Susan K Logan

Biosketch / Results /

Susan K Logan, Ph.D.

Associate Professor;
Departments of Urology (Urology) and Biochemistry and Molecular Pharmacology

Contact Info

Address
550 First Avenue
Floor 2nd floor Room 235A
Medical Science Building
New York, NY 10016

212-263-2921
Susan.Logan@nyumc.org


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Education

1993 — University of California, San Francisco, PostDoctoral Training
— Brandeis University, Graduate Education
1999 — New York University School of Medicine, PostDoctoral Training

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Research Summary

Androgen steroid hormones direct the genetic program dictating male development. The phenotypic consequences of mutations in androgen binding receptors include partial or complete feminization in males, sterility and cancer. It is also clear that androgen regulates cell growth although the mechanism is not understood. In particular, growth and differentiation of prostate epithelial cells is strictly regulated in response to circulating androgens and for this reason androgen ablation therapy is commonly used to effect prostate cancer regression. The research goal of my lab is to understand the androgen receptor signal transduction pathway regulating cell growth. The specific goals of the laboratory at this time are to: 1) uncover the role of androgen receptor binding proteins (coactivators and corepressors) in androgen-mediated prostate cell growth 2) develop new mouse models of prostate cancer progression and 3) create phosphorylation-specific anti-androgen receptor antibodies to be used in defining the functional role of androgen receptor in androgen-dependent and androgen-independent prostate cancer. Some of the technologies used in the lab include immunohistochemistry to compare the expression of androgen receptor coactivators in normal and cancer tissue of the prostate and breast, and transgenic mice to determine the oncogenic properties of signaling molecules and coactivators. In addition, the effect of novel molecules on androgen mediated cell cycle progression is determined using tetracycline-inducible cell lines, immunofluorescence analysis, and gene expression arrays. Through these studies we hope to advance our basic understanding of steroid receptor action, as well as provide a basis for new therapeutic approaches in prostate cancer.

Research Interests

Cellular Growth Control and Androgen Receptor

Research Keywords

prostate cancer, signal transduction, androgens, phosphorylation

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Androgen receptor coactivators that inhibit prostate cancer growth
Daniels, Garrett; Jha, Ruchi; Shen, Ying; Logan, Susan K; Lee, Peng
2014 ;2(1):62-70, American journal of clinical & experimental urology
— id: 1342092, year: 2014, vol: 2, page: 62, stat: Journal Article,

TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth
Daniels, Garrett; Li, Yirong; Gellert, Lan Lin; Zhou, Albert; Melamed, Jonathan; Wu, Xinyu; Zhang, Xinming; Zhang, David; Meruelo, Daniel; Logan, Susan K; Basch, Ross; Lee, Peng
2014 Feb;21(1):127-142, Endocrine-related cancer
— id: 1083962, year: 2014, vol: 21, page: 127, stat: Journal Article,

Metformin Targets c-MYC Oncogene to Prevent Prostate Cancer
Akinyeke, Tunde; Matsumura, Satoko; Wang, Xinying; Wu, Yingjie; Schalfer, Eric D; Saxena, Anjana; Yan, Wenbo; Logan, Susan K; Li, Xin
2013 Oct;:1120-1126, Carcinogenesis
— id: 574312, year: 2013, vol: , page: 1120, stat: Journal Article,

Mini-review: androgen receptor phosphorylation in prostate cancer
Daniels, Garrett; Pei, Zhiheng; Logan, Susan K; Lee, Peng
2013 ;1(1):25-29, American journal of clinical & experimental urology
— id: 1341312, year: 2013, vol: 1, page: 25, stat: Journal Article,

Mini-review: androgen receptor phosphorylation in prostrate cancer
Daniels, Garrett; Pei, Zhiheng; Logan, Susan K; Lee, Peng
2013 ;1:25-29, American journal of clinical & experimental urology
— id: 745662, year: 2013, vol: 1, page: 25, stat: Journal Article,

A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells
Imberg-Kazdan, Keren; Ha, Susan; Greenfield, Alex; Poultney, Christopher S; Bonneau, Richard; Logan, Susan K; Garabedian, Michael J
2013 Apr;23(4):581-591, Genome research
— id: 271252, year: 2013, vol: 23, page: 581, stat: Journal Article,

Inhibition of androgen receptor and ?-catenin activity in prostate cancer
Lee, E; Madar, A; David, G; Garabedian, MJ; Gupta, RD; Logan, SK
2013 ;110(39):15710-15715, Proceedings of the National Academy of Sciences of the United States of America
— id: 785132, year: 2013, vol: 110, page: 15710, stat: Journal Article,

Inhibition of androgen receptor and beta-catenin activity in prostate cancer
Lee, Eugine; Madar, Aviv; David, Gregory; Garabedian, Michael J; Dasgupta, Ramanuj; Logan, Susan K
2013 Sep;110(39):15710-15715, Proceedings of the National Academy of Sciences of the United States of America
— id: 542762, year: 2013, vol: 110, page: 15710, stat: Journal Article,

Analysis of URI Nuclear Interaction with RPB5 and Components of the R2TP/Prefoldin-Like Complex
Mita, Paolo; Savas, Jeffrey N; Ha, Susan; Djouder, Nabil; Yates, John R 3rd; Logan, Susan K
2013 ;8(5):e63879-e63879 e63879, PLoS one
— id: 346562, year: 2013, vol: 8, page: e63879, stat: Journal Article,

Expression of androgen receptor and its phosphorylated forms in breast cancer progression
Ren, Qinghu; Zhang, Liying; Ruoff, Rachel; Ha, Susan; Wang, Jinhua; Jain, Shilpa; Reuter, Victor; Gerald, William; Giri, Dilip D; Melamed, Jonathan; Garabedian, Michael J; Lee, Peng; Logan, Susan K
2013 Apr;:2532-2540, Cancer
— id: 302392, year: 2013, vol: , page: 2532, stat: Journal Article,

Anti-androgen resistance in prostate cancer cells chronically induced by interleukin-1beta
Staverosky, Julia A; Zhu, Xin-Hua; Ha, Susan; Logan, Susan K
2013 ;1(1):53-65, American journal of clinical & experimental urology
— id: 1342072, year: 2013, vol: 1, page: 53, stat: Journal Article,

Anti-androgen resistance in prostate cancer cells induced by IL-1beta
Zhu, X; Staverosky, J; Logan, S
2013 20 May 2013;31(15):-, Journal of clinical oncology
— id: 451822, year: 2013, vol: 31, page: , stat: Journal Article,

Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer
Ha, S; Iqbal, N J; Mita, P; Ruoff, R; Gerald, W L; Lepor, H; Taneja, S S; Lee, P; Melamed, J; Garabedian, M J; Logan, S K
2012 Sep;:3992-4000, Oncogene
— id: 178151, year: 2012, vol: , page: 3992, stat: Journal Article,

Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells
Levine, Paul M; Lee, Eugine; Greenfield, Alex; Bonneau, Richard; Logan, Susan K; Garabedian, Michael J; Kirshenbaum, Kent
2012 Oct;7(10):1693-1701, ACS chemical biology
— id: 181272, year: 2012, vol: 7, page: 1693, stat: Journal Article,

Mifepristone Inhibits GRbeta Coupled Prostate Cancer Cell Proliferation
Ligr, Martin; Li, Yirong; Logan, Susan K; Taneja, Samir; Melamed, Jonathan; Lepor, Hebert; Garabedian, Michael J; Lee, Peng
2012 Sep;188(3):981-988, Journal of urology
— id: 175921, year: 2012, vol: 188, page: 981, stat: Journal Article,

Androgen receptor levels are upregulated by Akt in prostate cancer
Ha, Susan; Ruoff, Rachel; Kahoud, Nicole; Franke, Thomas F; Logan, Susan K
2011 Apr;18(2):245-255, Endocrine-related cancer
— id: 136566, year: 2011, vol: 18, page: 245, stat: Journal Article,

Regulation of Androgen Receptor-Mediated Transcription by RPB5 Binding Protein URI/RMP
Mita, Paolo; Savas, Jeffrey N; Djouder, Nabil; Yates, John R 3rd; Ha, Susan; Ruoff, Rachel; Schafler, Eric D; Nwachukwu, Jerome C; Tanese, Naoko; Cowan, Nicholas J; Zavadil, Jiri; Garabedian, Michael J; Logan, Susan K
2011 Sep;31(17):3639-3652, Molecular & cellular biology
— id: 136514, year: 2011, vol: 31, page: 3639, stat: Journal Article,

LEF1 Identifies Androgen-Independent Epithelium in the Developing Prostate
Wu, Xinyu; Daniels, Garrett; Shapiro, Ellen; Xu, Kun; Huang, Hongying; Li, Yirong; Logan, Susan; Greco, M Alba; Peng, Yi; Monaco, Marie E; Melamed, Jonathan; Lepor, Herbert; Grishina, Irina; Lee, Peng
2011 Jun;25(6):1018-1026, Molecular endocrinology
— id: 132604, year: 2011, vol: 25, page: 1018, stat: Journal Article,

Glucocorticoid receptor DNA binding decoy is a gas
Garabedian, Michael J; Logan, Susan K
2010 ;3(108):pe5-pe5, Science signaling
— id: 106599, year: 2010, vol: 3, page: pe5, stat: Journal Article,

Higher Expression of Serine-213 Phosphorylated Androgen Receptor Level Is Associated With Prostate Cancer Recurrence
Jain, Shilpa; Ruoff, Rachael; Ha, Susan; Melamed, Jonathan; Wang, Jinhua; Ren, Qinghu; Lee, Peng; Logan, Susan
2010 OCT ;134(4):674-674, American journal of clinical pathology
— id: 113734, year: 2010, vol: 134, page: 674, stat: Journal Article,

High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance
Simpson, Natalie E; Lambert, W Marcus; Watkins, Renecia; Giashuddin, Shah; Huang, S Joseph; Oxelmark, Ellinor; Arju, Rezina; Hochman, Tsivia; Goldberg, Judith D; Schneider, Robert J; Reiz, Luiz Fernando Lima; Soares, Fernando Augusto; Logan, Susan K; Garabedian, Michael J
2010 Nov 1;70(21):8446-8456, Cancer research
— id: 114177, year: 2010, vol: 70, page: 8446, stat: Journal Article,

Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress
Grandinetti, Kathryn B; Jelinic, Petar; DiMauro, Teresa; Pellegrino, Jessica; Fernandez Rodriguez, Ruben; Finnerty, Patricia M; Ruoff, Rachel; Bardeesy, Nabeel; Logan, Susan K; David, Gregory
2009 Aug 15;69(16):6430-6437, Cancer research
— id: 101640, year: 2009, vol: 69, page: 6430, stat: Journal Article,

Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells
Nwachukwu, Jerome C; Mita, Paolo; Ruoff, Rachel; Ha, Susan; Wang, Qianben; Huang, S Joseph; Taneja, Samir S; Brown, Myles; Gerald, William L; Garabedian, Michael J; Logan, Susan K
2009 Apr 1;69(7):3140-3147, Cancer research
— id: 99292, year: 2009, vol: 69, page: 3140, stat: Journal Article,

Development of phosphorylation site-specific antibodies to nuclear receptors
Torra, Ines Pineda; Staverosky, Julia A; Ha, Susan; Logan, Susan K; Garabedian, Michael J
2009 ;505:221-235, Methods in molecular biology
— id: 92774, year: 2009, vol: 505, page: 221, stat: Journal Article,

Glucocorticoid receptor phosphorylation differentially affects target gene expression
Chen, Weiwei; Dang, Thoa; Blind, Raymond D; Wang, Zhen; Cavasotto, Claudio N; Hittelman, Adam B; Rogatsky, Inez; Logan, Susan K; Garabedian, Michael J
2008 Aug;22(8):1754-1766, Molecular endocrinology
— id: 80349, year: 2008, vol: 22, page: 1754, stat: Journal Article,

Atypical regulation of SRC-3
Garabedian, Michael J; Logan, Susan K
2008 Jul;33(7):301-304, Trends in biochemical sciences
— id: 80347, year: 2008, vol: 33, page: 301, stat: Journal Article,

Down-regulation of p57Kip2 induces prostate cancer in the mouse
Jin, Ren Jie; Lho, Yongsoo; Wang, Yongqing; Ao, Mingfang; Revelo, Monica Patricia; Hayward, Simon W; Wills, Marcia L; Logan, Susan K; Zhang, Pumin; Matusik, Robert J
2008 May 15;68(10):3601-3608, Cancer research
— id: 80348, year: 2008, vol: 68, page: 3601, stat: Journal Article,

Regulation of prostate cell growth through androgen receptor cofactors
Logan, SK; Nwachukwu, JC; Mita, P; Taneja, SS; Garabedian, MJ
2008 ;179(4):190-190, Journal of urology
— id: 104579, year: 2008, vol: 179, page: 190, stat: Journal Article,

The Heterochromatin Protein 1 Family is Regulated in Prostate Development and Cancer
Shapiro, Ellen; Huang, Hongying; Ruoff, Rachel; Lee, Peng; Tanese, Naoko; Logan, Susan K
2008 Apr 22;179(6):2435-2439, Journal of urology
— id: 78573, year: 2008, vol: 179, page: 2435, stat: Journal Article,

Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27
Nwachukwu, Jerome C; Li, Wenhui; Pineda-Torra, Ines; Huang, Hong Ying; Ruoff, Rachel; Shapiro, Ellen; Taneja, Samir S; Logan, Susan K; Garabedian, Michael J
2007 Dec;21(12):2864-2876, Molecular endocrinology
— id: 94948, year: 2007, vol: 21, page: 2864, stat: Journal Article,

ART-27: A novel coactivator with tumor suppressor function in the prostate
Feig, JL; Ha, S; Ruoff, R; Logan, SK
2006 MAR 26 ;231(4):658-658, Abstracts of papers (American Chemical Society)
— id: 68761, year: 2006, vol: 231, page: 658, stat: Journal Article,

EXPRESSION AND REGULATION OF GLUCOCORTICOID RECEPTOR IN HUMAN PLACENTAL VILLOUS FIBROBLASTS
Lee, Men-Jean; Wang, Zhen; Yee, Herman; Ma, Yuehong; Swenson, Nicole; Yang, Liubin; Kadner, Susan S; Baergen, Rebecca N; Logan, Susan K; Garabedian, Michael J; Guller, Seth
2005 Nov;146(11):4619-4626, Endocrinology
— id: 57670, year: 2005, vol: 146, page: 4619, stat: Journal Article,

Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function
Li, Wenhui; Cavasotto, Claudio N; Cardozo, Timothy; Ha, Susan; Dang, Thoa; Taneja, Samir S; Logan, Susan K; Garabedian, Michael J
2005 May 26;19(9):2273-2282, Molecular endocrinology
— id: 56038, year: 2005, vol: 19, page: 2273, stat: Journal Article,

Cell-specific regulation of androgen receptor phosphorylation in vivo
Taneja, Samir S; Ha, Susan; Swenson, Nicole K; Huang, Hong Ying; Lee, Peng; Melamed, Jonathan; Shapiro, Ellen; Garabedian, Michael J; Logan, Susan K
2005 Dec 9;280(49):40916-40924, Journal of biological chemistry
— id: 61359, year: 2005, vol: 280, page: 40916, stat: Journal Article,

ART-27, an androgen receptor coactivator regulated in prostate development and cancer
Taneja, Samir S; Ha, Susan; Swenson, Nicole K; Torra, Ines Pineda; Rome, Serge; Walden, Paul D; Huang, Hong Ying; Shapiro, Ellen; Garabedian, Michael J; Logan, Susan K
2004 Apr 2;279(14):13944-13952, Journal of biological chemistry
— id: 44732, year: 2004, vol: 279, page: 13944, stat: Journal Article,

ART-27, a novel androgen receptor (AR) interacting protein, is a potential. mediator of prostate eptihelial differentiation
Logan, S; Ha, S; Rome, S; Garabedian, MJ; Taneja, SS
2002 ;167(4):56-56, Journal of urology
— id: 104583, year: 2002, vol: 167, page: 56, stat: Journal Article,

Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus
Markus, Steven M; Taneja, Samir S; Logan, Susan K; Li, Wenhui; Ha, Susan; Hittelman, Adam B; Rogatsky, Inez; Garabedian, Michael J
2002 Feb;13(2):670-682, Molecular biology of the cell
— id: 39704, year: 2002, vol: 13, page: 670, stat: Journal Article,

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade
Andreev J; Galisteo ML; Kranenburg O; Logan SK; Chiu ES; Okigaki M; Cary LA; Moolenaar WH; Schlessinger J
2001 Jun 8;276(23):20130-20135, Journal of biological chemistry
— id: 21223, year: 2001, vol: 276, page: 20130, stat: Journal Article,

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
Falasca M; Logan SK; Lehto VP; Baccante G; Lemmon MA; Schlessinger J
1998 Jan 15;17(2):414-422, EMBO journal
— id: 7559, year: 1998, vol: 17, page: 414, stat: Journal Article,

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase
Rogatsky I; Logan SK; Garabedian MJ
1998 Mar 3;95(5):2050-2055, Proceedings of the National Academy of Sciences of the United States of America
— id: 7764, year: 1998, vol: 95, page: 2050, stat: Journal Article,

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
Logan SK; Falasca M; Hu P; Schlessinger J
1997 Oct;17(10):5784-5790, Molecular & cellular biology
— id: 7203, year: 1997, vol: 17, page: 5784, stat: Journal Article,

T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40
Logan SK; Hansell EJ; Damsky CH; Werb Z
1996 Jul;15(2):81-89, Matrix biology
— id: 57671, year: 1996, vol: 15, page: 81, stat: Journal Article,

Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
Logan, S K; Garabedian, M J; Campbell, C E; Werb, Z
1996 Jan 12;271(2):774-782, Journal of biological chemistry
— id: 106246, year: 1996, vol: 271, page: 774, stat: Journal Article,

Integrin switching regulates normal trophoblast invasion
Damsky CH; Librach C; Lim KH; Fitzgerald ML; McMaster MT; Janatpour M; Zhou Y; Logan SK; Fisher SJ
1994 Dec;120(12):3657-3666, Development
— id: 57672, year: 1994, vol: 120, page: 3657, stat: Journal Article,

Human placental cells transformed with temperature-sensitive simian virus 40 are immortalized and mimic the phenotype of invasive cytotrophoblasts at both permissive and nonpermissive temperatures
Logan SK; Fisher SJ; Damsky CH
1992 Nov 1;52(21):6001-6009, Cancer research
— id: 57673, year: 1992, vol: 52, page: 6001, stat: Journal Article,

Ovarian follicle cell enhancers from the Drosophila yolk protein genes: different segments of one enhancer have different cell-type specificities that interact to give normal expression
Logan SK; Wensink PC
1990 Apr;4(4):613-623, Genes & development
— id: 57674, year: 1990, vol: 4, page: 613, stat: Journal Article,

DNA regions that regulate the ovarian transcriptional specificity of Drosophila yolk protein genes
Logan SK; Garabedian MJ; Wensink PC
1989 Sep;3(9):1453-1461, Genes & development
— id: 57675, year: 1989, vol: 3, page: 1453, stat: Journal Article,