Marie E Monaco

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Marie E Monaco, Ph.D.

Associate Professor; Assist. Course Director/Physiology
Department of Neuroscience and Physiology (Neuro/Phys)

Contact Info

Address
423 E23rd
Floor 16 Room 16025W
Veterans Administration
new york, ny 10010

212-263-4184
Marie.Monaco@nyumc.org

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Education

1975-1977 — Dr. Monaco was a Postdoctoral Fellow in Cell Biololgy at the National Institutes of Health, Bethesda, MD, PostDoctoral Training
— Columbia University, Graduate Education

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Research Summary

Our laboratory is interested in the relationship between fatty acid activation and the aggressive phenotype in breast cancer. Our studies have demonstrated that expression of a specific isoform of fatty acyl-CoA synthetase (ACSL4) is negatively correlated with hormone/growth factor receptor status, and that forced expression of ACSL4 in the presence of receptors induces resistance to targeted therapies. The high expression level of ACSL4 in the most aggressive triple negative breast cancers suggests that it may comprise an appropriate target for the development of additional targeted therapies.

Research Interests

Lipid metabolism and hormone resistance in breast cancer

Research Keywords

lipid synthesis, lipid transport, phosphoinositides, signal transduction