Prashiela Manga

Biosketch / Results /

Prashiela Manga, Ph.D.

Assistant Professor;
Ronald O. Perelman Department of Dermatology (Fac) and Cell Biology (Cell Biology)

Contact Info

Address
522 First Ave
Floor 4 Room 407
Smilow Research Building
New York, NY 10016

212-263-9086, 212-263-5070
Prashiela.Manga@nyumc.org

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Education

1981-1997 — Univ of Witwaterand, Graduate Education
1997-2002 — NYU School of Medicine, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions
Lobach, Iryna; Fan, Ruzong; Manga, Prashiela
2014 ;7(1):51-60, Statistics & its interface
— id: 1015042, year: 2014, vol: 7, page: 51, stat: Journal Article,

Loss of Oca2 disrupts the unfolded protein response and increases resistance to endoplasmic reticulum stress in melanocytes
Cheng, Tsing; Orlow, Seth J; Manga, Prashiela
2013 Nov;26(6):826-834, Pigment cell & melanoma research
— id: 586232, year: 2013, vol: 26, page: 826, stat: Journal Article,

Report of a novel OCA2 gene mutation and an investigation of OCA2 variants on melanoma risk in a familial melanoma pedigree
Hawkes, Jason E; Cassidy, Pamela B; Manga, Prashiela; Boissy, Raymond E; Goldgar, David; Cannon-Albright, Lisa; Florell, Scott R; Leachman, Sancy A
2013 Jan;69(1):30-37, Journal of dermatological science
— id: 206362, year: 2013, vol: 69, page: 30, stat: Journal Article,

Biology and genetics of oculocutaneous albinism and vitiligo - common pigmentation disorders in southern Africa
Manga, Prashiela; Kerr, Robyn; Ramsay, Michele; Kromberg, Jennifer G R
2013 Dec;103(12):984-988, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
— id: 666442, year: 2013, vol: 103, page: 984, stat: Journal Article,

IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis
Wang, Claire Q F; Akalu, Yemsratch T; Suarez-Farinas, Mayte; Gonzalez, Juana; Mitsui, Hiroshi; Lowes, Michelle A; Orlow, Seth J; Manga, Prashiela; Krueger, James G
2013 Dec;133(12):2741-2752, Journal of investigative dermatology
— id: 666502, year: 2013, vol: 133, page: 2741, stat: Journal Article,

DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive oxygen species or apoptosis
Chawla, Smita; Kvalnes, Kalla; deLong, Mitchell A; Wickett, Randall; Manga, Prashiela; Boissy, Raymond E
2012 Oct;11(10):e28-e34, Journal of drugs in dermatology : JDD
— id: 836532, year: 2012, vol: 11, page: e28, stat: Journal Article,

Dysregulation of the unfolded protein response contributes to chemoresistance in melanocytes
Cheng, T; Orlow, S J; Manga, P
2012 May 2012;132:S131-S131, Journal of investigative dermatology
— id: 166924, year: 2012, vol: 132, page: S131, stat: Journal Article,

A role for the unfolded protein response in vitiligo
Manga, P; Toosi, S; Orlow, S J
2012 September 2012;25(5):685-686, Pigment cell & melanoma research
— id: 250132, year: 2012, vol: 25, page: 685, stat: Journal Article,

Engineering a new mouse model for vitiligo
Manga, Prashiela; Orlow, Seth J
2012 Jul;132(7):1752-1755, Journal of investigative dermatology
— id: 169522, year: 2012, vol: 132, page: 1752, stat: Journal Article,

Vitiligo inducing phenols increase production of IL6 and IL8 from melanocytes via the unfolded protein response
Toosi, S; Orlow, S J; Manga, P
2012 May 2012;132:S127-S127, Journal of investigative dermatology
— id: 166925, year: 2012, vol: 132, page: S127, stat: Journal Article,

Vitiligo-Inducing Phenols Activate the Unfolded Protein Response in Melanocytes Resulting in Upregulation of IL6 and IL8
Toosi, Siavash; Orlow, Seth J; Manga, Prashiela
2012 Jun;:2601-2609, Journal of investigative dermatology
— id: 174329, year: 2012, vol: , page: 2601, stat: Journal Article,

Melanocyte adaptation to ER stress and activation of the unfolded protein response in Oca2-null melanocytes
Cheng, T; Orlow, S J; Manga, P
2011 August 2011;24(4):810-810, Pigment cell & melanoma research
— id: 241432, year: 2011, vol: 24, page: 810, stat: Journal Article,

Impact of population genetic substructure on association studies and risk assessment for melanoma
Lobach I; Belitskaya-Levy I; Goldberg JD; Ostrer H; Berman RS; Pavlick AC; Shapiro RL; Osman I; Manga P
2011 ;29(Suppl):?-? #8521, Journal of clinical oncology
— id: 132473, year: 2011, vol: 29, page: ?, stat: Journal Article,

Informed reasoning: repositioning of nitisinone to treat oculocutaneous albinism
Manga, Prashiela; Orlow, Seth J
2011 Oct 3;121(10):3828-3831, Journal of clinical investigation
— id: 141072, year: 2011, vol: 121, page: 3828, stat: Journal Article,

Identifying novel therapeutic agents for vitiligo
Tan, A. U.; Orlow, S. J.; Manga, P.
2011 APR ;131(5):S121-S121, Journal of investigative dermatology
— id: 131840, year: 2011, vol: 131, page: S121, stat: Journal Article,

Role of oxidative stress and unfolded protein response in development of vitiligo
Toosi, S.; Orlow, S. J.; Manga, P.
2011 APR ;131(5):S120-S120, Journal of investigative dermatology
— id: 131839, year: 2011, vol: 131, page: S120, stat: Journal Article,

Differential adaptation to chronic ER stress in wildtype and Oca2 melanocytes
Cheng T.; Manga P.; Bis S.; Knoll K.; Orlow S.S.
2010 ;23(5):710-710, Pigment cell & melanoma research
— id: 113676, year: 2010, vol: 23, page: 710, stat: Journal Article,

Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
Kadekaro, Ana Luisa; Leachman, Sancy; Kavanagh, Renny J; Swope, Viki; Cassidy, Pamela; Supp, Dorothy; Sartor, Maureen; Schwemberger, Sandy; Babcock, George; Wakamatsu, Kazumasa; Ito, Shosuke; Koshoffer, Amy; Boissy, Raymond E; Manga, Prashiela; Sturm, Richard A; Abdel-Malek, Zalfa A
2010 Oct;24(10):3850-3860, FASEB journal
— id: 115707, year: 2010, vol: 24, page: 3850, stat: Journal Article,

Delineation of the unfolded protein response in melanocytes: Potential implications for vitiligo and UV response
Manga P.; Vega M.; Bis S.; Knoll K.; Orlow S.
2010 ;23(5):704-705, Pigment cell & melanoma research
— id: 113675, year: 2010, vol: 23, page: 704, stat: Journal Article,

From melanocyte to malignant metastatic melanoma
Manga, P; Hoek, KS; Davids, LM; Leachman, SA
2010 ;2010(1):- 798324, Dermatology research & practice
— id: 1059072, year: 2010, vol: 2010, page: , stat: Journal Article,

The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding
Manga, Prashiela; Bis, Sabina; Knoll, Kristen; Perez, Beremis; Orlow, Seth J
2010 Oct;23(5):627-634, Pigment cell & melanoma research
— id: 112422, year: 2010, vol: 23, page: 627, stat: Journal Article,

From melanocyte to malignant metastatic melanoma. L
Manga, Prashiela; Hoek, Keith S; Davids, Lester M; Leachman, Sancy A
2010 ;2010:?-?, Dermatology research & practice
— id: 113806, year: 2010, vol: 2010, page: ?, stat: Journal Article,

Identification of tyrosinase polymorphisms for use in melanoma risk assessment
Pervolaraki E; Lobach I; Belitskaya-Levy I; Ostrer H; Goldberg JD; Polsky D; Shapiro RL; Berman RS; Osman I; Manga P
2010 ;28(15S):?-? #8570, Journal of clinical oncology
— id: 111554, year: 2010, vol: 28, page: ?, stat: Journal Article,

Initiation of the unfolded protein response in melanocytes and melanoma
Bis, SG; Knoll, KE; Lolis, MS; Orlow, SJ; Manga, P
2009 APR ;129(5):S139-S139, Journal of investigative dermatology
— id: 97878, year: 2009, vol: 129, page: S139, stat: Journal Article,

Association of MDM2 SNP309, age of onset, and gender in cutaneous melanoma
Firoz, Elnaz F; Warycha, Melanie; Zakrzewski, Jan; Pollens, Danuta; Wang, Guimin; Shapiro, Richard; Berman, Russell; Pavlick, Anna; Manga, Prashiela; Ostrer, Harry; Celebi, Julide Tok; Kamino, Hideko; Darvishian, Farbod; Rolnitzky, Linda; Goldberg, Judith D; Osman, Iman; Polsky, David
2009 Apr 1;15(7):2573-2580, Clinical cancer research
— id: 104875, year: 2009, vol: 15, page: 2573, stat: Journal Article,

Developing genetic markers for melanoma risk assessment
Manga P.; Goldberg J.D.; Belitskaya-Levy I.; Lobach I.; Polsky D.; Pavlick A.; Shapiro R.; Berman R.; Osman I.; Ostrer H.
2009 ;27(15 Suppl 1):9046-9046, Journal of clinical oncology
— id: 111805, year: 2009, vol: 27, page: 9046, stat: Journal Article,

Evaluation of the melanocortin-1-receptor gene in melanoma predisposition, progression and recurrence
Sidash S; Ostrer H; Goldberg JD; Belitskaya-Levy I; Lobach I; Polsky D; Shapiro RL; Berman RS; Osman I; Manga P
2009 ;27:15S-15S, Journal of clinical oncology
— id: 102306, year: 2009, vol: 27, page: 15S, stat: Journal Article,

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research
Wich, Lindsay G; Hamilton, Heather K; Shapiro, Richard L; Pavlick, Anna; Berman, Russell S; Polsky, David; Goldberg, Judith D; Hernando, Eva; Manga, Prashiela; Krogsgaard, Michelle; Kamino, Hideko; Darvishian, Farbod; Lee, Peng; Orlow, Seth J; Ostrer, Harry; Bhardwaj, Nina; Osman, Iman
2009 ;1(1):35-43, American journal of translational research
— id: 105566, year: 2009, vol: 1, page: 35, stat: Journal Article,

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism
Bowling, Benjamin D; Doudican, Nicole; Manga, Prashiela; Orlow, Seth J
2008 Dec;63(1):37-43, Cancer chemotherapy & pharmacology
— id: 91428, year: 2008, vol: 63, page: 37, stat: Journal Article,

A role for the pink-eyed dilution protein in tyrosinase folding
Manga, P; Knoll, K; Fenton, J; Orlow, SJ
2008 APR ;21(2):261-262, Pigment cell & melanoma research
— id: 78651, year: 2008, vol: 21, page: 261, stat: Journal Article,

Does melanin have an SPF and can it be measured?
Epstein, H; Manga, P; Koshoffer, A; Story, D; Simion, T; Boissy, R
2007 SEP-OCT ;58(5):596-597, Journal of cosmetic science
— id: 87151, year: 2007, vol: 58, page: 596, stat: Journal Article,

A Role for Tyrosinase-Related Protein 1 in 4-tert-Butylphenol-Induced Toxicity in Melanocytes: Implications for Vitiligo
Manga, Prashiela; Sheyn, David; Yang, Fan; Sarangarajan, Rangaprasad; Boissy, Raymond E
2006 Nov;169(5):1652-1662, American journal of pathology
— id: 69049, year: 2006, vol: 169, page: 1652, stat: Journal Article,

On the etiology of contact/occupational vitiligo
Boissy, Raymond E; Manga, Prashiela
2004 Jun;17(3):208-214, Pigment cell research
— id: 68898, year: 2004, vol: 17, page: 208, stat: Journal Article,

Pink-eyed dilution protein controls the processing of tyrosinase
Chen, Kun; Manga, Prashiela; Orlow, Seth J
2002 Jun;13(6):1953-1964, Molecular biology of the cell
— id: 34784, year: 2002, vol: 13, page: 1953, stat: Journal Article,

Pink-eyed Dilution Protein Modulates Arsenic Sensitivity and Intracellular Glutathione Metabolism
Staleva, Liliana; Manga, Prashiela; Orlow, Seth J
2002 Dec;13(12):4206-4220, Molecular biology of the cell
— id: 34781, year: 2002, vol: 13, page: 4206, stat: Journal Article,

Abnormal tyrosinase processing and fate in melanocytes lacking the pink-eyed dilution gene
Chen, K; Manga, P; Orlow, S
2001 AUG ;117(2):510-510, Journal of investigative dermatology
— id: 54904, year: 2001, vol: 117, page: 510, stat: Journal Article,

Mislocalization of melanosomal proteins in melanocytes from mice with oculocutaneous albinism type 2
Manga P; Boissy RE; Pifko-Hirst S; Zhou BK; Orlow SJ
2001 Jun;72(6):695-710, Experimental eye research
— id: 21192, year: 2001, vol: 72, page: 695, stat: Journal Article,

Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1
Manga P; Orlow SJ
2001 Oct;14(5):362-367, Pigment cell research
— id: 34788, year: 2001, vol: 14, page: 362, stat: Journal Article,

Mutational analysis of the modulation of tyrosinase by tyrosinase-related proteins 1 and 2 in vitro
Manga P; Sato K; Ye L; Beermann F; Lamoreux ML; Orlow SJ
2000 Oct;13(5):364-374, Pigment cell research
— id: 34794, year: 2000, vol: 13, page: 364, stat: Journal Article,

The pink-eyed dilution gene and the molecular pathogenesis of tyrosinase-positive albinism (OCA2)
Manga P; Orlow SJ
1999 Nov;26(11):738-747, Journal of dermatology
— id: 11863, year: 1999, vol: 26, page: 738, stat: Journal Article,