Bhagavathi A Narayanan, Ph.D.

Associate Professor;
Department of Environmental Medicine

Contact Info

Address
57 Old Forge Road
Floor First floo Room 112
Sterling Forest
Tuxedo, NY 10987

Phone: 845-731-3624
Email: Bhagavathi.Narayanan@nyumc.org

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Education

1985 — Univ of Madras, Graduate Education
1991-1995 — Medical University of South Carolina, PostDoctoral Training

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Research Summary

CURRENT RESEARCH: Prostate cancer chemoprevention: Prostate cancer accounts for over 35% of all cancers among men in the United States. Our long-term goal is to understand prostate cancer biology and to identify innovative prevention strategies. ONGOING RESEARCH PROJECTS: 1. CANCER BIOLOGY (a)Monitoring the changes in the molecular profile of prostate cancer using: (i) Transgenic adenocarcinoma of the mouse prostate (TRAMP) and (ii) MNU/testosterone-induced rat prostate cancer models. (See Image 1) 2. CHEMOPREVENTION (a) Inflammation and anti-inflammatory agents. (b) To identify potential chemopreventive agents (Pharmaceutical and Natural), that could down regulate specific gene and/or protein targets involved in pro state carcinogenesis. To achieve this goal we are currently using preclinical models and the cells derived from these models. We are testing potential anti-inflammatory agents against PCa to determine (c) COX-2 dependent and/or independent mechanisms. (d) Chemopreventive agents that are currently under investigation including NSAIDs (Celecoxib, sulindac sulfone and NS398) Funded by R01NIH/NCI grants. (e) Natural agents under investigation are: Resveratrol, Curcumin, Omega-3 fatty acid (fish oil), 9-cis retinoic acid, and Ellagic acid. 3. RNAi MEDIATED CANCER PREVENTION APPROACHES (a) RNAi mediated COX-2 inhibition indicating the role non-COX-2 targets and COX-2 independent mechanisms (funded by R03 NIH/NCI grant). (See Image 2) See our publications for relevant studies.

Research Interests

Cancer biology and chemoprevention; Prostate cancer chemoprevention; Inflammation and COX-2 inhibitors; Chemoprevention; RNAi mediated cancer prevention approaches

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Antagonistic Effect of Small Molecule Inhibitors of Wnt/beta-Catenin in Multiple Myeloma
Narayanan, Bhagavathi A.; Doudican, Nicole A.; Park, Jeesun; Narayanan, Narayanan K.; Ramanuj, Dasgupta; Mazumder, Amitabha
2012 NOV 16;120(21):-, Blood
— id: 227552, year: 2012, vol: 120, page: , stat: Journal Article,

Antagonistic Effect of Small-molecule Inhibitors of Wnt/beta-catenin in Multiple Myeloma
Narayanan, Bhagavathi A; Doudican, Nicole A; Park, Jeesun; Xu, Dazhong; Narayanan, Narayanan K; Dasgupta, Ramanuj; Mazumder, Amitabha
2012 Nov;32(11):4697-4707, Anticancer research
— id: 182552, year: 2012, vol: 32, page: 4697, stat: Journal Article,

Epidermal growth factor-stimulated human cervical cancer cell growth is associated with EGFR and cyclin D1 activation, independent of COX-2 expression levels
Narayanan, Rajkishen; Kim, Hye Na; Narayanan, Narayanan K; Nargi, Dominick; Narayanan, Bhagavathi
2012 Jan;40(1):13-20, International journal of oncology
— id: 139735, year: 2012, vol: 40, page: 13, stat: Journal Article,

Modulation of PGE2-induced EP4 expression on snail signaling and the impact on epithelial-mesenchymal transition: significance of EP4 antagonism
Kim, Hye Na; Narayanan, Narayanan K; Lasano, Salamia; Narayanan, Bhagavathi
2011 Dec;31(12):4347-4357, Anticancer research
— id: 157619, year: 2011, vol: 31, page: 4347, stat: Journal Article,

Inflammatory processes of prostate tissue microenvironment drive rat prostate carcinogenesis: preventive effects of celecoxib
Narayanan, Narayanan K; Nargi, Dominick; Horton, Lori; Reddy, Bandaru S; Bosland, Maarten C; Narayanan, Bhagavathi A
2009 Feb 1;69(2):133-141, Prostate
— id: 91973, year: 2009, vol: 69, page: 133, stat: Journal Article,

Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice
Narayanan, Narayanan K; Nargi, Dominick; Randolph, Carla; Narayanan, Bhagavathi A
2009 Jul 1;125(1):1-8, International journal of cancer
— id: 98003, year: 2009, vol: 125, page: 1, stat: Journal Article,

Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence
Narayanan, Bhagavathi A; Reddy, Bandaru S; Bosland, Maarten C; Nargi, Dominick; Horton, Lori; Randolph, Carla; Narayanan, Narayanan K
2007 Oct 1;13(19):5965-5973, Clinical cancer research
— id: 75385, year: 2007, vol: 13, page: 5965, stat: Journal Article,

Anticancer effects of licofelone (ML-3000) in prostate cancer cells
Narayanan, Narayanan K; Nargi, Dominic; Attur, Mukundan; Abramson, Steven B; Narayanan, Bhagavathi A
2007 Jul-Aug;27(4B):2393-2402, Anticancer research
— id: 73813, year: 2007, vol: 27, page: 2393, stat: Journal Article,

Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
El-Bayoumy, Karam; Das, Arunangshu; Narayanan, Bhagavathi; Narayanan, Narayanan; Fiala, Emerich S; Desai, Dhimant; Rao, Chinthalapally V; Amin, Shantu; Sinha, Raghu
2006 Jul;27(7):1369-1376, Carcinogenesis
— id: 113685, year: 2006, vol: 27, page: 1369, stat: Journal Article,

Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets
Narayanan, Bhagavathi A
2006 Dec;6(8):711-727, Current cancer drug targets
— id: 69708, year: 2006, vol: 6, page: 711, stat: Journal Article,

RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Davis, Leland; Nargi, Dominick
2006 May;5(5):1117-1125, Molecular cancer therapeutics
— id: 64744, year: 2006, vol: 5, page: 1117, stat: Journal Article,

Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Pttman, Brian; Reddy, Bandaru S
2006 Feb 15;66(3):257-265, Prostate
— id: 62601, year: 2006, vol: 66, page: 257, stat: Journal Article,

Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells
Narayanan, Narayanan K; Narayanan, Bhagavathi A; Bosland, Maarten; Condon, Mark S; Nargi, Dominick
2006 Oct 1;119(7):1586-1598, International journal of cancer
— id: 64745, year: 2006, vol: 119, page: 1586, stat: Journal Article,

p53 is associated with negative regulation of epidermal growth factor receptor (EGFR) and Erk1/2 signaling by exisulind against adenocarcinoma of the mouse prostate
Narayanan, BA; Randolph, CJ; Narayanan, NK; Nargi, DL
2005 NOV ;14(11):2722S-2722S, Cancer epidemiology biomarkers & prevention
— id: 61898, year: 2005, vol: 14, page: 2722S, stat: Journal Article,

A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors
Narayanan, Narayanan K; Narayanan, Bhagavathi A; Reddy, Bandaru S
2005 Mar;26(3):785-792, International journal of oncology
— id: 49155, year: 2005, vol: 26, page: 785, stat: Journal Article,

Anti-inflammatory effects of omega-3 fatty acid promote differentiation in prostate cancer cells: Role of prohibitin, a highly conserved protein modulated by DHA
Narayanan, NK; Narayanan, BA; Bosland, MC; Nargi, D; Reddy, BS
2005 NOV ;14(11):2722S-2723S, Cancer epidemiology biomarkers & prevention
— id: 61899, year: 2005, vol: 14, page: 2722S, stat: Journal Article,

Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Desai, Dhimant; Pittman, Brian; Reddy, Bandaru S
2004 Dec;25(12):2443-2449, Carcinogenesis
— id: 49158, year: 2004, vol: 25, page: 2443, stat: Journal Article,

Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Pittman, Brian; Reddy, Bandaru S
2004 Nov 15;10(22):7727-7737, Clinical cancer research
— id: 49157, year: 2004, vol: 10, page: 7727, stat: Journal Article,

Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation
Narayanan, Narayanan K; Narayanan, Bhagavathi A; Nixon, Daniel W
2004 ;28(6):443-452, Cancer detection & prevention
— id: 49156, year: 2004, vol: 28, page: 443, stat: Journal Article,

Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray
El-Bayoumy, Karam; Narayanan, Bhagavathi A; Desai, Dhimant H; Narayanan, Narayanan K; Pittman, Brian; Amin, Shantu G; Schwartz, Joel; Nixon, Daniel W
2003 Sep;24(9):1505-1514, Carcinogenesis
— id: 49159, year: 2003, vol: 24, page: 1505, stat: Journal Article,

Suppression of N-methyl-N-nitrosourea/testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s)
Narayanan, Bhagavathi A; Condon, Mark S; Bosland, Maarten C; Narayanan, Narayanan K; Reddy, Bandaru S
2003 Aug 15;9(9):3503-3513, Clinical cancer research
— id: 44710, year: 2003, vol: 9, page: 3503, stat: Journal Article,

Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Re, Gian G; Nixon, Daniel W
2003 Mar 20;104(2):204-212, International journal of cancer
— id: 49161, year: 2003, vol: 104, page: 204, stat: Journal Article,

Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Simi, Barbara; Reddy, Bandaru S
2003 Mar 1;63(5):972-979, Cancer research
— id: 49160, year: 2003, vol: 63, page: 972, stat: Journal Article,

Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants
Narayanan, Bhagavathi A; Narayanan, Narayanan K; Stoner, Gary D; Bullock, Bryan P
2002 Mar 1;70(15):1821-1839, Life sciences
— id: 49162, year: 2002, vol: 70, page: 1821, stat: Journal Article,

Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells
Narayanan BA; Narayanan NK; Reddy BS
2001 Dec;19(6):1255-1262, International journal of oncology
— id: 49163, year: 2001, vol: 19, page: 1255, stat: Journal Article,

IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid
Narayanan BA; Re GG
2001 Jan-Feb;21(1A):359-364, Anticancer research
— id: 49164, year: 2001, vol: 21, page: 359, stat: Journal Article,

p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells
Narayanan BA; Geoffroy O; Willingham MC; Re GG; Nixon DW
1999 Mar 1;136(2):215-221, Cancer letters
— id: 49165, year: 1999, vol: 136, page: 215, stat: Journal Article,

The effect of all-trans and 9-cis retinoic acid on the steady state level of HPV16 E6/E7 mRNA and cell cycle in cervical carcinoma cells
Narayanan BA; Holladay EB; Nixon DW; Mauro CT
1998 ;63(7):565-573, Life sciences
— id: 49166, year: 1998, vol: 63, page: 565, stat: Journal Article,