Marie E Monaco

Biosketch / Results /

Marie Monaco

Associate Professor, Department of Neuroscience Institute
Neuroscience and Physiology

Contact Info

Address
450 East 29th Street
New York, NY 10016

212/263-4184
Marie.Monaco@nyumc.org

Education

1975-1977 — Dr. Monaco was a Postdoctoral Fellow in Cell Biololgy at the National Institutes of Health, Bethesda, MD, PostDoctoral Training
— Columbia University, Graduate Education

Research Summary

Our laboratory is interested in the relationship between fatty acid activation and the aggressive phenotype in breast cancer. Our studies have demonstrated that expression of a specific isoform of fatty acyl-CoA synthetase (ACSL4) is negatively correlated with hormone/growth factor receptor status, and that forced expression of ACSL4 in the presence of receptors induces resistance to targeted therapies. The high expression level of ACSL4 in the most aggressive triple negative breast cancers suggests that it may comprise an appropriate target for the development of additional targeted therapies.

Research Interests

Lipid metabolism and hormone resistance in breast cancer

Lipid metabolism in prostate cancer
Wu, Xinyu; Daniels, Garrett; Lee, Peng; Monaco, Marie E
2014-11-10; 2330-1910,American journal of clinical & experimental urology - id: 1342112, year: 2014 Journal Article; Review

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression
Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.
2013-03-08; 0893-3952,Modern pathology - id: 227182, year: 2013

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression
Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.
2013-03-15; 0023-6837,Laboratory investigation - id: 241022, year: 2013

Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer
Wu, Xinyu; Li, Yirong; Wang, Jinhua; Wen, Xin; Marcus, Max T; Daniels, Garrett; Zhang, David Y; Ye, Fei; Wang, Ling Hang; Du, Xinxin; Adams, Sylvia; Singh, Baljit; Zavadil, Jiri; Lee, Peng; Monaco, Marie E
2013-11-04; 1932-6203,PLoS one - id: 598522, year: 2013 Journal Article

Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism
Wu X; Xu K; Zhang L; Deng Y; Lee P; Shapiro E; Monaco M; Makarenkova HP; Li J; Lepor H; Grishina I
2012-02-05; 1095-564X,Developmental biology (Orlando) - id: 134432, year: 2011