Nandor Ludvig

Biosketch / Results /

Nandor Ludvig, M.D., Ph.D.

Research Associate Professor;
Department of Neurology (Neurology)

Contact Info

Address
223 East 34th Street
Ground Floor
Epilepsy Center
New York, NY 10016

718-270-1796
Nandor.Ludvig@nyumc.org


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Education

1979 — Univ of Pecs Medical School, Medical Education
1994 — Hungarian Academy of Sciences, Graduate Education

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Research Summary

The long-term objective of this project is to develop a novel medical implant for the treatment of intractable focal epilepsy, which affects approximately 10 million people worldwide. This experimental implant is named as "Subdural Hybrid Neuroprosthesis", as its recording/drug delivery component is placed between the dura and pia maters, and the device comprises both electrophysiological and pharmacological components. The general architecture and concept of the device was patented by us in 2002, with patents for the advanced versions are pending. It was designed to monitor the electrical and/or neurochemical activity of epileptogenic zones in the cerebral cortex, analyze the acquired signals real-time, and deliver antiepileptic drugs into the epileptogenic zones before or at the onset of seizures to promptly stop the abnormal neural activity and achieve therapeutic effect. Hardware components of this device are: a subdural electrode/catheter, a signal conditioner, a digital signal processor, a transcutaneously rechargeable power supply, an RF communication module, and a percutaneously refillable saline/antiepileptic drug minipump. We have developed the prototypes of these components, showed that microelectrode-using multineuron recording is likely the best way to predict seizures, and proved that muscimol is an ideal candidate for this localized, subdural epilepsy therapy. The significance of this project, presently funded by the Epilepsy Research Foundation, is that it will develop a therapeutic strategy for epileptic patients whose focal seizures cannot be controlled with traditional pharmacological and surgical treatments. Neuroscientists, epileptologists, neurosurgeons and bioengineers are working together to accomplish this goal.

Research Interests

Development of a subdural hybrid neuroprosthesis for the treatment of intractable focal epilepsy and other cerebral cortical disorders.

Research Keywords

Monkey; Hippocampus; Neuron recording; EEG; Seizure; Spatial memory; Place cells; Microdialysis; Hybrid Neuroprosthesis; Intractable epilepsy

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Subarachnoid pharmacodialysis for central nervous system disorders
Kral, John G; Ludvig, Nandor
2013 Feb;80(2):105-111, Medical hypotheses
— id: 947572, year: 2013, vol: 80, page: 105, stat: Journal Article,

An implantable triple-function device for local drug delivery, cerebrospinal fluid removal and EEG recording in the cranial subdural/subarachnoid space of primates
Ludvig N; Medveczky G; Rizzolo R; Tang HM; Baptiste SL; Doyle WK; Devinsky O; Carlson C; French JA; Kral JG; Charchaflieh J; Kuzniecky RI
2012 Jan;203(2):275-283, Journal of neuroscience methods
— id: 139939, year: 2012, vol: 203, page: 275, stat: Journal Article,

Autoradiographic evidence for the transmeningeal diffusion of muscimol into the neocortex in rats
Ludvig, Nandor; Switzer, Robert C 3rd; Tang, Hai M; Kuzniecky, Ruben I
2012 Mar;1441:1-8, Brain research
— id: 158274, year: 2012, vol: 1441, page: 1, stat: Journal Article,

Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys
Ludvig, Nandor; Tang, Hai M; Baptiste, Shirn L; Medveczky, Geza; Vaynberg, Jonathan K; Vazquez-Derose, Jacqueline; Stefanov, Dimitre G; Devinsky, Orrin; French, Jacqueline A; Carlson, Chad; Kuzniecky, Ruben I
2012 Jul;117(1):162-175, Journal of neurosurgery
— id: 171122, year: 2012, vol: 117, page: 162, stat: Journal Article,

Multi-layer coils for efficient Transcutaneous Power Transfer
Artan, N Sertac; Li, Xiaonin; Patel, Ramesh; Ning, Chengzhi; Ludvig, Nandor; Chao, H Jonathan
2011 ;2011:3031-3034, Conference Proceedings (IEEE Engineering in Medicine & Biology Society)
— id: 947562, year: 2011, vol: 2011, page: 3031, stat: Journal Article,

Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area
Ludvig, Nandor; Tang, Hai M; Artan, N Sertac; Mirowski, Piotr; Medveczky, Geza; Baptiste, Shirn L; Darisi, Sindhu; Kuzniecky, Ruben I; Devinsky, Orrin; French, Jacqueline A
2011 Apr 18;1385:182-191, Brain research
— id: 129321, year: 2011, vol: 1385, page: 182, stat: Journal Article,

Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats
Tang, Hai M; French, Jacqueline A; Kuzniecky, Ruben I; Devinsky, Orrin; Ludvig, Nandor
2011 Apr 25;494(2):135-138, Neuroscience letters
— id: 130302, year: 2011, vol: 494, page: 135, stat: Journal Article,

A high-performance transcutaneous battery charger for medical implants
Artan, N; Vanjani, Hitesh; Vashist, Gurudath; Fu, Zhen; Bhakthavatsala, Santosh; Ludvig, Nandor; Medveczky, Geza; Chao, H
2010 ;1:1581-1584, Conference Proceedings (IEEE Engineering in Medicine & Biology Society)
— id: 115443, year: 2010, vol: 1, page: 1581, stat: Journal Article,

Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats
Baptiste, Shirn L; Tang, Hai M; Kuzniecky, Ruben I; Devinsky, Orrin; French, Jacqueline A; Ludvig, Nandor
2010 Jan 29;469(3):421-424, Neuroscience letters
— id: 106495, year: 2010, vol: 469, page: 421, stat: Journal Article,

Subarachnoid pharmacotherapy for maximizing recovery after cortical ischemic stroke
Ludvig N.
2010 ;3(2):13-21, Journal of experimental stroke & translational medicine
— id: 113818, year: 2010, vol: 3, page: 13, stat: Journal Article,

Evolution and prospects for intracranial pharmacotherapy for refractory epilepsies: the subdural hybrid neuroprosthesis
Ludvig, Nandor; Medveczky, Geza; French, Jacqueline A; Carlson, Chad; Devinsky, Orrin; Kuzniecky, Ruben I
2010 ;2010:725696-725696, Epilepsy research & treatment
— id: 177156, year: 2010, vol: 2010, page: 725696, stat: Journal Article,

DETECTING ABNORMALLY LARGE-AMPLITUDE MULTI-NEURON BURSTS BEFORE FOCAL NEOCORTICAL EEG SEIZURE ONSET IN FREELY BEHAVING RATS
Artan, Nabi S.; Mirowski, P.; Tang, H. M.; Medveczky, G.; Baptiste, S. L.; Chao, H. J.; Devinsky, O.; Kuzniecky, R. I.; Ludvig, N.
2009 NOV;50:391-391, Epilepsia
— id: 654632, year: 2009, vol: 50, page: 391, stat: Journal Article,

Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications
Ludvig, Nandor; Baptiste, Shirn L; Tang, Hai M; Medveczky, Geza; von Gizycki, Hans; Charchaflieh, Jean; Devinsky, Orrin; Kuzniecky, Ruben I
2009 Apr;50(4):678-693, Epilepsia
— id: 95775, year: 2009, vol: 50, page: 678, stat: Journal Article,

CELLULAR ELECTROPHYSIOLOGICAL EFFECTS OF SEIZURE-PREVENTING CONCENTRATIONS OF TRANSMENINGEAL MUSCIMOL IN THE RAT NEOCORTEX
Ludvig, Nandor; Tang, H. M.; Baptiste, S. L.; Medveczky, G.; Artan, N. S.; Chao, H. J.; Mirowski, P.; Devinsky, O.; French, J.; Kuzniecky, R. I.
2009 NOV;50:390-391, Epilepsia
— id: 654622, year: 2009, vol: 50, page: 390, stat: Journal Article,

EPIDURAL AND SUBDURAL MUSCIMOL DELIVERIES IN RATS AND MONKEYS, RESPECTIVELY, PREVENT FOCAL SEIZURES AT CONCENTRATIONS THAT CAUSE NO BEHAVIORAL SIDE-EFFECTS
Baptiste, SL; Tang, HM; Devinsky, O; Kuzniecky, RI; Charchaflieh, J; von Gizycki, H; Ludvig, N
2008 DEC ;49(12):375-376, Epilepsia
— id: 91398, year: 2008, vol: 49, page: 375, stat: Journal Article,

Unmasking the CA1 ensemble place code by exposures to small and large environments: more place cells and multiple, irregularly arranged, and expanded place fields in the larger space
Fenton, Andre A; Kao, Hsin-Yi; Neymotin, Samuel A; Olypher, Andrey; Vayntrub, Yevgeniy; Lytton, William W; Ludvig, Nandor
2008 Oct 29;28(44):11250-11262, Journal of neuroscience
— id: 95957, year: 2008, vol: 28, page: 11250, stat: Journal Article,

Histological evidence for drug diffusion across the cerebral meninges into the underlying neocortex in rats
Ludvig, Nandor; Sheffield, Lynette G; Tang, Hai M; Baptiste, Shirn L; Devinsky, Orrin; Kuzniecky, Ruben I
2008 Jan 10;1188:228-232, Brain research
— id: 79135, year: 2008, vol: 1188, page: 228, stat: Journal Article,

Effects of subdural application of lidocaine in patients with focal epilepsy
Madhavan, Deepak; Mirowski, Piotr; Ludvig, Nandor; Carlson, Chad; Doyle, Werner; Devinsky, Orrin; Kuzniecky, Ruben
2008 Feb;78(2-3):235-239, Epilepsy research
— id: 78353, year: 2008, vol: 78, page: 235, stat: Journal Article,

EVIDENCE FOR INCREASED NEURONAL ELECTROPHYSIOLOGICAL ACTIVITY BEFORE EEG SEIZURE ONSET IN THE RAT NEOCORTICAL SEIZURE FOCUS
Tang, HM; Mirowski, P; Baptiste, SL; Devinsky, O; Kuzniecky, RI; Ludvig, N
2008 DEC ;49(12):382-382, Epilepsia
— id: 91399, year: 2008, vol: 49, page: 382, stat: Journal Article,

Transmeningeal delivery of GABA to control neocortical seizures in rats
John, Jenine E; Baptiste, Shirn L; Sheffield, Lynette G; von Gizycki, Hans; Kuzniecky, Ruben I; Devinsky, Orrin; Ludvig, Nandor
2007 Jun;75(1):10-17, Epilepsy research
— id: 72893, year: 2007, vol: 75, page: 10, stat: Journal Article,

Neocortical multi-neuron recording as a potential tool for predicting focal seizures
Ludvig, N; Tang, HM; Baptiste, SL; Kuzniecky, RI; Devinsky, O
2007 OCT ;48(1):388-388, Epilepsia
— id: 87156, year: 2007, vol: 48, page: 388, stat: Journal Article,

Effects of the subdural application of lidocaine on EEG spiking in patients with focal epilepsy
Madhavan, D; Mirowski, PW; Ludvig, N; Carlson, C; Devinsky, O; Doyle, W; Kuzniecky, R
2007 OCT ;48(4):307-308, Epilepsia
— id: 104242, year: 2007, vol: 48, page: 307, stat: Journal Article,

Histological evidence for transmeningeal drug diffusion in the rat cerebral cortex: A study on the neuropathological effects of epidurally delivered NMDA
Sheffield, LG; Baptiste, SL; Tang, HM; Kuzniecky, RI; Devinsky, O; Ludvig, N
2007 OCT ;48(1):310-310, Epilepsia
— id: 87155, year: 2007, vol: 48, page: 310, stat: Journal Article,

Elevated lactate suppresses neuronal firing in vivo and inhibits glucose metabolism in hippocampal slice cultures
Gilbert, Erin; Tang, J Michael; Ludvig, Nandor; Bergold, Peter J
2006 Oct 30;1117(1):213-223, Brain research
— id: 95958, year: 2006, vol: 1117, page: 213, stat: Journal Article,

Epidural delivery of the combination of GABA and adenosine terminates locally induced neocortical seizures in rats
John, JE; Baptiste, SL; Medveczky, G; von Gizycki, H; Kuzniecky, RI; Devinsky, O; Ludvig, N
2006 SEP ;47(3):219-219, Epilepsia
— id: 69539, year: 2006, vol: 47, page: 219, stat: Journal Article,

Epidural pentobarbital delivery can prevent locally induced neocortical seizures in rats: the prospect of transmeningeal pharmacotherapy for intractable focal epilepsy
Ludvig, Nandor; Kuzniecky, Ruben I; Baptiste, Shirn L; John, Jenine E; von Gizycki, Hans; Doyle, Werner K; Devinsky, Orrin
2006 Nov;47(11):1792-1802, Epilepsia
— id: 69701, year: 2006, vol: 47, page: 1792, stat: Journal Article,

Synchrony changes between hippocampal and neocortical EEG signals precede seizure activity induced by intrahippocampal NMDA application in freely behaving rats
von Gizycki, H; Baptiste, SL; Medveczky, G; Kuzniecky, RI; Devinsky, O; Ludvig, N
2006 SEP ;47(3):47-47, Epilepsia
— id: 69536, year: 2006, vol: 47, page: 47, stat: Journal Article,

Vector-analysis: Low-power-requiring software for real-time EEG seizure recognition/prediction in hybrid neuroprosthetic devices
Kovacs, L; Ludvig, N; Devinsky, O; Kuzniecky, RI
2005 SEP ;46(11):317-318, Epilepsia
— id: 59591, year: 2005, vol: 46, page: 317, stat: Journal Article,

Toward the development of a subdural hybrid neuroprosthesis for the treatment of intractable focal epilepsy
Ludvig, N; Kovacs, L; Medveczky, G; Kuzniecky, RI; Devinsky, O
2005 SEP ;46(11):270-270, Epilepsia
— id: 59588, year: 2005, vol: 46, page: 270, stat: Journal Article,

Developing a kainic acid-induced temporal lobe epilepsy model in behaving squirrel monkeys
Ludvig, N; Kuzniecky, RI; Moshe, SL; von Gizycki, H; Devinsky, O
2004 AUG-SEP ;45(3):210-211, Epilepsia
— id: 49021, year: 2004, vol: 45, page: 210, stat: Journal Article,

Detecting location-specific neuronal firing rate increases in the hippocampus of freely-moving monkeys
Ludvig, Nandor; Tang, Hai M; Gohil, Baiju C; Botero, Juan M
2004 Jul 16;1014(1-2):97-109, Brain research
— id: 61904, year: 2004, vol: 1014, page: 97, stat: Journal Article,

Spatial memory performance of freely-moving squirrel monkeys
Ludvig, Nandor; Tang, Hai M; Eichenbaum, Howard; Gohil, Baiju C
2003 Mar 18;140(1-2):175-183, Behavioural brain research
— id: 61905, year: 2003, vol: 140, page: 175, stat: Journal Article,

The use of a remote-controlled minivalve, carried by freely moving animals on their head, to achieve instant pharmacological effects in intracerebral drug-perfusion studies
Ludvig, Nandor; Kovacs, Lorant; Kando, Laszlo; Medveczky, Geza; Tang, Hai M; Eberle, Lawrence P; Lemon, Charles R
2002 Feb;9(1):23-31, Brain research protocols
— id: 61906, year: 2002, vol: 9, page: 23, stat: Journal Article,

Application of the combined single-cell recording/intracerebral microdialysis method to alcohol research in freely behaving animals
Ludvig, N; Fox, S E; Kubie, J L; Altura, B M; Altura, B T
1998 Feb;22(1):41-50, Alcoholism: clinical & experimental research
— id: 1221352, year: 1998, vol: 22, page: 41, stat: Journal Article,

Manipulation of pyramidal cell firing in the hippocampus of freely behaving rats by local application of K+ via microdialysis
Ludvig, N; Chao, K; Altura, B T; Altura, B M; Fox, S E
1996 ;6(2):97-108, Hippocampus
— id: 1221612, year: 1996, vol: 6, page: 97, stat: Journal Article,

The suppressant effect of ethanol, delivered via intrahippocampal microdialysis, on the firing of local pyramidal cells in freely behaving rats
Ludvig, N; Altura, B T; Fox, S E; Altura, B M
1995 Sep-Oct;12(5):417-421, Alcohol
— id: 1221682, year: 1995, vol: 12, page: 417, stat: Journal Article,