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Connie Newman, M.D.

Adjunct Associate Professor;
Department of Medicine (Endocrinology Div)

Contact Info


3 Red Fox Trail Floor 18 Room 18O36
Veterans Administration
Warren, NJ 07059


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— Beth Israel Medical Center (Medicine), Residency

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Research Summary

Previously, Dr. Newman studied mammary gland growth and development, and the role of novel pituitary factors, in primate and rodent models. Her earlier clinical research focused on new therapies for the treatment of pituitary tumors, including the effects of somatostatin analogues in patients with acromegaly. She has also investigated effects of growth hormone replacement on cardiopulmonary function in growth hormone deficient adults.

Research Interests

Dr. Newman has experience in designing, conducting and analyzing large cardiovascular outcomes trials of statins in diverse populations including patients with diabetes, stroke or TIA, cardiovascular disease, and chronic kidney disease. She served on the Steering Committee of the CARDS trial which evaluated the effects of atorvastatin 10 mg on heart attacks and stroke in about 2500 patients with diabetes. She also has worked on the SPARCL trial in patients with a history of stroke or TIA, and assisted with analysis of safety data from the SEARCH and SHARP trials. She has conducted meta-analyses of safety data from trials of statins, including a meta-analysis of cancer events and cancer death in 27 randomized controlled trials in about 170,000 patients. She is a member of the Cholesterol Treatment Trialists? Collaboration.

Dr. Newman is also investigating with collaborators at University of Oxford, UK the efficacy and safety of high dose Vitamin D, and is an investigator and member of the Steering Committee of BEST-D. BEST-D is a placebo-controlled randomized trial in elderly patients that compares effects of treatment for one year with vitamin D3 2000 IU/day versus 4000 IU/day on plasma biochemistry (including 25-hydroxy-vitamin D, parathyroid hormone, calcium, phosphorous, albumin and alkaline phosphatase), muscle symptoms and function, bone density, and selected cardiovascular endpoints such as blood pressure, arterial stiffness, and lipids.

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All data from NYU Health Sciences Library Faculty Bibliography — -


Effects of low dose versus high dose human growth hormone on body composition and lipids in adults with GH deficiency: a meta-analysis of placebo-controlled randomized trials
Newman, Connie B; Carmichael, John D; Kleinberg, David L
2014 May;:22-31, Pituitary
— id: 967312, year: 2014, vol: , page: 22, stat: Journal Article,

Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy
Emberson, Jonathan R.; Kearney, Patricia M.; Blackwell, Lisa; Newman, Connie; Reith, Christina; Bhala, Neeraj; Holland, Lisa; Peto, Richard; Keech, Anthony; Collins, Rory; Simes, John; Baigent, Colin;
2012 JAN 19;7(1 e29849 e29849):-, PLoS one
— id: 163085, year: 2012, vol: 7, page: , stat: Journal Article,

Moderate doses of hGH (0.64 mg/d) improve lipids but not cardiovascular function in GH-deficient adults with normal baseline cardiac function
Newman, Connie B; Frisch, Katalin A; Rosenzweig, Barry; Roubenoff, Ronenn; Rey, Mariano; Kidder, Teresa; Kong, Yuan; Pursnani, Amit; Sedlis, Steven P; Schwartzbard, Arthur; Kleinberg, David L
2011 Jan;96(1):122-132, Journal of clinical endocrinology & metabolism
— id: 138237, year: 2011, vol: 96, page: 122, stat: Journal Article,

Erratum: Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: The Collaborative Atorvastatin Diabetes Study (CARDS)
Charlton-Menys V.; Betteridge D.J.; Colhoun H.; Fuller J.; France M.; Hitman G.A.; Livingstone S.J.; Neil H.A.W.; Newman C.B.; Szarek M.; Demicco D.A.; Durrington P.N.
2009 ;52(3):556-, Diabetologia
— id: 92853, year: 2009, vol: 52, page: 556, stat: Journal Article,

Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: the Collaborative Atorvastatin Diabetes Study (CARDS)
Charlton-Menys, V; Betteridge, D J; Colhoun, H; Fuller, J; France, M; Hitman, G A; Livingstone, S J; Neil, H A W; Newman, C B; Szarek, M; DeMicco, D A; Durrington, P N
2009 Feb;52(2):218-225, Diabetologia
— id: 135224, year: 2009, vol: 52, page: 218, stat: Journal Article,

Targets of statin therapy: LDL cholesterol, non-HDL cholesterol, and apolipoprotein B in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS)
Charlton-Menys, Valentine; Betteridge, D John; Colhoun, Helen; Fuller, John; France, Michael; Hitman, Graham A; Livingstone, Shona J; Neil, H Andrew W; Newman, Connie B; Szarek, Michael; DeMicco, David A; Durrington, Paul N
2009 Mar;55(3):473-480, Clinical chemistry
— id: 102602, year: 2009, vol: 55, page: 473, stat: Journal Article,

The safety and tolerability of atorvastatin 10 mg in the Collaborative Atorvastatin Diabetes Study (CARDS)
Newman, Connie B; Szarek, Michael; Colhoun, Helen M; Betteridge, D John; Durrington, Paul N; Hitman, Graham A; Neil, H Andrew W; Demicco, David A; Auster, Sheila; Fuller, John H
2008 Sep;5(3):177-183, Diabetes & vascular disease research
— id: 87809, year: 2008, vol: 5, page: 177, stat: Journal Article,

Safety of atorvastatin derived from analysis of 44 completed trials in 9,416 patients
Newman, CB; Palmer, G; Silbershatz, H; Szarek, M
2003 SEP 15 ;92(6):670-676, American journal of cardiology
— id: 38579, year: 2003, vol: 92, page: 670, stat: Journal Article,

Medical therapy for acromegaly
Newman CB
1999 Mar;28(1):171-190, Endocrinology & metabolism clinics of North America
— id: 12023, year: 1999, vol: 28, page: 171, stat: Journal Article,

Octreotide as primary therapy for acromegaly
Newman CB; Melmed S; George A; Torigian D; Duhaney M; Snyder P; Young W; Klibanski A; Molitch ME; Gagel R; Sheeler L; Cook D; Malarkey W; Jackson I; Vance ML; Barkan A; Frohman L; Kleinberg DL
1998 Sep;83(9):3034-3040, Journal of clinical endocrinology & metabolism
— id: 57219, year: 1998, vol: 83, page: 3034, stat: Journal Article,

Adult growth hormone deficiency
Newman, CB; Kleinberg, DL
1998 MAY ;8(3):178-186, Endocrinologist
— id: 53450, year: 1998, vol: 8, page: 178, stat: Journal Article,

Newman CB
1997 ;6:47-51, Current therapy in endocrinology & metabolism
— id: 12409, year: 1997, vol: 6, page: 47, stat: Journal Article,

Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study
Wang C; Eyre DR; Clark R; Kleinberg D; Newman C; Iranmanesh A; Veldhuis J; Dudley RE; Berman N; Davidson T; Barstow TJ; Sinow R; Alexander G; Swerdloff RS
1996 Oct;81(10):3654-3662, Journal of clinical endocrinology & metabolism
— id: 18389, year: 1996, vol: 81, page: 3654, stat: Journal Article,

Safety and efficacy of long-term octreotide therapy of acromegaly: results of a multicenter trial in 103 patients--a clinical research center study
Newman CB; Melmed S; Snyder PJ; Young WF; Boyajy LD; Levy R; Stewart WN; Klibanski A; Molitch ME; Gagel RF
1995 Sep;80(9):2768-2775, Journal of clinical endocrinology & metabolism
— id: 56782, year: 1995, vol: 80, page: 2768, stat: Journal Article,

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development
Ruan W; Newman CB; Kleinberg DL
1992 Nov 15;89(22):10872-10876, Proceedings of the National Academy of Sciences of the United States of America
— id: 18391, year: 1992, vol: 89, page: 10872, stat: Journal Article,

Non-lactogenic effects of growth hormone on growth and insulin-like growth factor-I messenger ribonucleic acid of rat mammary gland
Kleinberg DL; Ruan W; Catanese V; Newman CB; Feldman M
1990 Jun;126(6):3274-3276, Endocrinology
— id: 18392, year: 1990, vol: 126, page: 3274, stat: Journal Article,

1990 APR ;38(2):A343-A343, Clinical research
— id: 98508, year: 1990, vol: 38, page: A343, stat: Journal Article,

Habibian, A; Stauffer, A; Resnick, D; Reicher, MA; Rafii, M; Kellerhouse, L; Zlatkin, MB; Newman, C; Sartoris, DJ
1989 Nov-Dec;13(6):968-975, Journal of computer assisted tomography
— id: 31612, year: 1989, vol: 13, page: 968, stat: Journal Article,

Effect of CV 205-502 in hyperprolactinaemic patients intolerant of bromocriptine
Newman CB; Hurley AM; Kleinberg DL
1989 Oct;31(4):391-400, Clinical endocrinology
— id: 18393, year: 1989, vol: 31, page: 391, stat: Journal Article,

Evidence for a nonprolactin, non-growth-hormone mammary mitogen in the human pituitary gland
Newman CB; Cosby H; Friesen HG; Feldman M; Cooper P; De Crescito V; Pilon M; Kleinberg DL
1987 Nov;84(22):8110-8114, Proceedings of the National Academy of Sciences of the United States of America
— id: 18394, year: 1987, vol: 84, page: 8110, stat: Journal Article,

The pituitary gland in primate mammary development: evidence that prolactin is not essential
Kleinberg DL; Newman CB
1986 ;464(22):37-43, Annals of the New York Academy of Sciences
— id: 18395, year: 1986, vol: 464, page: 37, stat: Journal Article,

1986 APR ;34(2):A645-A645, Clinical research
— id: 41408, year: 1986, vol: 34, page: A645, stat: Journal Article,