Maria Carmen Montesinos, Ph.D.

Adenosine receptor agonists for promotion of dermal wound healing
Valls, Maria D; Cronstein, Bruce N; Montesinos, M Carmen
2009 Apr 1;77(7):1117-1124, Biochemical pharmacology
— id: 96259, year: 2009, vol: 77, page: 1117, stat: Journal Article,

Contribution of annexin ii and plasminogen inhibitor-1 (PAI-1) in the proangiogenic effect of adenosine A2A receptor activation
Valls, MD; Williams, A; Cronstein, BN; Montesinos, MC
2008 MAY ;4(1):S119-S119, Purinergic signalling
— id: 86663, year: 2008, vol: 4, page: S119, stat: Journal Article,

The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice
Montesinos, M Carmen; Takedachi, Masahide; Thompson, Linda F; Wilder, Tuere F; Fernandez, Patricia; Cronstein, Bruce N
2007 May;56(5):1440-1445, Arthritis & rheumatism
— id: 96263, year: 2007, vol: 56, page: 1440, stat: Journal Article,

Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
Chan, E S L; Fernandez, P; Merchant, A A; Montesinos, M C; Trzaska, S; Desai, A; Tung, C F; Khoa, D N; Pillinger, M H; Reiss, A B; Tomic-Canic, M; Chen, J F; Schwarzschild, M A; Cronstein, B N
2006 Aug;54(8):2632-2642, Arthritis & rheumatism
— id: 68662, year: 2006, vol: 54, page: 2632, stat: Journal Article,

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
Chan, Edwin S L; Montesinos, Maria Carmen; Fernandez, Patricia; Desai, Avani; Delano, David L; Yee, Herman; Reiss, Allison B; Pillinger, Michael H; Chen, Jiang-Fan; Schwarzschild, Michael A; Friedman, Scott L; Cronstein, Bruce N
2006 Aug;148(8):1144-1155, British journal of pharmacology
— id: 66126, year: 2006, vol: 148, page: 1144, stat: Journal Article,

Adenosine A(2A) receptors and dermal fibrosis: a pathogenic role for adenosine in diffuse dermal fibrosis
Chan, ESL; Fernandez, P; Merchant, AA; Desai, A; Montesinos, MC; Tung, CF; Khoa, DN; Pillinger, MH; Reiss, AB; Tomic-Canic, M; Chen, JF; Schwarzschild, MA; Cronstein, BN
2006 SEP ;11(1):144-144, Journal of investigative dermatology symposium proceedings
— id: 76164, year: 2006, vol: 11, page: 144, stat: Journal Article,

Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis
Montesinos, M Carmen; Desai, Avani; Cronstein, Bruce N
2006 ;8(2):R53-R53, Arthritis research & therapy
— id: 69494, year: 2006, vol: 8, page: R53, stat: Journal Article,

An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation
Delano, David L; Montesinos, M Carmen; D'Eustachio, Peter; Wiltshire, Tim; Cronstein, Bruce N
2005 Feb;29(1):1-7, Inflammation
— id: 64161, year: 2005, vol: 29, page: 1, stat: Journal Article,

Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation
Delano, David L; Montesinos, M Carmen; Desai, Avani; Wilder, Tuere; Fernandez, Patricia; D'Eustachio, Peter; Wiltshire, Tim; Cronstein, Bruce N
2005 Aug;52(8):2567-2575, Arthritis & rheumatism
— id: 57722, year: 2005, vol: 52, page: 2567, stat: Journal Article,

Adenosine A2A Receptor Stimulation Increases Angiogenesis By Downregulating Production Of The Anti-Angiogenic Matrix Protein Thrombospondin 1 (TSP1)
Desai, Avani; Victor-Vega, Cassandre; Gadangi, Swathi; Montesinos, M Carmen; Chu, Charles C; Cronstein, Bruce N
2005 May;67(5):1406-1413, Molecular pharmacology
— id: 48700, year: 2005, vol: 67, page: 1406, stat: Journal Article,

Genetically-based resistance to methotrexate (MTX) in the air pouch model of acute inflammation
Delano, DL; Montesinos, MC; Desai, A; D'Eustachio, P; Wiltshire, T; Cronstein, BN
2004 SEP ;50(9):S367-S367, Arthritis & rheumatism
— id: 49044, year: 2004, vol: 50, page: S367, stat: Journal Article,

An inter-play between genetic background and gender determines the severity of inflammation induced in the mouse air pouch model of acute inflammation
Delano, DL; Montesinos, MC; Wiltshire, T; Cronstein, BN
2004 SEP ;50(9):S367-S367, Arthritis & rheumatism
— id: 49045, year: 2004, vol: 50, page: S367, stat: Journal Article,

Adenosine A2A receptor (A2AR) agonists enhance angiogenesis by diminishing expression of the anti-angiogenic protein thrombospondin 1 (TSP1)
Desai, A; Victor-Vega, C; Gadangi, S; Montesinos, MC; Cronstein, BN
2004 SEP ;50(9):S88-S88, Arthritis & rheumatism
— id: 49026, year: 2004, vol: 50, page: S88, stat: Journal Article,

Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis
Montesinos, M Carmen; Shaw, Jason P; Yee, Herman; Shamamian, Peter; Cronstein, Bruce N
2004 Jun;164(6):1887-1892, American journal of pathology
— id: 44836, year: 2004, vol: 164, page: 1887, stat: Journal Article,

Nivcobacterium bovis BCG-induced granuloma formation depends on CD39 (nucleoside triphosphate dephosphosphorylase) and adenosine A2A receptor
Mor, A; Montesinos, MC; Cronstein, BN
2004 SEP ;50(9):S129-S130, Arthritis & rheumatism
— id: 49028, year: 2004, vol: 50, page: S129, stat: Journal Article,

The role of adenosine in stress altered immunity
Oliver, SJ; Mathew, S; Montesinos, MC; Cronstein, BN
2004 SEP ;50(9):S520-S520, Arthritis & rheumatism
— id: 49049, year: 2004, vol: 50, page: S520, stat: Journal Article,

Activation of the adenosine A2A receptor increases expression of reverse cholesterol transport (RCT) proteins in monocytes/macrophages
Reiss, A; Rahman, M; Chan, E; Montesinos, M; Hasneen, K
2004 MAY 14 ;18(8):C261-C261, FASEB journal
— id: 46556, year: 2004, vol: 18, page: C261, stat: Journal Article,

Adenosine A2A receptor activation counteracts atherogenic effects of immune reactants on cholesterol flux in macrophages
Reiss, AB; Cronstein, BN; Chan, ES; Montesinos, MC; Ragolia, L; Carsons, S
2004 OCT 26 ;110(17):331-331, Circulation
— id: 55940, year: 2004, vol: 110, page: 331, stat: Journal Article,

Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages
Reiss, Allison B; Patel, Chirag A; Rahman, Mohammad M; Chan, Edwin S L; Hasneen, Kowser; Montesinos, Maria C; Trachman, Julie D; Cronstein, Bruce N
2004 Nov;10(11):BR420-BR425, Medical science monitor
— id: 69497, year: 2004, vol: 10, page: BR420, stat: Journal Article,

Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages
Reiss, Allison B; Rahman, Mohammad M; Chan, Edwin S L; Montesinos, M Carmen; Awadallah, Nahel W; Cronstein, Bruce N
2004 Sep;76(3):727-734, Journal of leukocyte biology
— id: 44864, year: 2004, vol: 76, page: 727, stat: Journal Article,

Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
Khoa, ND; Williams, AJ; Montesinos, MC; Reiss, AB; Cronstein, BN
2003 SEP ;48(9):S470-S471, Arthritis & rheumatism
— id: 55443, year: 2003, vol: 48, page: S470, stat: Journal Article,

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
Montesinos, M Carmen; Desai, Avani; Delano, Dave; Chen, Jiang-Fan; Fink, J Stephen; Jacobson, Marlene A; Cronstein, Bruce N
2003 Jan;48(1):240-247, Arthritis & rheumatism
— id: 34759, year: 2003, vol: 48, page: 240, stat: Journal Article,

Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis
Montesinos, MC; Shaw, J; Yee, H; Shamamian, P; Cronstein, BN
2003 SEP ;48(9):S443-S443, Arthritis & rheumatism
— id: 55442, year: 2003, vol: 48, page: S443, stat: Journal Article,

Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
Nguyen, D Khoa; Montesinos, M Carmen; Williams, Adrienne J; Kelly, Maureen; Cronstein, Bruce N
2003 Oct 15;171(8):3991-3998, Journal of immunology
— id: 39041, year: 2003, vol: 171, page: 3991, stat: Journal Article,

Adenosine A2A receptor activation upregulates expression of the cholesterol-metabolizing 27-hydroxylase enzyme and inhibits foam cell transformation in THP-1 human monocytes/macrophages
Reiss, AB; Rahman, MM; Chan, ESL; Montesinos, MC; Awadallah, NW; Hasneen, K; Cronstein, BN
2003 SEP ;48(9):S691-S691, Arthritis & rheumatism
— id: 55447, year: 2003, vol: 48, page: S691, stat: Journal Article,

TH1 Cytokines regulate adenosine receptor number and function in human microvascular endothelial cells
Khoa, ND; Montesinos, MC; Reiss, AB; Williams, AJ; Cronstein, BN
2002 SEP ;46(9):S400-S400, Arthritis & rheumatism
— id: 37122, year: 2002, vol: 46, page: S400, stat: Journal Article,

Regulation of G protein expression may contribute to functional modulation of adenosine A(2A) receptor function by inflammatory cytokines in human monocytoid THP-1 cells
Koha, ND; Montesinos, MC; Reiss, AB; Cronstein, BN
2002 AUG ;56(4):57-259, Drug development research
— id: 34092, year: 2002, vol: 56, page: 57, stat: Journal Article,

Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A(2A) Receptors
Montesinos, M Carmen; Desai, Avani; Chen, Jiang-Fan; Yee, Herman; Schwarzschild, Michael A; Fink, J Stephen; Cronstein, Bruce N
2002 Jun;160(6):2009-2018, American journal of pathology
— id: 27826, year: 2002, vol: 160, page: 2009, stat: Journal Article,

Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel)
Victor-Vega, Cassandre; Desai, Avani; Montesinos, M Carmen; Cronstein, Bruce N
2002 Feb;26(1):19-24, Inflammation
— id: 27827, year: 2002, vol: 26, page: 19, stat: Journal Article,

Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice
Weissmann, Gerald; Montesinos, M Carmen; Pillinger, Michael; Cronstein, Bruce N
2002 ;507:571-577, Advances in experimental medicine & biology
— id: 48720, year: 2002, vol: 507, page: 571, stat: Journal Article,

Adenosine mediates the antiinflammatory effects of methotrexate as well as its toxicities
Cronstein, BN; Montesinos, MC; Chan, E
2001 JAN-FEB ;52(1-2):394-396, Drug development research
— id: 55084, year: 2001, vol: 52, page: 394, stat: Journal Article,

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells
Khoa ND; Montesinos MC; Reiss AB; Delano D; Awadallah N; Cronstein BN
2001 Oct 1;167(7):4026-4032, Journal of immunology
— id: 26616, year: 2001, vol: 167, page: 4026, stat: Journal Article,

Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages
Reiss AB; Awadallah NW; Malhotra S; Montesinos MC; Chan ES; Javitt NB; Cronstein BN
2001 Nov;42(11):1913-1922, Journal of lipid research
— id: 26514, year: 2001, vol: 42, page: 1913, stat: Journal Article,

Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis
Montesinos MC; Yap JS; Desai A; Posadas I; McCrary CT; Cronstein BN
2000 Mar;43(3):656-663, Arthritis & rheumatism
— id: 9813, year: 2000, vol: 43, page: 656, stat: Journal Article,

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
Cronstein BN; Montesinos MC; Weissmann G
1999 May 25;96(11):6377-6381, Proceedings of the National Academy of Sciences of the United States of America
— id: 48705, year: 1999, vol: 96, page: 6377, stat: Journal Article,

Sites of action for future therapy: an adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice
Cronstein BN; Montesinos MC; Weissmann G
1999 Jul;7(4):361-363, Osteoarthritis & cartilage
— id: 9814, year: 1999, vol: 7, page: 361, stat: Journal Article,

Salicylates, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 (p50) of nuclear factor Kb (NFkappab).
Weissmann, Gerald; Montesinos, M Carmen; Cronstein, Bruce N
1999 Sep 12-15;59(1-6):2-2, Prostglandins & other lipid mediators
— id: 15835, year: 1999, vol: 59, page: 2, stat: Journal Article,

High dose aspirin (ASA) and sodium salicylate (SAL) are antiinflammatory in NF kappa B knockout and wild-type mice by an adenosine-dependent mechanism
Cronstein, BN; Montesinos, MC; Weissmann, G
1998 SEP ;41(9):S98-S98, Arthritis & rheumatism
— id: 53734, year: 1998, vol: 41, page: S98, stat: Journal Article,

Sulfasalazine (SSA) is antiinflammatory by a mechanism which is independent of NF kappa B
Montesinos, MC; Desai, A; Cronstein, BN
1998 SEP ;41(9):S98-S98, Arthritis & rheumatism
— id: 53735, year: 1998, vol: 41, page: S98, stat: Journal Article,

An adenosine A2a receptor agonist (CGS-21680) promotes wound closure in normal and urokinase plasminogen activator knockout (uPa-KO) but not tissue plasminogen activator knockout (tPA-KO) mice
Montesinos, MC; Shapiro, R; Desai, A; Cronstein, BN
1998 SEP ;41(9):S191-S191, Arthritis & rheumatism
— id: 53741, year: 1998, vol: 41, page: S191, stat: Journal Article,

The antiinflammatory effects of methotrexate are mediated by adenosine in the adjuvant arthritis model of rheumatoid arthritis
Montesinos, MC; Yap, J; McCrary, C; Cronstein, BN
1998 MAR ;46(3):229A-229A, Journal of investigative medicine
— id: 53503, year: 1998, vol: 46, page: 229A, stat: Journal Article,

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides
Morabito L; Montesinos MC; Schreibman DM; Balter L; Thompson LF; Resta R; Carlin G; Huie MA; Cronstein BN
1998 Jan 15;101(2):295-300, Journal of clinical investigation
— id: 7697, year: 1998, vol: 101, page: 295, stat: Journal Article,

Occupancy of C1Q receptors on endothelial cells (EC) by immune complexes (IC) downregulates mRNA for sterol 27-hydroxylase (27-OH ' ASE), the major mediator of extra-hepatic cholesterol metabolism
Reiss, AB; Malhotra, S; Javitt, NB; Grossi, EA; Galloway, AC; Montesinos, MC; Cronstein, BN
1998 SEP abstract #281;41(Suppl S):S79-S79, Arthritis & rheumatism
— id: 33431, year: 1998, vol: 41, page: S79, stat: Journal Article,

Signalling at endothelial cell C1q receptors is mediated by the intracellular calcium-independent activation of protein kinase C
McCrary, CT; Montesinos, MC; Cronstein, BN
1997 SEP ;40(9):593-593, Arthritis & rheumatism
— id: 53188, year: 1997, vol: 40, page: 593, stat: Journal Article,

Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors
Montesinos MC; Gadangi P; Longaker M; Sung J; Levine J; Nilsen D; Reibman J; Li M; Jiang CK; Hirschhorn R; Recht PA; Ostad E; Levin RI; Cronstein BN
1997 Nov 3;186(9):1615-1620, Journal of experimental medicine
— id: 7954, year: 1997, vol: 186, page: 1615, stat: Journal Article,

A novel function for ecto-5' nucleotidase (5'NT): Transduction of the antiinflammatory effects of methotrerate(MTX) in vitro and in vivo
Morabito, L; Montesinos, MC; Thompson, L; Resta, R; Balter, L; Schreibman, D; Cronstein, BN
1997 SEP ;40(9):602-602, Arthritis & rheumatism
— id: 53191, year: 1997, vol: 40, page: 602, stat: Journal Article,

The antiinflammatory effects of methotrexate are