to Nine Years Following the World Trade Center Disaster
Webber MP; Glaser MS; Weakley J; Soo J; Ye F; Zeig-Owens R; Weiden MD; Nolan A; Aldrich TK; Kelly K; Prezant D
2011 Sep 1;54(9):661-671, American journal of industrial medicine
— id: 137897, year: 2011, vol: 54, page: 661, stat: Journal Article,

Similar Exposure To World Trade Center (WTC) Dust Produced Variable Lung Function Decline: Defining Most And Least Effected Subgroups In The FDNY Cohort
Ferrier, Natalia; Nolan, Anna; Rom, Wiliam N; Comfort, Ashley L; Prezant, David J; Weiden, Michael D
2010 ;181:- #A1252, American journal of respiratory & critical care medicine
— id: 113679, year: 2010, vol: 181, page: , stat: Journal Article,

Neutrophils Activate Alveolar Macrophages By Producing Caspase-6 Mediated Cleavage Of Interleukin-1 Associated Kinase-M (IRAK-M) In Tuberculosis
Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Comfort, Ashley L; Rom, William N; Hoshino, Yoshihiko; Weiden, Michael D
2010 ;181:- #A3221, American journal of respiratory & critical care medicine
— id: 113677, year: 2010, vol: 181, page: , stat: Journal Article,

WTC PM2.5 stimulates a more intense inflammatory response in human BAL cells than other ambient PM2.5 from NYC and surrounding environs
Naveed B.; Weiden M.D.; Rom W.N.; Prezant D.J.; Comfort A.; Chen L.; Kwon S.; Chen Y.; Gordon T.; Nolan A.
2010 ;3(2):S48-S48, Clinical & Translational Science
— id: 111408, year: 2010, vol: 3, page: S48, stat: Journal Article,

Microparticle Activity Is Increased In Murine Polymicrobial Sepsis
Naveed, Bushra; Weiden, Michael D; Comfort, Ashley L; Chen, Yingdi; Kwon, Sophia; Rom, William N; Nolan, Anna
2010 ;181:- #1375, American journal of respiratory & critical care medicine
— id: 113680, year: 2010, vol: 181, page: , stat: Journal Article,

WTC PM2.5 Stimulates A More Intense Inflammatory Response In Human BAL Cells Than Other Ambient PM2.5 From NYC And Surrounding Environs
Naveed, Bushra; Weiden, Michael D; Rom, William N; Prezant, David J; Comfort, Ashley L; Chen, Yingdi; Kwon, Sophia; Chen, Lung Chi; Gordon, Terry; Nolan, Anna
2010 ;181:- #A1158, American journal of respiratory & critical care medicine
— id: 113678, year: 2010, vol: 181, page: , stat: Journal Article,

Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dust
Weiden, Michael D; Ferrier, Natalia; Nolan, Anna; Rom, William N; Comfort, Ashley; Gustave, Jackson; Zeig-Owens, Rachel; Zheng, Shugi; Goldring, Roberta M; Berger, Kenneth I; Cosenza, Kaitlyn; Lee, Roy; Webber, Mayris P; Kelly, Kerry J; Aldrich, Thomas K; Prezant, David J
2010 Mar;137(3):566-574, Chest
— id: 109029, year: 2010, vol: 137, page: 566, stat: Journal Article,

Caspase 6 cleaves the macrophage inhibitor IRAK-M in contact dependent innate immune activation
Kobayashi H; Nolan A; Naveed B; Hoshino Y; Hoshino S; Rom WN; Weiden MD
2009 April;179:A5689-A5689, American journal of respiratory & critical care medicine
— id: 101390, year: 2009, vol: 179, page: A5689, stat: Journal Article,

CD80 mediates the innate inflammatory response in murine polymicrobial sepsis
Naveed B; Nolan A; Weiden WN; Rom WN; Gold JA
2009 April;179:A1142-A1142, American journal of respiratory & critical care medicine
— id: 101392, year: 2009, vol: 179, page: A1142, stat: Journal Article,

Costimulatory molecules in the inflammatory response to PM2.5 exposure
Naveed B; Weiden MD; Nolan A; Kang GS; Rom WN; Chen LC
2009 April;179:A3138-A3138, American journal of respiratory & critical care medicine
— id: 101389, year: 2009, vol: 179, page: A3138, stat: Journal Article,

Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis
Nolan, Anna; Kobayashi, Hiroshi; Naveed, Bushra; Kelly, Ann; Hoshino, Yoshihiko; Hoshino, Satomi; Karulf, Matthew R; Rom, William N; Weiden, Michael D; Gold, Jeffrey A
2009 ;4(8):e6600-e6600, PLoS ONE
— id: 101388, year: 2009, vol: 4, page: e6600, stat: Journal Article,

World Trade Center collapse produced airway injury and air trapping
Weiden MD; Ferrier N; Nolan A; Rom WN; Comfort A; Gustave J; Zheng S; Goldring R; Berger K; Cosenz K; Beringer A; Glass L; Lee R; Zeig-Owens R; Webber M; Prezant DJ
2009 ;179:A5852-A5852, American journal of respiratory & critical care medicine
— id: 101391, year: 2009, vol: 179, page: A5852, stat: Journal Article,

CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis
Nolan, Anna; Weiden, Michael; Kelly, Ann; Hoshino, Yoshihiko; Hoshino, Satomi; Mehta, Nehal; Gold, Jeffrey A
2008 Feb 1;177(3):301-308, American journal of respiratory & critical care medicine
— id: 78804, year: 2008, vol: 177, page: 301, stat: Journal Article,

Gene expression profiles of bronchoalveolar cells in pulmonary TB
Raju, Bindu; Hoshino, Yoshihiko; Belitskaya-Levy, Ilana; Dawson, Rod; Ress, Stanley; Gold, Jeffrey A; Condos, Rany; Pine, Richard; Brown, Stuart; Nolan, Anna; Rom, William N; Weiden, Michael D
2008 Jan;88(1):39-51, Tuberculosis (Edinburgh, Scotland)
— id: 74211, year: 2008, vol: 88, page: 39, stat: Journal Article,

The CD80/86-CD28 interaction is significant to mortality in murine polymicrobial sepsis
Chitkara N; Ardilles EE; Gold JA; Weiden MD; Nolan A
2007 ;:A443-A443, American journal of respiratory & critical care medicine
— id: 101394, year: 2007, vol: , page: A443, stat: Journal Article,

Treatment with -1 antitrypsin confers protection from mortality in murine polymicrobial sepsis
Chitkara N; Ardilles EE; Gold JA; Weiden MD; Nolan A
2007 ;:A443-A443, American journal of respiratory & critical care medicine
— id: 101395, year: 2007, vol: , page: A443, stat: Journal Article,

Role of combined costimulatory molecule inhibition in sepsis
Gold JA; Nolan AM; Weiden MD
2007 ;:A900-A900, American journal of respiratory & critical care medicine
— id: 101393, year: 2007, vol: , page: A900, stat: Journal Article,

Benzodiazepine administration and need for mechanical ventilation in delirium tremens - Reply
Gold, JA; Nolan, A; Rimal, B; Nelson, L
2007 JUL ;35(7):1811-1812, Critical care medicine
— id: 73415, year: 2007, vol: 35, page: 1811, stat: Journal Article,

Exogenous interferon-alpha and interferon-gamma increase lethality of murine inhalational anthrax
Gold, Jeffrey A; Hoshino, Yoshihiko; Jones, Marcus B; Hoshino, Satomi; Nolan, Anna; Weiden, Michael D
2007 ;2(1):e736-e736, PLoS ONE
— id: 73818, year: 2007, vol: 2, page: e736, stat: Journal Article,

A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens
Gold, Jeffrey A; Rimal, Binaya; Nolan, Anna; Nelson, Lewis S
2007 Mar;35(3):724-730, Critical care medicine
— id: 71814, year: 2007, vol: 35, page: 724, stat: Journal Article,

Macrophage expressed co-stimulatory molecules CD80/86 in murine polymicrobial sepsis
Ardilles EE; Gold JA; Weiden MD; Nolan A
2006 ;:A648-A648, American journal of respiratory & critical care medicine
— id: 101396, year: 2006, vol: , page: A648, stat: Journal Article,

Blockade of CD80/86 improves survival in a murine model of polymicrobial sepsis
Gold JA; Nolan A; Mehta NL; Weiden MD
2006 ;:A644-A644, American journal of respiratory & critical care medicine
— id: 101397, year: 2006, vol: , page: A644, stat: Journal Article,

A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces need for mechanical ventilation in delirium tremens
Gold JA; Rimal B; Nolan A; Nelson LN
2006 ;:A735-A735, American journal of respiratory & critical care medicine
— id: 101398, year: 2006, vol: , page: A735, stat: Journal Article,

Role of macrophage costimulatory molecules in human sepsis
Mehta NL; Shih P; Nolan A; Weiden MD; Hoshino Y; Gold JA
2005 ;:A522-A522, American journal of respiratory & critical care medicine
— id: 101399, year: 2005, vol: , page: A522, stat: Journal Article,

Role of interferons in an in vivo model of inhalational anthrax
Gold JA; Jones MB; Levy DE; Hoshino Y; Nolan A; Weiden MD
2004 ;169:A230-A230, American journal of respiratory & critical care medicine
— id: 101401, year: 2004, vol: 169, page: A230, stat: Journal Article,

Exogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillus anthracis
Gold, Jeffrey A; Hoshino, Yoshihiko; Hoshino, Satomi; Jones, Marcus B; Nolan, Anna; Weiden, Michael D
2004 Mar;72(3):1291-1297, Infection & immunity
— id: 42240, year: 2004, vol: 72, page: 1291, stat: Journal Article,

Vascular endothelial growth factor blockade reduces serum cytokines in a murine model of polymicrobial sepsis
Nolan A; Thurston G; Weiden MD; Gold JA
2004 ;169:A118-A118, American journal of respiratory & critical care medicine
— id: 101400, year: 2004, vol: 169, page: A118, stat: Journal Article,

Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo
Nolan, Anna; Weiden, Michael D; Hoshino, Yoshihiko; Gold, Jeffrey A
2004 Dec;22(6):538-542, Shock
— id: 55783, year: 2004, vol: 22, page: 538, stat: Journal Article,

Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis
Nolan, Anna; Weiden, Michael D; Thurston, Gavin; Gold, Jeffrey A
2004 Oct;28(5):271-278, Inflammation
— id: 58737, year: 2004, vol: 28, page: 271, stat: Journal Article,

Role of CD 40 ligand in early sepsis
Shih PH; Nolan A; Tse D; Doshi AM; Weiden MD; Gold JA
2004 ;169:A635-A635, American journal of respiratory & critical care medicine
— id: 101402, year: 2004, vol: 169, page: A635, stat: Journal Article,

CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunity
Gold, Jeffrey A; Parsey, Merdad; Hoshino, Yoshihiko; Hoshino, Satomi; Nolan, Anna; Yee, Herman; Tse, Doris B; Weiden, Michael D
2003 Jun;71(6):3521-3528, Infection & immunity
— id: 39222, year: 2003, vol: 71, page: 3521, stat: Journal Article,

CD40 is integral to the innate immune response during polymicrobial sepsis
Nolan A; Parsey M; Hoshino Y; Yee H; Tse DT; Weiden MD; Gold JA
2003 ;167:A556-A556, American journal of respiratory & critical care medicine
— id: 101404, year: 2003, vol: 167, page: A556, stat: Journal Article,

Severe alcohol withdrawal in the ICU, treatments and complications
Rimal B; Nolan A; Gold JA
2003 ;167:A250-A250, American journal of respiratory & critical care medicine
— id: 101403, year: 2003, vol: 167, page: A250, stat: Journal Article,

Correlation of PPD status of immunocompetent tuberculosis patients and bronchoalveolar lavage (BAL) cell differential
Nolan A; Rom WN; Condos R; Raju B
2002 ;165:A288-A288, American journal of respiratory & critical care medicine
— id: 101405, year: 2002, vol: 165, page: A288, stat: Journal Article,