Biosketch / Results /

William Manger

Clinical Professor, Department of Rehabilitation Medicine

Contact Info

212/889-3557
William.Manger@nyumc.org

Education

1949-1950 — Columbia Presbyterian Medical Center (Medicine), Residency Training

Research Summary

Previously, we showed that Dahl salt-sensitive (DS) rats increase renal vascular resistance (RVR) in response to a feeding of excessive salt (8% NaCl) before total peripheral resistance increases and before hypertension occurs. Failure of renal vasculature to dilate, as normally occurs in salt-resistant (DR) rats fed a high salt diet, may play an etiologic role in developing hypertension in DS rats. We also showed that renal vasculature in DS rats is hyperreactive to vasoconstrictors (angiotensin II and norepinephrine) and hyporeactive to vasodilators (ANP and nitroprusside). ANP, via stimulation of cell-bound receptors and nitroprusside (NP), directly via nitric oxide (NO) generation, cause renal vasodilation by generating guanosine 3'5'-cyclic monophosphate (cGMP). To determine if defective renal vasodilation in DS rats is due to impaired production of cGMP, we examined the influence of NP infusion and salt intake on RVR and cGMP excretion in DS and DR rats. Our results demonstrated that salt feeding and NP infusion increase cGMP excretion and decrease RVR in DR rats (P<0.01), and, although this relationship was less clear in DS rats, a reciprocal relationship was indicated between RVR and cGMP excretion in all animals studied. A relatively small increase in cGMP was associated with maximal renal vasodilation. Salt feeding and NP infusion caused less increase in cGMP excretion in DS than in DR rats (P<0.01). These studies support the concept that impairment in cGMP generation may play a primary role in the kidneys' inability in DS rats to vasodilate in response to increased salt intake. Such an impairment could contribute to salt retention and development of hypertension.

Research Interests

Renal Hemodynamics and Urinary cGMP Excretion

Obesity Prevention in Young Schoolchildren: Results of a Pilot Study
Manger, William M; Manger, Lynn S; Minno, Alexander M; Killmeyer, Mike; Holzman, Robert S; Schullinger, John N; Roccella, Edward J. Obesity Prevention in Young Schoolchildren: Results of a Pilot Study. Journal of school health. 2012 Oct ;82(10):462-468 (179138)

Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats
Manger, William M; Simchon, Shlomoh; Stokes, Michael B; Reidy, Jason J; Kumar, Asok R; Baer, Leslie; Gallo, Gloria; Haddy, Francis J. Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats. Journal of hypertension. 2009 Mar ;27(3):587-598 (101236)

'Cerebral vasculitis': Mistaken cause of fluctuating blood pressure and neurological manifestations
Manger, WM. 'Cerebral vasculitis': Mistaken cause of fluctuating blood pressure and neurological manifestations. Kidney international. 2008 FEB ;73(3):354-359 (87177)

Adverse drug reactions in patients with phaeochromocytoma: incidence, prevention and management
Eisenhofer, Graeme; Rivers, Graham; Rosas, Alejandro L; Quezado, Zena; Manger, William M; Pacak, Karel. Adverse drug reactions in patients with phaeochromocytoma: incidence, prevention and management. Drug safety. 2007 ;30(11):1031-1062 (95341)

An overview of pheochromocytoma: history, current concepts, vagaries, and diagnostic challenges
Manger, William M. An overview of pheochromocytoma: history, current concepts, vagaries, and diagnostic challenges. Annals of the New York Academy of Sciences. 2006 Aug ;1073:1-20 (95342)