Biosketch / Results /

Mary Lynn Nierodzik

Assistant Professor, Department of Medicine
Perlmutter Cancer Center

Contact Info

Address
462 First Avenue
New York, NY 10016

212/263-3212

Education

1978-1982 — SUNY Health Science Center, Medical Education
1982 — SUNY Brooklyn, Medical Education
1982-1986 — SUNY Health Science Center (Medicine), Residency Training
1986-1990 — New York University School of Medicine (Hematology-Oncology), Clinical Fellowships
1986-1990 — NYU, Clinical Fellowships

Research Summary

Metastatic cancer is associated with a hypercoagulable state; tumor cells can generate thrombin on their surface. We study the biomolecular significance of thrombin receptors on tumor cells. Platelets are required for metastasis in vivo. We showed that treating platelets with thrombin enhanced the adhesion of naive tumor cells to platelets. Active thrombin was necessary on the platelet surface. Thrombin administration with murine tumor cells enhanced pulmonary metastasis via a tail-vein injection in syngeneic mice. The platelet GPIIb-lIla adhesive ligand receptor was important for platelet-tumor cell interaction in vitro and metastasis in vivo.

A unique seven-membrane spanning thrombin receptor was cloned by Vu and colleagues in 1991 which requires proteolysis to produce a tethered ligand capable of activating the thrombin receptor. The thrombin receptor activation peptide (TRAP) from the tethered end recapitulated the thrombin effect on transfected xenopus oocytes and human platelets. We demonstrated the presence of the cloned receptor by RT-PCR in human and murine tumor cells lines and human tumor samples. Thrombin or TRAP treatment of tumor cells supported enhanced adhesion to platelets and increased murine metastasis in syngeneic mice
Currrently were are developing clinical trials to assess the use of antithrombin agents as adjuvants to chemotherapy.

Research Interests

Biomolecular Significance of Thrombin Receptors on Tumor Cells. Clinical Trials in hematologic malignancies. Health care disparaties and outcomes research.

The impact of interventions on provider and treatment delays in head and neck cancer patients
Lai, D W; Kim, J; Marciscano, A; Buckley, S A; Schmidt, B L; Cohen, R F; Nierodzik, M L R; Myssiorek, D; DeLacure, M D; Sanfilippo, N; Seetharamu, N
2013-03-27; 0732-183x,Journal of clinical oncology - id: 249342, year: 2012

Trisomy 8 in myeloid leukemia cutis confirmed by fluorescence in situ hybridization analysis
Shvartsbeyn, Marianna; Meehan, Shane M; Gu, Ping; Nierodzik, Mary Lynn; Perle, Mary Ann
2012-10-22; 0303-6987,Journal of cutaneous pathology - id: 180076, year: 2012 Journal Article

Cancer portal project: a multidisciplinary approach to cancer care among Hispanic patients
Gany, Francesca; Ramirez, Julia; Nierodzick, Mary Lynn; McNish, Thelma; Lobach, Iryna; Leng, Jennifer
2012-02-05; 1935-469X,Journal of oncology practice - id: 131970, year: 2011

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma
Wu, Jennifer; Henderson, Charles; Feun, Lynn; Van Veldhuizen, Peter; Gold, Philip; Zheng, Hui; Ryan, Theresa; Blaszkowsky, Lawrence S; Chen, Haobin; Costa, Max; Rosenzweig, Barry; Nierodzik, MaryLynn; Hochster, Howard; Muggia, Franco; Abbadessa, Giovanni; Lewis, Jonathan; Zhu, Andrew X
2012-02-05; 1573-0646,Investigational new drugs - id: 138148, year: 2010

Tumor growth and metastasis
Nierodzik, ML; Karpatkin, S
2013-11-25; , - id: 644422, year: 2007