Bhagavathi A Narayanan

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Bhagavathi Narayanan

Research Associate Professor, Department of Environmental Medicine
Environmental Medicine

Contact Info

57 Old Forge Rd.
Tuxedo, NY 10987


Research Summary

CURRENT RESEARCH: Prostate cancer chemoprevention: Prostate cancer accounts for over 35% of all cancers among men in the United States. Our long-term goal is to understand prostate cancer biology and to identify innovative prevention strategies. ONGOING RESEARCH PROJECTS: 1. CANCER BIOLOGY (a)Monitoring the changes in the molecular profile of prostate cancer using: (i) Transgenic adenocarcinoma of the mouse prostate (TRAMP) and (ii) MNU/testosterone-induced rat prostate cancer models. (See Image 1) 2. CHEMOPREVENTION (a) Inflammation and anti-inflammatory agents. (b) To identify potential chemopreventive agents (Pharmaceutical and Natural), that could down regulate specific gene and/or protein targets involved in pro state carcinogenesis. To achieve this goal we are currently using preclinical models and the cells derived from these models. We are testing potential anti-inflammatory agents against PCa to determine (c) COX-2 dependent and/or independent mechanisms. (d) Chemopreventive agents that are currently under investigation including NSAIDs (Celecoxib, sulindac sulfone and NS398) Funded by R01NIH/NCI grants. (e) Natural agents under investigation are: Resveratrol, Curcumin, Omega-3 fatty acid (fish oil), 9-cis retinoic acid, and Ellagic acid. 3. RNAi MEDIATED CANCER PREVENTION APPROACHES (a) RNAi mediated COX-2 inhibition indicating the role non-COX-2 targets and COX-2 independent mechanisms (funded by R03 NIH/NCI grant). (See Image 2) See our publications for relevant studies.

Research Interests

Cancer biology and chemoprevention; Prostate cancer chemoprevention; Inflammation and COX-2 inhibitors; Chemoprevention; RNAi mediated cancer prevention approaches

Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer
Malla, Ritu; Ashby, Charles R Jr; Narayanan, Narayanan K; Narayanan, Bhagavathi; Faridi, Jesika S; Tiwari, Amit K
2015-07-17; 1090-2104,Biochemical & biophysical research communications - id: 1665732, year: 2015 Journal Article

Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo
Narayanan, Narayanan K; Kunimasa, Kazuhiro; Yamori, Yukio; Mori, Mari; Mori, Hideki; Nakamura, Kazuki; Miller, George; Manne, Upender; Tiwari, Amit K; Narayanan, Bhagavathi
2015-09-27; 2045-7634,Cancer medicine - id: 1787112, year: 2015 JOURNAL ARTICLE

Differential Activity of Brain Derived Neurotrophic Factor (BDNF) and RANKL in Promoting Osteoclast Activity in Multiple Myeloma Patients with or without Bone Disease
Narayanan, Bhagavathi A; Bruce, Cronstein; Aranzazu, Mediero; Mazumder, Amitabha
2015-03-19; 1528-0020,Blood - id: 1497712, year: 2014

Stromal Wnt/beta-catenin antagonism with DKK1 promotes clonal expansion of multiple myeloma is identified using hyaluronic acid based 3D hydrogel
Narayanan, Bhagavathi A; Duan, Bin; Butcher, Jonathan T; Mazumder, Amitabha; Narayanan, Narayanan K
2015-05-28; 1538-7445,Cancer research - id: 1599212, year: 2014

Characterization of Multiple Myeloma Clonal Cell Expansion and Stromal Wnt/beta-catenin Signaling in Hyaluronic Acid-based 3D Hydrogel
Narayanan, Narayanan K; Duan, Bin; Butcher, Jonathan T; Mazumder, Amitabha; Narayanan, Bhagavathi A
2014-01-20; 0258-851x,In vivo - id: 741252, year: 2014 Journal Article