Anna Nolan

Biosketch / Results /

Anna Nolan

Assistant Professor, Department of Medicine
Assistant Professor, Department of Environmental Medicine

Research Subject Safety Officer - GCRC

Contact Info

Address
462 First Avenue
New York, NY 10016

212/562-8242
Anna.Nolan@nyumc.org


Education

1992-1996 — SUNY HSC @ Brooklyn, Medical Education
1996-2000 — St. Luke's Roosevelt, Residency Training
2000-2003 — New York University, Clinical Fellowships

Research Summary

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

Research Keywords

inflammation, particulate matter, obstructive airways disease, World Trade Center, sepsis, environmental exposures, innate immunity, acute lung injury, chronic obstructive lung disease biomarkers, metabolomics, systems biology

Bronchial Reactivity and Lung Function After World Trade Center Exposure
Aldrich, Thomas K; Weakley, Jessica; Dhar, Sean; Hall, Charles B; Crosse, Tesha; Banauch, Gisela I; Weiden, Michael D; Izbicki, Gabriel; Cohen, Hillel W; Gupta, Aanchal; King, Camille; Christodoulou, Vasilios; Webber, Mayris P; Zeig-Owens, Rachel; Moir, William; Nolan, Anna; Kelly, Kerry J; Prezant, David J. Bronchial Reactivity and Lung Function After World Trade Center Exposure. Chest. 2016 Dec;150(6):1333-1340 (2370882)

Post-9/11/2001 lung function trajectories by sex and race in World Trade Center-exposed New York City emergency medical service workers
Vossbrinck, Madeline; Zeig-Owens, Rachel; Hall, Charles B; Schwartz, Theresa; Moir, William; Webber, Mayris P; Cohen, Hillel W; Nolan, Anna; Weiden, Michael D; Christodoulou, Vasilios; Kelly, Kerry J; Aldrich, Thomas K; Prezant, David J. Post-9/11/2001 lung function trajectories by sex and race in World Trade Center-exposed New York City emergency medical service workers. Occupational & environmental medicine. 2016 Nov 3;:?-? (2297432)

Nephroprotective strategies in septic shock: the VANISH trial
Kwon, Sophia; Crowley, George; Haider, Syed Hissam; Zhang, Liqun; Nolan, Anna. Nephroprotective strategies in septic shock: the VANISH trial [Comment]. Journal of thoracic disease. 2016 Nov;8(11):E1508-E1510 (2400602)

Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity
Zeig-Owens, Rachel; Nolan, Anna; Putman, Barbara; Singh, Ankura; Prezant, David J; Weiden, Michael D. Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity. American journal of industrial medicine. 2016 Sep;59(9):788-794 (2232082)

Blood Eosinophils and World Trade Center Exposure Predict Surgery in Chronic Rhinosinusitis: A 13.5-Year Longitudinal Study
Kwon, Sophia; Putman, Barbara; Weakley, Jessica; Hall, Charles B; Zeig-Owens, Rachel; Schwartz, Theresa; Olivieri, Brianne; Singh, Ankura; Huie, Maryann; Morrison, Debra; Webber, Mayris P; Cohen, Hillel W; Kelly, Kerry J; Aldrich, Thomas K; Nolan, Anna; Prezant, David J; Shohet, Michael R; Weiden, Michael D. Blood Eosinophils and World Trade Center Exposure Predict Surgery in Chronic Rhinosinusitis: A 13.5-Year Longitudinal Study. Annals of the American Thoracic Society. 2016 Aug;13(8):1253-1261 (2080052)