Ian J Mohr

Biosketch / Results /

Ian J Mohr, Ph.D.

Professor;
Department of Microbiology (Microbiology )

Contact Info

Address
550 First Avenue
Floor 2 Room 249
Medical Science Building
New York, NY 10016

212-263-0415
212-263-8276
Ian.Mohr@nyumc.org

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Education

— SUNY @ Stony Brook, Graduate Education

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Research Summary

My laboratory is trying to understand how cells regulate the synthesis of proteins by modifying a critical factor, eIF2. Physiological stress, ranging from heat shock to viral infection, prompts cells to phosphorylate the alpha subunit of eIF2. This incapacitates eIF2 and new protein synthesis ceases. Improper functioning of this signal circuit can lead to uncontrolled proliferation of cells. While kinases that phosphorylate eIF2 have been identified, the nature of other effectors that modulate eIF2 phosphorylation remains mysterious. We study herpes simplex virus type-1 (HSV-1) as a model to explore events that effect eIF2 phosphorylation.

Mutant viruses that lack the HSV-1 g34.5 gene fail to grow on many human malignant neuronal cells, as eIF2 is phosphorylated and protein synthesis is blocked. PKR, a cellular kinase involved in PDGF and interferon signaling, is activated by viral infection and phosphorylates eIF2a. We have isolated variant viruses that lack the g34.5 gene, yet grow on neuronal cells. These variants are second-site suppressors as they lack the g34.5 gene and contain additional mutations that affect a distinct viral genetic element, the SUP locus. Remarkably, specific removal of 583 base-pairs of DNA from the SUP locus completely precludes the accumulation of phosphorylated eIF2. Consequently, suppressor g34.5 variants can synthesize proteins and multiply on cells that fail to support replication of the parental g34.5 mutants. A major focus of the laboratory is to understand how alterations of the SUP locus allow the virus to overcome the actions of the activated PKR kinase. Understanding the nature of the SUP locus will thus elucidate events that occur prior to eIF2 phosphorylation and define a new effector involved in the control of protein synthesis. Additionally, the viral g34.5 gene contains a region homologous to a cellular gene (GADD34) induced in response to agents that promote growth arrest, DNA damage, and differentiation. Protein synthesis checkpoints controlled by PKR may function in all of these processes. Understanding how the HSV- 1 SUP locus effects PKR signaling may aid in identifying cellular molecules with similar functions. Viral genetics can thus provide a powerful inroad into key cellular signaling pathways.

A second area of interest involves the design and use of attenuated, replication competent viruses that can discriminate between normal and malignant cells. HSV-1 g34.5 mutant viruses are non-neurovirulent in animals, and appear to be sufficiently attenuated for intracranial administration. However, these mutant viruses grow poorly in neuronal tumors, imposing a major limitation on their effectiveness in destroying tumor tissue. The suppressor mutants described above have regained the ability to grow in neoplastic cells, but have retained the attenuated phenotype of the g34.5 parent virus. They are thus potentially ideal prototypes for a 3tumorcidal2 virus that could destroy malignant cells in the CNS.

Research Interests

Translational Control in Herpes Simplex Virus Infected Cells

Research Keywords

herpes virus, PKR signalling, translational control, viral genetics

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Co-opting the Fanconi Anemia Genomic Stability Pathway Enables Herpesvirus DNA Synthesis and Productive Growth
Karttunen, Heidi; Savas, Jeffrey N; McKinney, Caleb; Chen, Yu-Hung; Yates, John R 3rd; Hukkanen, Veijo; Huang, Tony T; Mohr, Ian
2014 Jun;:111-122, Molecular cell
— id: 1055622, year: 2014, vol: , page: 111, stat: Journal Article,

Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation
Kim, Ju Youn; Shiflett, Lora A; Linderman, Jessica A; Mohr, Ian; Wilson, Angus C
2014 ;1144:167-179, Methods in molecular biology
— id: 970092, year: 2014, vol: 1144, page: 167, stat: Journal Article,

Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication
McKinney, Caleb; Zavadil, Jiri; Bianco, Christopher; Shiflett, Lora; Brown, Stuart; Mohr, Ian
2014 Jan;6(1):9-17, Cell reports
— id: 759792, year: 2014, vol: 6, page: 9, stat: Journal Article,

Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e
Walsh, Derek; Mohr, Ian
2014 Apr;28(8):835-840, Genes & development
— id: 882092, year: 2014, vol: 28, page: 835, stat: Journal Article,

Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein
Kew, Chun; Lui, Pak-Yin; Chan, Chi-Ping; Liu, Xiang; Au, Shannon Wing Ngor; Mohr, Ian; Jin, Dong-Yan; Kok, Kin-Hang
2013 Dec;87(24):13141-13149, Journal of virology
— id: 687352, year: 2013, vol: 87, page: 13141, stat: Journal Article,

A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication
McKinney, Caleb; Yu, Dong; Mohr, Ian
2013 Aug;27(16):1809-1820, Genes & development
— id: 503662, year: 2013, vol: 27, page: 1809, stat: Journal Article,

Tinkering with translation: protein synthesis in virus-infected cells
Walsh, Derek; Mathews, Michael B; Mohr, Ian
2013 Jan;5(1):a012351-a012351 a012351, Cold Spring Harbor perspectives in biology
— id: 220722, year: 2013, vol: 5, page: a012351, stat: Journal Article,

Suppression of extracellular signal-regulated kinase activity in herpes simplex virus 1-infected cells by the us3 protein kinase
Chuluunbaatar, Uyanga; Roller, Richard; Mohr, Ian
2012 Aug;86(15):7771-7776, Journal of virology
— id: 171557, year: 2012, vol: 86, page: 7771, stat: Journal Article,

Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E
Herdy, Barbara; Jaramillo, Maritza; Svitkin, Yuri V; Rosenfeld, Amy B; Kobayashi, Mariko; Walsh, Derek; Alain, Tommy; Sean, Polen; Robichaud, Nathaniel; Topisirovic, Ivan; Furic, Luc; Dowling, Ryan J O; Sylvestre, Annie; Rong, Liwei; Colina, Rodney; Costa-Mattioli, Mauro; Fritz, Jorg H; Olivier, Martin; Brown, Earl; Mohr, Ian; Sonenberg, Nahum
2012 ;13(6):543-550, Nature immunology
— id: 169019, year: 2012, vol: 13, page: 543, stat: Journal Article,

Transient Reversal of Episome Silencing Precedes VP16-Dependent Transcription during Reactivation of Latent HSV-1 in Neurons
Kim, Ju Youn; Mandarino, Angelo; Chao, Moses V; Mohr, Ian; Wilson, Angus C
2012 Feb;8(2):e1002540-e1002540 e1002540, PLoS pathogens
— id: 159845, year: 2012, vol: 8, page: e1002540, stat: Journal Article,

Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication
Kobayashi, Mariko; Arias, Carolina; Garabedian, Alexandra; Palmenberg, Ann C; Mohr, Ian
2012 Oct;86(19):10686-10694, Journal of virology
— id: 178053, year: 2012, vol: 86, page: 10686, stat: Journal Article,

A primary neuron culture system for the study of herpes simplex virus latency and reactivation
Kobayashi, Mariko; Kim, Ju-Youn; Camarena, Vladimir; Roehm, Pamela C; Chao, Moses V; Wilson, Angus C; Mohr, Ian
2012 ;(62):?-?, Journal of visualized experiments : JoVE
— id: 164363, year: 2012, vol: , page: ?, stat: Journal Article,

Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor
Kobayashi, Mariko; Wilson, Angus C; Chao, Moses V; Mohr, Ian
2012 Jul;26(14):1527-1532, Genes & development
— id: 174034, year: 2012, vol: 26, page: 1527, stat: Journal Article,

A cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1
Kuhn, Maggie A; Nayak, Shruti; Camarena, Vladimir; Gardner, Jimmy; Wilson, Angus; Mohr, Ian; Chao, Moses V; Roehm, Pamela C
2012 Jan;33(1):87-92, Otology & neurotology
— id: 146264, year: 2012, vol: 33, page: 87, stat: Journal Article,

Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells
McKinney, Caleb; Perez, Cesar; Mohr, Ian
2012 Apr;109(15):5627-5632, Proceedings of the National Academy of Sciences of the United States of America
— id: 164345, year: 2012, vol: 109, page: 5627, stat: Journal Article,

Host translation at the nexus of infection and immunity
Mohr, Ian; Sonenberg, Nahum
2012 Oct;12(4):470-483, Cell host & microbe
— id: 180702, year: 2012, vol: 12, page: 470, stat: Journal Article,

A cultured affair: HSV latency and reactivation in neurons
Wilson, Angus C; Mohr, Ian
2012 Dec;20(12):604-611, Trends in microbiology
— id: 182432, year: 2012, vol: 20, page: 604, stat: Journal Article,

Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters
Xi, Xiangmei; Persson, Linda M; O'Brien, Michael W; Mohr, Ian; Wilson, Angus C
2012 Jan;86(2):1021-1033, Journal of virology
— id: 155938, year: 2012, vol: 86, page: 1021, stat: Journal Article,

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies
Zhou, H; Huang, HY; Shapiro, E; Lepor, H; Huang, WC; Mohammadi, M; Mohr, I; Tang, MS; Huang, C; Wu, XR
2012 Feb;:770-780, Carcinogenesis
— id: 162340, year: 2012, vol: , page: 770, stat: Journal Article,

A herpesvirus kinase that masquerades as Akt: You don't have to look like Akt, to act like it
Chuluunbaatar, Uyanga; Mohr, Ian
2011 Jul 1;10(13):2064-2068, Cell cycle
— id: 136511, year: 2011, vol: 10, page: 2064, stat: Journal Article,

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides
Gao, Ningguo; Shang, Jie; Huynh, Dang; Manthati, Vijaya L; Arias, Carolina; Harding, Heather P; Kaufman, Randal J; Mohr, Ian; Ron, David; Falck, John R; Lehrman, Mark A
2011 Sep;22(17):2994-3009, Molecular biology of the cell
— id: 136999, year: 2011, vol: 22, page: 2994, stat: Journal Article,

Translational control of the abundance of cytoplasmic poly(a) binding protein in human cytomegalovirus-infected cells
Perez, Cesar; McKinney, Caleb; Chulunbaatar, Uyanga; Mohr, Ian
2011 Jan;85(1):156-164, Journal of virology
— id: 115423, year: 2011, vol: 85, page: 156, stat: Journal Article,

Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation
Roehm, Pamela C; Camarena, Vladimir; Nayak, Shruti; Gardner, James B; Wilson, Angus; Mohr, Ian; Chao, Moses V
2011 Oct;121(10):2268-2275, Laryngoscope
— id: 137886, year: 2011, vol: 121, page: 2268, stat: Journal Article,

Viral subversion of the host protein synthesis machinery
Walsh, Derek; Mohr, Ian
2011 ;9(12):860-875, Nature reviews. Microbiology
— id: 141701, year: 2011, vol: 9, page: 860, stat: Journal Article,

Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons
Camarena, Vladimir; Kobayashi, Mariko; Kim, Ju Youn; Roehm, Pamela; Perez, Rosalia; Gardner, James; Wilson, Angus C; Mohr, Ian; Chao, Moses V
2010 Oct 21;8(4):320-330, Cell host & microbe
— id: 113951, year: 2010, vol: 8, page: 320, stat: Journal Article,

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication
Chuluunbaatar, Uyanga; Roller, Richard; Feldman, Morris E; Brown, Stuart; Shokat, Kevan M; Mohr, Ian
2010 Dec 1;24(23):2627-2639, Genes & development
— id: 114863, year: 2010, vol: 24, page: 2627, stat: Journal Article,

Activation of host translational control pathways by a viral developmental switch
Arias, Carolina; Walsh, Derek; Harbell, Jack; Wilson, Angus C; Mohr, Ian
2009 Mar;5(3):e1000334-e1000334, PLoS pathogens
— id: 98991, year: 2009, vol: 5, page: e1000334, stat: Journal Article,

Protein synthesis and translational control during viral infection
Mohr IJ; Pe'ery T; Mathews MB
Translational control in biology and medicine Cold Spring Harbor NY : Cold Spring Harbor Laboratory Press, 2007,
— id: 5267, year: 2008, vol: , page: 545, stat: Chapter,

Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells
Walsh, Derek; Arias, Carolina; Perez, Cesar; Halladin, David; Escandon, Martin; Ueda, Takeshi; Watanabe-Fukunaga, Rie; Fukunaga, Rikiro; Mohr, Ian
2008 Apr;28(8):2648-2658, Molecular & cellular biology
— id: 78356, year: 2008, vol: 28, page: 2648, stat: Journal Article,

Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements
Campbell, Stephanie A; Mulvey, Matthew; Mohr, Ian; Gromeier, Matthias
2007 Jan;81(2):791-799, Journal of virology
— id: 78854, year: 2007, vol: 81, page: 791, stat: Journal Article,

Herpes simplex virus as a therapy for cancer
Mohr I
Gene therapy for cancer Totowa NJ : Humana Press, 2007,
— id: 5268, year: 2007, vol: , page: 87, stat: Chapter,

Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor
Mulvey, Matthew; Arias, Carolina; Mohr, Ian
2007 Apr;81(7):3377-3390, Journal of virology
— id: 71416, year: 2007, vol: 81, page: 3377, stat: Journal Article,

Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein
Sanchez, Ricardo; Mohr, Ian
2007 Apr;81(7):3455-3464, Journal of virology
— id: 71417, year: 2007, vol: 81, page: 3455, stat: Journal Article,

Phosphorylation and dephosphorylation events that regulate viral mRNA translation
Mohr, Ian
2006 Jul;119(1):89-99, Virus research
— id: 65793, year: 2006, vol: 119, page: 89, stat: Journal Article,

Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions
Mulvey, Matthew; Arias, Carolina; Mohr, Ian
2006 Aug;80(15):7354-7363, Journal of virology
— id: 67538, year: 2006, vol: 80, page: 7354, stat: Journal Article,

Assembly of an active translation initiation factor complex by a viral protein
Walsh, Derek; Mohr, Ian
2006 Feb 15;20(4):461-472, Genes & development
— id: 64200, year: 2006, vol: 20, page: 461, stat: Journal Article,

To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control
Mohr, Ian
2005 Nov 21;24(52):7697-7709, Oncogene
— id: 78855, year: 2005, vol: 24, page: 7697, stat: Journal Article,

Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells
Walsh, Derek; Perez, Cesar; Notary, Joanna; Mohr, Ian
2005 Jul;79(13):8057-8064, Journal of virology
— id: 78856, year: 2005, vol: 79, page: 8057, stat: Journal Article,

Neutralizing innate host defenses to control viral translation in HSV-1 infected cells
Mohr, Ian
2004 Jan-Apr;23(1-2):199-220, International reviews of immunology
— id: 42631, year: 2004, vol: 23, page: 199, stat: Journal Article,

Full resistance of herpes simplex virus type 1-infected primary human cells to alpha interferon requires both the Us11 and gamma(1)34.5 gene products
Mulvey, Matthew; Camarena, Vladimir; Mohr, Ian
2004 Oct;78(18):10193-10196, Journal of virology
— id: 46131, year: 2004, vol: 78, page: 10193, stat: Journal Article,

Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells
Walsh, Derek; Mohr, Ian
2004 Apr 15;18(6):660-672, Genes & development
— id: 46105, year: 2004, vol: 18, page: 660, stat: Journal Article,

Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides
Benboudjema, Louisa; Mulvey, Matthew; Gao, Yuehua; Pimplikar, Sanjay W; Mohr, Ian
2003 Sep;77(17):9192-9203, Journal of virology
— id: 39108, year: 2003, vol: 77, page: 9192, stat: Journal Article,

Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer
Mohr, Ian
2003 Feb;3(1):113-125, Expert opinion on biological therapy
— id: 39236, year: 2003, vol: 3, page: 113, stat: Journal Article,

Regulation of eIF2? phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle
Mulvey, M; Poppers, J; Sternberg, D; Mohr, I
2003 ;77(20):10917-10928, Journal of virology
— id: 651192, year: 2003, vol: 77, page: 10917, stat: Journal Article,

Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle
Mulvey, Matthew; Poppers, Jeremy; Sternberg, David; Mohr, Ian
2003 Oct;77(20):10917-10928, Journal of virology
— id: 39054, year: 2003, vol: 77, page: 10917, stat: Journal Article,

Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activation
Poppers, Jeremy; Mulvey, Matthew; Perez, Cesar; Khoo, David; Mohr, Ian
2003 Jan;77(1):228-236, Journal of virology
— id: 39350, year: 2003, vol: 77, page: 228, stat: Journal Article,

Translation initiation and viral tricks
Schneider, Robert J; Mohr, Ian
2003 Mar;28(3):130-136, Trends in biochemical sciences
— id: 44998, year: 2003, vol: 28, page: 130, stat: Journal Article,

In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation
Ward, Stephen L; Scheuner, Donalyn; Poppers, Jeremy; Kaufman, Randal J; Mohr, Ian; Leib, David A
2003 Apr;77(8):4626-4634, Journal of virology
— id: 78857, year: 2003, vol: 77, page: 4626, stat: Journal Article,

Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation
Khoo, David; Perez, Cesar; Mohr, Ian
2002 Dec;76(23):11971-11981, Journal of virology
— id: 39570, year: 2002, vol: 76, page: 11971, stat: Journal Article,

Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein
Peters, Gregory A; Khoo, David; Mohr, Ian; Sen, Ganes C
2002 Nov;76(21):11054-11064, Journal of virology
— id: 78858, year: 2002, vol: 76, page: 11054, stat: Journal Article,

A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
Mohr I; Sternberg D; Ward S; Leib D; Mulvey M; Gluzman Y
2001 Jun;75(11):5189-5196, Journal of virology
— id: 20691, year: 2001, vol: 75, page: 5189, stat: Journal Article,

New ways of initiating translation in eukaryotes
Schneider, R; Agol, V I; Andino, R; Bayard, F; Cavener, D R; Chappell, S A; Chen, J J; Darlix, J L; Dasgupta, A; Donze, O; Duncan, R; Elroy-Stein, O; Farabaugh, P J; Filipowicz, W; Gale, M Jr; Gehrke, L; Goldman, E; Groner, Y; Harford, J B; Hatzglou, M; He, B; Hellen, C U; Hentze, M W; Hershey, J; Hershey, P; Hohn, T; Holcik, M; Hunter, C P; Igarashi, K; Jackson, R; Jagus, R; Jefferson, L S; Joshi, B; Kaempfer, R; Katze, M; Kaufman, R J; Kiledjian, M; Kimball, S R; Kimchi, A; Kirkegaard, K; Koromilas, A E; Krug, R M; Kruys, V; Lamphear, B J; Lemon, S; Lloyd, R E; Maquat, L E; Martinez-Salas, E; Mathews, M B; Mauro, V P; Miyamoto, S; Mohr, I; Morris, D R; Moss, E G; Nakashima, N; Palmenberg, A; Parkin, N T; Pe'ery, T; Pelletier, J; Peltz, S; Pestova, T V; Pilipenko, E V; Prats, A C; Racaniello, V; Read, G S; Rhoads, R E; Richter, J D; Rivera-Pomar, R; Rouault, T; Sachs, A; Sarnow, P; Scheper, G C; Schiff, L; Schoenberg, D R; Semler, B L; Siddiqui, A; Skern, T; Sonenberg, N; Sossin, W; Standart, N; Tahara, S M; Thomas, A A; Toulme, J J; Wilusz, J; Wimmer, E; Witherell, G; Wormington, M
2001 Dec;21(23):8238-8246, Molecular & cellular biology
— id: 1182252, year: 2001, vol: 21, page: 8238, stat: Journal Article,

New ways of initiating translation in eukaryotes?
Schneider, R; Agol, VI; Andino, R; Bayard, F; Cavener, DR; Chappell, SA; Chen, JJ; Darlix, JLE; Dasgupta, A; Donze, O; Duncan, R; Elroy-Stein, O; Farabaugh, PJ; Filipowicz, W; Gale, M; Gehrke, L; Goldman, E; Groner, Y; Harford, JB; Hatzoglou, M; He, B; Hellen, CUT; Hentze, MW; Hershey, J; Hershey, P; Hohn, T; Holcik, M; Hunter, CP; Igarashi, K; Jackson, R; Jagus, R; Jefferson, LS; Joshi, B; Kaempfer, R; Katze, MG; Kaufman, RJ; Kiledjian, M; Kimball, SR; Kimchi, A; Kirkegaard, K; Koromilas, AE; Krug, RM; Kruys, V; Lamphear, BJ; Lemon, S; Lloyd, RE; Maquat, LE; Martinez-Salas, E; Mathews, MB; Mauro, VP; Miyamoto, S; Mohr, I; Morris, DR; Moss, EG; Nakashima, N; Palmenberg, A; Parkin, NT; Pe'ery, T; Pelletier, J; Peltz, S; Pestova, TV; Pilipenko, EV; Prats, AC; Racaniello, V; Read, GS; Rhoads, RE; Richter, JD; Rivera-Pomar, R; Rouault, T; Sachs, A; Sarnow, P; Scheper, GC; Schiff, L; Schoenberg, DR; Semler, BL; Siddiqui, A; Skern, T; Sonenberg, N; Sossin, W; Standart, N; Tahara, SM; Thomas, AAM; Toulme, JJ; Wilusz, J; Wimmer, E; Witherell, G; Wormington, M
2001 DEC ;21(23):8238-8241, Molecular & cellular biology
— id: 54812, year: 2001, vol: 21, page: 8238, stat: Journal Article,

Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
Taneja S; MacGregor J; Markus S; Ha S; Mohr I
2001 Jul 17;98(15):8804-8808, Proceedings of the National Academy of Sciences of the United States of America
— id: 21150, year: 2001, vol: 98, page: 8804, stat: Journal Article,

Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein
Poppers J; Mulvey M; Khoo D; Mohr I
2000 Dec;74(23):11215-11221, Journal of virology
— id: 39520, year: 2000, vol: 74, page: 11215, stat: Journal Article,

A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function
Mulvey M; Poppers J; Ladd A; Mohr I
1999 Apr;73(4):3375-3385, Journal of virology
— id: 57545, year: 1999, vol: 73, page: 3375, stat: Journal Article,

Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene
He B; Chou J; Brandimarti R; Mohr I; Gluzman Y; Roizman B
1997 Aug;71(8):6049-6054, Journal of virology
— id: 18113, year: 1997, vol: 71, page: 6049, stat: Journal Article,

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function
Mohr I; Gluzman Y
1996 Sep 2;15(17):4759-4766, EMBO journal
— id: 18114, year: 1996, vol: 15, page: 4759, stat: Journal Article,

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase
Park P; Copeland W; Yang L; Wang T; Botchan MR; Mohr IJ
1994 Aug 30;91(18):8700-8704, Proceedings of the National Academy of Sciences of the United States of America
— id: 18115, year: 1994, vol: 91, page: 8700, stat: Journal Article,

Activation of BPV-1 replication in vitro by the transcription factor E2
Yang L; Li R; Mohr IJ; Clark R; Botchan MR
1991 Oct 17;353(6345):628-632, Nature
— id: 18116, year: 1991, vol: 353, page: 628, stat: Journal Article,

Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
Mohr IJ; Clark R; Sun S; Androphy EJ; MacPherson P; Botchan MR
1990 Dec 21;250(4988):1694-1699, Science
— id: 18117, year: 1990, vol: 250, page: 1694, stat: Journal Article,

Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication
Mohr IJ; Fairman MP; Stillman B; Gluzman Y
1989 Oct;63(10):4181-4188, Journal of virology
— id: 18118, year: 1989, vol: 63, page: 4181, stat: Journal Article,

Production of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen
Mohr IJ; Gluzman Y; Fairman MP; Strauss M; McVey D; Stillman B; Gerard RD
1989 Sep;86(17):6479-6483, Proceedings of the National Academy of Sciences of the United States of America
— id: 18119, year: 1989, vol: 86, page: 6479, stat: Journal Article,

Regulation of SV40 DNA replication by phosphorylation of T antigen
Mohr IJ; Stillman B; Gluzman Y
1987 Jan;6(1):153-160, EMBO journal
— id: 18121, year: 1987, vol: 6, page: 153, stat: Journal Article,

Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen
Strauss M; Argani P; Mohr IJ; Gluzman Y
1987 Oct;61(10):3326-3330, Journal of virology