Biosketch / Results /

Panaiyur Mohan, Ph.D.

Assistant Professor;
Department of Psychiatry

Contact Info

Address
140 Old Orangeburg Road
Orangeburg, NY 10962

854-398-5435
Panaiyur.Mohan@nyumc.org

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Education

— 1981-1988 Research Fellow, Joslin Diabetes Center, Boston, MA, PostDoctoral Training
— 1979-1981 Assistant Research Officer, National Institute of Nutrition, India, PostDoctoral Training
1980 — Osmania University, India, Graduate Education

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain
Subbanna, Shivakumar; Shivakumar, Madhu; Umapathy, Nagavedi S; Saito, Mariko; Mohan, Panaiyur S; Kumar, Asok; Nixon, Ralph A; Verin, Alexander D; Psychoyos, Delphine; Basavarajappa, Balapal S
2013 Jun;54:475-485, Neurobiology of disease
— id: 369642, year: 2013, vol: 54, page: 475, stat: Journal Article,

The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum (ER) Content and Distribution within Axons
Rao, Mala V; Mohan, Panaiyur S; Kumar, Asok; Yuan, Aidong; Montagna, Lee; Campbell, Jabbar; Espreafico, Enilza M; Julien, Jean P; Nixon, Ralph A
2011 ;6(2):e17087-e17087, PLoS one
— id: 126479, year: 2011, vol: 6, page: e17087, stat: Journal Article,

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel W; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jul 1;7(7):788-789, Autophagy
— id: 134440, year: 2011, vol: 7, page: 788, stat: Journal Article,

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jan;134(Pt 1):258-277, Brain
— id: 126481, year: 2011, vol: 134, page: 258, stat: Journal Article,

Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy
Kaur, Gurjinder; Mohan, Panaiyur; Pawlik, Monika; DeRosa, Steven; Fajiculay, Jay; Che, Shaoli; Grubb, Anders; Ginsberg, Stephen D; Nixon, Ralph A; Levy, Efrat
2010 Nov;177(5):2256-2267, American journal of pathology
— id: 126484, year: 2010, vol: 177, page: 2256, stat: Journal Article,

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A
2010 Jun 25;141(7):1146-1158, Cell
— id: 126485, year: 2010, vol: 141, page: 1146, stat: Journal Article,

Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines
Tizon, Belen; Sahoo, Susmita; Yu, Haung; Gauthier, Sebastien; Kumar, Asok R; Mohan, Panaiyur; Figliola, Matthew; Pawlik, Monika; Grubb, Anders; Uchiyama, Yasuo; Bandyopadhyay, Urmi; Cuervo, Ana Maria; Nixon, Ralph A; Levy, Efrat
2010 ;5(3):e9819-e9819, PLoS one
— id: 109506, year: 2010, vol: 5, page: e9819, stat: Journal Article,

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
Rao, Mala V; Mohan, Panaiyur S; Peterhoff, Corrinne M; Yang, Dun-Sheng; Schmidt, Stephen D; Stavrides, Philip H; Campbell, Jabbar; Chen, Yuanxin; Jiang, Ying; Paskevich, Peter A; Cataldo, Anne M; Haroutunian, Vahram; Nixon, Ralph A
2008 Nov 19;28(47):12241-12254, Journal of neuroscience
— id: 94362, year: 2008, vol: 28, page: 12241, stat: Journal Article,

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes
Vadasz, C; Smiley, J F; Figarsky, K; Saito, M; Toth, R; Gyetvai, B M; Oros, M; Kovacs, K K; Mohan, P; Wang, R
2007 Nov 9;149(3):561-572, Neuroscience
— id: 75475, year: 2007, vol: 149, page: 561, stat: Journal Article,

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W Haung; Cuervo, Ana Maria; Kumar, Asok; Peterhoff, Corrinne M; Schmidt, Stephen D; Lee, Ju-Hyun; Mohan, Panaiyur S; Mercken, Marc; Farmery, Mark R; Tjernberg, Lars O; Jiang, Ying; Duff, Karen; Uchiyama, Yasuo; Naslund, Jan; Mathews, Paul M; Cataldo, Anne M; Nixon, Ralph A
2005 Oct 10;171(1):87-98, Journal of cell biology
— id: 60255, year: 2005, vol: 171, page: 87, stat: Journal Article,

Autophagy in Alzheimer's disease pathogenesis
Nixon, RA; Yu, WH; Cuervo, AM; Cataldo, AM; Mathews, PM; Yang, DS; Zheng, P; Peterhoff, CM; Kumar, A; Jiang, Y; Peterson, J; Schmidt, SD; Mohan, P; Duff, K; Hassinger, L; Wegiel, J; Lamb, B
2004 JUL ;25(10):S70-S71, Neurobiology of aging
— id: 47716, year: 2004, vol: 25, page: S70, stat: Journal Article,

AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis
Ping, Z; Jiang, Y; Mohan, PS; Mathews, PM; Nixon, RA
2004 JUL ;25(10):S438-S438, Neurobiology of aging
— id: 47739, year: 2004, vol: 25, page: S438, stat: Journal Article,

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
Veeranna; Kaji T; Boland B; Odrljin T; Mohan P; Basavarajappa BS; Peterhoff C; Cataldo A; Rudnicki A; Amin N; Li BS; Pant HC; Hungund BL; Arancio O; Nixon RA
2004 Oct;165(3):795-805, American journal of pathology
— id: 46128, year: 2004, vol: 165, page: 795, stat: Journal Article,

Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimer's disease
Veeranna; Kaji, T; Boland, B; Odrljin, T; Mohan, P; Basavarajappa, BS; Peterhoff, C; Cataldo, AM; Rudnicki, A; Li, BS; Pant, HC; Hungund, BL; Arancio, O; Nixon, RA
2004 JUL ;25(10):S173-S173, Neurobiology of aging
— id: 47723, year: 2004, vol: 25, page: S173, stat: Journal Article,

Calpain activation in neurodegenerative diseases
Adamec, E; Mohan, P; Nixon, RA; Vonsattel, JP
2002 Jul-Aug;23(1S):S245- Abstract #918, Neurobiology of aging
— id: 32421, year: 2002, vol: 23, page: S245, stat: Journal Article,

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2
Adamec, Emil; Mohan, Panaiyur; Vonsattel, Jean P; Nixon, Ralph A
2002 Jul;104(1):92-104, Acta neuropathologica
— id: 32532, year: 2002, vol: 104, page: 92, stat: Journal Article,

AUTOPHAGY IN ALZHEIMER'S DISEASE: AUTOPHAGY - DEPENDENT GENERATION OF THE AMYLOID beta ( Abeta ) PEPTIDE
Nixon, R. A.; Yu, W. H.; Cataldo, A. M.; Mathews, P. M.; Wegiel, J.; Schmidt, S. D.; Ginsberg, S. D.; Peterhoff, C. M.; Terio, N.; Mohan, P.; Hassinger, L.; Kumar, A.; Lamb, B.
2002 ;2002:?-? #624.11, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 458992, year: 2002, vol: 2002, page: ?, stat: Journal Article,

Autophagic cell death: Relevance to Alzheimer disease neurodegeneration
Nixon, RA; Mathews, PM; Ginsberg, SD; Duff, K; Mohan, P; Cataldo, AM; Wegiel, J; Yu, WH; Schmidt, SD; Jacobsen, SP; Peterhoff, CM; Terio, N; Keller, JN; Hassinger, L
2002 Jul-Aug;23:S415-S416, Neurobiology of aging
— id: 32429, year: 2002, vol: 23, page: S415, stat: Journal Article,

Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density
Rao, Mala V; Engle, Linda J; Mohan, Panaiyur S; Yuan, Aidong; Qiu, Dike; Cataldo, Anne; Hassinger, Linda; Jacobsen, Stephen; Lee, Virginia M-Y; Andreadis, Athena; Julien, Jean-Pierre; Bridgman, Paul C; Nixon, Ralph A
2002 Oct 28;159(2):279-290, Journal of cell biology
— id: 32536, year: 2002, vol: 159, page: 279, stat: Journal Article,

In vivo perturbation of lysosomal function promotes neurodegeneration in the PS1m146V/APPPK67ON,M671L mouse model of Alzheimer's disease pathology
Nixon RA; Mathews PM; Cataldo AM; Mohan PS; Schmidt SD; Duff K; Berg M; Marks N; Peterhoff C; Sershen H
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2654, year: 2001, vol: , page: , stat: Chapter,

Experimental aging of the lysosomal system promotes neurodegeneration in the PS/APP mouse model of Alzheimer's disease pathology
Nixon, R. A.; Mathews, P. M.; Cataldo, A. M.; Mohan, P. S.; Marks, N.; Duff, K.; Berg, M.; Schmidt, S. D.; Jacobsen, S. P.; Jiang, Y.; Sershen, H.
2001 ;27(1):925-925, Abstracts (Society for Neuroscience)
— id: 115690, year: 2001, vol: 27, page: 925, stat: Journal Article,

Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease
Adamec E; Mohan PS; Cataldo AM; Vonsattel JP; Nixon RA
2000 ;100(3):663-675, Neuroscience
— id: 24717, year: 2000, vol: 100, page: 663, stat: Journal Article,

The lysosomal system and neurodegeneration in Alzheimer disease and related disorders
Nixon, R; Mathews, P; Cataldo, A; Mohan, P; Yang, A; Adamec, E; Duff, K
2000 FEB ;74(2):S42-S42, Journal of neurochemistry
— id: 54744, year: 2000, vol: 74, page: S42, stat: Journal Article,

Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation
Sanchez I; Hassinger L; Sihag RK; Cleveland DW; Mohan P; Nixon RA
2000 Nov 27;151(5):1013-1024, Journal of cell biology
— id: 24723, year: 2000, vol: 151, page: 1013, stat: Journal Article,

Calpain modulates secretion of soluble APP in human retinoblastoma (Y-79) cells
Mohan, P S; Terio, N; Achilleos, M; Nixon, R A
1999 Oct 23-28;25(1-2):1105-1105, Abstracts (Society for Neuroscience)
— id: 15847, year: 1999, vol: 25, page: 1105, stat: Journal Article,

Calpains in the pathogenesis of Alzheimer's disease
Nixon RA; Mohan PS
Calpain: pharmacology and toxicology of calcium-dependent protease Philadelphia : Taylor & Francis, 1999,
— id: 2660, year: 1999, vol: , page: 267, stat: Chapter,

Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis
Wang KK; Posmantur R; Nadimpalli R; Nath R; Mohan P; Nixon RA; Talanian RV; Keegan M; Herzog L; Allen H
1998 Aug 15;356(2):187-196, Archives of biochemistry & biophysics. ABB
— id: 7948, year: 1998, vol: 356, page: 187, stat: Journal Article,

Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system
Grynspan F; Griffin WB; Mohan PS; Shea TB; Nixon RA
1997 May 1;48(3):181-191, Journal of neuroscience research
— id: 24718, year: 1997, vol: 48, page: 181, stat: Journal Article,

Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity
Compaine A; Schein JD; Tabb JS; Mohan PS; Nixon RA
1995 Oct-Nov;27(4-5):385-396, Neurochemistry international
— id: 24719, year: 1995, vol: 27, page: 385, stat: Journal Article,

Proteolysis of protein kinase C: mM and microM calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M
Cressman CM; Mohan PS; Nixon RA; Shea TB
1995 Jul 3;367(3):223-227, FEBS letters
— id: 24720, year: 1995, vol: 367, page: 223, stat: Journal Article,

Purification and properties of high molecular weight calpastatin from bovine brain
Mohan PS; Nixon RA
1995 Feb;64(2):859-866, Journal of neurochemistry
— id: 24721, year: 1995, vol: 64, page: 859, stat: Journal Article,

Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease
Schwagerl AL; Mohan PS; Cataldo AM; Vonsattel JP; Kowall NW; Nixon RA
1995 Jan;64(1):443-446, Journal of neurochemistry
— id: 24722, year: 1995, vol: 64, page: 443, stat: Journal Article,

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease
Nixon RA; Saito KI; Grynspan F; Griffin WR; Katayama S; Honda T; Mohan PS; Shea TB; Beermann M
1994 Dec 15;747(3):77-91, Annals of the New York Academy of Sciences
— id: 25180, year: 1994, vol: 747, page: 77, stat: Journal Article,