Paolo G Mignatti

Biosketch / Results /

Paolo G Mignatti, M.D.

Associate Professor;
Departments of Medicine (Rheum Div) and Cell Biology (Cell Biology)

Contact Info

Address
550 First Avenue
Floor 15 Room W 16
New Bellevue
New York, NY 10016

212-598-7642
212-263-3161
Paolo.Mignatti@nyumc.org

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Research Summary

See pdf file attached.

Research Interests

Growth factors and proteinases in tumor invasion and angiogenesis.

Research Keywords

endothelial cells, fibroblast growth factor, vascular endothelial growth factor, angiogenesis

Research Documents

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

PKC? activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting
Monti, M; Donnini, S; Morbidelli, L; Giachetti, A; Mochly-Rosen, D; Mignatti, P; Ziche, M
2013 ;63:107-117, Journal of molecular & cellular cardiology
— id: 784922, year: 2013, vol: 63, page: 107, stat: Journal Article,

PKCepsilon activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting
Monti, Martina; Donnini, Sandra; Morbidelli, Lucia; Giachetti, Antonio; Mochly-Rosen, Daria; Mignatti, Paolo; Ziche, Marina
2013 Oct;63:107-117, Journal of molecular & cellular cardiology
— id: 612352, year: 2013, vol: 63, page: 107, stat: Journal Article,

TGF-beta1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38beta to Proapoptotic p38alpha
Ferrari, Giovanni; Terushkin, Vitaly; Wolff, Martin J; Zhang, Xiaodong; Valacca, Cristina; Poggio, Paolo; Pintucci, Giuseppe; Mignatti, Paolo
2012 May;10(5):605-614, Molecular cancer research
— id: 167501, year: 2012, vol: 10, page: 605, stat: Journal Article,

TGF-beta1 induces endothelial cell apoptosis by shifting VEGF activation of p38MAPK from the pro-survival p38 beta to pro-apoptotic p38 alpha
Mignatti, P; Ferrari, G; Terushkin, V; Wolff, M J; Zhang, X; Pintucci, G
2010 15 Dec 2010;21(24):-, Molecular biology of the cell
— id: 157723, year: 2010, vol: 21, page: , stat: Journal Article,

VEGFb, a splicing isoform of vascular endothelial growth factor, mediates induction of endothelial cell apoptosis by transforming growth factor-beta 1 (TGF-beta1)
Mignatti, P; Valacca, C
2010 15 Dec 2010;21(24):-, Molecular biology of the cell
— id: 157726, year: 2010, vol: 21, page: , stat: Journal Article,

Protein targets of inflammatory serine proteases and cardiovascular disease
Sharony, Ram; Yu, Pey-Jen; Park, Joy; Galloway, Aubrey C; Mignatti, Paolo; Pintucci, Giuseppe
2010 ;7:45-45, Journal of inflammation (London, England)
— id: 156190, year: 2010, vol: 7, page: 45, stat: Journal Article,

Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis
Ferrari, Giovanni; Cook, Brandoch D; Terushkin, Vitaly; Pintucci, Giuseppe; Mignatti, Paolo
2009 May;219(2):449-458, Journal of cellular physiology
— id: 97035, year: 2009, vol: 219, page: 449, stat: Journal Article,

Topical Mitogen-Activated Protein Kinases Inhibition Reduces Intimal Hyperplasia in Arterialized Vein Grafts
Gulkarov, Iosif; Bohmann, Katja; Cinnante, Karma M; Pirelli, Luigi; Yu, Pey-Jen; Grau, Juan B; Pintucci, Giuseppe; Galloway, Aubrey C; Mignatti, Paolo
2009 Jun 1;154(1):150-156, Journal of surgical research
— id: 96446, year: 2009, vol: 154, page: 150, stat: Journal Article,

Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3
Kallenbach, Klaus; Salcher, Rolf; Heim, Albert; Karck, Matthias; Mignatti, Paolo; Haverich, Axel
2009 Mar;49(3):750-758, Journal of vascular surgery
— id: 135230, year: 2009, vol: 49, page: 750, stat: Journal Article,

Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosis
Yu, Pey-Jen; Skolnick, Adam; Ferrari, Giovanni; Heretis, Katherine; Mignatti, Paolo; Pintucci, Giuseppe; Rosenzweig, Barry; Diaz-Cartelle, Juan; Kronzon, Itzhak; Perk, Gila; Pass, Harvey I; Galloway, Aubrey C; Grossi, Eugene A; Grau, Juan B
2009 Jul;138(1):196-199, Journal of thoracic & cardiovascular surgery
— id: 100629, year: 2009, vol: 138, page: 196, stat: Journal Article,

TGF-?1 induces rearrangement of FLK-1-VE-cadherin-?-catenin complex at the adherens junction through VEGF-mediated signaling
Cook, BD; Ferrari, G; Pintucci, G; Mignatti, P
2008 ;105(6):1367-1373, Journal of cellular biochemistry
— id: 652792, year: 2008, vol: 105, page: 1367, stat: Journal Article,

TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling
Cook, Brandoch D; Ferrari, Giovanni; Pintucci, Giuseppe; Mignatti, Paolo
2008 Dec 15;105(6):1367-1373, Journal of cellular biochemistry
— id: 92170, year: 2008, vol: 105, page: 1367, stat: Journal Article,

Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
D'Alessio, Silvia; Ferrari, Giovanni; Cinnante, Karma; Scheerer, William; Galloway, Aubrey C; Roses, Daniel F; Rozanov, Dmitri V; Remacle, Albert G; Oh, Eok-Soo; Shiryaev, Sergey A; Strongin, Alex Y; Pintucci, Giuseppe; Mignatti, Paolo
2008 Jan 4;283(1):87-99, Journal of biological chemistry
— id: 79292, year: 2008, vol: 283, page: 87, stat: Journal Article,

Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2): a novel mechanism for the control of FGF-2 and thrombin activity
Yu, P-J; Ferrari, G; Pirelli, L; Galloway, A C; Mignatti, P; Pintucci, G
2008 Apr 17;27(18):2594-2601, Oncogene
— id: 79088, year: 2008, vol: 27, page: 2594, stat: Journal Article,

TGF-beta 1 induced angiogenesis follows a time dependent sequence: apoptosis precedes cellular proliferation
Terushkin, Vitaly; Mignatti, Paolo
2007 ;1:33-33, Probe: the publication of research on biomedical endeavors
— id: 75324, year: 2007, vol: 1, page: 33, stat: Journal Article,

Basic fibroblast growth factor (FGF-2): the high molecular weight forms come of age
Yu, Pey-Jen; Ferrari, Giovanni; Galloway, Aubrey C; Mignatti, Paolo; Pintucci, Giuseppe
2007 Apr 1;100(5):1100-1108, Journal of cellular biochemistry
— id: 72034, year: 2007, vol: 100, page: 1100, stat: Journal Article,

Vascular injury and modulation of MAPKs: A targeted approach to therapy of restenosis
Yu, Pey-Jen; Ferrari, Giovanni; Pirelli, Luigi; Gulkarov, Iosif; Galloway, Aubrey C; Mignatti, Paolo; Pintucci, Giuseppe
2007 Jul;19(7):1359-1371, Cellular signalling
— id: 72033, year: 2007, vol: 19, page: 1359, stat: Journal Article,

VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis
Ferrari, Giovanni; Pintucci, Giuseppe; Seghezzi, Graziano; Hyman, Kevin; Galloway, Aubrey C; Mignatti, Paolo
2006 Nov 14;103(46):17260-17265, Proceedings of the National Academy of Sciences of the United States of America
— id: 69698, year: 2006, vol: 103, page: 17260, stat: Journal Article,

Mechanisms of c-reactive protein up-regulation in arterialized vein grafts
Gulkarov, Iosif; Pintucci, Giuseppe; Bohmann, Katja; Saunders, Paul C; Sullivan, Raymond F; Ferrari, Giovanni; Mignatti, Paolo; Galloway, Aubrey C
2006 Feb;139(2):254-262, Surgery
— id: 72035, year: 2006, vol: 139, page: 254, stat: Journal Article,

Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts
Pintucci, Giuseppe; Saunders, Paul C; Gulkarov, Iosif; Sharony, Ram; Kadian-Dodov, Daniella L; Bohmann, Katja; Baumann, F Gregory; Galloway, Aubrey C; Mignatti, Paolo
2006 Feb;20(2):398-400, FASEB journal
— id: 62809, year: 2006, vol: 20, page: 398, stat: Journal Article,

Inhibition of mitogen-activated protein kinases (MAPKs) as a strategy to prevent intimal hyperplasia following cardiovascular interventions
Pirelli L; Yu P-J; Gulkarov I; Galloway AC; Mignatti P; Pintucci G
2006 ;3(3):173-183, Vascular Disease Prevention
— id: 67520, year: 2006, vol: 3, page: 173, stat: Journal Article,

Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2
Sharony, Ram; Pintucci, Giuseppe; Saunders, Paul C; Grossi, Eugene A; Baumann, F Gregory; Galloway, Aubrey C; Mignatti, Paolo
2006 Apr;290(4):H1651-H1659, American journal of physiology. Heart & circulatory physiology
— id: 72036, year: 2006, vol: 290, page: H1651, stat: Journal Article,

Proteases and extracellular environment
Del Rosso, M; Fibbi, G; Schmitt, M; Mignatti, P
2005 FEB ;93(2):190-191, Thrombosis & haemostasis
— id: 48670, year: 2005, vol: 93, page: 190, stat: Journal Article,

PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus
Pintucci, Giuseppe; Yu, Pey-Jen; Saponara, Fiorella; Kadian-Dodov, Daniella L; Galloway, Aubrey C; Mignatti, Paolo
2005 Aug 15;95(6):1292-1300, Journal of cellular biochemistry
— id: 56377, year: 2005, vol: 95, page: 1292, stat: Journal Article,

Vein graft arterialization causes differential activation of mitogen-activated protein kinases
Saunders, Paul C; Pintucci, Giuseppe; Bizekis, Costas S; Sharony, Ram; Hyman, Kevin M; Saponara, Fiorella; Baumann, F Gregory; Grossi, Eugene A; Colvin, Stephen B; Mignatti, Paolo; Galloway, Aubrey C
2004 May;127(5):1276-1284, Journal of thoracic & cardiovascular surgery
— id: 45314, year: 2004, vol: 127, page: 1276, stat: Journal Article,

Activation of mitogen-activated protein kinases during preparation of vein grafts and modulation by a synthetic inhibitor
Bizekis, Costas; Pintucci, Giuseppe; Derivaux, Christopher C; Saponara, Fiorella; Kim, Jin-Hee; Hyman, Kevin M; Sharony, Ram; Grossi, Eugene A; Baumann, F Gregory; Mignatti, Paolo; Galloway, Aubrey C
2003 Sep;126(3):659-665, Journal of thoracic & cardiovascular surgery
— id: 156047, year: 2003, vol: 126, page: 659, stat: Journal Article,

A quantitative in vitro model of smooth muscle cell migration through the arterial wall using the human amniotic membrane
Kallenbach, Klaus; Fernandez, Harold A; Seghezzi, Graziano; Baumann, F Gregory; Patel, Sundeep; Grossi, Eugene A; Galloway, Aubrey C; Mignatti, Paolo
2003 Jun 1;23(6):1008-1013, Arteriosclerosis, thrombosis, & vascular biology
— id: 39254, year: 2003, vol: 23, page: 1008, stat: Journal Article,

Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2-/- microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2)
Pintucci, Giuseppe; Yu, Pey-Jen; Sharony, Ram; Baumann, F Gregory; Saponara, Fiorella; Frasca, Antonio; Galloway, Aubrey C; Moscatelli, David; Mignatti, Paolo
2003 Dec 1;90(5):1015-1025, Journal of cellular biochemistry
— id: 44759, year: 2003, vol: 90, page: 1015, stat: Journal Article,

Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells
Taverna, Simona; Ghersi, Giulio; Ginestra, Angela; Rigogliuso, Salvatrice; Pecorella, Sonia; Alaimo, Giovanna; Saladino, Francesca; Dolo, Vincenza; Dell'Era, Patrizia; Pavan, Antonio; Pizzolanti, Giuseppe; Mignatti, Paolo; Presta, Marco; Vittorelli, Maria Letizia
2003 Dec 19;278(51):51911-51919, Journal of biological chemistry
— id: 134708, year: 2003, vol: 278, page: 51911, stat: Journal Article,

Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF)
Green, D; Rafii, S; Froum, S; Pinnell, J; Mignatti, P; Pintucci, G
2002 NOV 16 ;100(11):681A-681A, Blood
— id: 37109, year: 2002, vol: 100, page: 681A, stat: Journal Article,

Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase
Hyman, Kevin M; Seghezzi, Graziano; Pintucci, Giuseppe; Stellari, Giulia; Kim, Jee Hyun; Grossi, Eugene A; Galloway, Aubrey C; Mignatti, Paolo
2002 Aug;132(2):173-179, Surgery
— id: 33331, year: 2002, vol: 132, page: 173, stat: Journal Article,

Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression
Malhotra, Sandeep; Newman, Elliot; Eisenberg, David; Scholes, John; Wieczorek, Rosemary; Mignatti, Paolo; Shamamian, Peter
2002 Apr;45(4):537-543, Diseases of the colon & rectum
— id: 27560, year: 2002, vol: 45, page: 537, stat: Journal Article,

Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism
Monea, S; Lehti, K; Keski-Oja, J; Mignatti, P
2002 AUG ;192(2):160-170, Journal of cellular physiology
— id: 55301, year: 2002, vol: 192, page: 160, stat: Journal Article,

Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF)
Pintucci, Giuseppe; Froum, Scott; Pinnell, Jared; Mignatti, Paolo; Rafii, Shahin; Green, David
2002 Nov;88(5):834-842, Thrombosis & haemostasis
— id: 156978, year: 2002, vol: 88, page: 834, stat: Journal Article,

Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells
Pintucci, Giuseppe; Moscatelli, David; Saponara, Fiorella; Biernacki, Peter R; Baumann, F Gregory; Bizekis, Costas; Galloway, Aubrey C; Basilico, Claudio; Mignatti, Paolo
2002 Apr;16(6):598-600, FASEB journal
— id: 34522, year: 2002, vol: 16, page: 598, stat: Journal Article,

Trophic effect of platelets on cultured endothelial cells is mediated by FGF-2 and VEGF
Pintucci, G; Froum, S; Rafii, S; Mignatti, P; Green, D
2001 NOV 16 ;98(11):56B-56B, Blood
— id: 55348, year: 2001, vol: 98, page: 56B, stat: Journal Article,

Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis
Shamamian P; Schwartz JD; Pocock BJ; Monea S; Whiting D; Marcus SG; Mignatti P
2001 Nov;189(2):197-206, Journal of cellular physiology
— id: 26640, year: 2001, vol: 189, page: 197, stat: Journal Article,

Depletion of polymorphonuclear neutrophis inhibits angiogenesis in vivo
Chuang N; Shapiro RL; Mignatti P; Roses DF; Shamamian P
2000 ;61:246-248, Surgical forum
— id: 25207, year: 2000, vol: 61, page: 246, stat: Journal Article,

Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis
Liao, F; Li, YW; O'Connor, W; Zanetta, L; Bassi, R; Santiago, A; Overholser, J; Hooper, A; Mignatti, P; Dejana, E; Hicklin, DJ; Bohlen, P
2000 DEC 15 ;60(24):6805-6810, Cancer research
— id: 55256, year: 2000, vol: 60, page: 6805, stat: Journal Article,

Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology
Mignatti P; Rifkin DB
2000 ;78(1):103-157, Advances in cancer research
— id: 27868, year: 2000, vol: 78, page: 103, stat: Journal Article,

Transforming growth factor beta 1 (TGF-b1) induces a growth factor cascade that results in extracellular-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation in endothelial cells
Seghezzi, G; Pintucci, G; Yun, J; Steinberg, BM; Ferdinand, B; Grossi, EA; Baumann, FG; Colvin, SB; Galloway, AC; Mignatti, P
2000 FEB ;35(2):296A-296A, Journal of the American College of Cardiology
— id: 33427, year: 2000, vol: 35, page: 296A, stat: Journal Article,

Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase-dependent tumor cell invasion
Shamamian P; Pocock BJ; Schwartz JD; Monea S; Chuang N; Whiting D; Marcus SG; Galloway AC; Mignatti P
2000 Feb;127(2):142-147, Surgery
— id: 9013, year: 2000, vol: 127, page: 142, stat: Journal Article,

Expression of Von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: a potential method for objective assessment of tumor angiogenesis
Zanetta L; Marcus SG; Vasile J; Dobryansky M; Cohen H; Eng K; Shamamian P; Mignatti P
2000 Jan 15;85(2):281-288, International journal of cancer
— id: 9014, year: 2000, vol: 85, page: 281, stat: Journal Article,

Inhibition of endothelial cell migration by gene transfer of tissue inhibitor of metalloproteinases-1
Fernandez HA; Kallenbach K; Seghezzi G; Grossi E; Colvin S; Schneider R; Mignatti P; Galloway A
1999 Apr;82(2):156-162, Journal of surgical research
— id: 12038, year: 1999, vol: 82, page: 156, stat: Journal Article,

Roles of MT1-MMP in the regulation of cell surface proteolysis
Monea S; Roberts B; Marcus SG; Shamamian P; Mignatti P
1999 Jun 30;878:703-706, Annals of the New York Academy of Sciences
— id: 9016, year: 1999, vol: 878, page: 703, stat: Journal Article,

Mechanical endothelial damage results in basic fibroblast growth factor-mediated activation of extracellular signal-regulated kinases
Pintucci G; Steinberg BM; Seghezzi G; Yun J; Apazidis A; Baumann FG; Grossi EA; Colvin SB; Mignatti P; Galloway AC
1999 Aug;126(2):422-427, Surgery
— id: 8488, year: 1999, vol: 126, page: 422, stat: Journal Article,

Modulation of matrix metalloproteinase activity in human saphenous vein grafts using adenovirus-mediated gene transfer
Fernandez HA; Kallenbach K; Seghezzi G; Mehrara B; Apazidis A; Baumann FG; Grossi EA; Colvin S; Mignatti P; Galloway AC
1998 Aug;124(2):129-136, Surgery
— id: 7562, year: 1998, vol: 124, page: 129, stat: Journal Article,

Roles of MT1-MMP in the regulation of cell surface proteolysis
Monea, S; Roberts, B; Marcus, S; Shamamian, P; Mignatti, P
1998 NOV ;9(11):175A-175A, Molecular biology of the cell
— id: 53644, year: 1998, vol: 9, page: 175A, stat: Journal Article,

Matrix metalloproteinase (MMP) 2 and 9 activity in experimental acute pancreatitis
Patel, S; Schwartz, J; Chaung, N; Marcus, SG; Pachter, HL; Deutsch, E; Galloway, AC; Eng, K; Mignatti, P; Shamamian, P
1998 APR 15 ;114(4):A1416-A1416, Gastroenterology
— id: 53478, year: 1998, vol: 114, page: A1416, stat: Journal Article,

Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice
Ren CJ; Ueda F; Roses DF; Harris MN; Mignatti P; Rifkin DB; Shapiro RL
1998 Jul 1;77(2):126-131, Journal of surgical research
— id: 12076, year: 1998, vol: 77, page: 126, stat: Journal Article,

Soluble factor(s) released from neutrophils activates endothelial cell matrix metalloproteinase-2
Schwartz JD; Monea S; Marcus SG; Patel S; Eng K; Galloway AC; Mignatti P; Shamamian P
1998 Apr;76(1):79-85, Journal of surgical research
— id: 9018, year: 1998, vol: 76, page: 79, stat: Journal Article,

Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase
Schwartz JD; Shamamian P; Monea S; Whiting D; Marcus SG; Galloway AC; Mignatti P
1998 Aug;124(2):232-238, Surgery
— id: 9017, year: 1998, vol: 124, page: 232, stat: Journal Article,

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis
Seghezzi G; Patel S; Ren CJ; Gualandris A; Pintucci G; Robbins ES; Shapiro RL; Galloway AC; Rifkin DB; Mignatti P
1998 Jun 29;141(7):1659-1673, Journal of cell biology
— id: 7787, year: 1998, vol: 141, page: 1659, stat: Journal Article,

Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells
Ginestra A; Monea S; Seghezzi G; Dolo V; Nagase H; Mignatti P; Vittorelli ML
1997 Jul 4;272(27):17216-17222, Journal of biological chemistry
— id: 8328, year: 1997, vol: 272, page: 17216, stat: Journal Article,

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants
Mazzieri R; Masiero L; Zanetta L; Monea S; Onisto M; Garbisa S; Mignatti P
1997 May 1;16(9):2319-2332, EMBO journal
— id: 8327, year: 1997, vol: 16, page: 2319, stat: Journal Article,

Requirement for plasmin and membrane type I matrix metalloproteinase in the cell surface activation of gelatinase A (MMP-2)
Monea, S; Lehti, K; Schwartz, J; Shamamian, P; Marcus, S; Galloway, AC; KeskiOja, J; Mignatti, P
1997 NOV ;8(5):434-434, Molecular biology of the cell
— id: 53159, year: 1997, vol: 8, page: 434, stat: Journal Article,

Activation of endothelial or tumor cell progelatinase A (MMP-2) by human polymorphonuclear neutrophils (PMN)
Schwartz, JD; Monea, S; Shamamian, P; Marcus, SG; Whiting, D; Galloway, AC; Mignatti, P
1997 NOV ;8(5):435-435, Molecular biology of the cell
— id: 53160, year: 1997, vol: 8, page: 435, stat: Journal Article,

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism of angiogenesis
Seghezzi, G; Patel, S; Ren, CJ; Pintucci, G; Gualandris, A; Robbins, E; Shapiro, RL; Galloway, AC; Rifkin, DB; Mignatti, P
1997 NOV ;8(5):1335-1335, Molecular biology of the cell
— id: 53166, year: 1997, vol: 8, page: 1335, stat: Journal Article,

Characterization of different forms of cell-associated matrix metalloproteinase-9 (MMP-9)
Mazzieri, R; Zanetta, L; Monea, S; Galloway, AC; Rifkin, DB; Mignatti, P
1996 DEC ;7(3):350-350, Molecular biology of the cell
— id: 53347, year: 1996, vol: 7, page: 350, stat: Journal Article,

Plasminogen activators and angiogenesis
Mignatti P; Rifkin DB
1996 4 March;213(Pt.1):33-50, Current topics in microbiology & immunology
— id: 42357, year: 1996, vol: 213, page: 33, stat: Journal Article,

Plasminogen activators and matrix metalloproteinases in angiogenesis
Mignatti P; Rifkin DB
1996 ;49(1-3):117-137, Enzyme & protein
— id: 57369, year: 1996, vol: 49, page: 117, stat: Journal Article,

Vesicles shed by tumor cells possess membrane-bound urokinase plasminogen activator and type IV collagenase
Monea, S; Ginestra, A; Seghezzi, G; Vittorelli, ML; Mignatti, P
1996 DEC ;7(3):352-352, Molecular biology of the cell
— id: 53348, year: 1996, vol: 7, page: 352, stat: Journal Article,

Tumor cell-conditioned medium stimulates expression of the urokinase receptor in vascular endothelial cells
Seghezzi, G; Marelli, R; Mandriota, S J; Nolli, M L; Mazzieri, R; Mignatti, P
1996 Nov;169(2):300-308, Journal of cellular physiology
— id: 133234, year: 1996, vol: 169, page: 300, stat: Journal Article,

Autocrine regulation of vascular endothelial growth factor (VEGF) expression by fibroblast growth factor-2 (FGF-2)
Seghezzi, G; Patel, S; Pintucci, G; Galloway, A; Rifkin, D; Mignatti, P
1996 DEC ;7(3):2045-2045, Molecular biology of the cell
— id: 53358, year: 1996, vol: 7, page: 2045, stat: Journal Article,

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms
Bikfalvi A; Klein S; Pintucci G; Quarto N; Mignatti P; Rifkin DB
1995 Apr;129(1):233-243, Journal of cell biology
— id: 6578, year: 1995, vol: 129, page: 233, stat: Journal Article,

Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
Mandriota SJ; Seghezzi G; Vassalli JD; Ferrara N; Wasi S; Mazzieri R; Mignatti P; Pepper MS
1995 Apr 28;270(17):9709-9716, Journal of biological chemistry
— id: 8441, year: 1995, vol: 270, page: 9709, stat: Journal Article,

Tumor cells secrete an angiogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells
Peverali FA; Mandriota SJ; Ciana P; Marelli R; Quax P; Rifkin DB; Della Valle G; Mignatti P
1994 Oct;161(1):1-14, Journal of cellular physiology
— id: 42358, year: 1994, vol: 161, page: 1, stat: Journal Article,

Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis
Blei F; Wilson EL; Mignatti P; Rifkin DB
1993 Jun;155(3):568-578, Journal of cellular physiology
— id: 8234, year: 1993, vol: 155, page: 568, stat: Journal Article,

Biology and biochemistry of proteinases in tumor invasion
Mignatti P; Rifkin DB
1993 Jan;73(1):161-195, Physiological reviews
— id: 56423, year: 1993, vol: 73, page: 161, stat: Journal Article,

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity
Flaumenhaft R; Abe M; Mignatti P; Rifkin DB
1992 Aug;118(4):901-909, Journal of cell biology
— id: 13507, year: 1992, vol: 118, page: 901, stat: Journal Article,

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex
Mignatti P; Morimoto T; Rifkin DB
1992 Apr;151(1):81-93, Journal of cellular physiology
— id: 42362, year: 1992, vol: 151, page: 81, stat: Journal Article,

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor
Mignatti P; Mazzieri R; Rifkin DB
1991 Jun;113(5):1193-1201, Journal of cell biology
— id: 42364, year: 1991, vol: 113, page: 1193, stat: Journal Article,

Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner
Mignatti P; Morimoto T; Rifkin DB
1991 Dec 15;88(24):11007-11011, Proceedings of the National Academy of Sciences of the United States of America
— id: 13815, year: 1991, vol: 88, page: 11007, stat: Journal Article,

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: a trivial phenomenon or a novel secretion mechanism?
Mignatti P; Rifkin DB
1991 Nov;47(3):201-207, Journal of cellular biochemistry
— id: 13859, year: 1991, vol: 47, page: 201, stat: Journal Article,

New observations on the intracellular localization and release of bFGF
Rifkin DB; Quarto N; Mignatti P; Bizik J; Moscatelli D
1991 ;638:204-206, Annals of the New York Academy of Sciences
— id: 14216, year: 1991, vol: 638, page: 204, stat: Journal Article,

Growth factor control of extracellular proteolysis
Rifkin DB; Moscatelli D; Bizik J; Quarto N; Blei F; Dennis P; Flaumenhaft R; Mignatti P
1990 Dec 2;32(3):313-318, Cell differentiation & development
— id: 14245, year: 1990, vol: 32, page: 313, stat: Journal Article,

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases
Mignatti P; Tsuboi R; Robbins E; Rifkin DB
1989 Feb;108(2):671-682, Journal of cell biology
— id: 10740, year: 1989, vol: 108, page: 671, stat: Journal Article,

The role of proteases in matrix breakdown during cellular invasion
Rifkin DB; Tsuboi R; Mignatti P
1989 Oct;140(4):1112-1113, American review of respiratory disease
— id: 10476, year: 1989, vol: 140, page: 1112, stat: Journal Article,

Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade
Mignatti P; Robbins E; Rifkin DB
1986 Nov 21;47(4):487-498, Cell
— id: 42379, year: 1986, vol: 47, page: 487, stat: Journal Article,

A PROTEASE CASCADE IN MELANOMA INVASION
MIGNATTI, P; RIFKIN, DB
1986 APR ;34(2):A768-A768, Clinical research
— id: 41419, year: 1986, vol: 34, page: A768, stat: Journal Article,

A PROTEASE CASCADE IN MELANOMA INVASION
MIGNATTI, P; RIFKIN, DB
1986 APR ;86(4):494-494, Journal of investigative dermatology
— id: 41473, year: 1986, vol: 86, page: 494, stat: Journal Article,

INHIBITORS OF SERINE PROTEINASES AND METALLOPROTEINASES BLOCK INVITRO INVASION BY B-16 MELANOMA-CELLS
Mignatti, P; Rifkin, DB
1986 Mar;27(2):57-57, Proceedings (American Association for Cancer Research)
— id: 31055, year: 1986, vol: 27, page: 57, stat: Journal Article,

Purification and biological activities of an angiogenesis factor from human placenta
Moscatelli DA; Presta M; Mignatti P; Mullins DE; Crowe RM; Rifkin DB
1986 Jul-Aug;6(4):861-863, Anticancer research
— id: 25423, year: 1986, vol: 6, page: 861, stat: Journal Article,

Plasminogen activators, activation inhibitors and alpha 2-macroglobulin produced by cultured normal and malignant human cells
Saksela, O; Vaheri, A; Schleuning, W D; Mignatti, P; Barlati, S
1984 May;33(5):609-616, International journal of cancer
— id: 171865, year: 1984, vol: 33, page: 609, stat: Journal Article,