Marie E Monaco

Biosketch / Results /

Marie Monaco

Associate Professor, Department of Neuroscience and Physiology
Assist. Course Director/Physiology

Contact Info

Address
423 East 23rd Street
New York, NY 10010

212/263-4184
Marie.Monaco@nyumc.org

Research Summary

Our laboratory is interested in the relationship between fatty acid activation and the aggressive phenotype in breast cancer. Our studies have demonstrated that expression of a specific isoform of fatty acyl-CoA synthetase (ACSL4) is negatively correlated with hormone/growth factor receptor status, and that forced expression of ACSL4 in the presence of receptors induces resistance to targeted therapies. The high expression level of ACSL4 in the most aggressive triple negative breast cancers suggests that it may comprise an appropriate target for the development of additional targeted therapies.

Research Interests

Lipid metabolism and hormone resistance in breast cancer

ACSL4 promotes prostate cancer growth, invasion and hormonal resistance
Wu, Xinyu; Deng, Fangming; Li, Yirong; Daniels, Garrett; Du, Xinxin; Ren, Qinghu; Wang, Jinhua; Wang, Ling Hang; Yang, Yang; Zhang, Valerio; Zhang, David; Ye, Fei; Melamed, Jonathan; Monaco, Marie E; Lee, Peng. ACSL4 promotes prostate cancer growth, invasion and hormonal resistance. Oncotarget. 2015 Dec 29;6(42):44849-44863 (1863642)

Lipid metabolism in prostate cancer
Wu, Xinyu; Daniels, Garrett; Lee, Peng; Monaco, Marie E. Lipid metabolism in prostate cancer. American journal of clinical & experimental urology. 2014 Jul 12;2(2):111-120 (1342112)

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression
Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.. Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression [Meeting Abstract]. Modern pathology. 2013 FEB;26(Suppl 2):243A-243A (227182)

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression
Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.. Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression [Meeting Abstract]. Laboratory investigation. 2013 FEB;93 1 1:243A-243A (241022)

Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer
Wu, Xinyu; Li, Yirong; Wang, Jinhua; Wen, Xin; Marcus, Max T; Daniels, Garrett; Zhang, David Y; Ye, Fei; Wang, Ling Hang; Du, Xinxin; Adams, Sylvia; Singh, Baljit; Zavadil, Jiri; Lee, Peng; Monaco, Marie E. Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer. PLoS one. 2013 Oct 14;8(10):e77060-e77060 e77060 (598522)