Elizabeth H Nardin

Biosketch / Results /

Elizabeth H Nardin, Ph.D.

Professor; PSAF DLAR Comte Disting Thng Comte
Departments of Microbiology (Microbiology ) and Medical Parasitology (MP Division )

Contact Info

Address
341 East 25 Street
Floor 4 Room 408
Old Public Health
New York, NY 10010

212-263-6819, 212-263-8194
212-263-8116
Elizabeth.Nardin@nyumc.org

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Education

1979 — Dr. Nardin received her Ph.D. degree in Parasitology from New York University (NYU) School of Medicine, Graduate Education
1980-1982 — Dr. Nardin was a Postdoctoral Fellow in the Department of Pathology at NYU School of Medicine, PostDoctoral Training

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Research Summary

The malaria resurgence in many parts of the world is due to the Plasmodium parasite''s development of chloroquine resistance and the Anopheline vector''s acquisition of insecticide resistance. Effective immunoprophylaxis would help prevent the 200 to 400 million cases of malaria now occurring each year.

Malaria infections begin when an infected mosquito''s bite injects motile sporozoites, which circulate briefly, then invade the host''s liver cells and develop there. These pre-erythrocytic stages present extra-and intracellular targets for humoral and cellular effector mechanisms. The demonstration that sporozoite-immunized human volunteers could be protected against malaria challenge has led to research on sporozoite-induced protective immune mechanisms.

Our investigations for vaccine development focus on defining the T- and B-cell epitopes of a major sporozoite (CS) surface antigen, the circumsporozoite protein, and identifying new antigenic targets in the sporozoite and hepatic stages of the malaria parasite. We study the specificity, effector function, and lymphokine secretion of T-cell clones from sporozoite-immunized human volunteers, as well as primate and rodent hosts, to determine their role in the immune response to the malaria parasite''s pre-erythrocytic stages. These studies provide a rationale for incorporating T- and B-cell epitopes into synthetic peptide vaccines to induce high-level cellular and humoral immunity against the malaria parasite. We have recently completed Phase I studies in human volunteers to assay the safety and immunogenocity of synthetic and recombinant subunit vaccines based on minimal T and B cell epitopes of the Plasmodium falciparum CS protein. Phase II studies are in progress to assay protection in the peptide-immunized vaccinees when challenged with viable P. falciparum sporozoites.

Research Interests

Mechanisms of Vaccine Induced Immunity to Malaria Parasites<br>

Research Keywords

malaria, vaccines<br>, CD4+ T cells, antibody, HLA<br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric P. falciparum circumsporozoite protein and the TLR5 agonist flagellin
Carapau, Daniel; Mitchell, Robert; Nacer, Adela; Shaw, Alan; Othoro, Caroline; Frevert, Ute; Nardin, Elizabeth
2013 Sep;:4350-4362, Infection & immunity
— id: 563932, year: 2013, vol: , page: 4350, stat: Journal Article,

Imaging murine NALT following intranasal immunization with flagellin-modified circumsporozoite protein malaria vaccines
Nacer, A; Carapau, D; Mitchell, R; Meltzer, A; Shaw, A; Frevert, U; Nardin, E H
2013 Jul;:267-282, Mucosal immunology
— id: 563942, year: 2013, vol: , page: 267, stat: Journal Article,

Plasmodium falciparum synthetic LbL microparticle vaccine elicits protective neutralizing antibody and parasite-specific cellular immune responses
Powell, Thomas J; Tang, Jie; Derome, Mary E; Mitchell, Robert A; Jacobs, Andrea; Deng, Yanhong; Palath, Naveen; Cardenas, Edwin; Boyd, James G; Nardin, Elizabeth
2013 Apr;31(15):1898-1904, Vaccine
— id: 287762, year: 2013, vol: 31, page: 1898, stat: Journal Article,

Synthetic LbL microparticle vaccines containing the conserved T1BT*epitope of Plasmodium falciparum elicit protective antibody and cellular immune responses with minimal inflammation
Powell, Thomas; Tang, Jie; DeRome, Mary; Jacobs, Andrea; Palath, Naveen; Cardenas, Edwin; Boyd, James; Mitchell, Robert; Nardin, Elizabeth
2012 MAY 1;188:-, Journal of immunology
— id: 169549, year: 2012, vol: 188, page: , stat: Journal Article,

Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to rneningococcal outer membrane protein complex
Przysiecki, Craig; Lucas, Bob; Mitchell, Robert; Carapau, Daniel; Wen, Zhiyun; Xu, Hui; Wang, Xin-Min; Nahas, Debbie; Wu, Chengwei; Hepler, Robert; Ottinger, Elizabeth; ter Meulen, Jan; Kaslow, David; Shiver, John; Nardin, Elizabeth
2012 NOV;2:-, Frontiers in cellular & infection microbiology
— id: 576242, year: 2012, vol: 2, page: , stat: Journal Article,

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope
Rudra, Jai S; Mishra, Satish; Chong, Anita S; Mitchell, Robert A; Nardin, Elizabeth H; Nussenzweig, Victor; Collier, Joel H
2012 Sep;33(27):6476-6484, Biomaterials
— id: 177036, year: 2012, vol: 33, page: 6476, stat: Journal Article,

The past decade in malaria synthetic peptide vaccine clinical trials
Nardin, Elizabeth
2010 Jan;6(1):27-38, Human vaccines
— id: 109208, year: 2010, vol: 6, page: 27, stat: Journal Article,

Plasmodium falciparum circumsporozoite protein synthetic repeat peptide conjugated to outer membrane protein complex generates a functional immune response in mice and rhesus monkeys
Przysiecki C.; Lucas B.; Mitchell R.; Carapau D.; Wen Z.; Xu H.; Wang X.-M.; Nahas D.; Hepler R.; Ottinger E.; Ter Meulen J.; Kaslow D.; SHIVer J.; Nardin E.
2010 ;83(5 SUPPL 1):177-177, American journal of tropical medicine & hygiene
— id: 134756, year: 2010, vol: 83, page: 177, stat: Journal Article,

Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein
Frevert, Ute; Moreno, Alberto; Calvo-Calle, J Mauricio; Klotz, Christian; Nardin, Elizabeth
2009 Jan;39(1):119-132, International journal for parasitology
— id: 105912, year: 2009, vol: 39, page: 119, stat: Journal Article,

IMAGING MURINE NALT FOLLOWING PROTECTIVE INTRANASAL IMMUNIZATION WITH PLASMODIUM FALCIPARUM CS PROTEIN CONJUGATED TO FLAGELLIN, A POTENT TLR5 AGONIST
Nacer, A; Carapau, D; Mitchell, R; Shaw, A; Frevert, U; Nardin, E
2009 NOV ;81(5):298-298, American journal of tropical medicine & hygiene
— id: 106990, year: 2009, vol: 81, page: 298, stat: Journal Article,

Enhanced immunogenicity of Plasmodium falciparum peptide vaccines using a topical adjuvant containing a potent synthetic Toll-like receptor 7 agonist, imiquimod
Othoro, Caroline; Johnston, Dean; Lee, Rebecca; Soverow, Jonathan; Bystryn, Jean-Claude; Nardin, Elizabeth
2009 Feb;77(2):739-748, Infection & immunity
— id: 96730, year: 2009, vol: 77, page: 739, stat: Journal Article,

Cellular effector mechanisms against Plasmodium liver stages
Frevert, Ute; Nardin, Elizabeth
2008 Oct;10(10):1956-1967, Cellular microbiology
— id: 93340, year: 2008, vol: 10, page: 1956, stat: Journal Article,

Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein
Gregson, Aric L; Oliveira, Giane; Othoro, Caroline; Calvo-Calle, J Mauricio; Thorton, George B; Nardin, Elizabeth; Edelman, Robert
2008 ;3(2):e1556-e1556, PLoS one
— id: 78859, year: 2008, vol: 3, page: e1556, stat: Journal Article,

Class II-restricted protective immunity induced by malaria sporozoites
Oliveira, Giane A; Kumar, Kota Arun; Calvo-Calle, J Mauricio; Othoro, Caroline; Altszuler, David; Nussenzweig, Victor; Nardin, Elizabeth H
2008 Mar;76(3):1200-1206, Infection & immunity
— id: 76387, year: 2008, vol: 76, page: 1200, stat: Journal Article,

A linear peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge
Calvo-Calle, J Mauricio; Oliveira, Giane A; Watta, Carol Othoro; Soverow, Jonathan; Parra-Lopez, Carlos; Nardin, Elizabeth H
2006 Dec;74(12):6929-6939, Infection & immunity
— id: 70022, year: 2006, vol: 74, page: 6929, stat: Journal Article,

Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein
Parra-Lopez, Carlos; Calvo-Calle, J Mauricio; Cameron, Thomas O; Vargas, Luis E; Salazar, Luz Mary; Patarroyo, Manuel E; Nardin, Elizabeth; Stern, Lawrence J
2006 May 26;281(21):14907-14917, Journal of biological chemistry
— id: 78860, year: 2006, vol: 281, page: 14907, stat: Journal Article,

Human malaria-specific IFN-Gamma T cell responses induced by virus like particles, comprised of hepatitis B virus core antigen and P-falciparum circumsporozoite protein T and B cell epitopes (ICC-1132), adjuvanted with alum as compared to ISA 720
Watta, CO; Oliveira, GA; Calvo-Calle, M; Boehmer, G; Kremsner, PG; Thornton, GB; Edelman, R; Gregson, A; Nardin, EH
2006 NOV ;75(5):318-319, American journal of tropical medicine & hygiene
— id: 71017, year: 2006, vol: 75, page: 318, stat: Journal Article,

Human CD4+ T cells induced by synthetic peptide malaria vaccine are comparable to cells elicited by attenuated Plasmodium falciparum sporozoites
Calvo-Calle, Jaime Mauricio; Oliveira, Giane A; Nardin, Elizabeth H
2005 Dec 1;175(11):7575-7585, Journal of immunology
— id: 61424, year: 2005, vol: 175, page: 7575, stat: Journal Article,

Effect of adjuvant on reactogenicity and long-term immunogenicity of the malaria Vaccine ICC-1132 in macaques
Langermans, Jan A M; Schmidt, Annette; Vervenne, Richard A W; Birkett, Ashley J; Calvo-Calle, J Mauricio; Hensmann, Meike; Thornton, George B; Dubovsky, Filip; Weiler, Horst; Nardin, Elizabeth; Thomas, Alan W
2005 Sep 30;23(41):4935-4943, Vaccine
— id: 78861, year: 2005, vol: 23, page: 4935, stat: Journal Article,

Erratum: Immediate-type hypersensitivity and other clinical reactions in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum (Vaccine (2003) 21 (269-280) PII: S0264410X02004681)
Edelman, R; Wasserman, SS; Kublin, JG; Bodison, SA; Nardin, EH; Oliveira, GA; Ansari, S; Diggs, CL; Kashala, OL; Schrneckpeper, BJ; Hamilton, RG
2003 ;21(19-20):2689-, Vaccine
— id: 651542, year: 2003, vol: 21, page: 2689, stat: Journal Article,

A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts
Birkett, A; Lyons, K; Schmidt, A; Boyd, D; Oliveira, G A; Siddique, A; Nussenzweig, R; Calvo-Calle, J M; Nardin, E
2002 Dec;70(12):6860-6870, Infection & immunity
— id: 165571, year: 2002, vol: 70, page: 6860, stat: Journal Article,

Immediate-type hypersensitivity and other clinical reactions in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoites
Edelman, Robert; Wasserman, Steven S; Kublin, James G; Bodison, Sacared A; Nardin, Elizabeth H; Oliveira, Giane A; Ansari, Sobia; Diggs, Carter L; Kashala, Oscar L; Schmeckpeper, Barbara J; Hamilton, Robert G
2002 Dec 13;21(3-4):269-280, Vaccine
— id: 78862, year: 2002, vol: 21, page: 269, stat: Journal Article,

Cutting edge: a new tool to evaluate human pre-erythrocytic malaria vaccines: rodent parasites bearing a hybrid Plasmodium falciparum circumsporozoite protein
Persson, Cathrine; Oliveira, Giane A; Sultan, Ali A; Bhanot, Purnima; Nussenzweig, Victor; Nardin, Elizabeth
2002 Dec 15;169(12):6681-6685, Journal of immunology
— id: 39354, year: 2002, vol: 169, page: 6681, stat: Journal Article,

Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein
Sinnis, Photini; Nardin, Elizabeth
2002 ;80(4):70-96, Chemical immunology
— id: 39631, year: 2002, vol: 80, page: 70, stat: Journal Article,

A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types
Nardin EH; Calvo-Calle JM; Oliveira GA; Nussenzweig RS; Schneider M; Tiercy JM; Loutan L; Hochstrasser D; Rose K
2001 Jan 1;166(1):481-489, Journal of immunology
— id: 26830, year: 2001, vol: 166, page: 481, stat: Journal Article,

Synthetic malaria peptide vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes
Nardin EH; Oliveira GA; Calvo-Calle JM; Castro ZR; Nussenzweig RS; Schmeckpeper B; Hall BF; Diggs C; Bodison S; Edelman R
2000 Nov;182(5):1486-1496, Journal of infectious diseases
— id: 29332, year: 2000, vol: 182, page: 1486, stat: Journal Article,

Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
Moreno CA; Rodriguez R; Oliveira GA; Ferreira V; Nussenzweig RS; Moya Castro ZR; Calvo-Calle JM; Nardin E
1999 Aug 20;18(1-2):89-99, Vaccine
— id: 8477, year: 1999, vol: 18, page: 89, stat: Journal Article,

Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials
Nardin E; Zavala F; Nussenzweig V; Nussenzweig RS
1999 Sep;41(1-3):397-402, Parassitologia
— id: 11814, year: 1999, vol: 41, page: 397, stat: Journal Article,

Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein
Nardin EH; Calvo-Calle JM; Oliveira GA; Clavijo P; Nussenzweig R; Simon R; Zeng W; Rose K
1998 Apr;16(6):590-600, Vaccine
— id: 8229, year: 1998, vol: 16, page: 590, stat: Journal Article,

Binding of malaria T cell epitopes to DR and DQ molecules in vitro correlates with immunogenicity in vivo: identification of a universal T cell epitope in the Plasmodium falciparum circumsporozoite protein
Calvo-Calle JM; Hammer J; Sinigaglia F; Clavijo P; Moya-Castro ZR; Nardin EH
1997 Aug 1;159(3):1362-1373, Journal of immunology
— id: 8411, year: 1997, vol: 159, page: 1362, stat: Journal Article,

The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases
Nardin EH; Oliveira GA; Calvo-Calle JM; Nussenzweig RS
1995 ;60:105-149, Advances in immunology
— id: 7025, year: 1995, vol: 60, page: 105, stat: Journal Article,

In vitro development of infectious liver stages of P. yoelii and P. berghei malaria in human cell lines
Calvo-Calle JM; Moreno A; Eling WM; Nardin EH
1994 Nov;79(3):362-373, Experimental parasitology
— id: 12872, year: 1994, vol: 79, page: 362, stat: Journal Article,

Immunogenicity of an alum-adsorbed synthetic multiple-antigen peptide based on B- and T-cell epitopes of the Plasmodium falciparum CS protein: possible vaccine application
de Oliveira GA; Clavijo P; Nussenzweig RS; Nardin EH
1994 Aug;12(11):1012-1017, Vaccine
— id: 12940, year: 1994, vol: 12, page: 1012, stat: Journal Article,

Anophelines in the state of Acre, Brazil, infected with Plasmodium falciparum, P. vivax, the variant P. vivax VK247 and P. malariae
Branquinho, M S; Lagos, C B; Rocha, R M; Natal, D; Barata, J M; Cochrane, A H; Nardin, E; Nussenzweig, R S; Kloetzel, J K
1993 Jul-Aug;87(4):391-394, Transactions of the Royal Society of Tropical Medicine & Hygiene
— id: 165526, year: 1993, vol: 87, page: 391, stat: Journal Article,

Immunogenicity of multiple antigen peptides containing B and non-repeat T cell epitopes of the circumsporozoite protein of Plasmodium falciparum
Calvo-Calle JM; de Oliveira GA; Clavijo P; Maracic M; Tam JP; Lu YA; Nardin EH; Nussenzweig RS; Cochrane AH
1993 Feb 15;150(4):1403-1412, Journal of immunology
— id: 13249, year: 1993, vol: 150, page: 1403, stat: Journal Article,

CD4+ T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein
Moreno A; Clavijo P; Edelman R; Davis J; Sztein M; Sinigaglia F; Nardin E
1993 Jul 1;151(1):489-499, Journal of immunology
— id: 8228, year: 1993, vol: 151, page: 489, stat: Journal Article,

T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages
Nardin EH; Nussenzweig RS
1993 ;11:687-727, Annual review of immunology
— id: 8410, year: 1993, vol: 11, page: 687, stat: Journal Article,

Recognition of different domains of the Plasmodium falciparum CS protein by the sera of naturally infected individuals compared with those of sporozoite-immunized volunteers
Calle JM; Nardin EH; Clavijo P; Boudin C; Stuber D; Takacs B; Nussenzweig RS; Cochrane AH
1992 Oct 15;149(8):2695-2701, Journal of immunology
— id: 13395, year: 1992, vol: 149, page: 2695, stat: Journal Article,

T cell responses to repeat and non-repeat regions of the circumsporozoite protein detected in volunteers immunized with Plasmodium falciparum sporozoites
Nardin E; Munesinghe YD; Moreno A; Clavijo P; Calle MC; Edelman R; Davis J; Herrington D; Nussenzweig RS
1992 ;87 Suppl 3:223-227, Memorias do Instituto Oswaldo Cruz
— id: 6465, year: 1992, vol: 87 Suppl 3, page: 223, stat: Journal Article,

Safety and immunogenicity of a recombinant sporozoite malaria vaccine against Plasmodium vivax
Herrington, D A; Nardin, E H; Losonsky, G; Bathurst, I C; Barr, P J; Hollingdale, M R; Edelman, R; Levine, M M
1991 Dec;45(6):695-701, American journal of tropical medicine & hygiene
— id: 163844, year: 1991, vol: 45, page: 695, stat: Journal Article,

Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals
Herrington, D; Davis, J; Nardin, E; Beier, M; Cortese, J; Eddy, H; Losonsky, G; Hollingdale, M; Sztein, M; Levine, M
1991 Nov;45(5):539-547, American journal of tropical medicine & hygiene
— id: 163848, year: 1991, vol: 45, page: 539, stat: Journal Article,

Inhibitory activity against Plasmodium vivax sporozoites induced by plasma from Saimiri monkeys immunized with circumsporozoite recombinant proteins or irradiated sporozoites
Millet, P; Collins, W E; Broderson, J R; Bathurst, I; Nardin, E H; Nussenzweig, R S
1991 Jul;45(1):44-48, American journal of tropical medicine & hygiene
— id: 163847, year: 1991, vol: 45, page: 44, stat: Journal Article,

Cytotoxic CD4+ T cells from a sporozoite-immunized volunteer recognize the Plasmodium falciparum CS protein
Moreno A; Clavijo P; Edelman R; Davis J; Sztein M; Herrington D; Nardin E
1991 Oct;3(10):997-1003, International immunology
— id: 13890, year: 1991, vol: 3, page: 997, stat: Journal Article,

Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein
Munesinghe DY; Clavijo P; Calle MC; Nussenzweig RS; Nardin E
1991 Dec;21(12):3015-3020, European journal of immunology
— id: 65750, year: 1991, vol: 21, page: 3015, stat: Journal Article,

T cell epitopes of the circumsporozoite protein of Plasmodium vivax. Recognition by lymphocytes of a sporozoite-immunized chimpanzee
Nardin E; Clavijo P; Mons B; van Belkum A; Ponnudurai T; Nussenzweig RS
1991 Mar 1;146(5):1674-1678, Journal of immunology
— id: 14126, year: 1991, vol: 146, page: 1674, stat: Journal Article,

Widespread reactivity of human sera with a variant repeat of the circumsporozoite protein of Plasmodium vivax
Cochrane AH; Nardin EH; de Arruda M; Maracic M; Clavijo P; Collins WE; Nussenzweig RS
1990 Nov;43(5):446-451, American journal of tropical medicine & hygiene
— id: 14301, year: 1990, vol: 43, page: 446, stat: Journal Article,

Further studies on the immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax
Collins, W E; Nussenzweig, R S; Ruebush, T K 2nd; Bathurst, I C; Nardin, E H; Gibson, H L; Campbell, G H; Barr, P J; Broderson, J R; Skinner, J C
1990 Dec;43(6):576-583, American journal of tropical medicine & hygiene
— id: 163842, year: 1990, vol: 43, page: 576, stat: Journal Article,

Human studies with synthetic peptide sporozoite vaccine (NANP)3-TT and immunization with irradiated sporozoites
Herrington, D A; Clyde, D F; Davis, J R; Baqar, S; Murphy, J R; Cortese, J F; Bank, R S; Nardin, E; DiJohn, D; Nussenzweig, R S
1990 ;68 Suppl:33-37, Bulletin of the World Health Organization
— id: 165531, year: 1990, vol: 68 Suppl, page: 33, stat: Journal Article,

Cellular and humoral immune responses to a recombinant P. falciparum CS protein in sporozoite-immunized rodents and human volunteers
Nardin, E H; Nussenzweig, R S; Altszuler, R; Herrington, D; Levine, M; Murphy, J; Davis, J; Bathurst, I; Barr, P; Romero, P
1990 ;68 Suppl:85-87, Bulletin of the World Health Organization
— id: 165530, year: 1990, vol: 68 Suppl, page: 85, stat: Journal Article,

T-CELL RESPONSES IN A SPOROZOITE-IMMUNIZED HUMAN VOLUNTEER AND A CHIMPANZEE
Nardin, EH
1990 Aug;25(1-3):43-48, Immunology letters
— id: 32050, year: 1990, vol: 25, page: 43, stat: Journal Article,

Immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax
Collins, W E; Nussenzweig, R S; Ballou, W R; Ruebush, T K 2nd; Nardin, E H; Chulay, J D; Majarian, W R; Young, J F; Wasserman, G F; Bathurst, I
1989 May;40(5):455-464, American journal of tropical medicine & hygiene
— id: 163856, year: 1989, vol: 40, page: 455, stat: Journal Article,

Sero-epidemiological studies of malaria in Indian tribes and monkeys of the Amazon Basin of Brazil
de Arruda, M; Nardin, E H; Nussenzweig, R S; Cochrane, A H
1989 Oct;41(4):379-385, American journal of tropical medicine & hygiene
— id: 163855, year: 1989, vol: 41, page: 379, stat: Journal Article,

Conserved repetitive epitope recognized by CD4+ clones from a malaria-immunized volunteer
Nardin EH; Herrington DA; Davis J; Levine M; Stuber D; Takacs B; Caspers P; Barr P; Altszuler R; Clavijo P; et al
1989 Dec 22;246(4937):1603-1606, Science
— id: 10397, year: 1989, vol: 246, page: 1603, stat: Journal Article,

Malaria vaccines: experience with sporozoite vaccines against falciparum malaria
Levine, M M; Herrington, D; Clyde, D; Murphy, J; Davis, J; Nussenzweig, R; Nardin, E; Felix, A; Heimer, E; Gillesen, D
1988 Sep;19(3):369-374, Southeast Asian journal of tropical medicine & public health
— id: 165573, year: 1988, vol: 19, page: 369, stat: Journal Article,

Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein
Nardin EH; Barr PJ; Heimer E; Etlinger HM
1988 Jul;18(7):1119-1122, European journal of immunology
— id: 11050, year: 1988, vol: 18, page: 1119, stat: Journal Article,

Use of synthetic and recombinant peptides in the study of host-parasite interactions in the malarias
Campbell, G H; Aley, S B; Ballou, W R; Hall, T; Hockmeyer, W T; Hoffman, S L; Hollingdale, M R; Howard, R J; Lyon, J A; Nardin, E H
1987 Nov;37(3):428-444, American journal of tropical medicine & hygiene
— id: 163854, year: 1987, vol: 37, page: 428, stat: Journal Article,

SAFETY AND IMMUNOGENICITY IN MAN OF A SYNTHETIC PEPTIDE MALARIA VACCINE AGAINST PLASMODIUM-FALCIPARUM SPOROZOITES
HERRINGTON, DA; CLYDE, DF; LOSONSKY, G; CORTESIA, M; MURPHY, JR; DAVIS, J; BAQAR, S; FELIX, AM; HEIMER, EP; GILLESSEN, D; NARDIN, E; NUSSENZWEIG, RS; NUSSENZWEIG, V; HOLLINGDALE, MR; LEVINE, MM
1987 JUL 16 ;328(6127):257-259, Nature
— id: 98534, year: 1987, vol: 328, page: 257, stat: Journal Article,

Induction of sporozoite-specific memory cells in mice immunized with a recombinant Plasmodium vivax circumsporozoite protein
Nardin EH; Barr PJ; Gibson HL; Collins WE; Nussenzweig RS; Nussenzweig V
1987 Dec;17(12):1763-1767, European journal of immunology
— id: 11307, year: 1987, vol: 17, page: 1763, stat: Journal Article,

Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; an in vitro assay of protective antibodies
Hollingdale, M R; Nardin, E H; Tharavanij, S; Schwartz, A L; Nussenzweig, R S
1984 Feb;132(2):909-913, Journal of immunology
— id: 165537, year: 1984, vol: 132, page: 909, stat: Journal Article,

Structural similarities among the protective antigens of sporozoites from different species of malaria parasites
Santoro F; Cochrane AH; Nussenzweig V; Nardin EH; Nussenzweig RS; Gwadz RW; Ferreira A
1983 Mar 10;258(5):3341-3345, Journal of biological chemistry
— id: 62010, year: 1983, vol: 258, page: 3341, stat: Journal Article,

Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes
Zavala F; Cochrane AH; Nardin EH; Nussenzweig RS; Nussenzweig V
1983 Jun 1;157(6):1947-1957, Journal of experimental medicine
— id: 23547, year: 1983, vol: 157, page: 1947, stat: Journal Article,

Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax
Nardin EH; Nussenzweig V; Nussenzweig RS; Collins WE; Harinasuta KT; Tapchaisri P; Chomcharn Y
1982 Jul 1;156(1):20-30, Journal of experimental medicine
— id: 62016, year: 1982, vol: 156, page: 20, stat: Journal Article,

Congenital transfer of antibodies against malarial sporozoites detected in Gambian infants
Nardin, E H; Nussenzweig, R S; Bryan, J H; McGregor, I A
1981 Nov;30(6):1159-1163, American journal of tropical medicin