Jerome Lowenstein, M.D.

The anglerfish and uremic toxins
Lowenstein, Jerome
2011 Jun;25(6):1781-1785, FASEB journal
— id: 134173, year: 2011, vol: 25, page: 1781, stat: Journal Article,

Chronic kidney disease
Neelakantappa, Kotresha; Lowenstein, Jerome
Medical aspects of disability : a handbook for the rehabilitation professional New York : Springer, c2011,
— id: 5794, year: 2011, vol: , page: ?, stat: Chapter,

Henderson's equation : a novel
Lowenstein, Jerome
Great Barrington MA : Gadd & Co., 2008,
— id: 1830, year: 2008, vol: , page: , stat: ,

The midnight meal and other essays about doctors, patients, and medicine
Lowenstein, Jerome
Ann Arbor MI : University of Michigan Press, 2005,
— id: 1829, year: 2005, vol: , page: , stat: ,

Chronic Kidney Disease
Neelakantappa, Kotresha; Lowenstein, Jerome
Medical aspects of disability : a handbook for the rehabilitation professional New York, NY, US: Springer Publishing Co, 2005,
The authors describe chronic kidney disease; functional adaptation to nephron loss; treatment of chronic renal failure; treatment of end stage renal failure; and physical, psychological, and vocational rehabilitation.
— id: 4092, year: 2005, vol: , page: 563, stat: Chapter,

Medical humanities at New York University School of Medicine: an array of rich programs in diverse settings
Krackov, Sharon K; Levin, Richard I; Catanese, Veronica; Rey, Mariano; Aull, Felice; Blagev, Denitza; Dreyer, Benard; Grieco, Anthony J; Hebert, Cristy; Kalet, Adina; Lipkin, Mack Jr; Lowenstein, Jerome; Ofri, Danielle; Stevens, David
2003 Oct;78(10):977-982, Academic medicine
The New York University School of Medicine has a rich tradition of cultivating programs in medical humanities and professionalism. They are drawn from the departments, centers, students, and faculty in the School of Medicine, have linkages throughout the university, and are interwoven into the fabric and culture of the institution. Some are centrally based in the School of Medicine's deans' office, and others are located in individual departments and receive support from the dean's office. This article describes representative programs for medical students and faculty. Curricular initiatives, the fundamental components of medical students' learning, include a course entitled 'The Physician, Patient, and Society,' a clerkship essay in the Medicine Clerkship, an opportunity for reflection during the medicine clerkship, and a medical humanities elective. In 2002, the Professionalism Initiative was launched to enhance and reflect the values of the medical profession. Its curriculum consists of a series of events that coordinate, particularly, with existing elements of the first-year curriculum (e.g., orientation week, a session during anatomy, a self-assessment workshop, and a peer-assessment workshop). The Master Scholars Program is a group of five, theme-based master societies consisting of faculty and students who share common interests around the society's themes. Programs developed for the societies include colloquia, faculty-led seminars, a mandatory student-mentoring program, and visiting scholars. Finally, the authors describe three high-quality literary publications created at New York University School of Medicine. Each of the initiatives undergoes regular critical examination and reflection that drive future planning
— id: 39038, year: 2003, vol: 78, page: 977, stat: Journal Article,

Where have all the giants gone? Reconciling medical education and the traditions of patient care with limitations on resident work hours
Lowenstein, Jerome
2003 Spring;46(2):273-282, Perspectives in biology & medicine
The Accreditation Council for Graduate Medical Education recently approved regulations that would prohibit residents from working more than 80 hours per week and more than 24 hours at a stretch. These regulations are scheduled to take effect in all U.S. teaching hospitals on 1 July 2003. Those who approve of the proposed regulations argue that house staff fatigue is responsible for physician error, depression, anger, and a lack of compassion for patients. But critics point to the adverse effects on key goals of house staff training--the development of accountability and responsibility. Can the rigorous discipline of medical education and the long tradition of medicine as a profession be reconciled with the current calls for limiting resident duty hours and on-call schedules? The intensity of patient care in teaching hospitals today is far greater than it was in the past. These changes in medical care make it critical to develop new programs that will reconcile rigorous, scientifically based humanistic medicine with the needs of patients and physicians. This will require imaginative and creative solutions that take a larger view of medical education and medical care than mere manpower calculations and numerical solutions focused simply on compliance with an 80-hour work week
— id: 95945, year: 2003, vol: 46, page: 273, stat: Journal Article,

Exploring asymmetry in the relationship between patients and physicians
Surbone, Antonella; Lowenstein, Jerome
2003 Fall;14(3):183-188, Journal of clinical ethics
— id: 46206, year: 2003, vol: 14, page: 183, stat: Journal Article,

The midnight meal and other essays about doctors, patients, and medicine
Lowenstein, Jerome
New Haven [Conn.] : Yale University Press, c1997,
— id: 551, year: 1997, vol: , page: , stat: ,

Acid and basics : a guide to understanding acid-base disorders
Lowenstein, Jerome
New York : Oxford University Press, 1993,
— id: 447, year: 1993, vol: , page: , stat: ,

Ranitidine-associated interstitial nephritis and Fanconi syndrome
Neelakantappa K; Gallo GR; Lowenstein J
1993 Aug;22(2):333-336, American journal of kidney diseases
Ranitidine is an H2 blocking agent widely used in the treatment of peptic ulcer disease. Although acute interstitial nephritis has been described in association with a related drug, cimetidine, this complication secondary to ranitidine has been reported only once before. We describe a patient who presented with acute renal failure and features of Fanconi syndrome in association with the use of ranitidine. Renal biopsy showed acute interstitial nephritis. The patient had renal tubular acidosis with alkaline urine, aminoaciduria, renal glycosuria, uricosuria, and phosphaturia. There was a marked disparity between the degree of elevation of urea nitrogen and creatinine concentrations in the serum that was attributable to diminished urea generation, since simultaneous measurement of inulin, creatinine, and urea clearances showed that they were comparably reduced. Urinary nitrogen loss in the form of aminoaciduria contributed significantly to decreased urea generation. Both acute renal failure and Fanconi syndrome resolved after treatment with prednisone
— id: 13099, year: 1993, vol: 22, page: 333, stat: Journal Article,

THE EFFECTS OF SEA-WATER ADAPTATION ON RENAL EICOSANOID PRODUCTION IN THE GOLDFISH (CARASSIUS-AURATUS)
Lowenstein, J
1991 Mar;98(2-3):389-396, Comparative biochemistry & physiology. B. Comparative biochemistry
1. The effect of sea water adaptation on renal eicosanoid production in the goldfish (Carassius auratus) was studied. 2. The major AA metabolites, averaging 48 and 41% of recovered radioactivity in fresh water and sea water adapted fish, co- migrated with 12- and 15-hydroxyeicosatetraenoic acid (HETE); PGE2 accounted for only 1.6% of radiolabeled product. 3. Microsomes from freshwater fish synthesized an NADPH-dependent eicosanoid which was not identified in microsomes from sea water adapted fish. This product(s) had a mobility similar to epoxyeicosatrienoic (EET) produced from arachidonate by a cytochrome P-450 epoxygenase. 4. Inhibition of cytochrome P- 450 epoxygenase might account for the marked reduction in GFR and the decrease in free water excretion which attend sea water adaptation
— id: 32221, year: 1991, vol: 98, page: 389, stat: Journal Article,

THE EFFECTS OF SEA-WATER ADAPTATION ON RENAL EICOSANOID METABOLISM IN THE GOLDFISH (CARASSIUS-AURATUS)
Lowenstein, J
1990 Apr;38(2):A575-A575, Clinical research
— id: 32074, year: 1990, vol: 38, page: A575, stat: Journal Article,

Refractory hypertension: definition, prevalence, pathophysiology, and management
Neusy AJ; Valeri A; Lowenstein J
1990 Nov;10(6):546-551, Seminars in nephrology
— id: 14285, year: 1990, vol: 10, page: 546, stat: Journal Article,

EICOSANOID PRODUCTION BY THE KIDNEY OF THE GOLDFISH (CARASSIUS-AURATUS)
LOWENSTEIN, J
1989 JAN ;35(1):295-295, Kidney international
— id: 98519, year: 1989, vol: 35, page: 295, stat: Journal Article,

Blood pressure and blood pressure variability following withdrawal of propranolol and clonidine
Neusy AJ; Lowenstein J
1989 Jan;29(1):18-24, Journal of clinical pharmacology
The effects of placebo, propranolol, and clonidine on blood pressure and blood pressure variability were examined in 14 subjects who had moderate essential hypertension. Hydrochlorothiazide was given throughout successive 4- to 5-week periods of placebo, propranolol, and clonidine administration. During each treatment period, subjects were admitted twice to the clinical research unit for 24-hour blood pressure monitoring performed during administration of placebo, propranolol and clonidine and repeated 1 to 2 weeks later during the first 24 hours after the abrupt cessation of placebo or drug administration. Blood pressure was recorded at 15-minute intervals using an automated noninvasive recorder (Arteriosonde, Roche, New Jersey). Systolic and diastolic blood pressure readings were averaged and the standard deviation taken as the measure of long-term variability (LTV). Systolic and diastolic blood pressure in sequential overlapping blocks of seven readings were averaged and the standard deviation calculated. Short-term variability (STV) was estimated as the average of the standard deviations of the running means. During placebo administration and withdrawal, systolic and diastolic blood pressures as well as LTV and STV were unchanged. Systolic and diastolic pressures did not differ during propranolol administration from those during propranolol withdrawal or placebo withdrawal. Systolic and diastolic LTV and STV did not differ during propranolol administration and withdrawal from those observed during placebo administration or withdrawal. After clonidine withdrawal, both systolic and diastolic pressures increased to values significantly greater than during clonidine administration. These values were significantly greater than those observed after placebo withdrawal, thereby indicating rebound hypertension. After clonidine withdrawal, seven of fourteen subjects developed systolic pressure rebound; diastolic pressure rebound was observed in three patients.(ABSTRACT TRUNCATED AT 250 WORDS)
— id: 10777, year: 1989, vol: 29, page: 18, stat: Journal Article,

EICOSANOID PRODUCTION BY THE KIDNEY OF THE GOLDFISH (CARASSIUS-AURATUS)
LOWENSTEIN, J
1988 JAN ;33(1):273-273, Kidney international
— id: 41837, year: 1988, vol: 33, page: 273, stat: Journal Article,

EICOSANOID PRODUCTION BY THE KIDNEY OF THE GOLDFISH (CARASSIUS- AURATUS)
Lowenstein, J
1987 Apr;35(3):A552-A552, Clinical research
— id: 31371, year: 1987, vol: 35, page: A552, stat: Journal Article,

THE EFFECTS OF PROPRANOLOL AND PRAZOSIN ON PLASMA-LIPIDS AND AORTIC ATHEROSLCEROSIS IN CHOLESTEROL-FED RABBITS
BLAU, A; NEUSY, AJ; LOWENSTEIN, J
1986 DEC ;4(4):S485-S487, Journal of hypertension
— id: 41719, year: 1986, vol: 4, page: S485, stat: Journal Article,

EFFECTS OF PRAZOSIN, ATENOLOL, AND THIAZIDE DIURETIC ON PLASMA-LIPIDS IN PATIENTS WITH ESSENTIAL-HYPERTENSION
NEUSY, AJ; LOWENSTEIN, J
1986 FEB 14 ;80(2A):94-99, American journal of medicine
— id: 41614, year: 1986, vol: 80, page: 94, stat: Journal Article,

INHIBITION OF MYOCARDIAL SODIUM-POTASSIUM PUMP ACTIVITY IN SEA-WATER ADAPTED GOLDFISH
Lowenstein, J
1985 ;27(1):195-195, Kidney international
— id: 30986, year: 1985, vol: 27, page: 195, stat: Journal Article,

THE EFFECTS OF TREATMENT ON TARGET ORGAN DAMAGE IN HYPERTENSIVE DISEASE
Lowenstein, J
1985 ;61(719):773-778, Journal of postgraduate medicine
— id: 30845, year: 1985, vol: 61, page: 773, stat: Journal Article,

Coronary heart disease : hypertension and other risk factors : proceedings of a satellite symposium of the First European Meeting
Hannsson, Lennart; Lowenstein, Jerome; Zanchetti, Alberto
New York : Technical Pub., 1984,
— id: 1832, year: 1984, vol: , page: , stat: ,

First-line therapy for hypertension : changing directions : proceedings of a symposium
Kaplan, Norman M; Lowenstein, Jerome
New York : American Journal of Cardiology, 1984,
— id: 1831, year: 1984, vol: , page: , stat: ,

EFFECTS OF PRAZOSIN ON SERUM-LIPIDS IN PATIENTS WITH ESSENTIAL-HYPERTENSION - A REVIEW OF THE FINDINGS PRESENTED AT THE SATELLITE SYMPOSIUM ON CORONARY HEART-DISEASE - HYPERTENSION AND OTHER RISK-FACTORS, MILAN, 1983
LOWENSTEIN, J
1984 ;53(3):A21-A23, American journal of cardiology
— id: 40858, year: 1984, vol: 53, page: A21, stat: Journal Article,

EFFECTS OF PRAZOSIN AND PROPRANOLOL ON SERUM-LIPIDS IN PATIENTS WITH ESSENTIAL-HYPERTENSION
LOWENSTEIN, J; NEUSY, AJ
1984 ;76(2A):79-84, American journal of medicine
— id: 41100, year: 1984, vol: 76, page: 79, stat: Journal Article,

THE EFFECTS OF PRAZOSIN AND PROPRANOLOL ON SERUM-LIPIDS IN PATIENTS WITH ESSENTIAL-HYPERTENSION
NEUSY, AJ; LOWENSTEIN, J
1983 ;31(2):A251-A251, Clinical research
— id: 40680, year: 1983, vol: 31, page: A251, stat: Journal Article,

SODIUM-CALCIUM EXCHANGE AND THE REGULATION OF VASCULAR SMOOTH-MUSCLE TONE
RUBENSTEIN, J; BOURLA, S; SHIH, Y; NEUSY, AJ; LOWENSTEIN, J
1983 ;23(1):176-176, Kidney international
— id: 40746, year: 1983, vol: 23, page: 176, stat: Journal Article,

CALCIUM DEPENDENCE OF BIPHASIC CONTRACTION OF AORTIC STRIPS
Bourla, S; Rubenstein, J; Shih, Y; Neusy, AJ; Lowenstein, J
1982 ;21(1):186-186, Kidney international
— id: 30495, year: 1982, vol: 21, page: 186, stat: Journal Article,

THE BIOCHEMICAL EFFECTS OF ANTIHYPERTENSIVE AGENTS AND THE IMPACT ON ATHEROSCLEROSIS
LOWENSTEIN, J; NEUSY, AJ
1982 ;4(3):S262-S264, Journal of cardiovascular pharmacology
— id: 40428, year: 1982, vol: 4, page: S262, stat: Journal Article,

THE EMERGENCY TREATMENT OF HYPERKALEMIA
Kunis, CL; Lowenstein, J
1981 ;65(1):165-176, Medical clinics of North America
— id: 30216, year: 1981, vol: 65, page: 165, stat: Journal Article,

Renal failure in minimal change nephrotic syndrome
Lowenstein J; Schacht RG; Baldwin DS
1981 Feb;70(2):227-233, American journal of medicine
Renal insufficiency, with serum creatinines ranging from 2.3 to 13.4 mg/dl, was observed in 15 patients with the minimal change nephrotic syndrome. Recovery of renal function occurred in association with diuretic therapy in 13, eight of whom subsequently underwent steroid-induced remission of the nephrotic syndrome. Two patients failed to undergo diuresis or to have a remission of the nephrotic syndrome and died with persistent renal failure. Glomerular filtration rate (Cinulin) was reduced out of proportion to renal plasma flow (CPAH) as evidenced by remarkably low filtration fractions ranging from 0.03 to 0.095. The invariable association between diuresis and recovery of renal function, the recurrence of renal failure when fluid reaccumulated and the finding of markedly depressed filtration fractions lead us to postulate that renal failure in minimal change nephrotic syndrome may be due to a reversible alteration in glomerular hemodynamics which is related to fluid retention and associated intrarenal edema
— id: 65186, year: 1981, vol: 70, page: 227, stat: Journal Article,

Rebound hypertension after sodium nitroprusside-induced hypotension
Cottrell JE; Illner P; Kittay MJ; Steele JM Jr; Lowenstein J; Turndorf H
1980 Feb;27(1):32-36, Clinical pharmacology & therapeutics
Patients undergoing surgical procedures using sodium nitroprusside-induced hypotension were studied to determine the role of the renin-angiotensin system in the pathogenesis of rebound hypertension (RH) after discontinuing sodium nitroprusside (SNP) infusion. Retrospective observations documented RH in 9 of 12 patients (group I) with a systolic blood pressure (SBP) increase from 112 +/- 3.92 before SNP to 144 +/- 5.60 torr 10 min after SNP (p less than 0.001). In 12 patients (group II), plasma renin activity (PRA) rose from 950 +/- 432 to 3,611 +/- 1.874 pg/ml/hr (p less than 0.0005) during SNP and remained elevated (2,504 +/- 792 pg/ml/hr) 30 min after cessation of SNP. SBP rose from a control (pre-SNP) value of 112 +/- 5.24 to 129 +/- 8.52 torr after discontinuation of SNP (p less than 0.05). Significant PRA and SBP changes did not occur in a matched group of patients (group III) who did not receive SNP. That RH after cessation of SNP infusion was associated with persistent elevation of PRA leads us to suggest that RH may be attributable to the unopposed effects of the renin-angiotensin system after the rapid plasma disappearance of SNP
— id: 45835, year: 1980, vol: 27, page: 32, stat: Journal Article,

Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass
Lieberman, A; Kronzon, I; Colvin, S; Lowenstein, J; Lieberman, I
1980 Apr;29(4):378-380, Annals of thoracic surgery
An organic mental syndrome developed in a patient soon after he underwent repair of a dissecting thoracic aortic aneurysm. The operation was accomplished with cardiopulmonary bypass. Initially, the mental changes were thought to be related to the operation. However, they subsequently were shown to be associated with propranolol. The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed
— id: 100151, year: 1980, vol: 29, page: 378, stat: Journal Article,

CLONIDINE - COMMENT
Lowenstein, J
1980 ;92(5):718-718, Annals of internal medicine
— id: 27988, year: 1980, vol: 92, page: 718, stat: Journal Article,

DRUGS 5 YEARS LATER - CLONIDINE
Lowenstein, J
1980 ;92(1):74-77, Annals of internal medicine
— id: 27931, year: 1980, vol: 92, page: 74, stat: Journal Article,

Life with hypertension : practical approaches to therapy (focus on prazosin)
Lowenstein, Jerome; Ryan, Coleman; Harter, Herschel
New York : Pfizer Laboratories, 1980,
— id: 1833, year: 1980, vol: , page: , stat: ,

Effect of a heptapeptide angiotensin analog on aldosterone secretion in the rabbit
Neusy AJ; Pessah M; Steele JM; Lowenstein J
1980 Jan;17(1):66-73, Kidney international
We examined the effects of an angiotensin III (AIII) analog, isoleucine-7 AIII (Ile7-AIII), on the steroidogenic and pressor responses to angiotensin II (AII) and AIII. AII or AIII (25 ng/kg/min) were infused alone or superimposed on an infusion of Ile7-AIII (100 ng/kg/min) in conscious male New Zealand rabbits. AII and AIII induced comparable increases in plasma aldosterone concentration, but AII exhibited significantly greater pressor effect. Ile7-AIII infusion resulted in significant inhibition of AII- but not AIII-induced steroidogenesis. Despite inhibition of aldosterone production, Ile7-AIII failed to block the pressor or renin-suppressing effect of AII. Inhibition of the steroidogenic effect of AII, but not of AII, by Ile7-AIII may be taken as evidence that adrenal stimulation by AII is direct and is not mediated by in vivo conversion to the heptapeptide. The ability of the heptapeptide analog to block aldosterone stimulation by the octapeptide AII suggests that adrenal receptors may, however, have a greater affinity for the heptapeptide
— id: 63312, year: 1980, vol: 17, page: 66, stat: Journal Article,

UNIMPAIRED BETA-ADRENERGIC RESPONSES DURING PRAZOSIN ADMINISTRATION
Buzzeo, LA; Steele, JM; Lowenstein, J
1979 ;211(2):345-349, Journal of pharmacology & experimental therapeutics
— id: 29707, year: 1979, vol: 211, page: 345, stat: Journal Article,

PRAZOSIN - MECHANISM OF ACTION AND ROLE IN ANTIHYPERTENSIVE THERAPY
Lowenstein, J; Steele, JM
1979 ;4(8):885-88?, Cardiovascular medicine
— id: 29725, year: 1979, vol: 4, page: 885, stat: Journal Article,

EFFECT OF DIETARY-SODIUM DEPLETION ON RESPONSES OF RABBIT AORTA TO ANGIOTENSIN-II (AII) AND NOREPINEPHRINE (NE)
Neusy, AJ; Garrett, J; Steele, JM; Lowenstein, J
1979 ;16(6):794-794, Kidney international
— id: 30061, year: 1979, vol: 16, page: 794, stat: Journal Article,

EFFECT OF PRAZOSIN ON RESPONSES TO INSULIN-INDUCED HYPOGLYCEMIA
Buzzeo, L; Steele, JM; Lowenstein, J
1978 ;26(3):A287-A287, Clinical research
— id: 29812, year: 1978, vol: 26, page: A287, stat: Journal Article,

Plasma renin and serum dopamine-beta-hydroxylase during orthostatic hypotension in quadriplegic man
Kamelhar DL; Steele JM Jr; Schacht RG; Lowenstein J; Naftchi NE
1978 May;59(5):212-216, Archives of physical medicine & rehabilitation
To determine whether orthostatic hypotension in patients with cervical spinal cord lesions is the result of impaired sympathetic nerve response and/or impaired renin release, serum dopamine-beta-hydroxylase (DbetaH) activity and plasma renin activity (PRA) were examined during passive tilting in 6 quadriplegic patients and in 6 able-bodied control subjects. Serum DbetaH was measured by an isotopic enzymatic method and PRA by radioimmunoassay. Following head-up tilting, quadriplegic subjects demonstrated a prompt, significant decrease in mean arterial pressure (MAP) and increase in heart rate (HR). DbetaH and PRA both increased significantly 15 minutes after tilt. In normal subjects, although HR increased, MAP was unchanged; DbetaH and PRA did not increase significantly during head-up tilt. The finding of increased DbetaH during tilt hypotension in quadriplegic patients provides evidence that reflex sympathetic nerve stimulation persists despite cervical cord transection. Increased PRA may be attributed to decreased renal perfusion pressure and increased sympathetic stimulation during tilt hypotension. These data suggest that orthostatic hypotension in quadriplegia patients cannot be attributed solely to failure of the sympathetic nervous system or the renin-angiotensin system to respond to the stimulus of orthostasis
— id: 20318, year: 1978, vol: 59, page: 212, stat: Journal Article,

Appraisal and reappraisal of cardiac therapy: prazosin
Lowenstein J; Steele JM Jr
1978 Feb;95(2):262-265, American heart journal
— id: 63272, year: 1978, vol: 95, page: 262, stat: Journal Article,

RENAL-FAILURE IN MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS)
Lowenstein, J; Schacht, RG; Baldwin, DS
1978 ;14(6):656-656, Kidney international
— id: 30163, year: 1978, vol: 14, page: 656, stat: Journal Article,

INHIBITION OF ALDOSTERONE PRODUCTION BY ISOLEUCINE-7 ANGIOTENSIN-III
Neusy, AJ; Pessah, M; Steele, JM; Lowenstein, J
1978 ;14(6):699-699, Kidney international
— id: 30164, year: 1978, vol: 14, page: 699, stat: Journal Article,

NONCOMPETITIVE INHIBITION OF ALDOSTERONE SECRETION BY AN ANALOG OF ANGIOTENSIN III
Neusy, AJ; Steele, JM; Lowenstein, J
1978 ;54(3):325-326, Bulletin of the New York Academy of Medicine
— id: 29955, year: 1978, vol: 54, page: 325, stat: Journal Article,

EFFECT OF AN AIII ANALOG ON ALDOSTERONE IN SODIUM DEPLETE RABBIT
Pessah, M; Neusy, AJ; Steele, JM; Lowenstein, J
1978 ;26(3):A311-A311, Clinical research
— id: 29918, year: 1978, vol: 26, page: A311, stat: Journal Article,

Lupus nephritis. Clinical course as related to morphologic forms and their transitions
Baldwin DS; Gluck MC; Lowenstein J; Gallo GR
1977 Jan;62(1):12-30, American journal of medicine
An intensive study of the course of lupus nephritis has been undertaken in 88 patients in whom strict morphologic criteria were utilized in classification. All were treated with steroid, and 17 received cytotoxic drugs in addition. Focal proliferative lupus nephritis generally follows a benign course except in the occasional instances when transition to the diffuse proliferative or membranous forms occurs. Membranous lupus nephritis, when characterized by persistent nephrotic syndrome, leads slowly to renal failure, but this progression is aborted in the one-third in whom remission of the nephrotic syndrome can be achieved. A fatal outcome occurs within five years in the majority of those with diffuse proliferative lupus nephritis and the nephrotic syndrome, often in association with necrotizing renal vasculitis, severe hypertension and accelerated renal failure. A small number with the diffuse proliferative form have a remission and then show only mesangial abnormalities, usually, however, with the appearance of glomerular sclerosis. Progressive glomerular sclerosis is observed in some patients and may be a sequel of the remission of the diffuse or focal proliferative lesions, or it may represent still another form of lupus nephritis. Mesangial immune deposits with or without proliferation, at times in the absence of clinical renal disease, are observed early in the course of systemic lupus erythematosus (SLE) and may proceed to the diffuse proliferative or membranous forms. The present observations serve to emphasize the importance of strict morphologic classification in the comparison of different treatment regimens for lupus nephritis. In view of the grave prognosis of established diffuse proliferative lupus nephritis, which probably evolves from a mesangial involvement common to all patients with SLE from its onset, early therapy may be the key to the management of lupus nephritis
— id: 59978, year: 1977, vol: 62, page: 12, stat: Journal Article,

PLASMA-RENIN AND SERUM DOPAMINE-BETA-HYDROXYLASE DURING ORTHOSTATIC HYPOTENSION IN QUADRIPLEGIC MAN
KAMELHAR, DL; STEELE, JM; SCHACHT, RG; LOWENSTEIN, J; SELL, GH; NAFTCHI, NE
1977 ;58(11):534-534, Archives of physical medicine & rehabilitation
— id: 39915, year: 1977, vol: 58, page: 534, stat: Journal Article,

ALDOSTERONE PRODUCTION DURING DIETARY SODIUM RESTRICTION AND BETA-ADRENERGIC-BLOCKADE
Lowenstein, J; Steele, JM
1977 ;11(2):128-135, Kidney international
— id: 29549, year: 1977, vol: 11, page: 128, stat: Journal Article,

SPECIFICITY OF VASCULAR, ADRENAL, AND RENAL RECEPTORS FOR ANGIOTENSIN
Neusy, AJ; Steele, JM; Lowenstein, J
1977 ;12(6):506-506, Kidney international
— id: 29963, year: 1977, vol: 12, page: 506, stat: Journal Article,

Failure of sodium restriction to abolish exaggerated natriuresis in poststreptococcal glomerulonephritis
Schacht RG; Steele JM Jr; Lowenstein J; Baldwin DS
1977 ;18(6):333-341, Nephron
Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extracellular fluid volume might play a role in the response to acute saline infusion. Plasma renin activity (PRA) and PRA responsiveness to sodium depletion were normal, suggesting that extracellular fluid volume was not increased. In all patients, extracellular fluid volume decreased during sodium restriction, as judged by weight loss, cumulative negative sodium balance, small decreases in measured plasma volume, and appropriate increases of PRA and plasma aldosterone concentration. Hypertonic saline infusion provoked exaggerated natriuresis in all patients equally as well after dietary sodium restriction as before. Exaggerated natriuresis in poststreptococcal glomerulonephritis occurs without evidence of chronic expansion of extracellular fluid volume and is not affected by reduction of extracellular fluid volume
— id: 65188, year: 1977, vol: 18, page: 333, stat: Journal Article,

HYPERTHYROIDISM AFTER PROPRANOLOL WITHDRAWAL
SHENKMAN, L; PODRID, P; LOWENSTEIN, J
1977 ;238(3):237-239, JAMA
— id: 39949, year: 1977, vol: 238, page: 237, stat: Journal Article,

Renal failure after open heart surgery
Bhat JG; Gluck MC; Lowenstein J; Baldwin DS
1976 Jun;84(6):677-682, Annals of internal medicine
One hundred fifty of 490 patients undergoing open heart surgery had renal failure attributable to cardiopulmonary bypass. In 69, serum creatinine concentrations did not exceed 2 mg/dl and returned to normal by the fourth postoperative day. In 60 patients, serum creatinine attained levels between 2 and 5 mg/dl, oliguria did not develop, and recovery of renal function occurred within 4 to 37 days. Serum creatinine increased to levels exceeding 5 mg/dl in 21 patients, 11 of whom were oliguric. Despite dialysis, 14 of these patients died from cardiac causes or sepsis. Prolonged cardiopulmonary bypass time, hypotension, oliguria, low output syndrome, and hemoglobinemia during open heart surgery correlated with the development of renal failure postoperatively. Although severe renal failure was an uncommon complication after open heart surgery, its occurrence carried a grave prognosis
— id: 65190, year: 1976, vol: 84, page: 677, stat: Journal Article,

SERUM DOPAMINE-BETA-HYDROXYLASE AND PLASMA-RENIN ACTIVITIES DURING TILTING IN QUADRIPLEGIA
Kamelhar, DL; Steele, JM; Schacht, RG; Lowenstein, J; Naftchi, NE
1976 ;24(3):A224-A224, Clinical research
— id: 28750, year: 1976, vol: 24, page: A224, stat: Journal Article,

ADRENAL-RESPONSE TO 7-ISOLEUCINE ANGIOTENSIN-III RABBIT
Neusy, AJ; Steele, JM; Lowenstein, J
1976 ;10(6):534-534, Kidney international
— id: 29646, year: 1976, vol: 10, page: 534, stat: Journal Article,

ABSENCE OF RENIN STIMULATION OR TACHYCARDIA DURING ANTIHYPERTENSIVE THERAPY WITH PRAZOSIN
STEELE, JM; LOWENSTEIN, J
1976 ;24(3):A258-A258, Clinical research
— id: 98709, year: 1976, vol: 24, page: A258, stat: Journal Article,

EFFECTS OF DES-ASP1-ANGIOTENSIN-2 ON BLOOD-PRESSURE, PLASMA ALDOSTERONE CONCENTRATION, AND PLASMA-RENIN ACTIVITY IN RABBIT
Steele, JM; Neusy, AJ; Lowenstein, J
1976 ;38(6):113-116, Circulation research
— id: 29422, year: 1976, vol: 38, page: 113, stat: Journal Article,

ALDOSTERONE RESPONSE DURING PROPRANOLOL-INDUCED SUPPRESSION OF PLASMA-RENIN ACTIVITY
Lowenstein, J; Steele, JM
1975 ;51(10):1175-1175, Bulletin of the New York Academy of Medicine
— id: 28635, year: 1975, vol: 51, page: 1175, stat: Journal Article,

PHYSIOLOGIC EFFECTS OF DES-1-ASP ANGIOTENSIN-II IN RABBIT
Steele, JM; Lowenstein, J
1975 ;23(3):A375-A375, Clinical research
— id: 28656, year: 1975, vol: 23, page: A375, stat: Journal Article,

PHYSIOLOGIC EFFECTS OF DES-1-ASP ANGIOTENSIN-II IN RABBIT
Steele, JM; Lowenstein, J
1975 ;8(6):443-443, Kidney international
— id: 29508, year: 1975, vol: 8, page: 443, stat: Journal Article,

EFFECT OF UNILATERAL NEPHRECTOMY ON RENAL RESPONSE TO SALINE LOADING IN RABBIT
Hayes, JS; Fein, F; Lowenste[...], J; Baldwin, DS
1974 ;50(3):405-405, Bulletin of the New York Academy of Medicine
— id: 28461, year: 1974, vol: 50, page: 405, stat: Journal Article,

ALDOSTERONE RESPONSE DURING PROPRANOLOL-INDUCED SUPPRESSION OF PLASMA-RENIN ACTIVITY
Lowenstein, J; Steele, JM
1974 ;6(6):A68-A69, Kidney international
— id: 28691, year: 1974, vol: 6, page: A68, stat: Journal Article,

Differential effects of an angiotensin II analogue on pressor and adrenal receptors in the rabbit
Steele JM Jr; Lowenstein J
1974 Oct;35(4):592-600, Circulation research
— id: 62306, year: 1974, vol: 35, page: 592, stat: Journal Article,

Membranous glomerulonephritis. Evolution of clinical and pathologic features
Gluck MC; Gallo G; Lowenstein J; Baldwin DS
1973 Jan;78(1):1-12, Annals of internal medicine
— id: 65167, year: 1973, vol: 78, page: 1, stat: Journal Article,

MEMBRANOUS GLOMERULONEPHRITIS - REPLY
GLUCK, MC; GALLO, G; LOWENSTE.J; BALDWIN, DS
1973 ;79(2):286-287, Annals of internal medicine
— id: 39783, year: 1973, vol: 79, page: 286, stat: Journal Article,

HYPOKALEMIA AND HYPERKALEMIA
LOWENSTE.J
1973 ;57(6):1435-1439, Medical clinics of North America
— id: 98758, year: 1973, vol: 57, page: 1435, stat: Journal Article,

DIFFERENTIAL EFFECTS OF AN ANGIOTENSIN-II ANALOG ON VASCULAR AND ADRENAL RECEPTORS
STEELE, JM; LOWENSTE.J
1973 ;48(4):71-71, Circulation
— id: 46744, year: 1973, vol: 48, page: 71, stat: Journal Article,

Renal mechanism for DOCA escape in man
Schacht, R G; Lowenstein, J; Baldwin, D S
1971 Oct;47(10):1233-1233, Bulletin of the New York Academy of Medicine
— id: 65170, year: 1971, vol: 47, page: 1233, stat: Journal Article,

The clinical course of the proliferative and membranous forms of lupus nephritis
Baldwin DS; Lowenstein J; Rothfield NF; Gallo G; McCluskey RT
1970 Dec;73(6):929-942, Annals of internal medicine
— id: 65169, year: 1970, vol: 73, page: 929, stat: Journal Article,

Intrarenal pressure and exaggerated natriuresis in essential hypertension
Lowenstein J; Beranbaum ER; Chasis H; Baldwin DS
1970 Mar;38(3):359-374, Clinical science
— id: 65174, year: 1970, vol: 38, page: 359, stat: Journal Article,

Renal hemodynamic response to osmotic diuresis in man
Baldwin DS; Lowenstein J; Chasis H
1967 Aug-Sep;125(4):1259-1264, Proceedings of the Society for Experimental Biology & Medicine
— id: 65177, year: 1967, vol: 125, page: 1259, stat: Journal Article,

Vascular and extravascular volumes of the kidney of man
Effros RM; Lowenstein J; Baldwin DS; Chinard FP
1967 Feb;20(2):162-173, Circulation research
— id: 65172, year: 1967, vol: 20, page: 162, stat: Journal Article,

The distribution of intrarenal blood flow in normal and hypertensive man
Lowenstein J; Steinmetz PR; Effros RM; Demeester M; Chasis H; Baldwin DS; Gomez DM
1967 Feb;35(2):250-259, Circulation
— id: 65173, year: 1967, vol: 35, page: 250, stat: Journal Article,

Functional blood volume and distribution of specific blood flow in the kidney of man
Gomez DM; Demeester M; Steinmetz PR; Lowenstein J; Sammons BP; Baldwin DS; Chasis H
1965 Jul;20(4):703-708, Journal of applied physiology
— id: 65176, year: 1965, vol: 20, page: 703, stat: Journal Article,

THE EXCRETION OF ACID IN UNILATERAL RENAL DISEASE IN MAN
STEINMETZ, P R; EISINGER, R P; LOWENSTEIN, J
1965 Apr;44:582-591, Journal of clinical investigation
— id: 128376, year: 1965, vol: 44, page: 582, stat: Journal Article,

MULTIPLE MYELOMA. II. PROTEIN ABNORMALITIES ASSOCIATED WITH PROLIFERATIVE DISORDERS OF PLASMA CELLS AND LYMPHOCYTES
FRANKLIN, E C; LOWENSTEIN, J
1964 Apr;124:144-164, Seminars in hematology
— id: 119653, year: 1964, vol: 124, page: 144, stat: Journal Article,

HEAVY CHAIN DISEASE- A NEW DISORDER OF SERUM GAMMA-GLOBULINS : REPORT OF THE FIRST CASE
FRANKLIN, E C; LOWENSTEIN, J; BIGELOW, B; MELTZER, M
1964 Sep;37:332-350, American journal of medicine
— id: 119652, year: 1964, vol: 37, page: 332, stat: Journal Article,