Biosketch / Results /

Panaiyur Mohan, Ph.D.

Assistant Professor;
Department of Psychiatry

Contact Info

Address
140 Old Orangeburg Road
Orangeburg, NY 10962

854-398-5435
Panaiyur.Mohan@nyumc.org

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Education

— 1981-1988 Research Fellow, Joslin Diabetes Center, Boston, MA, PostDoctoral Training
— 1979-1981 Assistant Research Officer, National Institute of Nutrition, India, PostDoctoral Training
1980 — Osmania University, India, Graduate Education

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Research Summary

My research aims to understand the role of proteases in the pathogenesis of dege nerative diseases. Proteases play an important role in the cascade of events lea ding to cell death. Abnormal processing of proteins is an early event in several major degenerative disorders. We are particularly interested in characterizing the role of calpains (calcium-activated proteases) in Alzheimer's disease (AD) and Parkinson's disease (PD) and in understanding the interplay among the calpai n, caspase and cathepsin proteolytic systems in programmed cell death. I use bo th biochemical and immunochemical techniques to study proteases in postmortem hu man and animal tissues and in cell culture models. These studies also focus on t he regulation of endogenous inhibitors that modulate the activities of the prote ases. Based on our discovery of elevated lysosomal hydrolases in CSF of AD pati ents, we are developing a diagnostic test for Alzheimer's disease. I am current ly developing a sensitive assay for cathepsin D, a lysosomal enzyme especially e levated in AD brain and cerebrospinal fluid (CSF). The assay in conjunction with other available markers in CSF, such as tau protein and amyloid ( peptide, will yield a profile with increased detection sensitivity.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain
Subbanna, Shivakumar; Shivakumar, Madhu; Umapathy, Nagavedi S; Saito, Mariko; Mohan, Panaiyur S; Kumar, Asok; Nixon, Ralph A; Verin, Alexander D; Psychoyos, Delphine; Basavarajappa, Balapal S
2013 Jun;54:475-485, Neurobiology of disease
— id: 369642, year: 2013, vol: 54, page: 475, stat: Journal Article,

The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum (ER) Content and Distribution within Axons
Rao, Mala V; Mohan, Panaiyur S; Kumar, Asok; Yuan, Aidong; Montagna, Lee; Campbell, Jabbar; Espreafico, Enilza M; Julien, Jean P; Nixon, Ralph A
2011 ;6(2):e17087-e17087, PLoS one
— id: 126479, year: 2011, vol: 6, page: e17087, stat: Journal Article,

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel W; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jul 1;7(7):788-789, Autophagy
— id: 134440, year: 2011, vol: 7, page: 788, stat: Journal Article,

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jan;134(Pt 1):258-277, Brain
— id: 126481, year: 2011, vol: 134, page: 258, stat: Journal Article,

Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy
Kaur, Gurjinder; Mohan, Panaiyur; Pawlik, Monika; DeRosa, Steven; Fajiculay, Jay; Che, Shaoli; Grubb, Anders; Ginsberg, Stephen D; Nixon, Ralph A; Levy, Efrat
2010 Nov;177(5):2256-2267, American journal of pathology
— id: 126484, year: 2010, vol: 177, page: 2256, stat: Journal Article,

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A
2010 Jun 25;141(7):1146-1158, Cell
— id: 126485, year: 2010, vol: 141, page: 1146, stat: Journal Article,

Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines
Tizon, Belen; Sahoo, Susmita; Yu, Haung; Gauthier, Sebastien; Kumar, Asok R; Mohan, Panaiyur; Figliola, Matthew; Pawlik, Monika; Grubb, Anders; Uchiyama, Yasuo; Bandyopadhyay, Urmi; Cuervo, Ana Maria; Nixon, Ralph A; Levy, Efrat
2010 ;5(3):e9819-e9819, PLoS one
— id: 109506, year: 2010, vol: 5, page: e9819, stat: Journal Article,

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
Rao, Mala V; Mohan, Panaiyur S; Peterhoff, Corrinne M; Yang, Dun-Sheng; Schmidt, Stephen D; Stavrides, Philip H; Campbell, Jabbar; Chen, Yuanxin; Jiang, Ying; Paskevich, Peter A; Cataldo, Anne M; Haroutunian, Vahram; Nixon, Ralph A
2008 Nov 19;28(47):12241-12254, Journal of neuroscience
— id: 94362, year: 2008, vol: 28, page: 12241, stat: Journal Article,

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes
Vadasz, C; Smiley, J F; Figarsky, K; Saito, M; Toth, R; Gyetvai, B M; Oros, M; Kovacs, K K; Mohan, P; Wang, R
2007 Nov 9;149(3):561-572, Neuroscience
— id: 75475, year: 2007, vol: 149, page: 561, stat: Journal Article,

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W Haung; Cuervo, Ana Maria; Kumar, Asok; Peterhoff, Corrinne M; Schmidt, Stephen D; Lee, Ju-Hyun; Mohan, Panaiyur S; Mercken, Marc; Farmery, Mark R; Tjernberg, Lars O; Jiang, Ying; Duff, Karen; Uchiyama, Yasuo; Naslund, Jan; Mathews, Paul M; Cataldo, Anne M; Nixon, Ralph A
2005 Oct 10;171(1):87-98, Journal of cell biology
— id: 60255, year: 2005, vol: 171, page: 87, stat: Journal Article,

Autophagy in Alzheimer's disease pathogenesis
Nixon, RA; Yu, WH; Cuervo, AM; Cataldo, AM; Mathews, PM; Yang, DS; Zheng, P; Peterhoff, CM; Kumar, A; Jiang, Y; Peterson, J; Schmidt, SD; Mohan, P; Duff, K; Hassinger, L; Wegiel, J; Lamb, B
2004 JUL ;25(10):S70-S71, Neurobiology of aging
— id: 47716, year: 2004, vol: 25, page: S70, stat: Journal Article,

AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis
Ping, Z; Jiang, Y; Mohan, PS; Mathews, PM; Nixon, RA
2004 JUL ;25(10):S438-S438, Neurobiology of aging
— id: 47739, year: 2004, vol: 25, page: S438, stat: Journal Article,

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
Veeranna; Kaji T; Boland B; Odrljin T; Mohan P; Basavarajappa BS; Peterhoff C; Cataldo A; Rudnicki A; Amin N; Li BS; Pant HC; Hungund BL; Arancio O; Nixon RA
2004 Oct;165(3):795-805, American journal of pathology
— id: 46128, year: 2004, vol: 165, page: 795, stat: Journal Article,

Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimer's disease
Veeranna; Kaji, T; Boland, B; Odrljin, T; Mohan, P; Basavarajappa, BS; Peterhoff, C; Cataldo, AM; Rudnicki, A; Li, BS; Pant, HC; Hungund, BL; Arancio, O; Nixon, RA
2004 JUL ;25(10):S173-S173, Neurobiology of aging
— id: 47723, year: 2004, vol: 25, page: S173, stat: Journal Article,

Calpain activation in neurodegenerative diseases
Adamec, E; Mohan, P; Nixon, RA; Vonsattel, JP
2002 Jul-Aug;23(1S):S245- Abstract #918, Neurobiology of aging
— id: 32421, year: 2002, vol: 23, page: S245, stat: Journal Article,

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2
Adamec, Emil; Mohan, Panaiyur; Vonsattel, Jean P; Nixon, Ralph A
2002 Jul;104(1):92-104, Acta neuropathologica
— id: 32532, year: 2002, vol: 104, page: 92, stat: Journal Article,

AUTOPHAGY IN ALZHEIMER'S DISEASE: AUTOPHAGY - DEPENDENT GENERATION OF THE AMYLOID beta ( Abeta ) PEPTIDE
Nixon, R. A.; Yu, W. H.; Cataldo, A. M.; Mathews, P. M.; Wegiel, J.; Schmidt, S. D.; Ginsberg, S. D.; Peterhoff, C. M.; Terio, N.; Mohan, P.; Hassinger, L.; Kumar, A.; Lamb, B.
2002 ;2002:?-? #624.11, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 458992, year: 2002, vol: 2002, page: ?, stat: Journal Article,

Autophagic cell death: Relevance to Alzheimer disease neurodegeneration
Nixon, RA; Mathews, PM; Ginsberg, SD; Duff, K; Mohan, P; Cataldo, AM; Wegiel, J; Yu, WH; Schmidt, SD; Jacobsen, SP; Peterhoff, CM; Terio, N; Keller, JN; Hassinger, L
2002 Jul-Aug;23:S415-S416, Neurobiology of aging
— id: 32429, year: 2002, vol: 23, page: S415, stat: Journal Article,

Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density
Rao, Mala V; Engle, Linda J; Mohan, Panaiyur S; Yuan, Aidong; Qiu, Dike; Cataldo, Anne; Hassinger, Linda; Jacobsen, Stephen; Lee, Virginia M-Y; Andreadis, Athena; Julien, Jean-Pierre; Bridgman, Paul C; Nixon, Ralph A
2002 Oct 28;159(2):279-290, Journal of cell biology
— id: 32536, year: 2002, vol: 159, page: 279, stat: Journal Article,

In vivo perturbation of lysosomal function promotes neurodegeneration in the PS1m146V/APPPK67ON,M671L mouse model of Alzheimer's disease pathology
Nixon RA; Mathews PM; Cataldo AM; Mohan PS; Schmidt SD; Duff K; Berg M; Marks N; Peterhoff C; Sershen H
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2654, year: 2001, vol: , page: , stat: Chapter,

Experimental aging of the lysosomal system promotes neurodegeneration in the PS/APP mouse model of Alzheimer's disease pathology
Nixon, R. A.; Mathews, P. M.; Cataldo, A. M.; Mohan, P. S.; Marks, N.; Duff, K.; Berg, M.; Schmidt, S. D.; Jacobsen, S. P.; Jiang, Y.; Sershen, H.
2001 ;27(1):925-925, Abstracts (Society for Neuroscience)
— id: 115690, year: 2001, vol: 27, page: 925, stat: Journal Article,

Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease
Adamec E; Mohan PS; Cataldo AM; Vonsattel JP; Nixon RA
2000 ;100(3):663-675, Neuroscience
— id: 24717, year: 2000, vol: 100, page: 663, stat: Journal Article,

The lysosomal system and neurodegeneration in Alzheimer disease and related disorders
Nixon, R; Mathews, P; Cataldo, A; Mohan, P; Yang, A; Adamec, E; Duff, K
2000 FEB ;74(2):S42-S42, Journal of neurochemistry
— id: 54744, year: 2000, vol: 74, page: S42, stat: Journal Article,

Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation
Sanchez I; Hassinger L; Sihag RK; Cleveland DW; Mohan P; Nixon RA
2000 Nov 27;151(5):1013-1024, Journal of cell biology
— id: 24723, year: 2000, vol: 151, page: 1013, stat: Journal Article,

Calpain modulates secretion of soluble APP in human retinoblastoma (Y-79) cells
Mohan, P S; Terio, N; Achilleos, M; Nixon, R A
1999 Oct 23-28;25(1-2):1105-1105, Abstracts (Society for Neuroscience)
— id: 15847, year: 1999, vol: 25, page: 1105, stat: Journal Article,

Calpains in the pathogenesis of Alzheimer's disease
Nixon RA; Mohan PS
Calpain: pharmacology and toxicology of calcium-dependent protease Philadelphia : Taylor & Francis, 1999,
— id: 2660, year: 1999, vol: , page: 267, stat: Chapter,

Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis
Wang KK; Posmantur R; Nadimpalli R; Nath R; Mohan P; Nixon RA; Talanian RV; Keegan M; Herzog L; Allen H
1998 Aug 15;356(2):187-196, Archives of biochemistry & biophysics. ABB
— id: 7948, year: 1998, vol: 356, page: 187, stat: Journal Article,

Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system
Grynspan F; Griffin WB; Mohan PS; Shea TB; Nixon RA
1997 May 1;48(3):181-191, Journal of neuroscience research
— id: 24718, year: 1997, vol: 48, page: 181, stat: Journal Article,

Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity
Compaine A; Schein JD; Tabb JS; Mohan PS; Nixon RA
1995 Oct-Nov;27(4-5):385-396, Neurochemistry international
— id: 24719, year: 1995, vol: 27, page: 385, stat: Journal Article,

Proteolysis of protein kinase C: mM and microM calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M
Cressman CM; Mohan PS; Nixon RA; Shea TB
1995 Jul 3;367(3):223-227, FEBS letters
— id: 24720, year: 1995, vol: 367, page: 223, stat: Journal Article,

Purification and properties of high molecular weight calpastatin from bovine brain
Mohan PS; Nixon RA
1995 Feb;64(2):859-866, Journal of neurochemistry
— id: 24721, year: 1995, vol: 64, page: 859, stat: Journal Article,

Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease
Schwagerl AL; Mohan PS; Cataldo AM; Vonsattel JP; Kowall NW; Nixon RA
1995 Jan;64(1):443-446, Journal of neurochemistry
— id: 24722, year: 1995, vol: 64, page: 443, stat: Journal Article,

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease
Nixon RA; Saito KI; Grynspan F; Griffin WR; Katayama S; Honda T; Mohan PS; Shea TB; Beermann M
1994 Dec 15;747(3):77-91, Annals of the New York Academy of Sciences
— id: 25180, year: 1994, vol: 747, page: 77, stat: Journal Article,