Catherine S. Manno

Biosketch / Results /

Catherine S. Manno, M.D.

Pat and John Rosenwald Professor of Pediatrics; Chair of the Department of Pediatrics
Department of Pediatrics (Fac)

Clinical Addresses

145 E. 32nd Street
14th Floor Penthouse, Room 1410
New York, NY 10016
Handicap Access: yes
Phone: 646-754-2286

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Medical Specialties

Cancer, Pediatrics, Pediatric Hematology-Oncology

Medical Expertise

Pediatric Hematology/Oncology

Clinical Responsibilities

Dr. Manno holds an A.B. in zoology from Duke University and an M.D. from Hahnemann Medical College, where she earned top awards for both scholastic excellence in pediatrics and overall academic achievement, and was inducted into the Alpha Omega Alpha Medical Honor Society. She completed her residency in pediatrics at St. Christopher's Hospital for Children in Philadelphia and fellowship training in pediatric hematology-oncology at The Children's Hospital of Philadelphia. She is a Fellow of the American Academy of Pediatrics, a member of the American Pediatric Society as well as a member of the medical and scientific advisory committee of the National Hemophilia Foundation. Dr. Manno has held an array of key administrative roles. She has been president of the executive committee of the medical staff and co-chaired the Clinical Translational Research Center Council, the Hematology-Oncology Fellowship Committee and the Clinical Affairs Committee of the Department of Pediatrics.



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Board Certification

1983 — Ab Pediatrics - Pediatrics
1984 — Ab Pediatrics (Pediatric Hematology-Oncology)


1978 — Hahnemann University, Medical Education
1978-1981 — St Christopher?s Hosp. For Children (Pediatric), Residency Training
1981-1983 — Children's Hospital of Philadelphia (Hematology & Oncolog), Clinical Fellowships

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Research Interests

Dr. Manno has been the principal investigator of several clinical research studies in the area of hemophilia, most recently leading a Phase I study of gene transfer into the liver in subjects with hemophilia B. She lectures widely on topics such as gene therapy for hemophilia, neonatal transfusion medicine and bleeding disorders in childrena??all areas in which she has published widely in peer-reviewed research journals, editorials, chapters and books.

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All data from NYU Health Sciences Library Faculty Bibliography — -


Pediatric hematology
Manno, Catherine S
2013 Dec;60(6):xv-xvi, Pediatric clinics of North America
— id: 641632, year: 2013, vol: 60, page: xv, stat: Journal Article,

Preface Pediatric Hematology
Manno, Catherine S.
2013 DEC;60(6):XV-XVI, Pediatric clinics of North America
— id: 746322, year: 2013, vol: 60, page: XV, stat: Journal Article,

Associations between intracranial haemorrhage and prescribed prophylaxis in a large cohort of haemophilia patients in the United States
Witmer, Char; Presley, Rodney; Kulkarni, Roshni; Soucie, J Michael; Manno, Catherine S; Raffini, Leslie
2011 Jan;152(2):211-216, British journal of haematology
— id: 138280, year: 2011, vol: 152, page: 211, stat: Journal Article,

Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study
Seif, Alix E; Manno, Catherine S; Sheen, Cecilia; Grupp, Stephan A; Teachey, David T
2010 Mar 18;115(11):2142-2145, Blood
— id: 115318, year: 2010, vol: 115, page: 2142, stat: Journal Article,

Dose of prophylactic platelet transfusions and prevention of hemorrhage
Slichter, Sherrill J; Kaufman, Richard M; Assmann, Susan F; McCullough, Jeffrey; Triulzi, Darrell J; Strauss, Ronald G; Gernsheimer, Terry B; Ness, Paul M; Brecher, Mark E; Josephson, Cassandra D; Konkle, Barbara A; Woodson, Robert D; Ortel, Thomas L; Hillyer, Christopher D; Skerrett, Donna L; McCrae, Keith R; Sloan, Steven R; Uhl, Lynne; George, James N; Aquino, Victor M; Manno, Catherine S; McFarland, Janice G; Hess, John R; Leissinger, Cindy; Granger, Suzanne
2010 Feb 18;362(7):600-613, New England journal of medicine
— id: 115317, year: 2010, vol: 362, page: 600, stat: Journal Article,

Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant
Teachey, David T; Jubelirer, Tracey; Baluarte, H Jorge; Wade, Amanda; Manno, Catherine S
2009 Dec;53(6):1114-1116, Pediatric blood & cancer
— id: 115319, year: 2009, vol: 53, page: 1114, stat: Journal Article,

Incidence of bleeding complications in pediatric patients with type 1 von Willebrand disease undergoing adenotonsillar procedures
Witmer, Char M; Elden, Lisa; Butler, Regina B; Manno, Catherine S; Raffini, Leslie J
2009 Jul;155(1):68-72, Journal of pediatrics
— id: 115321, year: 2009, vol: 155, page: 68, stat: Journal Article,

The clinical management of hemophilia and head trauma: a survey of current clinical practice among pediatric hematology/oncology physicians
Witmer, Char M; Manno, Catherine S; Butler, Regina B; Raffini, Leslie J
2009 Sep;53(3):406-410, Pediatric blood & cancer
— id: 115320, year: 2009, vol: 53, page: 406, stat: Journal Article,

A prospective observational study of IVC filters in pediatric patients
Raffini, Leslie; Cahill, Anne Marie; Hellinger, Jeffrey; Manno, Catherine
2008 Oct;51(4):517-520, Pediatric blood & cancer
— id: 90491, year: 2008, vol: 51, page: 517, stat: Journal Article,

CD8(+) T-cell responses to adeno-associated virus capsid in humans
Mingozzi, Federico; Maus, Marcela V; Hui, Daniel J; Sabatino, Denise E; Murphy, Samuel L; Rasko, John E J; Ragni, Margaret V; Manno, Catherine S; Sommer, Jurg; Jiang, Haiyan; Pierce, Glenn F; Ertl, Hildegund C J; High, Katherine A
2007 Apr;13(4):419-422, Nature medicine
— id: 87024, year: 2007, vol: 13, page: 419, stat: Journal Article,

Utility of computed tomography of the head following head trauma in boys with haemophilia
Witmer, C M; Raffini, L J; Manno, C S
2007 Sep;13(5):560-566, Haemophila
— id: 87023, year: 2007, vol: 13, page: 560, stat: Journal Article,

Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B
Jiang, Haiyan; Pierce, Glenn F; Ozelo, Margareth C; de Paula, Erich V; Vargas, Joseph A; Smith, Peter; Sommer, Jurg; Luk, Alvin; Manno, Catherine S; High, Katherine A; Arruda, Valder R
2006 Sep;14(3):452-455, Molecular therapy
— id: 87025, year: 2006, vol: 14, page: 452, stat: Journal Article,

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Manno, Catherine S; Pierce, Glenn F; Arruda, Valder R; Glader, Bertil; Ragni, Margaret; Rasko, John J; Ozelo, Margareth C; Hoots, Keith; Blatt, Philip; Konkle, Barbara; Dake, Michael; Kaye, Robin; Razavi, Mahmood; Zajko, Albert; Zehnder, James; Rustagi, Pradip K; Nakai, Hiroyuki; Chew, Amy; Leonard, Debra; Wright, J Fraser; Lessard, Ruth R; Sommer, Jurg M; Tigges, Michael; Sabatino, Denise; Luk, Alvin; Jiang, Haiyan; Mingozzi, Federico; Couto, Linda; Ertl, Hildegund C; High, Katherine A; Kay, Mark A
2006 Mar;12(3):342-347, Nature medicine
— id: 87028, year: 2006, vol: 12, page: 342, stat: Journal Article,

Cystic fibrosis as a risk factor for recurrent venous thrombosis at a pediatric tertiary care hospital
Raffini, Leslie J; Raybagkar, Deepti; Blumenstein, Marilyn S; Rubenstein, Ronald C; Manno, Catherine S
2006 May;148(5):659-664, Journal of pediatrics
— id: 87027, year: 2006, vol: 148, page: 659, stat: Journal Article,

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
Teachey, David T; Obzut, Dana A; Axsom, Kelly; Choi, John K; Goldsmith, Kelly C; Hall, Junior; Hulitt, Jessica; Manno, Catherine S; Maris, John M; Rhodin, Nicholas; Sullivan, Kathleen E; Brown, Valerie I; Grupp, Stephan A
2006 Sep 15;108(6):1965-1971, Blood
— id: 87026, year: 2006, vol: 108, page: 1965, stat: Journal Article,

Use of recombinant factor VIIa for refractory hemorrhage during extracorporeal membrane oxygenation
Dominguez, T E; Mitchell, M; Friess, S H; Huh, J W; Manno, C S; Ravishankar, C; Gaynor, J W; Tabbutt, S
2005 May;6(3):348-351, Pediatric critical care medicine
— id: 87031, year: 2005, vol: 6, page: 348, stat: Journal Article,

Management of bleeding disorders in children
Manno, Catherine S
2005 ;:416-422, Hematology (American Society of Hematology. Education Program)
— id: 87029, year: 2005, vol: , page: 416, stat: Journal Article,

Therapeutic choices in the current millennium: hemophilia workshop highlights
Mathew, Prasad; Manno, Catherine S; Aledort, Louis M
2005 Oct 15;45(5):611-615, Pediatric blood & cancer
— id: 87030, year: 2005, vol: 45, page: 611, stat: Journal Article,

Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)
Teachey, David T; Manno, Catherine S; Axsom, Kelly M; Andrews, Timothy; Choi, John K; Greenbaum, Barbara H; McMann, Joseph M; Sullivan, Kathleen E; Travis, Susan F; Grupp, Stephan A
2005 Mar 15;105(6):2443-2448, Blood
— id: 87032, year: 2005, vol: 105, page: 2443, stat: Journal Article,

Emerging and receding risks of therapeutic regimens for haemophilia
Farrugia, A; Manno, C S; Evatt, B L
2004 Oct;10 Suppl 4:47-54, Haemophila
— id: 87033, year: 2004, vol: 10 Suppl 4, page: 47, stat: Journal Article,

HIV infection presenting as severe autoimmune hemolytic anemia with disseminated intravascular coagulation in an infant
Rheingold, Susan R; Burnham, Jon M; Rutstein, Richard; Manno, Catherine S
2004 Jan;26(1):9-12, Journal of pediatric hematology/oncology
— id: 87034, year: 2004, vol: 26, page: 9, stat: Journal Article,

The promise of third-generation recombinant therapy and gene therapy
Manno, Catherine S
2003 Jul;40(3 Suppl 3):23-28, Seminars in hematology
— id: 87035, year: 2003, vol: 40, page: 23, stat: Journal Article,

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
Manno, Catherine S; Chew, Amy J; Hutchison, Sylvia; Larson, Peter J; Herzog, Roland W; Arruda, Valder R; Tai, Shing Jen; Ragni, Margaret V; Thompson, Arthur; Ozelo, Margareth; Couto, Linda B; Leonard, Debra G B; Johnson, Frederick A; McClelland, Alan; Scallan, Ciaran; Skarsgard, Erik; Flake, Alan W; Kay, Mark A; High, Katherine A; Glader, Bertil
2003 Apr 15;101(8):2963-2972, Blood
— id: 87036, year: 2003, vol: 101, page: 2963, stat: Journal Article,

Transfusion of the patient with congenital coagulation defects
Shusterman, Suzanne; Manno, Catherine S
Blood banking and transfusion medicine : basic principles and practice Philadelphia PA : Churchill Livingstone, 2003,
— id: 5472, year: 2003, vol: , page: ?, stat: Chapter,

Pediatric transfusion therapy
Herman, Jay H; Manno, Catherine Scott
Bethesda MD : AABB Press, 2002,
— id: 2201, year: 2002, vol: , page: , stat: ,

Gene therapy for bleeding disorders
Manno, Catherine S
2002 Nov;9(6):511-515, Current opinion in hematology
— id: 87038, year: 2002, vol: 9, page: 511, stat: Journal Article,

Guidelines for assessing appropriateness of pediatric transfusion
Roseff, Susan D; Luban, Naomi L C; Manno, Catherine S
2002 Nov;42(11):1398-1413, Transfusion
— id: 87037, year: 2002, vol: 42, page: 1398, stat: Journal Article,

Does red-cell T activation matter?
Eder, A F; Manno, C S
2001 Jul;114(1):25-30, British journal of haematology
— id: 87041, year: 2001, vol: 114, page: 25, stat: Journal Article,

Hemoglobinopathies: an opportunity to study cardiac disease
Manno, C S; Jessup, M
2001 Oct 1;111(5):407-408, American journal of medicine
— id: 87040, year: 2001, vol: 111, page: 407, stat: Journal Article,

Complex regional pain syndrome in pediatric patients with severe factor VIII deficiency
Norris, C F; Bingham, P M; Butler, R B; Manno, C S
2001 Dec;23(9):620-622, Journal of pediatric hematology/oncology
— id: 87039, year: 2001, vol: 23, page: 620, stat: Journal Article,

Distinguished Career Award of the American Society of Pediatric Hematology/Oncology for 2000
Cohen, A; Manno, C
2000 Jul-Aug;22(4):296-298, Journal of pediatric hematology/oncology
— id: 115325, year: 2000, vol: 22, page: 296, stat: Journal Article,

Leukocyte reduction of blood components: public policy and new technology
Dzik, S; Aubuchon, J; Jeffries, L; Kleinman, S; Manno, C; Murphy, M F; Popovsky, M A; Sayers, M; Silberstein, L E; Slichter, S J; Vamvakas, E C
2000 Jan;14(1):34-52, Transfusion medicine reviews
— id: 505582, year: 2000, vol: 14, page: 34, stat: Journal Article,

Neonatal lupus erythematosus with microvascular hemolysis
Hariharan, D; Manno, C S; Seri, I
2000 Jul-Aug;22(4):351-354, Journal of pediatric hematology/oncology
— id: 87042, year: 2000, vol: 22, page: 351, stat: Journal Article,

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
Kay, M A; Manno, C S; Ragni, M V; Larson, P J; Couto, L B; McClelland, A; Glader, B; Chew, A J; Tai, S J; Herzog, R W; Arruda, V; Johnson, F; Scallan, C; Skarsgard, E; Flake, A W; High, K A
2000 Mar;24(3):257-261, Nature genetics
— id: 87044, year: 2000, vol: 24, page: 257, stat: Journal Article,

Blood transfusion support in pediatric cardiovascular surgery
Kwiatkowski, J L; Manno, C S
1999 Aug;21(1):63-72, Transfusion science
— id: 87043, year: 1999, vol: 21, page: 63, stat: Journal Article,

Treatment options for bleeding episodes in patients undergoing immune tolerance therapy
Manno, C S
1999 Sep;5 Suppl 3:33-41, Haemophila
— id: 87045, year: 1999, vol: 5 Suppl 3, page: 33, stat: Journal Article,

Transfusion practices in infants receiving assisted ventilation
Cohen, A; Manno, C
1998 Mar;25(1):97-111, Clinics in perinatology
— id: 115324, year: 1998, vol: 25, page: 97, stat: Journal Article,

Prevalence of the factor V leiden mutation in children and neonates with thromboembolic disease
Hagstrom, J N; Walter, J; Bluebond-Langner, R; Amatniek, J C; Manno, C S; High, K A
1998 Dec;133(6):777-781, Journal of pediatrics
— id: 87046, year: 1998, vol: 133, page: 777, stat: Journal Article,

Diagnosis and management of iron-induced heart disease in Cooley's anemia
Jessup, M; Manno, C S
1998 Jun 30;850:242-250, Annals of the New York Academy of Sciences
— id: 87047, year: 1998, vol: 850, page: 242, stat: Journal Article,

Clinical impact of anti-D in intravenous immunoglobulin
Friedman, D F; Lukas, M B; Larson, P J; Douglas, S D; Manno, C S
1997 Apr;37(4):450-452, Transfusion
— id: 87050, year: 1997, vol: 37, page: 450, stat: Journal Article,

Superior in vivo response of recombinant factor VIII concentrate in children with hemophilia A
Kelly, K M; Butler, R B; Farace, L; Cohen, A R; Manno, C S
1997 Apr;130(4):537-540, Journal of pediatrics
— id: 87051, year: 1997, vol: 130, page: 537, stat: Journal Article,

The presurgical management with erythrocytapheresis of a patient with a high-oxygen-affinity, unstable Hb variant (Hb Bryn Mawr)
Larson, P J; Friedman, D F; Reilly, M P; Kattamis, A C; Asakura, T; Fortina, P; Cohen, A R; Kim, H C; Manno, C S
1997 Jul;37(7):703-707, Transfusion
— id: 87048, year: 1997, vol: 37, page: 703, stat: Journal Article,

Screening for hereditary spherocytosis by use of automated erythrocyte indexes
Michaels, L A; Cohen, A R; Zhao, H; Raphael, R I; Manno, C S
1997 Jun;130(6):957-960, Journal of pediatrics
— id: 87049, year: 1997, vol: 130, page: 957, stat: Journal Article,

Alloimmunization to platelets in heavily transfused patients with sickle cell disease
Friedman, D F; Lukas, M B; Jawad, A; Larson, P J; Ohene-Frempong, K; Manno, C S
1996 Oct 15;88(8):3216-3222, Blood
— id: 87054, year: 1996, vol: 88, page: 3216, stat: Journal Article,

Delayed hemolytic transfusion reaction due to anti-Go(a), an antibody against the low-prevalence Gonzales antigen
Larson, P J; Lukas, M B; Friedman, D F; Manno, C S
1996 Dec;53(4):248-250, American journal of hematology
— id: 87052, year: 1996, vol: 53, page: 248, stat: Journal Article,

What's new in transfusion medicine?
Manno, C S
1996 Jun;43(3):793-808, Pediatric clinics of North America
— id: 87055, year: 1996, vol: 43, page: 793, stat: Journal Article,

Recombinant human erythropoietin reduces the need for erythrocyte and platelet transfusions in pediatric patients with sarcoma: a randomized, double-blind, placebo-controlled trial
Porter, J C; Leahey, A; Polise, K; Bunin, G; Manno, C S
1996 Nov;129(5):656-660, Journal of pediatrics
— id: 87053, year: 1996, vol: 129, page: 656, stat: Journal Article,

Treatment of refractory Evans syndrome with alternate-day cyclosporine and prednisone
Rackoff, W R; Manno, C S
1994 May;16(2):156-159, American journal of pediatric hematology-oncology
— id: 87056, year: 1994, vol: 16, page: 156, stat: Journal Article,

Use of acetyl chloride/methanol for assumed selective methylation of plasma nonesterified fatty acids results in significant methylation of esterified fatty acids
Hallaq, Y; Becker, T C; Manno, C S; Laposata, M
1993 Apr;28(4):355-360, Lipids
— id: 87059, year: 1993, vol: 28, page: 355, stat: Journal Article,

Coagulation defects in neonates during cardiopulmonary bypass
Jobes, D R; Nicolson, S C; Steven, J M; Manno, C S
1993 May;55(5):1283-1284, Annals of thoracic surgery
— id: 87058, year: 1993, vol: 55, page: 1283, stat: Journal Article,

Desmopressin does not decrease bleeding after cardiac operation in young children
Reynolds, L M; Nicolson, S C; Jobes, D R; Steven, J M; Norwood, W I; McGonigle, M E; Manno, C S
1993 Dec;106(6):954-958, Journal of thoracic & cardiovascular surgery
— id: 87057, year: 1993, vol: 106, page: 954, stat: Journal Article,

Diffuse chondrolytic arthritis in sickle cell disease
Schumacher, H R Jr; Van Linthoudt, D; Manno, C S; Cuckler, J M; Athreya, B H
1993 Feb;20(2):385-389, Journal of rheumatology
— id: 87060, year: 1993, vol: 20, page: 385, stat: Journal Article,

Low recovery in vivo of highly purified factor VIII in patients with hemophilia
Manno, C S; Butler, R B; Cohen, A R
1992 Nov;121(5 Pt 1):814-818, Journal of pediatrics
— id: 87061, year: 1992, vol: 121, page: 814, stat: Journal Article,

Difficult pediatric diagnoses. Bruising and bleeding
Manno, C S
1991 Jun;38(3):637-655, Pediatric clinics of North America
— id: 87062, year: 1991, vol: 38, page: 637, stat: Journal Article,

Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children
Manno, C S; Hedberg, K W; Kim, H C; Bunin, G R; Nicolson, S; Jobes, D; Schwartz, E; Norwood, W I
1991 Mar 1;77(5):930-936, Blood
— id: 87063, year: 1991, vol: 77, page: 930, stat: Journal Article,

Splenectomy in mild hereditary spherocytosis: is it worth the risk?
Manno, C S; Cohen, A R
1989 Fall;11(3):300-303, American journal of pediatric hematology-oncology
— id: 87064, year: 1989, vol: 11, page: 300, stat: Journal Article,

Rapid excretion of gallium-67 isotope in an iron-overloaded patient receiving high-dose intravenous deferoxamine
Baker, D L; Manno, C S
1988 Dec;29(4):230-232, American journal of hematology
— id: 87065, year: 1988, vol: 29, page: 230, stat: Journal Article,

Sickle cell anemia and cholelithiasis
Manno, C S; Cohen, A R; Schwartz, E
1988 ;18(2):178-178, Pediatric radiology
— id: 87066, year: 1988, vol: 18, page: 178, stat: Journal Article,

Update on hemoglobinopathies
Liebhaber, S A; Manno, C S
1983 Jul;29(10):1-74, Disease-a-month
— id: 87068, year: 1983, vol: 29, page: 1, stat: Journal Article,

Biventricular function in sickle-cell anemia: radionuclide angiographic and thallium-201 scintigraphic evaluation
Manno, B V; Burka, E R; Hakki, A H; Manno, C S; Iskandrian, A S; Noone, A M
1983 Sep 1;52(5):584-587, American journal of cardiology
— id: 87067, year: 1983, vol: 52, page: 584, stat: Journal Article,