George Lipkin

Biosketch / Results /

George Lipkin, M.D.

Professor;
Ronald O. Perelman Department of Dermatology (Fac)

Clinical Addresses

530 FIRST AVENUE
NEW YORK, NY 10016
Hours: Tue. 12 - 6; Thu. 1 - 6
Phone: 212-689-4884
Fax: 212-263-7847

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Medical Specialties

Dermatology

Medical Expertise

Warts, Rosacea, Vitiligo, Hair Diseases, Melanoma, Skin Cancer, General Dermatology, Nail Disease, Psoriasis

Reviewer for Cancer Research, Cancer, Journal of Investigative Dermatology, Science, Quaterly Review of Biology, Yearbook of Dermatology.

Languages

French, Spanish

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, CIGNA EPO/POS, Cigna PPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP HMO, HIP MEDICARE, HIP POS, MAGNACARE PPO, NYS EMPIRE PLAN, OXFORD FREEDOM, Oxford Medicare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UPN Elite

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1961 — Ab Dermatology - Dermatology

Education

1955 — SUNY Downstate Medical Center, Medical Education
1955-1956 — Montefiore Medical Center (Rotating Internship), Internship
1956-1957 — NYU Medical Center (Dermatology), Residency Training
1956-1961 — NYU Medical Center (Dermatolgy), Residency Training

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Research Summary

Current treatment of malignancy is hindered by tumor cell heterogeneity and progressive clonal evolution. Reversion of the malignant phenotype by differentiation agents could favorably alter the tumor/host relationship by stabilizing phenotypes and reducing heterogeneity. We have identified a unique endogenous inhibitor in a revertant melanoma line, which restores normal growth control--density-, anchorage-, and serum-dependence--to melanoma cells. It induces early Gl growth arrest, differentiation antigens, and decreased susceptibility to natural killer cells with increased vulnerability to cytotoxic T cells and with increased class I MHC expression. Effects are nontoxic, reversible, and transcend species and tissue barriers. Treated melanoma and hepatoma cells exhibited striking cytoskeletal reorganization, including changes in an actin-binding substrate for phosphorylation by the EGF receptor. In situ treatment of lethal hamster melanoma transplants with liposome-entrapped partially purified inhibitor for 30 days led to complete tumor regression and 100% survival. In situ administration of inhibitor in an aqueous suspension to C57BL/6J mice with established subcutaneous Lewis lung carcinomas led to regression of 75% of tumors (no survivors in control mice). This new inhibitor appears to favorably alter the biologic balance between tumor and host by reducing heterogeneity, restoring sensitivity to normal environmental signals governing growth, and inducing surface markers which alert and facilitate host response. We have partially purified this inhibitor and distinguished it from other known tumor inhibitors. Our laboratory's focus is on completing purification, well under way, and developing a new, powerful, nontoxic, biologically rational, and more effective therapy for currently incurable cancers.

Research Interests

Reversing Malignant Melanoma-Restoring Host Control

Research Keywords

growth control, melanoma inhibitor, phenotype reversion

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Syringocystadenoma
Mundi, Jyoti P; Rose, Amy E; Boyd, Kevin P; Patel, Rishi R; Lipkin, George
2013 ;19(12):20722-20722, Dermatology online journal
— id: 702782, year: 2013, vol: 19, page: 20722, stat: Journal Article,

Pseudoxanthoma elasticum
Gonzalez, Mercedes E; Votava, Henry J; Lipkin, George; Sanchez, Miguel
2009 ;15(8):17-17, Dermatology online journal
— id: 107815, year: 2009, vol: 15, page: 17, stat: Journal Article,

Plasticity of the cancer cell: implications for epigenetic control of melanoma and other malignancies
Lipkin, George
2008 Sep;128(9):2152-2155, Journal of investigative dermatology
— id: 83100, year: 2008, vol: 128, page: 2152, stat: Journal Article,

Acral dermatoses
Lipkin G
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3668, year: 2001, vol: , page: 6, stat: Chapter,

Making room for high-risk ideas
Lipkin G
2000 Jan;136(1):67-67, Archives of dermatology
— id: 11866, year: 2000, vol: 136, page: 67, stat: Journal Article,

A tribute to Bernie
Baer RL; Bystryn JC; Cohen D; Curwin J; Freedberg IM; Kopf AW; Lipkin G; Podwal M; Shupack J
1994 Feb;16(1):89-96, American journal of dermatopathology
— id: 16106, year: 1994, vol: 16, page: 89, stat: Journal Article,

MODULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ACCOMPANIES REVERSION OF MALIGNANT-MELANOMA PHENOTYPE BY CONTACT INHIBITORY FACTOR
LIPKIN, G; MERUELO, D
1992 APR ;40(2):A528-A528, Clinical research
— id: 52018, year: 1992, vol: 40, page: A528, stat: Journal Article,

MODULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ACCOMPANIES REVERSION OF MALIGNANT-MELANOMA PHENOTYPE BY CONTACT INHIBITORY FACTOR
LIPKIN, G; MERUELO, D
1992 APR ;98(4):643-643, Journal of investigative dermatology
— id: 52034, year: 1992, vol: 98, page: 643, stat: Journal Article,

Castleman's tumor and erosive lichen planus: coincidence or association?Report of a case
Ashinoff R; Cohen R; Lipkin G
1989 Nov;21(5 Pt 2):1076-1080, Journal of the American Academy of Dermatology
— id: 10433, year: 1989, vol: 21, page: 1076, stat: Journal Article,

CONTACT INHIBITORY FACTOR (CIF) INDUCES MORPHOLOGIC REORGANIZATION IN MOUSE MALIGNANT-MELANOMA AND KIRSTEN SARCOMA VIRUS-TRANSFORMED RAT FIBROBLAST CELLS
HIGGINS, PJ; LIPKIN, G; ROSENBERG, M
1988 APR ;36(3):A655-A655, Clinical research
— id: 41796, year: 1988, vol: 36, page: A655, stat: Journal Article,

CONTACT INHIBITORY FACTOR (CIF) INDUCES MORPHOLOGIC REORGANIZATION IN MOUSE MALIGNANT-MELANOMA AND KIRSTEN SARCOMA VIRUS-TRANSFORMED RAT FIBROBLAST CELLS
HIGGINS, PJ; LIPKIN, G; ROSENBERG, M
1988 APR ;90(4):569-569, Journal of investigative dermatology
— id: 41804, year: 1988, vol: 90, page: 569, stat: Journal Article,

CAN MODULATION OF THE MALIGNANT PHENOTYPE BY AN ENDOGENOUS INHIBITOR LEAD TO TUMOR-REGRESSION INVIVO
LIPKIN, G; ROSENBERG, M; FASS, E
1988 APR ;65(4):462-&, Journal of the American Oil Chemists Society
— id: 41779, year: 1988, vol: 65, page: 462, stat: Journal Article,

Contact-inhibitory factor induces alterations in the distribution and content of specific cytoskeletal elements in an established line of rat hepatic tumor cells
Higgins PJ; Lipkin G; Rosenberg M; Ryan MP
1987 Dec 15;40(6):792-801, International journal of cancer
— id: 18494, year: 1987, vol: 40, page: 792, stat: Journal Article,

Liposome-entrapped contact inhibitory factor: transfer of capacity for density-dependent growth to melanoma cells
Fass, E; Lipkin, G; Rosenberg, M
1986 Sep;87(3):309-312, Journal of investigative dermatology
— id: 67448, year: 1986, vol: 87, page: 309, stat: Journal Article,

Contact inhibitory factor also restores anchorage and serum dependence to hamster melanoma cells
Lipkin G; Rosenberg M; Klaus-Kovtun V
1986 Sep;87(3):305-308, Journal of investigative dermatology
— id: 16604, year: 1986, vol: 87, page: 305, stat: Journal Article,

Susceptibility to NK cell lysis is abolished in tumor cells by a factor which restores their contact inhibited growth
Nabi ZF; Zucker-Franklin D; Lipkin G; Rosenberg M
1986 Oct 1;58(7):1461-1465, Cancer
— id: 15723, year: 1986, vol: 58, page: 1461, stat: Journal Article,

CONTACT INHIBITED GROWTH RENDERS TUMOR-CELLS RESISTANT TO NATURAL-KILLER CELL-LYSIS
ZUCKERFRANKLIN, D; LIPKIN, G; NABI, ZF; ROSENBERG, M
1986 APR ;34(2):A728-A728, Clinical research
— id: 41414, year: 1986, vol: 34, page: A728, stat: Journal Article,

Vitiligo-related pigment cell differentiation antigens are expressed on malignant melanoma cells following phenotypic reversion induced by contact inhibitory factor
Lipkin G; Naughton GK; Rosenberg M; Bystryn JC
1985 ;30(1):35-39, Differentiation
— id: 57429, year: 1985, vol: 30, page: 35, stat: Journal Article,

EXPRESSION OF VITILIGO-RELATED PIGMENT CELL-DIFFERENTIATION ANTIGENS ON MELANOMA-CELLS AFTER PHENOTYPIC REVERSION BY CONTACT INHIBITORY FACTOR
Lipkin, G; Naughton, GK; Rosenberg, M; Bystryn, JC
1985 ;33(2):A662-A662, Clinical research
— id: 30756, year: 1985, vol: 33, page: A662, stat: Journal Article,

EXPRESSION OF VITILIGO-RELATED PIGMENT CELL-DIFFERENTIATION ANTIGENS ON MELANOMA-CELLS AFTER PHENOTYPIC REVERSION BY CONTACT INHIBITORY FACTOR
Lipkin, G; Naughton, GK; Rosenberg, M; Bystryn, JC
1985 ;84(4):295-295, Journal of investigative dermatology
— id: 30765, year: 1985, vol: 84, page: 295, stat: Journal Article,

Alpha 1-antitrypsin deficiency genes: contributory defect in a subset of psoriatics?
Lipkin G; Galdston M; Kueppers F
1984 Oct;11(4 Pt 1):615-619, Journal of the American Academy of Dermatology
— id: 16605, year: 1984, vol: 11, page: 615, stat: Journal Article,

ALPHA-1-ANTITRYPSIN DEFICIENCY GENES IN A SUBSET OF PSORIATICS
LIPKIN, G; GALDSTON, M; KUEPPERS, F
1984 ;32(3):A713-A713, Clinical research
— id: 40780, year: 1984, vol: 32, page: A713, stat: Journal Article,

ALPHA-1-ANTITRYPSIN DEFICIENCY GENES IN A SUBSET OF PSORIATICS
LIPKIN, G; KUEPPERS, F
1984 ;32(2):A599-A599, Clinical research
— id: 40840, year: 1984, vol: 32, page: A599, stat: Journal Article,

EXPRESSION OF VITILIGO-RELATED PIGMENT CELL-DIFFERENTIATION ANTIGENS ON MELANOMA-CELLS AFTER PHENOTYPIC REVERSION BY CONTACT INHIBITORY FACTOR
LIPKIN, G; NAUGHTON, GK; ROSENBERG, M; BYSTRYN, JC
1984 ;32(3):A713-A713, Clinical research
— id: 40781, year: 1984, vol: 32, page: A713, stat: Journal Article,

Expression of vitiligo antigen on a revertant line of hamster melanoma cells
Naughton GK; Lipkin G; Bystryn JC
1984 Nov;83(5):317-319, Journal of investigative dermatology
— id: 16261, year: 1984, vol: 83, page: 317, stat: Journal Article,

INDUCTION OF PHENOTYPIC CHANGE BY CONTACT INHIBITORY FACTOR
Lipkin, G; Rosenberg, M
1981 ;60(4):341-342, Bollettino della'Instituto Sieroterapico Milanese
— id: 30509, year: 1981, vol: 60, page: 341, stat: Journal Article,

Malignancy in controlled regression. A new aspect of pathology
Lipkin G
1980 Spring;2(1):75-77, American journal of dermatopathology
— id: 16606, year: 1980, vol: 2, page: 75, stat: Journal Article,

A potent inhibitor of normal and transformed cell growth derived from contact-inhibited cells
Lipkin G; Knecht ME; Rosenberg M
1978 Mar;38(3):635-643, Cancer research
— id: 16608, year: 1978, vol: 38, page: 635, stat: Journal Article,

Glycoprotein-containing factor that mediates contact inhibition of growth
Lipkin G; Knecht ME; Rosenberg M
1978 Jun 20;312(1):382-391, Annals of the New York Academy of Sciences
— id: 16607, year: 1978, vol: 312, page: 382, stat: Journal Article,

Biochemical studies of a protein which restores contact inhibition of growth to malignant melanocytes
Knecht ME; Lipkin G
1977 Aug;108(1):15-22, Experimental cell research
— id: 16610, year: 1977, vol: 108, page: 15, stat: Journal Article,

BIOCHEMICAL STUDIES OF A PROTEIN WHICH RESTORES CONTACT INHIBITION OF GROWTH TO MALIGNANT MELANOCYTES
Knecht, ME; Lipkin, G
1977 ;18(MAR):142-142, Proceedings (American Association for Cancer Research)
— id: 29587, year: 1977, vol: 18, page: 142, stat: Journal Article,

Restoration of in vitro growth control to malignant cells
Lipkin G; Knecht ME; Rosenberg M
1977 Nov;40(5 Suppl):2699-2705, Cancer
— id: 16609, year: 1977, vol: 40, page: 2699, stat: Journal Article,

Contact inhibition of growth is restored to malignant melanocytes of man and mouse by a hamster protein
Lipkin G; Knecht ME
1976 Oct 15;102(2):341-348, Experimental cell research
— id: 16611, year: 1976, vol: 102, page: 341, stat: Journal Article,

Factors affecting growth of normal and malignant cells in vitro
Lipkin G; Rosenberg M; Knecht ME
1976 Jun 15;25(12):1333-1337, Biochemical pharmacology
— id: 16612, year: 1976, vol: 25, page: 1333, stat: Journal Article,

POTENT INHIBITOR OF NORMAL AND TRANSFORMED-CELL GROWTH DERIVED FROM CONTACT INHIBITED MELANOCYTES
Lipkin, G; Knecht, ME
1976 ;24(3):A494-A494, Clinical research
— id: 28761, year: 1976, vol: 24, page: A494, stat: Journal Article,

POTENT INHIBITOR OF NORMAL AND TRANSFORMED-CELL GROWTH DERIVED FROM CONTACT-INHIBITED MELANOCYTES
Lipkin, G; Knecht, ME
1976 ;66(4):280-280, Journal of investigative dermatology
— id: 28772, year: 1976, vol: 66, page: 280, stat: Journal Article,

BIOCHEMICAL ASPECTS OF A PROTEIN WHICH RESTORES CONTACT INHIBITION OF GROWTH TO MALIGNANT MELANOCYTES
Knecht, ME; Lipkin, G
1975 ;23(3):A452-A452, Clinical research
— id: 28545, year: 1975, vol: 23, page: A452, stat: Journal Article,

BIOCHEMICAL ASPECTS OF A PROTEIN WHICH RESTORES CONTACT INHIBITION OF GROWTH TO MALIGNANT MELANOCYTES
Knecht, ME; Lipkin, G
1975 ;64(3):211-211, Journal of investigative dermatology
— id: 28572, year: 1975, vol: 64, page: 211, stat: Journal Article,

[Restoration of growth contact inhibition in malignant melanocytes from man, mice, and hamsters]
Lipkin G; Knecht ME
1975 Oct 18;105(42):1360-1364, Schweizerische medizinische wochenschrift = Journal suisse de medecine
— id: 16613, year: 1975, vol: 105, page: 1360, stat: Journal Article,

CONTACT INHIBITION OF GROWTH - RESTORATION IN MALIGNANT MELANOCYTES OF MAN, MOUSE, AND HAMSTER
Lipkin, G; Knecht, ME
1975 ;23(3):A453-A453, Clinical research
— id: 28546, year: 1975, vol: 23, page: A453, stat: Journal Article,

CONTACT INHIBITION OF GROWTH - RESTORATION IN MALIGNANT MELANOCYTES OF MAN, MOUSE, AND HAMSTER
Lipkin, G; Knecht, ME
1975 ;64(3):211-212, Journal of investigative dermatology
— id: 28573, year: 1975, vol: 64, page: 211, stat: Journal Article,

HAMSTER MELANOCYTE CONTACT-INHIBITORY FACTOR (MCIF) - EFFECTS TRANSCEND TISSUE AND SPECIES BARRIERS
Lipkin, G; Knecht, ME
1975 ;16(MAR):140-140, Proceedings (American Association for Cancer Research)
— id: 28667, year: 1975, vol: 16, page: 140, stat: Journal Article,

[Proceeding a protein factor re-establishing the contact-inhibition of hamster melanoma cells in vitro]
Knecht M; Lipkin G
1974 ;148(5):275-275, Dermatologica
— id: 16615, year: 1974, vol: 148, page: 275, stat: Journal Article,

A diffusible factor restoring contact inhibition of growth to malignant melanocytes
Lipkin G; Knecht ME
1974 Mar;71(3):849-853, Proceedings of the National Academy of Sciences of the United States of America
— id: 16614, year: 1974, vol: 71, page: 849, stat: Journal Article,

MELANOCYTE CONTACT-INHIBITORY FACTOR (MCIF) - TRANSFER OF NORMAL IN-VITRO GROWTH-CONTROL TO HAMSTER MALIGNANT MELANOCYTES
Lipkin, G; Knecht, ME
1974 ;15(MAR):61-61, Proceedings (American Association for Cancer Research)
— id: 28452, year: 1974, vol: 15, page: 61, stat: Journal Article,

Pigment transformation and induction
Lipkin G
1973 Jun;60(6):381-398, Journal of investigative dermatology
— id: 16616, year: 1973, vol: 60, page: 381, stat: Journal Article,

PIGMENT INDUCTION IN SYNCHRONIZED AMELANOTIC MELANOCYTES BY SYNTHETIC RNA, A HALOGENATED THYMIDINE ANALOG, AND DMSO
Lipkin, G; Hodgins, LT
1973 ;46(5):710-711, Yale journal of biology & medicine
— id: 28465, year: 1973, vol: 46, page: 710, stat: Journal Article,

Pigment transformation and induction in hamster malignant amelanotic melanocytes. An effect of nucleic acids from hamster benign blue nevus
Lipkin, G
1971 Jul;57(1):49-65, Journal of investigative dermatology
— id: 16617, year: 1971, vol: 57, page: 49, stat: Journal Article,

Studies of the lipids of dog skin. IV. The in vivo incorporation of blood lipids into the lipids of isolated perfused dog skin
Lipkin G; Wheatley VR; Woo TH; March C
1968 Jun;50(6):456-458, Journal of investigative dermatology
— id: 16619, year: 1968, vol: 50, page: 456, stat: Journal Article,

Influence of anti-lymphocyte serum on malignant melanoma
Wolf-Jurgensen P; Kopf AW; Lipkin G; Bart RS
1968 Dec;51(6):441-444, Journal of investigative dermatology
— id: 16618, year: 1968, vol: 51, page: 441, stat: Journal Article,

Lipogenesis from amino acids in perfused isolated dog skin
Wheatley VR; Lipkin G; Woo TH
1967 Mar;8(2):84-89, Journal of lipid research
— id: 39028, year: 1967, vol: 8, page: 84, stat: Journal Article,

Studies of the lipids of dog skin. 3. The in vivo incorporation of acetate, pyruvate, and certain amino acids into the lipids of isolated perfused dog skin
Lipkin G; Wheatley VR; March C
1965 Nov;45(5):356-361, Journal of investigative dermatology
— id: 16620, year: 1965, vol: 45, page: 356, stat: Journal Article,

CHANGING PATTERNS OF SENSITIVITY TO COMMON CONTACT ALLERGENS
BAER RL; LIPKIN G; KANOF NB; BIONDI E
1964 Jan;89:3-8, Archives of dermatology
— id: 60073, year: 1964, vol: 89, page: 3, stat: Journal Article,

SKIN COPPER LEVELS IN PSORIASIS
LIPKIN, G; GOWDEY, J; WHEATLEY, V R
1964 Feb;42:205-207, Journal of investigative dermatology
— id: 124569, year: 1964, vol: 42, page: 205, stat: Journal Article,

DISCUSSION OF WEIDMAN A
LIPKIN, G; BAER, RL; KOPF, A; COSTELLO, MJ; TOLMACH, JA
1963 ;88(3):359-&, Archives of dermatology
— id: 685212, year: 1963, vol: 88, page: 359, stat: Journal Article,