David A Moscatelli

Biosketch / Results /

David A Moscatelli, Ph.D.

Professor; Instructor-Cell Biology & Histology
Department of Cell Biology (Cell Biology)

Contact Info

Address
550 First Avenue
Dept. of Cell Biology Floor 6 Room 650A
Medical Science Building
New York, NY 10016

212-263-7815
212-263-8139
David.Moscatelli@nyumc.org

« Back to Results

Education

1971-1977 — University of California, Berkeley, Graduate Education
1977-1978 — The Rockefeller University, PostDoctoral Training
1978-1981 — New York University School of Medicine, PostDoctoral Training

« Back to Results

Research Summary

My research explores the interplay between the prostate and its vasculature and how the balance of signals between these two compartments is disturbed in prostate cancer. The prostate is an androgen-sensitive organ: it regresses upon androgen withdrawal (e.g. castration) and regenerates after androgen repletion. One of the first cell compartments to respond to androgen withdrawal is the vascular endothelium. Prostate capillary endothelial cells begin to undergo apoptosis within 24 h after androgen ablation. Similarly, the blood vessel endothelium is one of the first cell compartments to initiate DNA synthesis after androgen repletion. These observations led us to propose that endothelial cell growth factors may be under androgen regulation in the prostate. We have found that the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) is regulated by androgen in prostate. We have also found that blocking VEGF signals inhibits expansion of the vasculature in castrated animals given androgen and blocks the regeneration of the organ. Similarly, overexpression of VEGF in androgen-regulated prostate tumor cells can convert them to androgen-independent growth. These findings suggest that VEGF is one of the key modulators of the prostate response to androgen. We are also exploring the role of another class of signaling molecules, the angiopoietins, in prostate growth. Angiopoietin-1 binds to the tie-2 receptor, which is restricted to endothelial cells, and promotes vascular maturation. A related molecule, angiopoietin-2, also binds to tie-2 but does not transmit a signal, thereby acting as a competitive inhibitor of angiopoietin-1. Although angiopoietin-1 has been thought to act primarily on endothelial cells, we have found that it can directly affect the growth of prostate epithelial cells. We are currently exploring the interaction between angiopoietin-1 and angiopoietin-2 in the regulation of prostate epithelial growth and prostate vascular growth. Finally, we are examining the relationship between the prostatic vasculature and prostatic stem cells. We have found that vascular density is highest in the proximal region of the prostate, where the stem cells reside. Current research explores the signals from the stem cells that might regulate the vascular density in this region. In addition, we will determine if altering the vascular supply in the proximal region alters its ability to harbor stem cells.

Research Interests

Regulation of Vascular Growth Factors in the Prostate

Research Keywords

angiogenesis, fibroblast growth factor, heparan sulfate, proteoglycans, receptors

« Back to Results

All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Bmi-1, stem cells and prostate carcinogenesis
Moscatelli, David; Lynette Wilson, E
2011 May;13(3):353-354, Asian journal of andrology
— id: 131955, year: 2011, vol: 13, page: 353, stat: Journal Article,

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways. L
Blum, Roy; Gupta, Rashmi; Burger, Patricia E; Ontiveros, Christopher S; Salm, Sarah N; Xiong, Xiaozhong; Kamb, Alexander; Wesche, Holger; Marshall, Lisa; Cutler, Gene; Wang, Xiangyun; Zavadil, Jiri; Moscatelli, David; Wilson, E Lynette
2010 ;5(9):?-?, PLoS one
— id: 113814, year: 2010, vol: 5, page: ?, stat: Journal Article,

PINing Down the Origin of Prostate Cancer
Moscatelli, David; Wilson, E Lynette
2010 Aug 4;2(43):43ps38-43ps38, Science translational medicine
— id: 111550, year: 2010, vol: 2, page: 43ps38, stat: Journal Article,

Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
Blum, Roy; Gupta, Rashmi; Burger, Patricia E; Ontiveros, Christopher S; Salm, Sarah N; Xiong, Xiaozhong; Kamb, Alexander; Wesche, Holger; Marshall, Lisa; Cutler, Gene; Wang, Xiangyun; Zavadil, Jiri; Moscatelli, David; Wilson, E Lynette
2009 ;4(5):e5722-e5722, PLoS one
— id: 99241, year: 2009, vol: 4, page: e5722, stat: Journal Article,

High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells
Burger, Patricia E; Gupta, Rashmi; Xiong, Xiaozhong; Ontiveros, Christopher S; Salm, Sarah N; Moscatelli, David; Wilson, E Lynette
2009 Sep;27(9):2220-2228, Stem cells
— id: 948112, year: 2009, vol: 27, page: 2220, stat: Journal Article,

Endothelial cells support the growth of prostate tissue in vivo
Bates, Michael; Kovalenko, Bruce; Wilson, E Lynette; Moscatelli, David
2008 Jun 1;68(8):893-901, Prostate
— id: 79381, year: 2008, vol: 68, page: 893, stat: Journal Article,

Prostate cells express two isoforms of fibroblast growth factor receptor 1 with different affinities for fibroblast growth factor-2
Roghani, Monireh; Moscatelli, David
2007 Feb 1;67(2):115-124, Prostate
— id: 70858, year: 2007, vol: 67, page: 115, stat: Journal Article,

Vascular endothelial growth factor and angiopoietin are required for prostate regeneration
Wang, Gui-Min; Kovalenko, Bruce; Huang, Yili; Moscatelli, David
2007 Apr 1;67(5):485-499, Prostate
— id: 71923, year: 2007, vol: 67, page: 485, stat: Journal Article,

Vascular density is highest in the proximal region of the mouse prostate
Wang, Gui-Min; Kovalenko, Bruce; Wilson, E Lynette; Moscatelli, David
2007 Jun 15;67(9):968-975, Prostate
— id: 72722, year: 2007, vol: 67, page: 968, stat: Journal Article,

Proximal prostatic stem cells are programmed to regenerate a proximal-distal ductal axis
Goto, Ken; Salm, Sarah N; Coetzee, Sandra; Xiong, Xiaozhong; Burger, Patricia E; Shapiro, Ellen; Lepor, Herbert; Moscatelli, David; Wilson, E Lynette
2006 Aug;24(8):1859-1868, Stem cells
— id: 72058, year: 2006, vol: 24, page: 1859, stat: Journal Article,

Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue
Burger, Patricia E; Xiong, Xiaozhong; Coetzee, Sandra; Salm, Sarah N; Moscatelli, David; Goto, Ken; Wilson, E Lynette
2005 May 17;102(20):7180-7185, Proceedings of the National Academy of Sciences of the United States of America
— id: 72723, year: 2005, vol: 102, page: 7180, stat: Journal Article,

Retinal blood vessels develop in response to local VEGF-A signals in the absence of blood flow
Curatola, Anna Maria; Moscatelli, David; Norris, Asma; Hendricks-Munoz, Karen
2005 Aug;81(2):147-158, Experimental eye research
— id: 58065, year: 2005, vol: 81, page: 147, stat: Journal Article,

TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts
Salm, Sarah N; Burger, Patricia E; Coetzee, Sandra; Goto, Ken; Moscatelli, David; Wilson, E Lynette
2005 Jul;170(1):81-90, Journal of cell biology
— id: 56205, year: 2005, vol: 170, page: 81, stat: Journal Article,

Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
Takao, Tetsuya; Tsujimura, Akira; Coetzee, Sandra; Salm, Sarah N; Lepor, Herbert; Shapiro, Ellen; Moscatelli, David; Wilson, E Lynette
2003 Jan 1;54(1):17-24, Prostate
— id: 35189, year: 2003, vol: 54, page: 17, stat: Journal Article,

Fibroblast growth factors
Moscatelli D; Rifkin DB
Tumor angiogenesis and microcirculation New York : Dekker, 2001,
— id: 2767, year: 2001, vol: , page: 227, stat: Chapter,

Generation of active TGF-beta by prostatic cell cocultures using novel basal and luminal prostatic epithelial cell lines
Salm SN; Koikawa Y; Ogilvie V; Tsujimura A; Coetzee S; Moscatelli D; Moore E; Lepor H; Shapiro E; Sun TT; Wilson EL
2000 Jul;184(1):70-79, Journal of cellular physiology
— id: 11685, year: 2000, vol: 184, page: 70, stat: Journal Article,

Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions
Liuzzo JP; Petanceska SS; Moscatelli D; Devi LA
1999 May;5(5):320-333, Molecular medicine
— id: 6154, year: 1999, vol: 5, page: 320, stat: Journal Article,

Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester
Liuzzo JP; Moscatelli D
1996 Jan 1;87(1):245-255, Blood
— id: 8004, year: 1996, vol: 87, page: 245, stat: Journal Article,

Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1
Roghani M; Mohammadi M; Schlessinger J; Moscatelli D
1996 Dec 6;271(49):31154-31159, Journal of biological chemistry
— id: 8518, year: 1996, vol: 271, page: 31154, stat: Journal Article,

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
Chow RL; Roux GD; Roghani M; Palmer MA; Rifkin DB; Moscatelli DA; Lang RA
1995 Dec;121(12):4383-4393, Development
— id: 6894, year: 1995, vol: 121, page: 4383, stat: Journal Article,

POTENT 2'-AMINO-2'-DEOXYPYRIMIDINE RNA INHIBITORS OF BASIC FIBROBLAST GROWTH-FACTOR
JELLINEK, D; GREEN, LS; BELL, C; LYNOTT, CK; GILL, N; VARGEESE, C; KIRSCHENHEUTER, G; MCGEE, DPC; ABESINGHE, P; PIEKEN, WA; SHAPIRO, R; RIFKIN, DB; MOSCATELLI, D; JANJIC, N
1995 SEP 12 ;34(36):11363-11372, Biochemistry
— id: 86739, year: 1995, vol: 34, page: 11363, stat: Journal Article,

Fibroblast growth factor-2 can mediate cell attachment by linking receptors and heparan sulfate proteoglycans on neighboring cells
Richard C; Liuzzo JP; Moscatelli D
1995 Oct 13;270(41):24188-24196, Journal of biological chemistry
— id: 6861, year: 1995, vol: 270, page: 24188, stat: Journal Article,

Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells
Moscatelli D
1994 Sep;160(3):555-562, Journal of cellular physiology
— id: 12896, year: 1994, vol: 160, page: 555, stat: Journal Article,

Studies on FGF-2: nuclear localization and function of high molecular weight forms and receptor binding in the absence of heparin
Rifkin DB; Moscatelli D; Roghani M; Nagano Y; Quarto N; Klein S; Bikfalvi A
1994 Sep;39(1):102-4; discussion 104, Molecular reproduction & development
— id: 6730, year: 1994, vol: 39, page: 102, stat: Journal Article,

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding
Roghani M; Mansukhani A; Dell'Era P; Bellosta P; Basilico C; Rifkin DB; Moscatelli D
1994 Feb 11;269(6):3976-3984, Journal of biological chemistry
— id: 6499, year: 1994, vol: 269, page: 3976, stat: Journal Article,

Expression of int-2 oncogene in Kaposi's sarcoma lesions
Huang YQ; Li JJ; Moscatelli D; Basilico C; Nicolaides A; Zhang WG; Poiesz BJ; Friedman-Kien AE
1993 Mar;91(3):1191-1197, Journal of clinical investigation
— id: 13228, year: 1993, vol: 91, page: 1191, stat: Journal Article,

The FGF family of growth factors and oncogenes
Basilico C; Moscatelli D
1992 ;59:115-165, Advances in cancer research
— id: 13785, year: 1992, vol: 59, page: 115, stat: Journal Article,

Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin
Mansukhani A; Dell'Era P; Moscatelli D; Kornbluth S; Hanafusa H; Basilico C
1992 Apr 15;89(8):3305-3309, Proceedings of the National Academy of Sciences of the United States of America
— id: 13631, year: 1992, vol: 89, page: 3305, stat: Journal Article,

Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix
Moscatelli D
1992 Dec 25;267(36):25803-25809, Journal of biological chemistry
— id: 8403, year: 1992, vol: 267, page: 25803, stat: Journal Article,

Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms
Roghani M; Moscatelli D
1992 Nov 5;267(31):22156-22162, Journal of biological chemistry
— id: 8404, year: 1992, vol: 267, page: 22156, stat: Journal Article,

Interaction of basic fibroblast growth factor with extracellular matrix and receptors
Moscatelli D; Flaumenhaft R; Saksela O
1991 ;638:177-181, Annals of the New York Academy of Sciences
— id: 14235, year: 1991, vol: 638, page: 177, stat: Journal Article,

New observations on the intracellular localization and release of bFGF
Rifkin DB; Quarto N; Mignatti P; Bizik J; Moscatelli D
1991 ;638:204-206, Annals of the New York Academy of Sciences
— id: 14216, year: 1991, vol: 638, page: 204, stat: Journal Article,

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF
Mansukhani A; Moscatelli D; Talarico D; Levytska V; Basilico C
1990 Jun;87(11):4378-4382, Proceedings of the National Academy of Sciences of the United States of America
— id: 14420, year: 1990, vol: 87, page: 4378, stat: Journal Article,

Growth factor control of extracellular proteolysis
Rifkin DB; Moscatelli D; Bizik J; Quarto N; Blei F; Dennis P; Flaumenhaft R; Mignatti P
1990 Dec 2;32(3):313-318, Cell differentiation & development
— id: 14245, year: 1990, vol: 32, page: 313, stat: Journal Article,

Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term stimulation of plasminogen activator production and DNA synthesis
Flaumenhaft R; Moscatelli D; Saksela O; Rifkin DB
1989 Jul;140(1):75-81, Journal of cellular physiology
— id: 10556, year: 1989, vol: 140, page: 75, stat: Journal Article,

Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin
Moscatelli D; Quarto N
1989 Nov;109(5):2519-2527, Journal of cell biology
— id: 10446, year: 1989, vol: 109, page: 2519, stat: Journal Article,

Recent developments in the cell biology of basic fibroblast growth factor
Rifkin DB; Moscatelli D
1989 Jul;109(1):1-6, Journal of cell biology
— id: 10568, year: 1989, vol: 109, page: 1, stat: Journal Article,

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential
Delli-Bovi P; Curatola AM; Newman KM; Sato Y; Moscatelli D; Hewick RM; Rifkin DB; Basilico C
1988 Jul;8(7):2933-2941, Molecular & cellular biology
— id: 11053, year: 1988, vol: 8, page: 2933, stat: Journal Article,

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
Hatten ME; Lynch M; Rydel RE; Sanchez J; Joseph-Silverstein J; Moscatelli D; Rifkin DB
1988 Feb;125(2):280-289, Developmental biology (Orlando)
— id: 11190, year: 1988, vol: 125, page: 280, stat: Journal Article,

The development of a quantitative RIA for basic fibroblast growth factor using polyclonal antibodies against the 157 amino acid form of human bFGF. The identification of bFGF in adherent elicited murine peritoneal macrophages
Joseph-Silverstein J; Moscatelli D; Rifkin DB
1988 Jun 13;110(2):183-192, Journal of immunological methods
— id: 11065, year: 1988, vol: 110, page: 183, stat: Journal Article,

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells
Moscatelli D
1988 Aug;107(2):753-759, Journal of cell biology
— id: 11025, year: 1988, vol: 107, page: 753, stat: Journal Article,

Multiple forms of an angiogenesis factor: basic fibroblast growth factor
Moscatelli D; Joseph-Silverstein J; Presta M; Rifkin DB
1988 Jan;70(1):83-87, Biochimie
— id: 11285, year: 1988, vol: 70, page: 83, stat: Journal Article,

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis
Moscatelli D; Rifkin DB
1988 Aug 3;948(1):67-85, Biochimica & biophysica acta
— id: 10990, year: 1988, vol: 948, page: 67, stat: Journal Article,

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation
Saksela O; Moscatelli D; Sommer A; Rifkin DB
1988 Aug;107(2):743-751, Journal of cell biology
— id: 11021, year: 1988, vol: 107, page: 743, stat: Journal Article,

Synthesis of collagenase and plasminogen activator by endothelial cells
Moscatelli D; Gross JL; Jaffe EA; Rifkin DB
Biology of endothelial cells Boston : Kluwer, 1984,
— id: 2766, year: 1984, vol: , page: 429, stat: Chapter,

Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells
Moscatelli D; Jaffe E; Rifkin DB
1980 Jun;20(2):343-351, Cell
— id: 27437, year: 1980, vol: 20, page: 343, stat: Journal Article,

Effects of depletion of K+, Na+, or Ca2+ on DNA synthesis and cell cation content in chick embryo fibroblasts
Moscatelli D; Sanui H; Rubin AH
1979 Oct;101(1):117-128, Journal of cellular physiology
— id: 27433, year: 1979, vol: 101, page: 117, stat: Journal Article,

Hormonal control of hyaluronic acid production in fibroblasts and its relation to nucleic acid and protein synthesis
Moscatelli D; Rubin H
1977 Apr;91(1):79-88, Journal of cellular physiology
— id: 27432, year: 1977, vol: 91, page: 79, stat: Journal Article,

Increased hyaluronic acid production on stimulation of DNA synthesis in chick embryo fibroblasts
Moscatelli D; Rubin H
1975 Mar 6;254(5495):65-66, Nature
— id: 27431, year: 1975, vol: 254, page: 65, stat: Journal Article,