Cynthia Ann Loomis

Biosketch / Results /

Cynthia Ann Loomis, M.D., Ph.D.

Assistant Professor; Core Dir Resch Histopath CoDir Path Grg Trng
Departments of Pathology (Pathology), Ronald O. Perelman Department of Dermatology (Research Admin) and Cell Biology (Cell Biology)

Contact Info

Address
550 First Avenue
Dept. of Pathology Floor 1st Room 126
Medical Science Building
New York, NY 10016

212-263-6827
212-263-8179
Cindy.Loomis@med.nyu.edu

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Research Summary

During embryonic development, key regulatory molecules specify the fates of individual cells as well as the overall shapes, sizes and distributions of organs and other structures. Mutations in such regulatory genes often result in serious congenital malformations. Our laboratory is interested in studying the molecular and cellular mechanisms by which such regulatory genes direct mammalian skin and limb development.

Working in collaboration with Dr. Alexandra Joyner, also at the NYU School of Medicine, we have shown that Engrailed-1 (En1), a homeodomain-containing transcription factor, is essential for dorsal-ventral patterning of the developing limb and overlying skin. Loss of En1 function results in the loss of ventral (palmar) limb structures, such as sweat glands and sesamoid bones, and the ventral duplication of dorsal paw structures, such as hairs and nails. Our studies have shown that En1 directs ventral limb development in part by inhibiting ventral ectoderm expression of "dorsalizing" signalling molecules, which can then reprogram the adjacent mesenchyme to a dorsal fate. Our more recent studies indicate that En1 also acts during later palmer/planter ectoderm differentiation as well as during interfollicular mesenchyme differentiation. We are interested in using these and other mouse mutants to further investigate the genetic regulation of skin and epidermal appendage (hair, gland and nail) development as it relates to dorsal-ventral patterning of the limb as well to other body sites, such as the head.

In addition to its early and late functions in dorsal-ventral limb patterning, we have also shown that En1 is required to promote maturation of the apical ectodermal ridge (AER), a signalling center required for distal limb outgrowth. In the absence of En1, the AER precursor cells are delayed in their initiation of the morphogenetic movements necessary to form a tightly compacted ridge along the distal limb margin. This initial delay in AER compaction frequently results in the formation of ectopic AERs and the subseqeunt development of ectopic digits. We are using a variety of genetic strategies, including the generation of double mutants as well as transgenic and chimeric mice, to investigate the underlying mechanisms governing AER formation.

Research Interests

Molecular Mechanisms Underlying Skin and Limb Patterning

Research Keywords

development, Engrailed-1, limb patterning, skin

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Genetic Suppression of Inflammation Blocks the Tumor-Promoting Effects of TGF-beta in Gastric Tissue
Rifkin, Daniel B; Ota, Mitsuhiko; Horiguchi, Masahito; Fang, Victoria; Shibahara, Kotaro; Kadota, Kyuichi; Loomis, Cynthia; Cammer, Michael
2014 Mar;:?-?, Cancer research
— id: 831432, year: 2014, vol: , page: ?, stat: Journal Article,

Allergic Contact Dermatitis to Gamma-Irradiated WEBCOL Alcohol Prep Pads
Firoz, Elnaz F; Turnbull, Rowena K; Loomis, Cynthia A; Brownell, Isaac
2013 Nov;30(6):e281-e282, Pediatric dermatology
— id: 665962, year: 2013, vol: 30, page: e281, stat: Journal Article,

Hedgehog Signaling in Neonatal and Adult Lung
Liu, Li; Kugler, Matthias C; Loomis, Cynthia A; Samdani, Rashmi; Zhao, Zhicheng; Chen, Gregory J; Brandt, Julia P; Brownell, Isaac; Joyner, Alexandra L; Rom, William N; Munger, John S
2013 Feb;:703-710 e59461, American journal of respiratory cell & molecular biology
— id: 353072, year: 2013, vol: , page: 703, stat: Journal Article,

Wnt activation in nail epithelium couples nail growth to digit regeneration
Takeo, Makoto; Chou, Wei Chin; Sun, Qi; Lee, Wendy; Rabbani, Piul; Loomis, Cynthia; Taketo, M Mark; Ito, Mayumi
2013 Jul;499(7457):228-232, Nature
— id: 426072, year: 2013, vol: 499, page: 228, stat: Journal Article,

Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1
Deckelbaum, Ron A; Holmes, Greg; Zhao, Zhicheng; Tong, Chunxiang; Basilico, Claudio; Loomis, Cynthia A
2012 Apr;139(7):1346-1358, Development
— id: 159856, year: 2012, vol: 139, page: 1346, stat: Journal Article,

Method for tracking core-contributed publications
Loomis, Cynthia A; Curchoe, Carol Lynn
2012 Dec;23(4):122-127, Journal of biomolecular techniques
— id: 197472, year: 2012, vol: 23, page: 122, stat: Journal Article,

Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells
Brownell, Isaac; Guevara, Elizabeth; Bai, C Brian; Loomis, Cynthia A; Joyner, Alexandra L
2011 May 6;8(5):552-565, Cell Stem Cell
— id: 133414, year: 2011, vol: 8, page: 552, stat: Journal Article,

The Hedgehog response gene Gli1 marks multipotent stem cells in the telogen bulge
Brownell, Isaac; Loomis, Cynthia A.; Joyner, Alexandra L.
2010 SEP ;130(4):S88-S88, Journal of investigative dermatology
— id: 113755, year: 2010, vol: 130, page: S88, stat: Journal Article,

ADAM12: a potential target for the treatment of chronic wounds
Harsha, Asheesh; Stojadinovic, Olivera; Brem, Harold; Sehara-Fujisawa, Atsuko; Wewer, Ulla; Loomis, Cynthia A; Blobel, Carl P; Tomic-Canic, Marjana
2008 Aug;86(8):961-969, Journal of Molecular Medicine (Berlin)
— id: 79473, year: 2008, vol: 86, page: 961, stat: Journal Article,

ADAM12: a potential target for treatment of chronic wounds
Harsha, A; Stojadinovic, O; Loomis, CA; Blobel, CP; Tomic-Canic, M
2007 APR ;127(2):S37-S37, Journal of investigative dermatology
— id: 71618, year: 2007, vol: 127, page: S37, stat: Journal Article,

STAT3 signaling and the hyper-IgE syndrome
Levy, David E; Loomis, Cynthia A
2007 Oct 18;357(16):1655-1658, New England journal of medicine
— id: 93454, year: 2007, vol: 357, page: 1655, stat: Journal Article,

The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling
Deckelbaum, Ron A; Majithia, Amit; Booker, Thomas; Henderson, Janet E; Loomis, Cynthia A
2006 Jan;133(1):63-74, Development
— id: 64195, year: 2006, vol: 133, page: 63, stat: Journal Article,

Conditional ablation of epidermal En1 reveals a postnatal regulatory role
Pechar, D; Kraus, P; Loomis, CA
2006 APR ;126(1):98-98, Journal of investigative dermatology
— id: 70334, year: 2006, vol: 126, page: 98, stat: Journal Article,

Developmental analysis of nail development
Pechar, D; Zhao, Z; Loomis, CA
2004 MAR ;122(3):A109-A109, Journal of investigative dermatology
— id: 46580, year: 2004, vol: 122, page: A109, stat: Journal Article,

Detailed characterization of eccrine gland development
Sanchez, L; Tong, C; Loomis, CA
2004 MAR ;122(3):A112-A112, Journal of investigative dermatology
— id: 46583, year: 2004, vol: 122, page: A112, stat: Journal Article,

Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge
Guo, Qiuxia; Loomis, Cynthia; Joyner, Alexandra L
2003 Dec 1;264(1):166-178, Developmental biology (Orlando)
— id: 44888, year: 2003, vol: 264, page: 166, stat: Journal Article,

What syndrome is this? Nail-patella syndrome
Buddin, Deidre; Loomis, Cynthia; Shwayder, Tor; Chang, Mary Wu
2002 Sep-Oct;19(5):454-456, Pediatric dermatology
— id: 39389, year: 2002, vol: 19, page: 454, stat: Journal Article,

PTCH (patched) and XPA genes in radiation-induced basal cell carcinomas
Burns FJ; Shore RE; Roy N; Loomis C; Zhao P
Radiation and Homeostasis : proceedings of the International Symposium of Radiation and Homeostasis, held in Kyoto, Japan, 13-16 July 2001 Amsterdam ; Boston : Elsevier, 2002,
— id: 3100, year: 2002, vol: , page: 175, stat: Chapter,

Hair vs. eccrine gland: Timing and competition of skin appendage specification on the limb
Loomis, C; Tong, C; Kraus, P
2002 JUL ;119(1):290-290, Journal of investigative dermatology
— id: 55288, year: 2002, vol: 119, page: 290, stat: Journal Article,

Fibroma induction in rat skin following single or multiple doses of 1.0 GeV/nucleon 56Fe ions from the Brookhaven Alternating Gradient Synchrotron (AGS)
Burns FJ; Zhao P; Xu G; Roy N; Loomis C
2001 ;17 Suppl 1(8):194-195, Physica medica
— id: 32228, year: 2001, vol: 17 Suppl 1, page: 194, stat: Journal Article,

Some distal limb structures develop in mice lacking Sonic hedgehog signaling
Kraus P; Fraidenraich D; Loomis CA
2001 Jan;100(1):45-58, Mechanisms of development
— id: 16621, year: 2001, vol: 100, page: 45, stat: Journal Article,

Engrailed1 is critical for repression of nail-type differentiation in mouse
Kraus, P; Tong, CX; Loomis, CA; Perelman, RO
2001 JUL 1 ;235(1):195-195, Developmental biology (Orlando)
— id: 54997, year: 2001, vol: 235, page: 195, stat: Journal Article,

An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
Lee JD; Kraus P; Gaiano N; Nery S; Kohtz J; Fishell G; Loomis CA; Treisman JE
2001 May 1;233(1):122-136, Developmental biology (Orlando)
— id: 20707, year: 2001, vol: 233, page: 122, stat: Journal Article,

Development and morphogenesis of the skin
Loomis CA
2001 ;17(2):183-210, Advances in dermatology
— id: 34998, year: 2001, vol: 17, page: 183, stat: Journal Article,

Keratosis pilaris and variants
Schmults CD; Loomis C
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3714, year: 2001, vol: , page: 96, stat: Chapter,

Engrailed-1 in postnatal skin homeostasis and hair cycling
Birge, M B; Tong, C; Kraus, P; Loomis, C A
2000 May 10-14;114(4):824-824, Journal of investigative dermatology
— id: 15816, year: 2000, vol: 114, page: 824, stat: Journal Article,

Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
Kimmel RA; Turnbull DH; Blanquet V; Wurst W; Loomis CA; Joyner AL
2000 Jun 1;14(11):1377-1389, Genes & development
— id: 11671, year: 2000, vol: 14, page: 1377, stat: Journal Article,

Two lineage boundaries and EN1 coordinate AER formation
Kimmel, RA; Turnbull, DH; Blanquet, V; Wurst, W; Loomis, CA; Joyner, AL
2000 JUN 1 ;222(1):227-227, Developmental biology (Orlando)
— id: 54559, year: 2000, vol: 222, page: 227, stat: Journal Article,

Distal most limb structures develop despite absence of Shh signaling in mouse
Kraus, P; Fraidenraich, D; Basilico, C; Loomis, CA
2000 JUN 1 ;222(1):267-267, Developmental biology (Orlando)
— id: 54562, year: 2000, vol: 222, page: 267, stat: Journal Article,

Engrailed-1 (En1) expression by the dermal papilla affects hair size in mouse skin
Birge, MB; Tong, CX; Mohan, S; Perone, J; Loomis, CA
1999 APR ;112(4):524-524, Journal of investigative dermatology
— id: 54078, year: 1999, vol: 112, page: 524, stat: Journal Article,

En1 plays multiple roles in vertebrate limb development
Kimmel, R; Loomis, C; Losos, K; Turnbull, D; Joyner, A
1999 JUN 1 ;210(1):228-228, Developmental biology (Orlando)
— id: 54019, year: 1999, vol: 210, page: 228, stat: Journal Article,

Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression
Manabe M; Lim HW; Winzer M; Loomis CA
1999 Feb;135(2):177-181, Archives of dermatology
— id: 7399, year: 1999, vol: 135, page: 177, stat: Journal Article,

Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development
Hanks MC; Loomis CA; Harris E; Tong CX; Anson-Cartwright L; Auerbach A; Joyner A
1998 Nov;125(22):4521-4530, Development
— id: 7339, year: 1998, vol: 125, page: 4521, stat: Journal Article,

Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
Loomis CA; Kimmel RA; Tong CX; Michaud J; Joyner AL
1998 Mar;125(6):1137-1148, Development
— id: 7664, year: 1998, vol: 125, page: 1137, stat: Journal Article,

Engrailed-1 expression and regulatory role during skin appendage development
Mohan, S; Tong, CX; Perone, J; Chubak, B; Kimmel, R; Joyner, AL; Loomis, CA
1998 APR ;110(4):603-603, Journal of investigative dermatology
— id: 53525, year: 1998, vol: 110, page: 603, stat: Journal Article,

Role of En1 in vertebrate limb patterning
Kimmel, RA; Loomis, CA; Joyner, AL
1997 ;186(2):B230-B230, Developmental biology (Orlando)
— id: 104601, year: 1997, vol: 186, page: B230, stat: Journal Article,

American Academy of Dermatology 1997 Awards for Young Investigators in Dermatology. The role of Engrailed-1 in limb development and skin patterning
Loomis C
1997 Nov;37(5 Pt 1):774-775, Journal of the American Academy of Dermatology
— id: 12225, year: 1997, vol: 37, page: 774, stat: Journal Article,

Linear hypopigmentation and hyperpigmentation, including mosaicism
Loomis CA
1997 Mar;16(1):44-53, Seminars in cutaneous medicine & surgery
— id: 7205, year: 1997, vol: 16, page: 44, stat: Journal Article,

Engrailed-1 (En1) plays multiple roles in patterning of the distal limb and development of the overlying skin
Loomis, CA; Tong, XC; Zeitler, E; Kimmel, RA; Paulson, M; Hanks, M; Joyner, AL
1997 APR ;108(4):241-241, Journal of investigative dermatology
— id: 53217, year: 1997, vol: 108, page: 241, stat: Journal Article,

The mouse Engrailed-1 gene and ventral limb patterning
Loomis CA; Harris E; Michaud J; Wurst W; Hanks M; Joyner AL
1996 Jul 25;382(6589):360-363, Nature
— id: 56881, year: 1996, vol: 382, page: 360, stat: Journal Article,

Cutaneous findings in mosaicism and chimerism
Loomis CA; Orlow SJ
1996 ;3:87-92, Current opinion in dermatology
— id: 48978, year: 1996, vol: 3, page: 87, stat: Journal Article,

The role of Engrailed-1 in epidermal appendage formation and skin patterning
Loomis, CA; Michaud, J; Hanks, M; Joyner, AL
1996 APR ;106(4):171-171, Journal of investigative dermatology
— id: 52997, year: 1996, vol: 106, page: 171, stat: Journal Article,

Trichohyalin expression in skin tumors: retrieval of trichohyalin antigenicity in tissues by microwave irradiation
Manabe M; Yaguchi H; Iqbal Butt K; O'Guin WM; Loomis CA; Sung TT; Ogawa H
1996 May;35(5):325-329, International journal of dermatology
— id: 16622, year: 1996, vol: 35, page: 325, stat: Journal Article,

EXPRESSION OF A TRICHOHYALIN GENE UNDER THE CONTROL OF AN RSV PROMOTOR IN HUMAN EPIDERMAL-KERATINOCYTES
LOOMIS, C; OGUIN, WM
1995 APR ;104(4):641-641, Journal of investigative dermatology
— id: 87383, year: 1995, vol: 104, page: 641, stat: Journal Article,

THE CLONING AND CHARACTERIZATION OF THE GENE ENCODING MURINE TRICHOHYALIN
OGUIN, WM; SUN, TT; LOOMIS, CA
1994 APR ;102(4):607-607, Journal of investigative dermatology
— id: 52347, year: 1994, vol: 102, page: 607, stat: Journal Article,

Characterization of a keratinocyte-specific extracellular epitope of desmoglein. Implications for desmoglein heterogeneity and function
Loomis CA; Kolega J; Manabe M; Sun TT
1992 Aug 15;267(23):16676-16684, Journal of biological chemistry
— id: 13478, year: 1992, vol: 267, page: 16676, stat: Journal Article,

REDUCED LEVEL OF DESMOGLEIN IN BASAL-CELL CARCINOMA AND FOLLICULOCENTRIC BASALOID PROLIFERATION
MEHREL, T; MANABE, M; WHITE, W; LESHIN, B; LOOMIS, C; SANCHEZ, M; LAVKER, RM; SUN, TT
1991 APR ;39(2):A527-A527, Clinical research
— id: 51627, year: 1991, vol: 39, page: A527, stat: Journal Article,

REDUCED LEVEL OF DESMOGLEIN IN BASAL-CELL CARCINOMA AND FOLLICULOCENTRIC BASALOID PROLIFERATION
MEHREL, T; MANABE, M; WHITE, W; LESHIN, B; LOOMIS, C; SANCHEZ, M; LAVKER, RM; SUN, TT
1991 APR ;96(4):619-619, Journal of investigative dermatology
— id: 51644, year: 1991, vol: 96, page: 619, stat: Journal Article,

The major pathways of keratinocyte differentiation as defined by keratin expression: an overview
Galvin S; Loomis C; Manabe M; Dhouailly D; Sun TT
1989 ;4:277-99; discussion 300, Advances in dermatology
— id: 10852, year: 1989, vol: 4, page: 277, stat: Journal Article,

Sequence of an expressed human beta-tubulin gene containing ten Alu family members
Lee MG; Loomis C; Cowan NJ
1984 Jul 25;12(14):5823-5836, Nucleic acids research
— id: 17157, year: 1984, vol: 12, page: 5823, stat: Journal Article,