Herbert Lepor

Biosketch / Results /

Herbert Lepor, M.D.

Professor; Martin Spatz Chair Dept of Urology; Urology Chief
Departments of Urology (Chair) and Biochemistry and Molecular Pharmacology
NYU Urology Associates

Clinical Addresses

NEW YORK, NY 10016
Hours: Tue. 8 - 5; Fri. 8 - 5
Handicap Access: yes
Phone: 646-825-6327
Fax: 646-825-6399

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Medical Specialties

Cancer, Urology

Medical Expertise

Prostate Cancer, Urethral Stricture, Prostate Disorders, Genitourinary Cancer


Empire BC/BS PPO, Empire BCBS Child Health Plus, Empire BCBS EPO, Empire BCBS HMO, Empire BCBS Healthy NY, Empire BCBS Indemnity, Empire BCBS POS, Empire BCBS PPO, Multiplan, OXFORD EXCHANGE, Oxford Freedom Plan, Oxford Liberty, UHC EPO, UHC HMO, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS

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Board Certification

2006 — Ab Urology - Urology


1975-1979 — Johns Hopkins University, Medical Education
1979-1981 — Johns Hopkins Hospital, Residency Training
1981-1985 — Johns Hopkins Hospital, Residency Training

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Research Summary

We characterize the neuropharmacology and neurophysiology of the prostate. Thus far, we have characterized the alpha1, alpha2, muscarinic cholinergic, DHP, and endothelin receptors in the prostate using radioligand receptor-binding studies. Additionally, we determined the cellular localization and physiological role of these receptors using autoradiography, isometric tension studies, and in vivo studies. Recently, we characterized and localized the alpha1 adrenoceptor subtypes in the human prostate. The clinical relevance of these investigations relates to the management of benign prostatic hyperplasia (BPH), a very common disease that causes bladder dysfunction and lower urinary tract symptoms in the aging male population. Bladder outlet obstructions secondary to BPH appear to be an important factor in the pathophysiology of the disease process. Alpha1 antagonists are routinely used to treat BPH. The tension of prostate smooth muscle is mediated by the alpha1 endothelin receptors and nitric oxide. In future investigations, we will study the role of endothelin antagonists and nitric oxide agonists.

Research Interests

Neuropharmacology and Physiology of the Prostate

Research Keywords

alpha1 adrenoceptor subtypes, benign prostatic hyperplasia, nitric oxide agonists, prostate, receptors