Patrick Meere, M.D.

Effect of a perioperative intra-articular injection on pain control and early range of motion following bilateral TKA
Fajardo, Marc; Collins, Jason; Landa, Joshua; Adler, Edward; Meere, Patrick; Di Cesare, Paul E
2011 May;34(5):354-354, Orthopedics (Thorofare NJ)
Pain control after total knee arthroplasty (TKA) is integral in the immediate postoperative period for early rehabilitation. Numerous different methods of postoperative analgesia are available, but each has its own risk of adverse side effects. This study was performed to prospectively evaluate the benefits of an intra-articular analgesic injection in patients undergoing bilateral TKA.Thirty consecutive patients undergoing bilateral TKA were enrolled in this prospective, randomized, controlled study. Each patient was randomized to receive (1) a perioperative intra-articular mixture of morphine, bupivacaine with epinephrine, and ketorolac in 1 knee, and (2) injectable sterile saline in the contralateral knee. Each patient acted as his or her own internal control. The pharmacologically injected knee had statistically significantly less pain immediately postoperatively when compared to the control knee and displayed significantly increased range of motion within the first week of rehabilitation.The use of an intraoperative intra-articular injection with the above drug combination significantly reduces patient pain and increases postoperative mobility with no apparent risks following bilateral TKA
— id: 134721, year: 2011, vol: 34, page: 354, stat: Journal Article,

Massive wear and metallosis of an Acetabular Cup System presenting as pseudodislocation
Sathappan, Sathappan S; Wee, James; Ginat, Daniel; Meere, Patrick
2009 Jun;32(6):449-449, Orthopedics (Thorofare NJ)
In primary and revision total hip arthroplasty (THA), the acetabular component continues to pose greater challenges than the femoral component. Numerous factors lead to polyethylene wear, which subsequently affects primary THA survival. Progressive polyethylene wear is associated with the occurrence of osteolysis, especially overlying the acetabulum, which can lead to component loosening and subsequent revision. Polyethylene failure usually manifests as massive liner wear up to the metal shell, fracture of the liner, or a combination of both. There is often a small amount of metallosis associated with this pathology. To our knowledge, massive wear of the acetabular metal shell, however, has not previously been reported in the literature. This article describes a case of massive wear through a polyethylene liner and the acetabular metal shell of an Acetabular Cup System (DePuy, Leeds, United Kingdom) that presented as an apparent dislocation 13 years following the index operation. The pseudodislocation was intraoperatively found to be penetration of the femoral head through the acetabular shell. The acetabular component was consequently revised to a larger cementless cup. The femoral component was mechanically stable and required no revision. Patients with long-standing Acetabular Cup System THA may experience acetabular metal shell wear-through phenomena presenting as a pseudodislocation, and this possibility should be taken into consideration during preoperative planning
— id: 101288, year: 2009, vol: 32, page: 449, stat: Journal Article,

"Floating total knee": ipsilateral periprosthetic fractures of the distal femur and proximal tibia after total knee arthroplasty
Jeong, Gerard K; Pettrone, Sarah K; Liporace, Frank A; Meere, Patrick A
2006 Jan;21(1):138-140, Journal of arthroplasty
Currently, there are more than 300000 primary total knee arthroplasty (TKA) performed annually in the United States. It is estimated that 0.3% to 2.5% of these patients will sustain a periprosthetic fracture in association with a TKA [Haidukewych GJ, Jacofsky DJ, Hanssen AD. Treatment of periprosthetic fractures around a total knee arthroplasty. J Knee Surg 2003;16:111]. The first report of a periprosthetic fracture involving a TKA occurred in 1977 [Callaghan JJ. Periprosthetic fractures of the acetabulum during and following total hip arthroplasty. Instr Course Lect 1998;47:231]. The majority of periprosthetic fractures associated with a TKA are distal femoral fractures [Berry D. Epidemiology: hip and knee. In: Callaghan J, Duncan C, editors. Periprosthetic fractures after major joint replacement. Philadelphia: WB Saunders; 1999. p. 183]. Periprosthetic tibial fractures are rare and usually involve the medial tibial plateau in the presence of a loose component [Rand JA, Coventry MB. Stress fractures after total knee arthroplasty. J Bone Joint Surg Am 1980;62:226, Hanssen AD, Stuart MJ]. Treatment of periprosthetic tibial fractures. Clin Orthop 2000; p. 91]. The following case report describes the management of simultaneous ipsilateral distal femoral and proximal tibial periprosthetic fractures associated with a TKA. The patient was informed that data concerning the case would be submitted for publication. To our knowledge, this 'floating total knee' injury has not been previously reported
— id: 64646, year: 2006, vol: 21, page: 138, stat: Journal Article,

Musculoskeletal complications associated with lysosomal storage disorders: Gaucher disease and Hurler-Scheie syndrome (mucopolysaccharidosis type I) [Review, Tutorial]
Pastores, Gregory M; Meere, Patrick A
2005 Jan;17(1):70-78, Current opinion in rheumatology
PURPOSE OF REVIEW: Enzyme therapy for lysosomal storage disorders directed at correcting the underlying cause of disease represents the most significant recent advance in patient management. This review focuses on two disease groups: glycosphingolipidoses and mucopolysaccharidoses. Specifically, Gaucher disease and Hurler-Scheie syndrome have been selected as the prototypical disorder for each respective class. RECENT FINDINGS: Musculoskeletal complications are encountered in several of the lysosomal storage disorders and often represent a major source of extraneurologic morbidity, particularly in the subacute or chronic variants. Enzyme therapy has led to improvements in physical and functional well-being. However, bone involvement remains a recalcitrant feature, especially among patients with established disease before institution of therapy. SUMMARY: Early diagnosis and appropriate timely intervention are critical in achieving the best therapeutic results. A better understanding of the fundamental mechanisms of bone pathology may enable the identification of complementary approaches (eg, the use of bisphosphonates for severe osteopenia) for optimized outcomes. Symptomatic care and rigorous physical and occupational therapy remain critical components of a comprehensive management approach
— id: 50284, year: 2005, vol: 17, page: 70, stat: Journal Article,

A simple method for construction of an articulating antibiotic-loaded cement spacer
Shin, Steven S; Della Valle, Craig J; Ong, Bernard C; Meere, Patrick A
2002 Sep;17(6):785-787, Journal of arthroplasty
A 2-stage exchange protocol has been used widely in North America for management of infected total hip arthroplasties. Many surgeons choose to use an antibiotic-loaded cement spacer in the interval before reimplantation of the final prosthesis. We propose a simple technique for the construction of an articulating antibiotic-loaded spacer for use as part of 2-stage exchange protocol for the treatment of infected total hip arthroplasties
— id: 56390, year: 2002, vol: 17, page: 785, stat: Journal Article,