Melissa Jill Nirenberg

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Melissa Jill Nirenberg, M.D., Ph.D.

Associate Professor; Assoc Dir Adult Neurology Residency Program
Department of Neurology (Movement Disorders Div)

Clinical Addresses

NEW YORK, NY 10016
Hours: Mon. 9 - 5; Tue. 9 - 5; Wed. 9 - 5
Handicap Access: yes
Phone: 212-263-4838
Fax: 212-263-7721

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Medical Specialties


Medical Expertise

Parkinson's Disease, Movement Disorders

Clinical Responsibilities

Diagnosis and treatment of patients with a wide variety of movement disorders, including Parkinson's Disease, atypical parkinsonism, hemifacial spasm, tremor, dystonia, restless legs syndrome, ataxia, tics, and myoclonus. Therapeutic botulinum toxin injections for movement disorders such as blepharospasm, spasmodic torticollis, Meige syndrome, and hemifacial spasm.

Background information: Melissa J. Nirenberg, MD, PhD pursued her undergraduate education at Yale University, graduating magna cum laude with Distinction in English. She was subsequently awarded a PhD in Neuroscience from the Weill Cornell Graduate School of Medical Sciences. Her doctoral research included investigation of the neuroanatomy of the dopamine-containing neurons that are affected in Parkinson's disease and related disorders. She earned her MD from Weill Cornell Medical School, where she received awards for the highest achievement in the graduating class in both Medicine and Pediatrics. After medical school, Dr. Nirenberg completed a residency in Neurology at the University of California, San Francisco. She then completed a three-year fellowship in Movement Disorders at the Columbia University Center for Parkinson's Disease and Other Movement Disorders. From 2005-2012, Dr. Nirenberg was a faculty member in the Department of Neurology and Neuroscience at Weill Cornell, where she was also Associate Director of the Tri-Institutional MD-PhD Program and Associate Director of the Weill Cornell Parkinson's Disease and Movement Disorders Institute. Dr. Nirenberg joined the faculty of the NYU in 2012, where she is currently an Associate Professor of Neurology, Associate Director of the Neurology Residency Program, and Associate Director of Clinical Services in the Parkinson's and Movement Disorders Center.



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Board Certification

2013 — Ab Psychiatry & Neurology - Neurology


1990-1998 — Cornell University Medical College, Medical Education
1998-1999 — University of California, San Fran (Internal Medicine), Internship
1999-2002 — University of California, San Fran (Neurology), Residency Training
2002-2005 — Columbia University Medical Center (Movement Disorders), Clinical Fellowships

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Research Interests

Psychiatric, cognitive, and other non-motor manifestations of Parkinson's disease - Impulse control disorders related to dopamine agonist medications - Dopamine agonist withdrawal syndrome - Clinical trials of novel treatments for Parkinson's disease - Stem cell research of Parkinson's disease and related disorders - Neuroimaging studies of Parkinson's disease and related disorders - Quality of life in Parkinson's disease

Research Keywords

Parkinson's disease, movement disorders, impulse control disorder, anxiety, depression, apathy, cognitive symptoms, psychiatric, nonmotor, dopamine agonist withdrawal syndrome, DAWS, quality of care, quality of life, stem cell, clinical trial, neuroprotection

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All data from NYU Health Sciences Library Faculty Bibliography — -


A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
Beal, M Flint; Oakes, David; Shoulson, Ira; Henchcliffe, Claire; Galpern, Wendy R; Haas, Richard; Juncos, Jorge L; Nutt, John G; Voss, Tiffini Smith; Ravina, Bernard; Shults, Clifford M; Helles, Karen; Snively, Victoria; Lew, Mark F; Griebner, Brian; Watts, Arthur; Gao, Shan; Pourcher, Emmanuelle; Bond, Louisette; Kompoliti, Katie; Agarwal, Pinky; Sia, Cherissa; Jog, Mandar; Cole, Linda; Sultana, Munira; Kurlan, Roger; Richard, Irene; Deeley, Cheryl; Waters, Cheryl H; Figueroa, Angel; Arkun, Ani; Brodsky, Matthew; Ondo, William G; Hunter, Christine B; Jimenez-Shahed, Joohi; Palao, Alicia; Miyasaki, Janis M; So, Julie; Tetrud, James; Reys, Liza; Smith, Katharine; Singer, Carlos; Blenke, Anita; Russell, David S; Cotto, Candace; Friedman, Joseph H; Lannon, Margaret; Zhang, Lin; Drasby, Edward; Kumar, Rajeev; Subramanian, Thyagarajan; Ford, Donna Stuppy; Grimes, David A; Cote, Diane; Conway, Jennifer; Siderowf, Andrew D; Evatt, Marian Leslie; Sommerfeld, Barbara; Lieberman, Abraham N; Okun, Michael S; Rodriguez, Ramon L; Merritt, Stacy; Swartz, Camille Louise; Martin, W R Wayne; King, Pamela; Stover, Natividad; Guthrie, Stephanie; Watts, Ray L; Ahmed, Anwar; Fernandez, Hubert H; Winters, Adrienna; Mari, Zoltan; Dawson, Ted M; Dunlop, Becky; Feigin, Andrew S; Shannon, Barbara; Nirenberg, Melissa Jill; Ogg, Mattson; Ellias, Samuel A; Thomas, Cathi-Ann; Frei, Karen; Bodis-Wollner, Ivan; Glazman, Sofya; Mayer, Thomas; Hauser, Robert A; Pahwa, Rajesh; Langhammer, April; Ranawaya, Ranjit; Derwent, Lorelei; Sethi, Kapil D; Farrow, Buff; Prakash, Rajan; Litvan, Irene; Robinson, Annette; Sahay, Alok; Gartner, Maureen; Hinson, Vanessa K; Markind, Samuel; Pelikan, Melisa; Perlmutter, Joel S; Hartlein, Johanna; Molho, Eric; Evans, Sharon; Adler, Charles H; Duffy, Amy; Lind, Marlene; Elmer, Lawrence; Davis, Kathy; Spears, Julia; Wilson, Stephanie; Leehey, Maureen A; Hermanowicz, Neal; Niswonger, Shari; Shill, Holly A; Obradov, Sanja; Rajput, Alex; Cowper, Marilyn; Lessig, Stephanie; Song, David; Fontaine, Deborah; Zadikoff, Cindy; Williams, Karen; Blindauer, Karen A; Bergholte, Jo; Propsom, Clara Schindler; Stacy, Mark A; Field, Joanne; Mihaila, Dragos; Chilton, Mark; Uc, Ergun Y; Sieren, Jeri; Simon, David K; Kraics, Lauren; Silver, Althea; Boyd, James T; Hamill, Robert W; Ingvoldstad, Christopher; Young, Jennifer; Thomas, Karen; Kostyk, Sandra K; Wojcieszek, Joanne; Pfeiffer, Ronald F; Panisset, Michel; Beland, Monica; Reich, Stephen G; Cines, Michelle; Zappala, Nancy; Rivest, Jean; Zweig, Richard; Lumina, L Pepper; Hilliard, Colette Lynn; Grill, Stephen; Kellermann, Marye; Tuite, Paul; Rolandelli, Susan; Kang, Un Jung; Young, Joan; Rao, Jayaraman; Cook, Maureen M; Severt, Lawrence; Boyar, Karyn
2014 Mar;:543-552, JAMA Neurology
— id: 890692, year: 2014, vol: , page: 543, stat: Journal Article,

Sex differences in cerebral energy metabolism in Parkinson's disease: A phosphorus magnetic resonance spectroscopic imaging study
Weiduschat, Nora; Mao, Xiangling; Beal, M Flint; Nirenberg, Melissa J; Shungu, Dikoma C; Henchcliffe, Claire
2014 May;20(5):545-548, Parkinsonism & related disorders
— id: 1004762, year: 2014, vol: 20, page: 545, stat: Journal Article,

Prospective cohort study of impulse control disorders in Parkinson's disease
Bastiaens, Jesse; Dorfman, Benjamin J; Christos, Paul J; Nirenberg, Melissa J
2013 Jan;:557-561, Movement disorders
— id: 214192, year: 2013, vol: , page: 557, stat: Journal Article,

Multi-modal imaging study of the posterior cingulate in Parkinson's disease
Huang, C; Dyke, J P; Voss, H U; Tsiouris, A J; Henchcliffe, C; Piboolnurak, P; Severt, L; Ravdin, L D; Maniscalco, J S; Solnes, L; Nirenberg, M J
2013 2013;3:120-120, Journal of Parkinson's disease
— id: 688322, year: 2013, vol: 3, page: 120, stat: Journal Article,

Dopamine agonist withdrawal syndrome: implications for patient care
Nirenberg, Melissa J
2013 Aug;30(8):587-592, Drugs & aging
— id: 458612, year: 2013, vol: 30, page: 587, stat: Journal Article,

Impulse control and related disorders in Parkinson's disease
Weintraub, Daniel; Nirenberg, Melissa J
2013 ;11(2):63-71, Neuro-degenerative diseases
— id: 203332, year: 2013, vol: 11, page: 63, stat: Journal Article,

Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome
Dorfman, Benjamin J; Nirenberg, Melissa J
2012 Jun;:63-71, Parkinsonism & related disorders
— id: 214202, year: 2012, vol: , page: 63, stat: Journal Article,

Clinical characteristics of exacerbations in Parkinson disease
Zheng, Karen S; Dorfman, Benjamin J; Christos, Paul J; Khadem, Nasim R; Henchcliffe, Claire; Piboolnurak, Panida; Nirenberg, Melissa J
2012 May;18(3):120-124, Neurologist
— id: 166192, year: 2012, vol: 18, page: 120, stat: Journal Article,

Clinical predictors of frequent patient telephone calls in Parkinson's disease
Liu, Anli A; Boxhorn, Christine E; Klufas, Michael A; Christos, Paul J; Thorne, Jeffrey T; Shih, Angela Y; Tsankova, Nadejda M; Dorfman, Benjamin J; Henchcliffe, Claire; Piboolnurak, Panida; Nirenberg, Melissa J
2011 Feb;17(2):95-99, Parkinsonism & related disorders
— id: 166191, year: 2011, vol: 17, page: 95, stat: Journal Article,

Carbidopa/levodopa pharmacy errors in Parkinson's disease
Khadem, Nasim R; Nirenberg, Melissa J
2010 Dec;25(16):2867-2871, Movement disorders
— id: 166190, year: 2010, vol: 25, page: 2867, stat: Journal Article,

Dopamine agonist withdrawal syndrome and non-motor symptoms after Parkinson's disease surgery
Nirenberg, Melissa J
2010 Nov;133(11):e155; author reply e156-e155; author reply e156 e155; author reply e156, Brain
— id: 166189, year: 2010, vol: 133, page: e155; author reply e156, stat: Journal Article,

Nocturnal eating in restless legs syndrome
Nirenberg, Melissa J; Waters, Cheryl
2010 Jan;25(1):126-127, Movement disorders
— id: 166186, year: 2010, vol: 25, page: 126, stat: Journal Article,

Dopamine agonist withdrawal syndrome in Parkinson disease
Rabinak, Christina A; Nirenberg, Melissa J
2010 Jan;67(1):58-63, Archives of neurology
— id: 166188, year: 2010, vol: 67, page: 58, stat: Journal Article,

Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease
Henchcliffe, Claire; Shungu, Dikoma C; Mao, Xiangling; Huang, Chaorui; Nirenberg, Melissa J; Jenkins, Bruce G; Beal, M Flint
2008 Dec;1147:206-220, Annals of the New York Academy of Sciences
— id: 166185, year: 2008, vol: 1147, page: 206, stat: Journal Article,

Multiple system atrophy in a patient with the spinocerebellar ataxia 3 gene mutation
Nirenberg, Melissa J; Libien, Jenny; Vonsattel, Jean-Paul; Fahn, Stanley
2007 Jan;22(2):251-254, Movement disorders
— id: 166178, year: 2007, vol: 22, page: 251, stat: Journal Article,

Compulsive eating and weight gain related to dopamine agonist use
Nirenberg, Melissa J; Waters, Cheryl
2006 Apr;21(4):524-529, Movement disorders
— id: 166176, year: 2006, vol: 21, page: 524, stat: Journal Article,

The role of levodopa and catechol-omethyltransferase inhibitors
Nirenberg, Melissa J; Fahn, Stanley
Principles of treatment in Parkinson's disease Philadelphia, PA : Butterworth-Heinemann/Elsevier, c2005,
— id: 166485, year: 2005, vol: , page: ?, stat: Chapter,

Nirenberg, MJ; Frucht, SJ
2005 May;7(3):221-230, Current treatment options in neurology
— id: 166175, year: 2005, vol: 7, page: 221, stat: Journal Article,

Chronic neuropathic pain associated with imiquimod: report of 2 cases
Yi, B Alexander; Nirenberg, Melissa J; Goldstein, Sanford M; Berger, Timothy G
2005 Feb;52(2 Suppl 1):57-58, Journal of the American Academy of Dermatology
— id: 166173, year: 2005, vol: 52, page: 57, stat: Journal Article,

Region-specific targeting of dopamine D2-receptors and somatodendritic vesicular monoamine transporter 2 (VMAT2) within ventral tegmental area subdivisions
Pickel, Virginia M; Chan, June; Nirenberg, Melissa J
2002 Aug;45(2):113-124, Synapse
— id: 166150, year: 2002, vol: 45, page: 113, stat: Journal Article,

Regional and subcellular distribution of a neutral and basic amino acid transporter in forebrain neurons containing nitric oxide synthase
Pickel, V M; Pohorille, A; Chan, J; Tate, S S; Nirenberg, M J
1999 Feb;404(4):459-472, Journal of comparative neurology
— id: 166210, year: 1999, vol: 404, page: 459, stat: Journal Article,

Ultrastructural localization of the vesicular monoamine transporter 2 in mesolimbic and nigrostriatal dopaminergic neurons
Nirenberg, M J; Chan, J; Liu, Y; Edwards, R H; Pickel, V M
1998 ;42:240-243, Advances in pharmacology (New York)
— id: 166208, year: 1998, vol: 42, page: 240, stat: Journal Article,

Catecholamines, opioids, and vagal afferents in the nucleus of the solitary tract
Pickel, V M; Aicher, S A; Aoki, C; Cheng, P Y; Nirenberg, M J
1998 ;42:642-645, Advances in pharmacology (New York)
— id: 166209, year: 1998, vol: 42, page: 642, stat: Journal Article,

Vesicular monoamine transporter-2: immunogold localization in striatal axons and terminals
Nirenberg, M J; Chan, J; Liu, Y; Edwards, R H; Pickel, V M
1997 Jun;26(2):194-198, Synapse
— id: 166204, year: 1997, vol: 26, page: 194, stat: Journal Article,

The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens
Nirenberg, M J; Chan, J; Pohorille, A; Vaughan, R A; Uhl, G R; Kuhar, M J; Pickel, V M
1997 Sep;17(18):6899-6907, Journal of neuroscience
— id: 166207, year: 1997, vol: 17, page: 6899, stat: Journal Article,

Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area
Nirenberg, M J; Chan, J; Vaughan, R A; Uhl, G R; Kuhar, M J; Pickel, V M
1997 Jun;17(11):4037-4044, Journal of neuroscience
— id: 166205, year: 1997, vol: 17, page: 4037, stat: Journal Article,

Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area
Nirenberg, M J; Chan, J; Vaughan, R A; Uhl, G R; Kuhar, M J; Pickel, V M
1997 Jul;17(14):5255-5262, Journal of neuroscience
— id: 166206, year: 1997, vol: 17, page: 5255, stat: Journal Article,

Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine
Nirenberg, M J; Chan, J; Liu, Y; Edwards, R H; Pickel, V M
1996 Jul;16(13):4135-4145, Journal of neuroscience
— id: 166202, year: 1996, vol: 16, page: 4135, stat: Journal Article,

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
Nirenberg, M J; Vaughan, R A; Uhl, G R; Kuhar, M J; Pickel, V M
1996 Jan;16(2):436-447, Journal of neuroscience
— id: 166201, year: 1996, vol: 16, page: 436, stat: Journal Article,

Ultrastructural view of central catecholaminergic transmission: immunocytochemical localization of synthesizing enzymes, transporters and receptors
Pickel, V M; Nirenberg, M J; Milner, T A
1996 Dec;25(12):843-856, Journal of neurocytology
— id: 166203, year: 1996, vol: 25, page: 843, stat: Journal Article,

The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei
Nirenberg, M J; Liu, Y; Peter, D; Edwards, R H; Pickel, V M
1995 Sep;92(19):8773-8777, Proceedings of the National Academy of Sciences of the United States of America
— id: 166198, year: 1995, vol: 92, page: 8773, stat: Journal Article,

Immunocytochemical localization of the renal neutral and basic amino acid transporter in rat adrenal gland, brainstem, and spinal cord
Nirenberg, M J; Tate, S S; Mosckovitz, R; Udenfriend, S; Pickel, V M
1995 Jun;356(4):505-522, Journal of comparative neurology
— id: 166197, year: 1995, vol: 356, page: 505, stat: Journal