Biosketch / Results /

Paul M. Mathews, Ph.D.

Assistant Professor;
Department of Psychiatry

Contact Info

Address
140 Old Orangeburg Road
Orangeburg, NY 10962

845-398-5428
845-398-5422
Paul.Mathews@nyumc.org


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Education

— 1992-1994 Fellow, Cell Biology, University of Lausanne, Switzerland, PostDoctoral Training
— 1995-1997 Resident Fellow, Neurobiology, McLean Hospital, Harvard Medical School, Department of Psychiatry, PostDoctoral Training
— Johns Hopkins Univ, Graduate Education
1991 — Johns Hopkins Univ, Medical Education

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Research Summary

We are focused on understanding the role of the endosomal-lysosomal system in neurodegeneration, specifically the dysfunction of the neuronal endosomal-lysosomal system seen in Alzheimer''s disease (AD), and possible synergism between these AD changes and aging-related lysosomal changes and the development of neuropathology. My background is in cell biology and membrane protein trafficking, so my interests inevitably gravitate towards understanding how alterations in vesicular trafficking and/or the trafficking of specific membrane proteins and their ligands through the endosomal-lysosomal system impacts the disease''s progression. Currently, we are using in vitro cell models as well as amyloid depositing transgenic mice to examine the following aspects of the neuronal endosomal-lysosomal system: The neuronal endosomal system appears to be upregulated very early in sporadic AD. We are modeling this by overexpressing important trafficking and regulatory proteins of the endosomal system, such as the mannose 6-phosphate receptors and various rab GTPases. In these models, we can examine changes in APP metabolism, ask whether Abeta generation or clearance is affected, and determine the impact of endosomal upregulation on other proteins that may play a prominent role in neuronal degeneration. The endosome plays a critical role in the metabolism of APP. We are examining the interplay between APP trafficking and its delivery to and dwell-time in various cellular compartments with specific cleavage events, such as those mediated by the beta- or alpha-secretases. Furthering our understanding of cellular events that regulate the trafficking of APP, either along pathways that promote Abeta generation or along non-amyloidogenic pathways, is likely to be critical to our understanding of the function(s) of APP and its metabolites as well as developing anti-Abeta treatments. We are also investigating the relationship between endosomal proteolysis of APP and presenilin function, including specific cleavage at residues 40 or 42 of Abeta. In vivo, we are manipulating the lysosomal system in transgenic mice brains by infusing drugs that regulate specific proteolytic systems. Our goal here is to mimic in a mouse the aging-related lysosomal changes seen in human neurons, thereby more completely reproducing the multiple stresses (Abeta, lysosomal, cytoskeletal) faced by a human neuron during the progression of Alzheimer''s disease. Finally, in support of these projects, we have made a substantial effort to develop tools, primarily monoclonal antibodies and related assays such as ELISAs, that allow us to detect with high specificity and great sensitivity many of the key metabolites of APP.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Early Endosomal Abnormalities and Cholinergic Neuron Degeneration in Amyloid-beta Protein Precursor Transgenic Mice
Choi, Jennifer H K; Kaur, Gurjinder; Mazzella, Matthew J; Morales-Corraliza, Jose; Levy, Efrat; Mathews, Paul M
2013 Jan;34(3):691-700, Journal of Alzheimer's disease
— id: 231162, year: 2013, vol: 34, page: 691, stat: Journal Article,

Interactome Analyses of Mature gamma-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
Jeon, Amy Hye Won; Bohm, Christopher; Chen, Fusheng; Huo, Hairu; Ruan, Xueying; Ren, Carl He; Ho, Keith; Qamar, Seema; Mathews, Paul M; Fraser, Paul E; Mount, Howard T J; St George-Hyslop, Peter; Schmitt-Ulms, Gerold
2013 May;288(21):15352-15366, Journal of biological chemistry
— id: 387052, year: 2013, vol: 288, page: 15352, stat: Journal Article,

Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
Morales-Corraliza, Jose; Schmidt, Stephen D; Mazzella, Matthew J; Berger, Jason D; Wilson, Donald A; Wesson, Daniel W; Jucker, Mathias; Levy, Efrat; Nixon, Ralph A; Mathews, Paul M
2013 Jan;34(1):137-145, Neurobiology of aging
— id: 180342, year: 2013, vol: 34, page: 137, stat: Journal Article,

Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of tau Protein Following Onset of Diabetes in NOD Mice
Papon, Marie-Amelie; El Khoury, Noura B; Marcouiller, Francois; Julien, Carl; Morin, Francoise; Bretteville, Alexis; Petry, Franck R; Gaudreau, Simon; Amrani, Abdelaziz; Mathews, Paul M; Hebert, Sebastien S; Planel, Emmanuel
2013 Feb;62(2):609-617, Diabetes
— id: 221422, year: 2013, vol: 62, page: 609, stat: Journal Article,

Chronic anti-murine Abeta immunization preserves odor guided behaviors in an Alzheimer's beta-amyloidosis model
Wesson, Daniel W; Morales-Corraliza, Jose; Mazzella, Matthew J; Wilson, Donald A; Mathews, Paul M
2013 Jan;237:96-102, Behavioural brain research
— id: 182472, year: 2013, vol: 237, page: 96, stat: Journal Article,

Calpastatin modulates APP processing in the brains of beta-amyloid depositing but not wild-type mice
Morales-Corraliza, Jose; Berger, Jason D; Mazzella, Matthew J; Neubert, Thomas A; Ghiso, Jorge; Rao, Mala V; Staufenbiel, Matthias; Nixon, Ralph A; Mathews, Paul M
2012 Jun;33(6):1125.e9-1125.18, Neurobiology of aging
— id: 164336, year: 2012, vol: 33, page: 1125.e9, stat: Journal Article,

Abeta measurement by enzyme-linked immunosorbent assay
Schmidt, Stephen D; Mazzella, Matthew J; Nixon, Ralph A; Mathews, Paul M
2012 ;849:507-527, Methods in molecular biology
— id: 166104, year: 2012, vol: 849, page: 507, stat: Journal Article,

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including abeta
Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M
2012 ;849:493-506, Methods in molecular biology
— id: 166105, year: 2012, vol: 849, page: 493, stat: Journal Article,

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Delay, Charlotte; Calon, Frederic; Mathews, Paul; Hebert, Sebastien S
2011 ;6:70-70, Molecular neurodegeneration
— id: 140551, year: 2011, vol: 6, page: 70, stat: Journal Article,

Catabolism of Alzheimer's amyloid-b: Implications for brain clearance and plaque deposition
McIntee F.L.; Giannoni P.; Blais S.; Neubert T.; Mathews P.; Rostagno A.; Ghiso J.
2011 ;8:?-?, Neuro-degenerative diseases
— id: 136531, year: 2011, vol: 8, page: ?, stat: Journal Article,

Synaptic Autoregulation by Metalloproteases and {gamma}-Secretase
Restituito, Sophie; Khatri, Latika; Ninan, Ipe; Mathews, Paul M; Liu, Xin; Weinberg, Richard J; Ziff, Edward B
2011 Aug 24;31(34):12083-12093, Journal of neuroscience
— id: 136951, year: 2011, vol: 31, page: 12083, stat: Journal Article,

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel W; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jul 1;7(7):788-789, Autophagy
— id: 134440, year: 2011, vol: 7, page: 788, stat: Journal Article,

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jan;134(Pt 1):258-277, Brain
— id: 126481, year: 2011, vol: 134, page: 258, stat: Journal Article,

Dietary fat and cholesterol cause neuronal endosomal abnormalities and basal forebrain cholinergic degeneration in wild-type mice
Choi, JHK; Boyer-Boiteau, A; Morales-Corraliza, J; Ginsberg, SD; Levy, E; Mathews, PM
2010 ;6:?-? #S188, Alzheimer's and dementia
— id: 463422, year: 2010, vol: 6, page: ?, stat: Journal Article,

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
Coomaraswamy, Janaky; Kilger, Ellen; Wolfing, Heidrun; Schafer, Claudia; Kaeser, Stephan A; Wegenast-Braun, Bettina M; Hefendehl, Jasmin K; Wolburg, Hartwig; Mazzella, Matthew; Ghiso, Jorge; Goedert, Michel; Akiyama, Haruhiko; Garcia-Sierra, Francisco; Wolfer, David P; Mathews, Paul M; Jucker, Mathias
2010 Apr 27;107(17):7969-7974, Proceedings of the National Academy of Sciences of the United States of America
— id: 137823, year: 2010, vol: 107, page: 7969, stat: Journal Article,

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
Jiang, Ying; Mullaney, Kerry A; Peterhoff, Corrinne M; Che, Shaoli; Schmidt, Stephen D; Boyer-Boiteau, Anne; Ginsberg, Stephen D; Cataldo, Anne M; Mathews, Paul M; Nixon, Ralph A
2010 Jan 26;107(4):1630-1635, Proceedings of the National Academy of Sciences of the United States of America
— id: 126490, year: 2010, vol: 107, page: 1630, stat: Journal Article,

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice
Bernardo, Alexandra; Harrison, Fiona E; McCord, Meghan; Zhao, Jiali; Bruchey, Aleksandra; Davies, Sean S; Jackson Roberts, L 2nd; Mathews, Paul M; Matsuoka, Yasuji; Ariga, Toshio; Yu, Robert K; Thompson, Rebecca; McDonald, Michael P
2009 Nov;30(11):1777-1791, Neurobiology of aging
— id: 95388, year: 2009, vol: 30, page: 1777, stat: Journal Article,

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model
Choi, Jennifer H K; Berger, Jason D; Mazzella, Matthew J; Morales-Corraliza, Jose; Cataldo, Anne M; Nixon, Ralph A; Ginsberg, Stephen D; Levy, Efrat; Mathews, Paul M
2009 Sep;110(6):1818-1827, Journal of neurochemistry
— id: 126493, year: 2009, vol: 110, page: 1818, stat: Journal Article,

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
Grathwohl, Stefan A; Kalin, Roland E; Bolmont, Tristan; Prokop, Stefan; Winkelmann, Georg; Kaeser, Stephan A; Odenthal, Jorg; Radde, Rebecca; Eldh, Therese; Gandy, Sam; Aguzzi, Adriano; Staufenbiel, Matthias; Mathews, Paul M; Wolburg, Hartwig; Heppner, Frank L; Jucker, Mathias
2009 Nov;12(11):1361-1363, Nature neuroscience
— id: 139850, year: 2009, vol: 12, page: 1361, stat: Journal Article,

Complexes of amyloid-beta and cystatin C in the human central nervous system
Mi, Weiqian; Jung, Sonia S; Yu, Haung; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Tagliavini, Fabrizio; Levy, Efrat
2009 ;18(2):273-280, Journal of Alzheimer's disease
— id: 126494, year: 2009, vol: 18, page: 273, stat: Journal Article,

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice
Morales-Corraliza, Jose; Mazzella, Matthew J; Berger, Jason D; Diaz, Nicole S; Choi, Jennifer H K; Levy, Efrat; Matsuoka, Yasuji; Planel, Emmanuel; Mathews, Paul M
2009 ;4(9):e7134-e7134, PLoS one
— id: 106444, year: 2009, vol: 4, page: e7134, stat: Journal Article,

The in vivo brain interactome of the amyloid precursor protein
Bai, Yu; Markham, Kelly; Chen, Fusheng; Weerasekera, Rasanjala; Watts, Joel; Horne, Patrick; Wakutani, Yosuke; Bagshaw, Rick; Mathews, Paul M; Fraser, Paul E; Westaway, David; St George-Hyslop, Peter; Schmitt-Ulms, Gerold
2008 Jan;7(1):15-34, Molecular & cellular proteomics
— id: 95390, year: 2008, vol: 7, page: 15, stat: Journal Article,

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
Cataldo, Anne M; Mathews, Paul M; Boiteau, Anne Boyer; Hassinger, Linda C; Peterhoff, Corrinne M; Jiang, Ying; Mullaney, Kerry; Neve, Rachael L; Gruenberg, Jean; Nixon, Ralph A
2008 Aug;173(2):370-384, American journal of pathology
— id: 95387, year: 2008, vol: 173, page: 370, stat: Journal Article,

Dysregulation of amyloid precursor protein levels, but not Abeta levels in Ts65Dn mouse brain
Choi, JHK; Diaz, NS; Mazzella, MJ; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2008 ;4:?-? #T208-T209, Alzheimer's and dementia
— id: 463382, year: 2008, vol: 4, page: ?, stat: Journal Article,

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
Trinchese, Fabrizio; Fa', Mauro; Liu, Shumin; Zhang, Hong; Hidalgo, Ariel; Schmidt, Stephen D; Yamaguchi, Hisako; Yoshii, Narihiko; Mathews, Paul M; Nixon, Ralph A; Arancio, Ottavio
2008 Aug;118(8):2796-2807, Journal of clinical investigation
— id: 95386, year: 2008, vol: 118, page: 2796, stat: Journal Article,

Dysregulation of brain APP in the Ts65Dn Down syndrome mouse
Choi, JH; Mazzella, MJ; Berger, JD; Cataldo, AM; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2007 AUG ;102(3):131-131, Journal of neurochemistry
— id: 74183, year: 2007, vol: 102, page: 131, stat: Journal Article,

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins
Dorval, Veronique; Mazzella, Matthew J; Mathews, Paul M; Hay, Ronald T; Fraser, Paul E
2007 Jun 1;404(2):309-316, Biochemical journal
— id: 95392, year: 2007, vol: 404, page: 309, stat: Journal Article,

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
Elder, Gregory A; Cho, Julie Y; English, Daniel F; Franciosi, Sonia; Schmeidler, James; Sosa, Miguel A Gama; Gasperi, Rita De; Fisher, Edward A; Mathews, Paul M; Haroutunian, Vahram; Buxbaum, Joseph D
2007 Aug;102(4):1220-1231, Journal of neurochemistry
— id: 73883, year: 2007, vol: 102, page: 1220, stat: Journal Article,

Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626))
Gandy, S; Zhang, Y-W; Ikin, A; Schmidt, SD; Bogush, A; Levy, E; Sheffield, R; Nixon, RA; Liao, F-F; Mathews, PM; Xu, H; Ehrlich, ME
2007 ;103(3):1272-, Journal of neurochemistry
— id: 643112, year: 2007, vol: 103, page: 1272, stat: Journal Article,

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (vol 102, pg 619, 2007)
Gandy, S; Zhang, YW; Ikin, A; Schmidt, SD; Bogush, A; Levy, E; Sheffield, R; Nixon, RA; Liao, FF; Mathews, PM; Xu, HX; Ehrlich, ME
2007 NOV ;103(3):1272-1272, Journal of neurochemistry
— id: 74687, year: 2007, vol: 103, page: 1272, stat: Journal Article,

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
Gandy, Sam; Zhang, Yun-wu; Ikin, Annat; Schmidt, Stephen D; Bogush, Alexey; Levy, Efrat; Sheffield, Roxanne; Nixon, Ralph A; Liao, Francesca-Fang; Mathews, Paul M; Xu, Huaxi; Ehrlich, Michelle E
2007 Aug;102(3):619-626, Journal of neurochemistry
— id: 95391, year: 2007, vol: 102, page: 619, stat: Journal Article,

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
Mi, Weiqian; Pawlik, Monika; Sastre, Magdalena; Jung, Sonia S; Radvinsky, David S; Klein, Andrew M; Sommer, John; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Levy, Efrat
2007 Dec;39(12):1440-1442, Nature genetics
— id: 95389, year: 2007, vol: 39, page: 1440, stat: Journal Article,

Endosome function and pathology in Alzheimer's disease
Cataldo, AM; Mathews, PM; Peterhoff, CM; Boyer-Boiteau, A; Jiang, Y; Nixon, RA
2006 MAR ;96(1):71-71, Journal of neurochemistry
— id: 62904, year: 2006, vol: 96, page: 71, stat: Journal Article,

Dysregulation of brain APP in the Ts65Dn Down syndrome mouse
Choi, JHK; Diaz, NS; Mazzella, MJ; Peterson, JN; Cataldo, AM; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2006 ;2:?-? #S236, Alzheimer's and dementia
— id: 463402, year: 2006, vol: 2, page: ?, stat: Journal Article,

APP expression modulated AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts
Jiang, Y; Mullaney, KA; Che, S; Schmidt, SD; Mathews, PM; Cataldo, AM; Ginsberg, SD; Nixon, RA
2006 ;2:?-? #S250, Alzheimer's and dementia
— id: 463392, year: 2006, vol: 2, page: ?, stat: Journal Article,

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
Meyer-Luehmann, Melanie; Coomaraswamy, Janaky; Bolmont, Tristan; Kaeser, Stephan; Schaefer, Claudia; Kilger, Ellen; Neuenschwander, Anton; Abramowski, Dorothee; Frey, Peter; Jaton, Anneliese L; Vigouret, Jean-Marie; Paganetti, Paolo; Walsh, Dominic M; Mathews, Paul M; Ghiso, Jorge; Staufenbiel, Matthias; Walker, Lary C; Jucker, Mathias
2006 Sep 22;313(5794):1781-1784, Science
— id: 81091, year: 2006, vol: 313, page: 1781, stat: Journal Article,

Endosome dysfunction in Alzheimer's disease: Genetic links and implications for synapse failure and neurodegeneration
Nixon, RA; Cataldo, A; Mathews, P; Jiang, Y; Ginsberg, SD; Peterhoff, C
2006 DEC ;31(2):S28-S28, Neuropsychopharmacology
— id: 70911, year: 2006, vol: 31, page: S28, stat: Journal Article,

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Radde, Rebecca; Bolmont, Tristan; Kaeser, Stephan A; Coomaraswamy, Janaky; Lindau, Dennis; Stoltze, Lars; Calhoun, Michael E; Jaggi, Fabienne; Wolburg, Hartwig; Gengler, Simon; Haass, Christian; Ghetti, Bernardino; Czech, Christian; Holscher, Christian; Mathews, Paul M; Jucker, Mathias
2006 Sep;7(9):940-946, EMBO reports
— id: 95394, year: 2006, vol: 7, page: 940, stat: Journal Article,

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
Sano, Yoshitake; Nakaya, Tadashi; Pedrini, Steve; Takeda, Shizu; Iijima-Ando, Kanae; Iijima, Koichi; Mathews, Paul M; Itohara, Shigeyoshi; Gandy, Sam; Suzuki, Toshiharu
2006 ;1:e51-e51, PLoS one
— id: 95393, year: 2006, vol: 1, page: e51, stat: Journal Article,

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment
Tate, Barbara A; Mathews, Paul M
2006 May 25;2006(10):re2-re2, Science of aging knowledge environment
— id: 95395, year: 2006, vol: 2006, page: re2, stat: Journal Article,

Deficiency in neuronal TGF-beta signaling promotes neurodegeneratbn and Alzheimer's pathology
Tesseur, I; Zou, K; Esposito, L; Bard, F; Berber, E; Van Can, J; Lin, AH; Crews, L; Tremblay, P; Mathews, P; Mucke, L; Masliah, E; Wyss-Coray, T
2006 NOV ;116(11):3060-3069, Journal of clinical investigation
— id: 69257, year: 2006, vol: 116, page: 3060, stat: Journal Article,

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
Mastrangelo, Peter; Mathews, Paul M; Chishti, M Azhar; Schmidt, Stephen D; Gu, Yongjun; Yang, Jing; Mazzella, Matthew J; Coomaraswamy, Janaky; Horne, Patrick; Strome, Bob; Pelly, Heather; Levesque, Georges; Ebeling, Chris; Jiang, Ying; Nixon, Ralph A; Rozmahel, Richard; Fraser, Paul E; St George-Hyslop, Peter; Carlson, George A; Westaway, David
2005 Jun 21;102(25):8972-8977, Proceedings of the National Academy of Sciences of the United States of America
— id: 95396, year: 2005, vol: 102, page: 8972, stat: Journal Article,

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W Haung; Cuervo, Ana Maria; Kumar, Asok; Peterhoff, Corrinne M; Schmidt, Stephen D; Lee, Ju-Hyun; Mohan, Panaiyur S; Mercken, Marc; Farmery, Mark R; Tjernberg, Lars O; Jiang, Ying; Duff, Karen; Uchiyama, Yasuo; Naslund, Jan; Mathews, Paul M; Cataldo, Anne M; Nixon, Ralph A
2005 Oct 10;171(1):87-98, Journal of cell biology
— id: 60255, year: 2005, vol: 171, page: 87, stat: Journal Article,

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
Cataldo, Anne M; Peterhoff, Corrinne M; Schmidt, Stephen D; Terio, Nicole B; Duff, Karen; Beard, Margaret; Mathews, Paul M; Nixon, Ralph A
2004 Aug;63(8):821-830, Journal of neuropathology & experimental neurology
— id: 95397, year: 2004, vol: 63, page: 821, stat: Journal Article,

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
Hasegawa, Hiroshi; Sanjo, Nobuo; Chen, Fusheng; Gu, Yong-Jun; Shier, Cortney; Petit, Agnes; Kawarai, Toshitaka; Katayama, Taiichi; Schmidt, Stephen D; Mathews, Paul M; Schmitt-Ulms, Gerold; Fraser, Paul E; St George-Hyslop, Peter
2004 Nov 5;279(45):46455-46463, Journal of biological chemistry
— id: 95398, year: 2004, vol: 279, page: 46455, stat: Journal Article,

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Herzig, Martin C; Winkler, David T; Burgermeister, Patrick; Pfeifer, Michelle; Kohler, Esther; Schmidt, Stephen D; Danner, Simone; Abramowski, Dorothee; Sturchler-Pierrat, Christine; Burki, Kurt; van Duinen, Sjoerd G; Maat-Schieman, Marion L C; Staufenbiel, Matthias; Mathews, Paul M; Jucker, Mathias
2004 Sep;7(9):954-960, Nature neuroscience
— id: 95399, year: 2004, vol: 7, page: 954, stat: Journal Article,

Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised
Lacombe P; Mathews PM; Schmidt SD; Breidert T; Heneka MT; Landreth GE; Feinstein DL; Galea E
2004 Jul 2;1(1):11-11, Journal of neuroinflammation
— id: 61232, year: 2004, vol: 1, page: 11, stat: Journal Article,

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
Laudon, Hanna; Mathews, Paul M; Karlstrom, Helena; Bergman, Anna; Farmery, Mark R; Nixon, Ralph A; Winblad, Bengt; Gandy, Samuel E; Lendahl, Urban; Lundkvist, Johan; Naslund, Jan
2004 Apr;89(1):44-53, Journal of neurochemistry
— id: 42252, year: 2004, vol: 89, page: 44, stat: Journal Article,

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide
Pawlik, Monika; Sastre, Magdalena; Calero, Miguel; Mathews, Paul M; Schmidt, Stephen D; Nixon, Ralph A; Levy, Efrat
2004 ;22(1-2):13-18, Journal of molecular neuroscience
— id: 42253, year: 2004, vol: 22, page: 13, stat: Journal Article,

Cerebral hemorrhage and amytoid-? [3]
Atwood, CS; Perry, G; Smith, MA; Pfeifer, M; Boncristiano, S; Bondolfi, L; Stalder, A; Deller, T; Staufenbiel, M; Mathews, PM; Jucker, M
2003 ;299(5609):1014-, Science
— id: 651782, year: 2003, vol: 299, page: 1014, stat: Journal Article,

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo
Burns, Mark; Gaynor, Kate; Olm, Vicki; Mercken, Marc; LaFrancois, John; Wang, Lili; Mathews, Paul M; Noble, Wendy; Matsuoka, Yasuji; Duff, Karen
2003 Jul 2;23(13):5645-5649, Journal of neuroscience
— id: 36834, year: 2003, vol: 23, page: 5645, stat: Journal Article,

Extracellular amyloid formation and associated pathology in neural grafts
Meyer-Luehmann, Melanie; Stalder, Martina; Herzig, Martin C; Kaeser, Stephan A; Kohler, Esther; Pfeifer, Michelle; Boncristiano, Sonia; Mathews, Paul M; Mercken, Marc; Abramowski, Dorothee; Staufenbiel, Matthias; Jucker, Mathias
2003 Apr;6(4):370-377, Nature neuroscience
— id: 34106, year: 2003, vol: 6, page: 370, stat: Journal Article,

In vivo reduction of amyloid-beta by a mutant copper transporter
Phinney, Amie L; Drisaldi, Bettina; Schmidt, Stephen D; Lugowski, Stan; Coronado, Veronica; Liang, Yan; Horne, Patrick; Yang, Jing; Sekoulidis, Joannis; Coomaraswamy, Janaky; Chishti, M Azhar; Cox, Diane W; Mathews, Paul M; Nixon, Ralph A; Carlson, George A; St George-Hyslop, Peter; Westaway, David
2003 Nov;100(24):14193-14198, Proceedings of the National Academy of Sciences of the United States of America
— id: 159199, year: 2003, vol: 100, page: 14193, stat: Journal Article,

Rab5 overexpression in a cell model of AD-related endocytic abnormalities influences processing of beta APP
Grbovic, OM; Schmidt, SD; Mathews, PM; Nixon, RA; Cataldo, AM
2002 Jul-Aug;23(1):50-, Neurobiology of aging
— id: 32405, year: 2002, vol: 23, page: 50, stat: Journal Article,

Quantitation of beta-cleaved carboxy-terminal fragments of APP with a novel ELISA
Jiang, Y; Schmidt, SD; Mercken, M; Mathews, PM; Nixon, RA
2002 Jul-Aug;23(1):62-, Neurobiology of aging
— id: 32406, year: 2002, vol: 23, page: 62, stat: Journal Article,

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein. INHIBITION OF CALPAINS ENHANCES ENDOSOMAL GENERATION OF beta -CLEAVED C-TERMINAL APP FRAGMENTS
Mathews, Paul M; Jiang, Ying; Schmidt, Stephen D; Grbovic, Olivera M; Mercken, Marc; Nixon, Ralph A
2002 Sep 27;277(39):36415-36424, Journal of biological chemistry
— id: 32534, year: 2002, vol: 277, page: 36415, stat: Journal Article,

Altered APP trafficking and a role for the early endosome in increased beta CTF generation following calpain inhibition
Mathews, PM; Nixon, RA; Jiang, Y; Schmidt, SD; Grbovic, OM; Mercken, M; Cataldo, AM
2002 Jul-Aug;23(1):671-, Neurobiology of aging
— id: 32414, year: 2002, vol: 23, page: 671, stat: Journal Article,

AUTOPHAGY IN ALZHEIMER'S DISEASE: AUTOPHAGY - DEPENDENT GENERATION OF THE AMYLOID beta ( Abeta ) PEPTIDE
Nixon, R. A.; Yu, W. H.; Cataldo, A. M.; Mathews, P. M.; Wegiel, J.; Schmidt, S. D.; Ginsberg, S. D.; Peterhoff, C. M.; Terio, N.; Mohan, P.; Hassinger, L.; Kumar, A.; Lamb, B.
2002 ;2002:?-? #624.11, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 458992, year: 2002, vol: 2002, page: ?, stat: Journal Article,

Autophagic cell death: Relevance to Alzheimer disease neurodegeneration
Nixon, RA; Mathews, PM; Ginsberg, SD; Duff, K; Mohan, P; Cataldo, AM; Wegiel, J; Yu, WH; Schmidt, SD; Jacobsen, SP; Peterhoff, CM; Terio, N; Keller, JN; Hassinger, L
2002 Jul-Aug;23:S415-S416, Neurobiology of aging
— id: 32429, year: 2002, vol: 23, page: S415, stat: Journal Article,

Cerebral hemorrhage after passive anti-Abeta immunotherapy
Pfeifer, M; Boncristiano, S; Bondolfi, L; Stalder, A; Deller, T; Staufenbiel, M; Mathews, P M; Jucker, M
2002 Nov 15;298(5597):1379-1379, Science
— id: 32570, year: 2002, vol: 298, page: 1379, stat: Journal Article,

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
Rozmahel, Richard; Mount, Howard T J; Chen, Fusheng; Nguyen, Van; Huang, Jean; Erdebil, Serap; Liauw, Jennifer; Yu, Gang; Hasegawa, Hiroshe; Gu, YongJun; Song, You-Qiang; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Bergeron, Catherine; Fraser, Paul; Westaway, David; St George-Hyslop, Peter
2002 Oct 29;99(22):14452-14457, Proceedings of the National Academy of Sciences of the United States of America
— id: 32537, year: 2002, vol: 99, page: 14452, stat: Journal Article,

Murine A beta co-deposition in transgenic mice: Analyses with species-specific antibodies and comparison of human and murine A beta 42 : A beta 40 ratios
Schmidt, S; Jiang, Y; Duff, KEK; Nixon, RA; Mathews, PM; Herzig, MC; Jucker, M; Chishti, MA; Westaway, D; Mercken, M; Staufenbiel, M
2002 Jul-Aug;23(1):920-, Neurobiology of aging
— id: 32422, year: 2002, vol: 23, page: 920, stat: Journal Article,

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
Yang, Dun-Sheng; Tandon, Anurag; Chen, Fusheng; Yu, Gang; Yu, Haung; Arawaka, Shigeki; Hasegawa, Hiroshi; Duthie, Monika; Schmidt, Stephen D; Ramabhadran, Triprayer V; Nixon, Ralph A; Mathews, Paul M; Gandy, Samuel E; Mount, Howard T J; St George-Hyslop, Peter; Fraser, Paul E
2002 Aug 2;277(31):28135-28142, Journal of biological chemistry
— id: 62376, year: 2002, vol: 277, page: 28135, stat: Journal Article,

Autophagy-dependent generation of the amyloid-beta (A beta) peptide
Yu, WH; Schmidt, SD; Jiang, Y; Mathews, PM; Nixon, RA; Hassinger, L; Cataldo, A
2002 Jul-Aug;23(1):48-, Neurobiology of aging
— id: 32404, year: 2002, vol: 23, page: 48, stat: Journal Article,

Accelerated A-beta generation in a cell model of Alzheimer's disease-related endosomal-lysomal system upregulation
Mathews PM; Guerra CB; Jiang Y; Kao BH; Dinakar R; Mehta P; Cataldo AM; Nixon RA
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2653, year: 2001, vol: , page: 461, stat: Chapter,

The neuronal endosomal-lysosomal system in Alzheimer's disease
Nixon RA; Mathews PM; Cataldo AM
2001 Feb;3(1):97-107, Journal of Alzheimer's disease
— id: 32538, year: 2001, vol: 3, page: 97, stat: Journal Article,

In vivo perturbation of lysosomal function promotes neurodegeneration in the PS1m146V/APPPK67ON,M671L mouse model of Alzheimer's disease pathology
Nixon RA; Mathews PM; Cataldo AM; Mohan PS; Schmidt SD; Duff K; Berg M; Marks N; Peterhoff C; Sershen H
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2654, year: 2001, vol: , page: , stat: Chapter,

Experimental aging of the lysosomal system promotes neurodegeneration in the PS/APP mouse model of Alzheimer's disease pathology
Nixon, R. A.; Mathews, P. M.; Cataldo, A. M.; Mohan, P. S.; Marks, N.; Duff, K.; Berg, M.; Schmidt, S. D.; Jacobsen, S. P.; Jiang, Y.; Sershen, H.
2001 ;27(1):925-925, Abstracts (Society for Neuroscience)
— id: 115690, year: 2001, vol: 27, page: 925, stat: Journal Article,

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus C; Pearson J; McLaurin J; Mathews PM; Jiang Y; Schmidt SD; Chishti MA; Horne P; Heslin D; French J; Mount HT; Nixon RA; Mercken M; Bergeron C; Fraser PE; St George-Hyslop P; Westaway D
2000 Dec 21-28;408(6815):979-982, Nature
— id: 24772, year: 2000, vol: 408, page: 979, stat: Journal Article,

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
Mathews PM; Cataldo AM; Kao BH; Rudnicki AG; Qin X; Yang JL; Jiang Y; Picciano M; Hulette C; Lippa CF; Bird TD; Nochlin D; Walter J; Haass C; Levesque L; Fraser PE; Andreadis A; Nixon RA
2000 Oct;6(10):878-891, Molecular medicine
— id: 25504, year: 2000, vol: 6, page: 878, stat: Journal Article,

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review
Nixon RA; Cataldo AM; Mathews PM
2000 Oct;25(9-10):1161-1172, Neurochemical research
— id: 24724, year: 2000, vol: 25, page: 1161, stat: Journal Article,

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1
Levesque L; Annaert W; Craessaerts K; Mathews PM; Seeger M; Nixon RA; Van Leuven F; Gandy S; Westaway D; St George-Hyslop P; De Strooper B; Fraser PE
1999 Aug;5(8):542-554, Molecular medicine
— id: 24709, year: 1999, vol: 5, page: 542, stat: Journal Article,

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
Capell A; Saffrich R; Olivo JC; Meyn L; Walter J; Grunberg J; Mathews P; Nixon R; Dotti C; Haass C
1997 Dec;69(6):2432-2440, Journal of neurochemistry
— id: 24765, year: 1997, vol: 69, page: 2432, stat: Journal Article,