Nicholas E Geacintov, Ph.D.

Structural, energetic and dynamic properties of guanine(C8)-thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair
Ding S; Kropachev K; Cai Y; Kolbanovskiy M; Durandina SA; Liu Z; Shafirovich V; Broyde S; Geacintov NE
2012 Dec 1;:2506-2517 #, Nucleic acids research
— id: 142430, year: 2012, vol: , page: 2506, stat: Journal Article,

Sequence-Dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward Oxidation
Lim KS; Taghizadeh K; Wishnok JS; Babu IR; Shafirovich V; Geacintov NE; Dedon PC
2012 Feb;25(2):366-373, Chemical research in toxicology
— id: 142429, year: 2012, vol: 25, page: 366, stat: Journal Article,

Intercalative conformations of the 14R (+)- and 14S (-)-trans-anti-DB[a,l]P-N-dA adducts: molecular modeling and MD simulations
Cai, Yuqin; Ding, Shuang; Geacintov, Nicholas E; Broyde, Suse
2011 Apr 18;24(4):522-531, Chemical research in toxicology
— id: 142435, year: 2011, vol: 24, page: 522, stat: Journal Article,

Robert shapiro (1935-2011)
Geacintov, Nicholas E; Broyde, Suse
2011 Nov 21;24(11):2055-2056, Chemical research in toxicology
— id: 142431, year: 2011, vol: 24, page: 2055, stat: Journal Article,

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells
Hendel, Ayal; Krijger, Peter H L; Diamant, Noam; Goren, Zohar; Langerak, Petra; Kim, Jungmin; Reissner, Thomas; Lee, Kyoo-young; Geacintov, Nicholas E; Carell, Thomas; Myung, Kyungjae; Tateishi, Satoshi; D'Andrea, Alan; Jacobs, Heinz; Livneh, Zvi
2011 Sep;7(9):e1002262-e1002262, PLoS Genetics
— id: 140324, year: 2011, vol: 7, page: e1002262, stat: Journal Article,

Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene
Krzeminski, Jacek; Kropachev, Konstantin; Kolbanovskiy, Marina; Reeves, Dara; Kolbanovskiy, Alexander; Yun, Byeong-Hwa; Geacintov, Nicholas E; Amin, Shantu; El-Bayoumy, Karam
2011 Jan 14;24(1):65-72, Chemical research in toxicology
— id: 142436, year: 2011, vol: 24, page: 65, stat: Journal Article,

Solvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contexts
Lee, Young-Ae; Liu, Zhi; Dedon, Peter C; Geacintov, Nicholas E; Shafirovich, Vladimir
2011 Jul 25;12(11):1731-1739, Chembiochem : a European journal of chemical biology
— id: 142433, year: 2011, vol: 12, page: 1731, stat: Journal Article,

Probing for DNA damage with beta-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro
Liu, Yang; Reeves, Dara; Kropachev, Konstantin; Cai, Yuqin; Ding, Shuang; Kolbanovskiy, Marina; Kolbanovskiy, Alexander; Bolton, Judith L; Broyde, Suse; Van Houten, Bennett; Geacintov, Nicholas E
2011 Jul 15;10(7):684-696, DNA repair (Amsterdam)
— id: 138981, year: 2011, vol: 10, page: 684, stat: Journal Article,

Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions
Reeves, Dara A; Mu, Hong; Kropachev, Konstantin; Cai, Yuqin; Ding, Shuang; Kolbanovskiy, Alexander; Kolbanovskiy, Marina; Chen, Ying; Krzeminski, Jacek; Amin, Shantu; Patel, Dinshaw J; Broyde, Suse; Geacintov, Nicholas E
2011 Nov 1;39(20):8752-8764, Nucleic acids research
— id: 142432, year: 2011, vol: 39, page: 8752, stat: Journal Article,

Generation of guanine-thymidine cross-links in DNA by peroxynitrite/carbon dioxide
Yun, Byeong Hwa; Geacintov, Nicholas E; Shafirovich, Vladimir
2011 Jul 18;24(7):1144-1152, Chemical research in toxicology
— id: 142434, year: 2011, vol: 24, page: 1144, stat: Journal Article,

Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion
Cai, Yuqin; Kropachev, Konstantin; Xu, Rong; Tang, Yijin; Kolbanovskii, Marina; Kolbanovskii, Alexander; Amin, Shantu; Patel, Dinshaw J; Broyde, Suse; Geacintov, Nicholas E
2010 Jun 11;399(3):397-409, Journal of molecular biology
— id: 142440, year: 2010, vol: 399, page: 397, stat: Journal Article,

Base sequence context effects on nucleotide excision repair
Cai, Yuqin; Patel, Dinshaw J; Broyde, Suse; Geacintov, Nicholas E
2010 ;2010:?-?, Journal of nucleic acids
— id: 142439, year: 2010, vol: 2010, page: ?, stat: Journal Article,

A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorigen stabilizes nucleosome core particle structure
Cai, Yuqin; Wang, Lihua; Ding, Shuang; Schwaid, Adam; Geacintov, Nicholas E; Broyde, Suse
2010 Nov 23;49(46):9943-9945, Biochemistry
— id: 142437, year: 2010, vol: 49, page: 9943, stat: Journal Article,

Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway
Dreij, Kristian; Rhrissorrakrai, Kahn; Gunsalus, Kristin C; Geacintov, Nicholas E; Scicchitano, David A
2010 Jun;31(6):1149-1157, Carcinogenesis
— id: 142441, year: 2010, vol: 31, page: 1149, stat: Journal Article,

Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4
Rechkoblit, Olga; Kolbanovskiy, Alexander; Malinina, Lucy; Geacintov, Nicholas E; Broyde, Suse; Patel, Dinshaw J
2010 Mar;17(3):379-388, Nature structural & molecular biology
— id: 142445, year: 2010, vol: 17, page: 379, stat: Journal Article,

Oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine by oxyl radicals produced by photolysis of azo compounds
Shao, Jie; Geacintov, Nicholas E; Shafirovich, Vladimir
2010 May 17;23(5):933-938, Chemical research in toxicology
— id: 142443, year: 2010, vol: 23, page: 933, stat: Journal Article,

Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds
Shao, Jie; Geacintov, Nicholas E; Shafirovich, Vladimir
2010 May 20;114(19):6685-6692, Journal of physical chemistry. B. Condensed matter, materials, surfaces, interfaces & biophysical
— id: 142442, year: 2010, vol: 114, page: 6685, stat: Journal Article,

One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection
Yun, Byeong Hwa; Dedon, Peter C; Geacintov, Nicholas E; Shafirovich, Vladimir
2010 May-Jun;86(3):563-570, Photochemistry & photobiology
— id: 142444, year: 2010, vol: 86, page: 563, stat: Journal Article,

Base Flipping Free Energy Profiles for Damaged and Undamaged DNA
Zheng H; Cai Y; Ding S; Tang Y; Kropachev K; Zhou Y; Wang L; Wang S; Geacintov NE; Zhang Y; Broyde S
2010 Dec 20;23(12):1868-1870, Chemical research in toxicology
— id: 142438, year: 2010, vol: 23, page: 1868, stat: Journal Article,

Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals
Cai, Yuqin; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2009 Jan 9;385(1):30-44, Journal of molecular biology
— id: 142454, year: 2009, vol: 385, page: 30, stat: Journal Article,

Methylation of 2'-deoxyguanosine by a free radical mechanism
Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2009 Sep 24;113(38):12773-12781, Journal of physical chemistry. B. Condensed matter, materials, surfaces, interfaces & biophysical
— id: 142448, year: 2009, vol: 113, page: 12773, stat: Journal Article,

The role of one-electron reduction of lipid hydroperoxides in causing DNA damage
Crean, Conor; Shao, Jie; Yun, Byeong Hwa; Geacintov, Nicholas E; Shafirovich, Vladimir
2009 Oct 12;15(40):10634-10640, Chemistry (Weinheim an der Bergstrasse, Germany)
— id: 142446, year: 2009, vol: 15, page: 10634, stat: Journal Article,

Absolute configurations of spiroiminodihydantoin and allantoin stereoisomers: comparison of computed and measured electronic circular dichroism spectra
Ding, Shuang; Jia, Lei; Durandin, Alexander; Crean, Conor; Kolbanovskiy, Alexander; Shafirovich, Vladimir; Broyde, Suse; Geacintov, Nicholas E
2009 Jun;22(6):1189-1193, Chemical research in toxicology
— id: 142451, year: 2009, vol: 22, page: 1189, stat: Journal Article,

Absolute configurations of DNA lesions determined by comparisons of experimental ECD and ORD spectra with DFT calculations
Ding, Shuang; Kolbanovskiy, Alexander; Durandin, Alexander; Crean, Conor; Shafirovich, Vladimir; Broyde, Suse; Geacintov, Nicholas E
2009 ;21 Suppl 1:E231-E241, Chirality
— id: 142455, year: 2009, vol: 21 Suppl 1, page: E231, stat: Journal Article,

Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB
Jia, Lei; Kropachev, Konstantin; Ding, Shuang; Van Houten, Bennett; Geacintov, Nicholas E; Broyde, Suse
2009 Sep 29;48(38):8948-8957, Biochemistry
— id: 142447, year: 2009, vol: 48, page: 8948, stat: Journal Article,

The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions
Kropachev, Konstantin; Kolbanovskii, Marina; Cai, Yuqin; Rodriguez, Fabian; Kolbanovskii, Alexander; Liu, Yang; Zhang, Lu; Amin, Shantu; Patel, Dinshaw; Broyde, Suse; Geacintov, Nicholas E
2009 Mar 13;386(5):1193-1203, Journal of molecular biology
— id: 138982, year: 2009, vol: 386, page: 1193, stat: Journal Article,

Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases
Rechkoblit, Olga; Malinina, Lucy; Cheng, Yuan; Geacintov, Nicholas E; Broyde, Suse; Patel, Dinshaw J
2009 May 13;17(5):725-736, Structure
— id: 142453, year: 2009, vol: 17, page: 725, stat: Journal Article,

Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells
Wang, Zhican; Edirisinghe, Praneeth; Sohn, Johann; Qin, Zhihui; Geacintov, Nicholas E; Thatcher, Gregory R J; Bolton, Judy L
2009 Jun;22(6):1129-1136, Chemical research in toxicology
— id: 142452, year: 2009, vol: 22, page: 1129, stat: Journal Article,

Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase
Xu, Pingna; Oum, Lida; Lee, Yuan-Cho; Geacintov, Nicholas E; Broyde, Suse
2009 Jun 9;48(22):4677-4690, Biochemistry
— id: 142450, year: 2009, vol: 48, page: 4677, stat: Journal Article,

NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms
Zhang, Na; Ding, Shuang; Kolbanovskiy, Alexander; Shastry, Anant; Kuzmin, Vladimir A; Bolton, Judy L; Patel, Dinshaw J; Broyde, Suse; Geacintov, Nicholas E
2009 Aug 4;48(30):7098-7109, Biochemistry
— id: 142449, year: 2009, vol: 48, page: 7098, stat: Journal Article,

Lesion processing: high-fidelity versus lesion-bypass DNA polymerases
Broyde, Suse; Wang, Lihua; Rechkoblit, Olga; Geacintov, Nicholas E; Patel, Dinshaw J
2008 May;33(5):209-219, Trends in biochemical sciences
— id: 142463, year: 2008, vol: 33, page: 209, stat: Journal Article,

DNA adduct structure-function relationships: comparing solution with polymerase structures
Broyde, Suse; Wang, Lihua; Zhang, Ling; Rechkoblit, Olga; Geacintov, Nicholas E; Patel, Dinshaw J
2008 Jan;21(1):45-52, Chemical research in toxicology
— id: 142468, year: 2008, vol: 21, page: 45, stat: Journal Article,

Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU)
Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2008 Oct 15;45(8):1125-1134, Free radical biology & medicine
— id: 142458, year: 2008, vol: 45, page: 1125, stat: Journal Article,

Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals
Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2008 Feb;21(2):358-373, Chemical research in toxicology
— id: 142466, year: 2008, vol: 21, page: 358, stat: Journal Article,

Oxidation of guanine by carbonate radicals derived from photolysis of carbonatotetramminecobalt(III) complexes and the pH dependence of intrastrand DNA cross-links mediated by guanine radical reactions
Crean, Conor; Lee, Young Ae; Yun, Byeong Hwa; Geacintov, Nicholas E; Shafirovich, Vladimir
2008 Aug 11;9(12):1985-1991, Chembiochem : a European journal of chemical biology
— id: 142460, year: 2008, vol: 9, page: 1985, stat: Journal Article,

Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines
Crean, Conor; Uvaydov, Yuriy; Geacintov, Nicholas E; Shafirovich, Vladimir
2008 Feb;36(3):742-755, Nucleic acids research
— id: 142467, year: 2008, vol: 36, page: 742, stat: Journal Article,

Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase
Dimitri, Alexandra; Jia, Lei; Shafirovich, Vladimir; Geacintov, Nicholas E; Broyde, Suse; Scicchitano, David A
2008 Aug 2;7(8):1276-1288, DNA repair (Amsterdam)
— id: 142461, year: 2008, vol: 7, page: 1276, stat: Journal Article,

Conformational properties of equilenin-DNA adducts: stereoisomer and base effects
Ding, Shuang; Shapiro, Robert; Cai, Yuqin; Geacintov, Nicholas E; Broyde, Suse
2008 May;21(5):1064-1073, Chemical research in toxicology
— id: 142462, year: 2008, vol: 21, page: 1064, stat: Journal Article,

Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry
Ding, Shuang; Wang, Yan; Kolbanovskiy, Alexander; Durandin, Alexander; Bolton, Judy L; van Breemen, Richard B; Broyde, Suse; Geacintov, Nicholas E
2008 Sep;21(9):1739-1748, Chemical research in toxicology
— id: 142459, year: 2008, vol: 21, page: 1739, stat: Journal Article,

The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions
Jia, Lei; Geacintov, Nicholas E; Broyde, Suse
2008 Nov;36(20):6571-6584, Nucleic acids research
— id: 142457, year: 2008, vol: 36, page: 6571, stat: Journal Article,

Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesions
Lee, Young Ae; Durandin, Alexander; Dedon, Peter C; Geacintov, Nicholas E; Shafirovich, Vladimir
2008 Feb 14;112(6):1834-1844, Journal of physical chemistry. B. Condensed matter, materials, surfaces, interfaces & biophysical
— id: 142465, year: 2008, vol: 112, page: 1834, stat: Journal Article,

DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants
Margolin, Yelena; Shafirovich, Vladimir; Geacintov, Nicholas E; DeMott, Michael S; Dedon, Peter C
2008 Dec 19;283(51):35569-35578, Journal of biological chemistry
— id: 142456, year: 2008, vol: 283, page: 35569, stat: Journal Article,

Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism
Xu, Pingna; Oum, Lida; Geacintov, Nicholas E; Broyde, Suse
2008 Mar 4;47(9):2701-2709, Biochemistry
— id: 142464, year: 2008, vol: 47, page: 2701, stat: Journal Article,

Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair
Cai, Yuqin; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2007 Nov 23;374(2):292-305, Journal of molecular biology
— id: 142469, year: 2007, vol: 374, page: 292, stat: Journal Article,

4-hydroxyequilenin-adenine lesions in DNA duplexes: stereochemistry, damage site, and structure
Ding, Shuang; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2007 Jan 9;46(1):182-191, Biochemistry
— id: 142476, year: 2007, vol: 46, page: 182, stat: Journal Article,

Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies
Jia, Lei; Shafirovich, Vladimir; Geacintov, Nicholas E; Broyde, Suse
2007 May 8;46(18):5305-5314, Biochemistry
— id: 142473, year: 2007, vol: 46, page: 5305, stat: Journal Article,

Mechanisms of oxidation of guanine in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate
Lee, Young Ae; Yun, Byeong Hwa; Kim, Seog K; Margolin, Yelena; Dedon, Peter C; Geacintov, Nicholas E; Shafirovich, Vladimir
2007 ;13(16):4571-4581, Chemistry (Weinheim an der Bergstrasse, Germany)
— id: 142477, year: 2007, vol: 13, page: 4571, stat: Journal Article,

The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions
Mocquet, Vincent; Kropachev, Konstantin; Kolbanovskiy, Marina; Kolbanovskiy, Alexander; Tapias, Angels; Cai, Yuqin; Broyde, Suse; Geacintov, Nicholas E; Egly, Jean-Marc
2007 Jun 20;26(12):2923-2932, EMBO journal
— id: 142471, year: 2007, vol: 26, page: 2923, stat: Journal Article,

Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase
Perlow-Poehnelt, Rebecca A; Likhterov, Ilya; Wang, Lihua; Scicchitano, David A; Geacintov, Nicholas E; Broyde, Suse
2007 Jan 12;282(2):1397-1408, Journal of biological chemistry
— id: 142475, year: 2007, vol: 282, page: 1397, stat: Journal Article,

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context
Rodriguez, Fabian A; Cai, Yuqin; Lin, Chin; Tang, Yijin; Kolbanovskiy, Alexander; Amin, Shantu; Patel, Dinshaw J; Broyde, Suse; Geacintov, Nicholas E
2007 ;35(5):1555-1568, Nucleic acids research
— id: 142479, year: 2007, vol: 35, page: 1555, stat: Journal Article,

Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins
Ruan, Qian; Liu, Tongming; Kolbanovskiy, Alexander; Liu, Yang; Ren, Jian; Skorvaga, Milan; Zou, Yue; Lader, Joshua; Malkani, Brijesh; Amin, Shantu; Van Houten, Bennett; Geacintov, Nicholas E
2007 Jun 12;46(23):7006-7015, Biochemistry
— id: 142472, year: 2007, vol: 46, page: 7006, stat: Journal Article,

The stereochemistry of benzo[a]pyrene-2'-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases
Subach, Oksana M; Maltseva, Diana V; Shastry, Anant; Kolbanovskiy, Alexander; Klimasauskas, Saulius; Geacintov, Nicholas E; Gromova, Elizaveta S
2007 Apr;274(8):2121-2134, FEBS journal
— id: 142474, year: 2007, vol: 274, page: 2121, stat: Journal Article,

Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase
Xu, Pingna; Oum, Lida; Beese, Lorena S; Geacintov, Nicholas E; Broyde, Suse
2007 ;35(13):4275-4288, Nucleic acids research
— id: 142478, year: 2007, vol: 35, page: 4275, stat: Journal Article,

Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage
Yun, Byeong Hwa; Lee, Young Ae; Kim, Seog K; Kuzmin, Vladimir; Kolbanovskiy, Alexander; Dedon, Peter C; Geacintov, Nicholas E; Shafirovich, Vladimir
2007 Aug 1;129(30):9321-9332, Journal of the American Chemical Society
— id: 142470, year: 2007, vol: 129, page: 9321, stat: Journal Article,

Assignment of absolute configurations of the enantiomeric spiroiminodihydantoin nucleobases by experimental and computational optical rotatory dispersion methods
Durandin, Alexander; Jia, Lei; Crean, Conor; Kolbanovskiy, Alexander; Ding, Shuang; Shafirovich, Vladimir; Broyde, Suse; Geacintov, Nicholas E
2006 Jul;19(7):908-913, Chemical research in toxicology
— id: 142480, year: 2006, vol: 19, page: 908, stat: Journal Article,

Flexible 5-guanidino-4-nitroimidazole DNA lesions: structures and thermodynamics
Jia, Lei; Shafirovich, Vladimir; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2006 May 30;45(21):6644-6655, Biochemistry
— id: 142482, year: 2006, vol: 45, page: 6644, stat: Journal Article,

Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation
Margolin, Yelena; Cloutier, Jean-Francois; Shafirovich, Vladimir; Geacintov, Nicholas E; Dedon, Peter C
2006 Jul;2(7):365-366, Nature Chemical Biology
— id: 142481, year: 2006, vol: 2, page: 365, stat: Journal Article,

Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion
Rechkoblit, Olga; Malinina, Lucy; Cheng, Yuan; Kuryavyi, Vitaly; Broyde, Suse; Geacintov, Nicholas E; Patel, Dinshaw J
2006 Jan;4(1):e11-e11, PLoS biology
— id: 142486, year: 2006, vol: 4, page: e11, stat: Journal Article,

A sensitive probe for the detection of Zn(II) by time-resolved fluorescence
Royzen, Maksim; Durandin, Alexander; Young, Victor G Jr; Geacintov, Nicholas E; Canary, James W
2006 Mar 29;128(12):3854-3855, Journal of the American Chemical Society
— id: 142484, year: 2006, vol: 128, page: 3854, stat: Journal Article,

Impact of benzo[a]pyrene-2'-deoxyguanosine lesions on methylation of DNA by SssI and HhaI DNA methyltransferases
Subach, Oksana M; Baskunov, Vladimir B; Darii, Maria V; Maltseva, Diana V; Alexandrov, Dmitrii A; Kirsanova, Olga V; Kolbanovskiy, Alexander; Kolbanovskiy, Marina; Johnson, Francis; Bonala, Radha; Geacintov, Nicholas E; Gromova, Elizaveta S
2006 May 16;45(19):6142-6159, Biochemistry
— id: 142483, year: 2006, vol: 45, page: 6142, stat: Journal Article,

Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells
Zhao, Bo; Wang, Jillian; Geacintov, Nicholas E; Wang, Zhigang
2006 ;34(2):417-425, Nucleic acids research
— id: 142485, year: 2006, vol: 34, page: 417, stat: Journal Article,

Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease
Baskunov, Vladimir B; Subach, Fedor V; Kolbanovskiy, Alexandr; Kolbanovskiy, Marina; Eremin, Sergei A; Johnson, Francis; Bonala, Radha; Geacintov, Nicholas E; Gromova, Elizaveta S
2005 Jan 25;44(3):1054-1066, Biochemistry
— id: 142498, year: 2005, vol: 44, page: 1054, stat: Journal Article,

Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: insight from oxygen-18 labeling experiments
Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2005 Aug 12;44(32):5057-5060, Angewandte Chemie. International edition in English
— id: 142490, year: 2005, vol: 44, page: 5057, stat: Journal Article,

Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics
Ding, Shuang; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2005 Nov 8;44(44):14565-14576, Biochemistry
— id: 142487, year: 2005, vol: 44, page: 14565, stat: Journal Article,

Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication
Hsu, Gerald W; Huang, Xuanwei; Luneva, Natalia P; Geacintov, Nicholas E; Beese, Lorena S
2005 Feb 4;280(5):3764-3770, Journal of biological chemistry
— id: 142497, year: 2005, vol: 280, page: 3764, stat: Journal Article,

Spiroiminodihydantoin lesions derived from guanine oxidation: structures, energetics, and functional implications
Jia, Lei; Shafirovich, Vladimir; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2005 Apr 26;44(16):6043-6051, Biochemistry
— id: 142492, year: 2005, vol: 44, page: 6043, stat: Journal Article,

Structural and thermodynamic features of spiroiminodihydantoin damaged DNA duplexes
Jia, Lei; Shafirovich, Vladimir; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2005 Oct 11;44(40):13342-13353, Biochemistry
— id: 142489, year: 2005, vol: 44, page: 13342, stat: Journal Article,

Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin
Kolbanovskiy, Alexander; Kuzmin, Vladimir; Shastry, Anant; Kolbanovskaya, Marina; Chen, Dandan; Chang, Minsun; Bolton, Judith L; Geacintov, Nicholas E
2005 Nov;18(11):1737-1747, Chemical research in toxicology
— id: 142488, year: 2005, vol: 18, page: 1737, stat: Journal Article,

Interactions of human replication protein A with single-stranded DNA adducts
Liu, Yiyong; Yang, Zhengguan; Utzat, Christopher D; Liu, Yu; Geacintov, Nicholas E; Basu, Ashis K; Zou, Yue
2005 Jan 15;385(Pt 2):519-526, Biochemical journal
— id: 142499, year: 2005, vol: 385, page: 519, stat: Journal Article,

Combination of nitrogen dioxide radicals with 8-oxo-7,8-dihydroguanine and guanine radicals in DNA: oxidation and nitration end-products
Misiaszek, Richard; Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2005 Feb 23;127(7):2191-2200, Journal of the American Chemical Society
— id: 142496, year: 2005, vol: 127, page: 2191, stat: Journal Article,

Combination reactions of superoxide with 8-Oxo-7,8-dihydroguanine radicals in DNA: kinetics and end products
Misiaszek, Richard; Uvaydov, Yuriy; Crean, Conor; Geacintov, Nicholas E; Shafirovich, Vladimir
2005 Feb 25;280(8):6293-6300, Journal of biological chemistry
— id: 142495, year: 2005, vol: 280, page: 6293, stat: Journal Article,

Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine
Suzuki, Naomi; Yasui, Manabu; Geacintov, Nicholas E; Shafirovich, Vladimir; Shibutani, Shinya
2005 Jun 28;44(25):9238-9245, Biochemistry
— id: 142491, year: 2005, vol: 44, page: 9238, stat: Journal Article,

Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations
Wang, Lihua; Wu, Min; Yan, S Frank; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2005 Mar;18(3):441-456, Chemical research in toxicology
— id: 142494, year: 2005, vol: 18, page: 441, stat: Journal Article,

Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement
Zhang, Na; Lin, Chin; Huang, Xuanwei; Kolbanovskiy, Aleksandr; Hingerty, Brian E; Amin, Shantu; Broyde, Suse; Geacintov, Nicholas E; Patel, Dinshaw J
2005 Mar 4;346(4):951-965, Journal of molecular biology
— id: 142493, year: 2005, vol: 346, page: 951, stat: Journal Article,

Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping
Misiaszek, Richard; Crean, Conor; Joffe, Avrum; Geacintov, Nicholas E; Shafirovich, Vladimir
2004 Jul 30;279(31):32106-32115, Journal of biological chemistry
— id: 142502, year: 2004, vol: 279, page: 32106, stat: Journal Article,

The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches
Perlow-Poehnelt, Rebecca A; Likhterov, Ilya; Scicchitano, David A; Geacintov, Nicholas E; Broyde, Suse
2004 Aug 27;279(35):36951-36961, Journal of biological chemistry
— id: 142501, year: 2004, vol: 279, page: 36951, stat: Journal Article,

Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene
Wu, Min; Yan, S Frank; Tan, Jian; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2004 Sep 1;9:2807-2818, Frontiers in biosciences
— id: 142500, year: 2004, vol: 9, page: 2807, stat: Journal Article,

Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template
Yan, S Frank; Wu, Min; Geacintov, Nicholas E; Broyde, Suse
2004 Jun 22;43(24):7750-7765, Biochemistry
— id: 142503, year: 2004, vol: 43, page: 7750, stat: Journal Article,

DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair
Zou, Yue; Ma, Huaxian; Minko, Irina G; Shell, Steven M; Yang, Zhengguan; Qu, Youxing; Xu, Ying; Geacintov, Nicholas E; Lloyd, R Stephen
2004 Apr 13;43(14):4196-4205, Biochemistry
— id: 142504, year: 2004, vol: 43, page: 4196, stat: Journal Article,

Conformations of stereoisomeric base adducts to 4-hydroxyequilenin
Ding, Shuang; Shapiro, Robert; Geacintov, Nicholas E; Broyde, Suse
2003 Jun;16(6):695-707, Chemical research in toxicology
— id: 142510, year: 2003, vol: 16, page: 695, stat: Journal Article,

Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa
Huang, Xuanwei; Kolbanovskiy, Alexander; Wu, Xiaohua; Zhang, Yanbin; Wang, Zhigang; Zhuang, Ping; Amin, Shantu; Geacintov, Nicholas E
2003 Mar 4;42(8):2456-2466, Biochemistry
— id: 142514, year: 2003, vol: 42, page: 2456, stat: Journal Article,

Metal ion-directed outside binding of small DNA ligand
Ihara, Toshihiro; Ikegami, Takashi; Fujii, Tomohiro; Kitamura, Yusuke; Sueda, Shinji; Takagi, Makoto; Geacintov, Nicholas E; Jyo, Akinori
2003 ;(3):85-86, Nucleic acids research. Supplement (2001)
— id: 142516, year: 2003, vol: , page: 85, stat: Journal Article,

DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions
Joffe, Avrum; Geacintov, Nicholas E; Shafirovich, Vladimir
2003 Dec;16(12):1528-1538, Chemical research in toxicology
— id: 142505, year: 2003, vol: 16, page: 1528, stat: Journal Article,

Oxidative generation of guanine radicals by carbonate radicals and their reactions with nitrogen dioxide to form site specific 5-guanidino-4-nitroimidazole lesions in oligodeoxynucleotides
Joffe, Avrum; Mock, Steven; Yun, Byeong Hwa; Kolbanovskiy, Alexander; Geacintov, Nicholas E; Shafirovich, Vladimir
2003 Aug;16(8):966-973, Chemical research in toxicology
— id: 142509, year: 2003, vol: 16, page: 966, stat: Journal Article,

Modulation of human nucleotide excision repair by 5-methylcytosines
Muheim, Regula; Buterin, Tonko; Colgate, Katharine C; Kolbanovsij, Alexander; Geacintov, Nicholas E; Naegeli, Hanspeter
2003 Mar 25;42(11):3247-3254, Biochemistry
— id: 142513, year: 2003, vol: 42, page: 3247, stat: Journal Article,

Construction and purification of site-specifically modified DNA templates for transcription assays
Perlow, Rebecca A; Schinecker, Thomas M; Kim, Se Jun; Geacintov, Nicholas E; Scicchitano, David A
2003 Apr 1;31(7):e40-e40, Nucleic acids research
— id: 142512, year: 2003, vol: 31, page: e40, stat: Journal Article,

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences
Schinecker, Thomas M; Perlow, Rebecca A; Broyde, Suse; Geacintov, Nicholas E; Scicchitano, David A
2003 Oct 15;31(20):6004-6015, Nucleic acids research
— id: 142507, year: 2003, vol: 31, page: 6004, stat: Journal Article,

Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta
Xie, Zhongwen; Braithwaite, Elena; Guo, Dongyu; Zhao, Bo; Geacintov, Nicholas E; Wang, Zhigang
2003 Sep 30;42(38):11253-11262, Biochemistry
— id: 142508, year: 2003, vol: 42, page: 11253, stat: Journal Article,

Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts
Yan, Shixiang; Wu, Min; Buterin, Tonko; Naegeli, Hanspeter; Geacintov, Nicholas E; Broyde, Suse
2003 Mar 4;42(8):2339-2354, Biochemistry
— id: 142515, year: 2003, vol: 42, page: 2339, stat: Journal Article,

Simulating structural and thermodynamic properties of carcinogen-damaged DNA
Yan, Shixiang; Wu, Min; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2003 Apr;84(4):2137-2148, Biophysical journal
— id: 142511, year: 2003, vol: 84, page: 2137, stat: Journal Article,

Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease
Zou, Yue; Shell, Steven M; Utzat, Christopher D; Luo, Charlie; Yang, Zhengguan; Geacintov, Nicholas E; Basu, Ashis K
2003 Nov 4;42(43):12654-12661, Biochemistry
— id: 142506, year: 2003, vol: 42, page: 12654, stat: Journal Article,

Trapping of DNA nucleotide excision repair factors by nonrepairable carcinogen adducts
Buterin, Tonko; Hess, Martin T; Gunz, Daniela; Geacintov, Nicholas E; Mullenders, Leon H; Naegeli, Hanspeter
2002 Aug 1;62(15):4229-4235, Cancer research
— id: 142522, year: 2002, vol: 62, page: 4229, stat: Journal Article,

Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery
Geacintov, Nicholas E; Broyde, Suse; Buterin, Tonko; Naegeli, Hanspeter; Wu, Min; Yan, Shixiang; Patel, Dinshaw J
2002 Nov 5;65(3):202-210, Biopolymers
— id: 142519, year: 2002, vol: 65, page: 202, stat: Journal Article,

Fluorescence characteristics of site-specific and stereochemically distinct benzo[a]pyrene diol epoxide-DNA adducts as probes of adduct conformation
Huang, Weidong; Amin, Shantu; Geacintov, Nicholas E
2002 Feb;15(2):118-126, Chemical research in toxicology
— id: 142530, year: 2002, vol: 15, page: 118, stat: Journal Article,

Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context
Huang, Xuanwei; Colgate, Katharine C; Kolbanovskiy, Aleksandr; Amin, Shantu; Geacintov, Nicholas E
2002 Mar;15(3):438-444, Chemical research in toxicology
— id: 142528, year: 2002, vol: 15, page: 438, stat: Journal Article,

DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner
Perlow, Rebecca A; Kolbanovskii, Alexander; Hingerty, Brian E; Geacintov, Nicholas E; Broyde, Suse; Scicchitano, David A
2002 Aug 2;321(1):29-47, Journal of molecular biology
— id: 142521, year: 2002, vol: 321, page: 29, stat: Journal Article,

trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases
Rechkoblit, Olga; Zhang, Yanbin; Guo, Dongyu; Wang, Zhigang; Amin, Shantu; Krzeminsky, Jacek; Louneva, Natalia; Geacintov, Nicholas E
2002 Aug 23;277(34):30488-30494, Journal of biological chemistry
— id: 142520, year: 2002, vol: 277, page: 30488, stat: Journal Article,

Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes
Ruan, Qian; Kolbanovskiy, Alexander; Zhuang, Ping; Chen, Junxin; Krzeminski, Jacek; Amin, Shantu; Geacintov, Nicholas E
2002 Feb;15(2):249-261, Chemical research in toxicology
— id: 142529, year: 2002, vol: 15, page: 249, stat: Journal Article,

Photochemically catalyzed generation of site-specific 8-nitroguanine adducts in DNA by the reaction of long-lived neutral guanine radicals with nitrogen dioxide
Shafirovich, Vladimir; Mock, Steven; Kolbanovskiy, Alexander; Geacintov, Nicholas E
2002 Apr;15(4):591-597, Chemical research in toxicology
— id: 142526, year: 2002, vol: 15, page: 591, stat: Journal Article,

Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)
Suzuki, Naomi; Ohashi, Eiji; Kolbanovskiy, Alexander; Geacintov, Nicholas E; Grollman, Arthur P; Ohmori, Haruo; Shibutani, Shinya
2002 May 14;41(19):6100-6106, Biochemistry
— id: 142524, year: 2002, vol: 41, page: 6100, stat: Journal Article,

Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability
Wu, Min; Yan, Shixiang; Patel, Dinshaw J; Geacintov, Nicholas E; Broyde, Suse
2002 Aug 1;30(15):3422-3432, Nucleic acids research
— id: 142523, year: 2002, vol: 30, page: 3422, stat: Journal Article,

Conformational analysis of a 4-hydroxyequilenin Guanine adduct using density functional theory
Yan, Shixiang; Wu, Min; Ding, Shuang; Geacintov, Nicholas E; Broyde, Suse
2002 May;15(5):648-653, Chemical research in toxicology
— id: 142525, year: 2002, vol: 15, page: 648, stat: Journal Article,

Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa
Zhang, Yanbin; Wu, Xiaohua; Guo, Dongyu; Rechkoblit, Olga; Geacintov, Nicholas E; Wang, Zhigang
2002 Dec 29;510(1-2):23-35, Mutation research
— id: 142517, year: 2002, vol: 510, page: 23, stat: Journal Article,

Lesion bypass activities of human DNA polymerase mu
Zhang, Yanbin; Wu, Xiaohua; Guo, Dongyu; Rechkoblit, Olga; Taylor, John-Stephen; Geacintov, Nicholas E; Wang, Zhigang
2002 Nov 15;277(46):44582-44587, Journal of biological chemistry
— id: 142518, year: 2002, vol: 277, page: 44582, stat: Journal Article,

Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion
Zhang, Yanbin; Wu, Xiaohua; Rechkoblit, Olga; Geacintov, Nicholas E; Taylor, John-Stephen; Wang, Zhigang
2002 Apr 1;30(7):1630-1638, Nucleic acids research
— id: 142527, year: 2002, vol: 30, page: 1630, stat: Journal Article,

The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution
Khan AU; Kovacic D; Kolbanovskiy A; Desai M; Frenkel K; Geacintov NE
2000 Mar 28;97(7):2984-2989, Proceedings of the National Academy of Sciences of the United States of America
— id: 34041, year: 2000, vol: 97, page: 2984, stat: Journal Article,

Mutagenic potential of stereoisomeric bay region (+)- and (-)-cis-anti-benzo[a]pyrene diol epoxide-N2-2'-deoxyguanosine adducts in Escherichia coli and simian kidney cells
Fernandes, A; Liu, T; Amin, S; Geacintov, N E; Grollman, A P; Moriya, M
1998 Jul;37(28):10164-10172, Biochemistry
— id: 343252, year: 1998, vol: 37, page: 10164, stat: Journal Article,

Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2'-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality
Moriya, M; Spiegel, S; Fernandes, A; Amin, S; Liu, T; Geacintov, N; Grollman, A P
1996 Dec;35(51):16646-16651, Biochemistry
— id: 343362, year: 1996, vol: 35, page: 16646, stat: Journal Article,

Translesional synthesis on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)
Shibutani, S; Margulis, L A; Geacintov, N E; Grollman, A P
1993 Jul;32(29):7531-7541, Biochemistry
— id: 343552, year: 1993, vol: 32, page: 7531, stat: Journal Article,