Cynthia Gail Leichman

Biosketch / Results /

Cynthia Gail Leichman, M.D., M.A.

Member of the Faculty;
Department of Medicine (Hematology Div)
NYU Medical Oncology Associates

Clinical Addresses

Perlmutter Cancer Center
160 East 34th Street, 11th Floor
New York, NY 10016
Handicap Access: yes
Phone: 212-731-5725

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Medical Specialties

Cancer, Medical Oncology

Medical Expertise

Esophageal Cancer, Gastrointestinal Cancers, Colon Cancer, Gallbladder Cancer, Gastric (Stomach) Cancer, Colorectal Cancer, Pancreatic Cancer, Rectal Cancer, Liver Cancer, Breast Oncology, Breast Cancer



Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1982 — Ab Internal Medicine - Internal Medicine
1989 — Ab Internal Medicine (Medical Oncology)


1974-1977 — Wayne State University, Medical Education
1977-1980 — Wayne State University (Internal Medicine), Internship
1977-1980 — Wayne State University (Internal Medicine), Residency Training
1980-1983 — Wayne State University (Medical Oncology), Clinical Fellowships

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All data from NYU Health Sciences Library Faculty Bibliography — -


Significantly Worse Colostomy-Free Survival in Human Immunodeficiency Virus Positive Patients After Definitive Chemoradiation for Anal Cancer
Grew, D; Bitterman, D; Leichman, C; Leichman, L; Du, K
2014 SEP 1;90:S398-S399, International journal of radiation oncology biology physics
— id: 1313762, year: 2014, vol: 90, page: S398, stat: Journal Article,

Radiation Therapy Improves Survival in Small Cell Rectal Cancer: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data
Hsu, H. C. ; Leichman, C. G. ; Du, K. L.
2013 OCT 1;87(2 S S):S188-S188, International journal of radiation oncology biology physics
— id: 657462, year: 2013, vol: 87, page: S188, stat: Journal Article,

Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Ixabepilone or Paclitaxel in Early Stage Breast Cancer and Evaluation of betaIII-Tubulin Expression as a Predictive Marker
Saura, Cristina; Tseng, Ling-Ming; Chan, Stephen; Chacko, Raju T; Campone, Mario; Manikhas, Alexy; Nag, Shona M; Leichman, Cynthia G; Dasappa, Lokanatha; Fasching, Peter A; Hurtado de Mendoza, Fernando; Symmans, W Fraser; Liu, David; Mukhopadhyay, Pralay; Horak, Christine; Xing, Guan; Pusztai, Lajos
2013 ;18(7):787-794, Oncologist
— id: 490082, year: 2013, vol: 18, page: 787, stat: Journal Article,

Multicenter, randomized phase II trial of bevacizumab plus folinic acid, fluorouracil, gemcitabine (FFG) versus bevacizumab plus folinic acid, fluorouracil, oxaliplatin (FOLFOX4) as first-line therapy for patients with advanced colorectal cancer
Madajewicz, Stefan; Waterhouse, David M; Ritch, Paul S; Khan, M Qaseem; Higby, Donald J; Leichman, Cynthia G; Malik, Sandeep K; Hentschel, Patricia; Gill, John F; Zhao, Luping; Nicol, Steven J
2012 Apr;30(2):772-778, Investigational new drugs
— id: 164140, year: 2012, vol: 30, page: 772, stat: Journal Article,

Phase II study of sorafenib with gemcitabine and erlotinib (GES) in first-line advanced pancreatic cancer
Cohen, D J; Leichman, L P; Love, E; Ryan, T; Leichman, C G; Newman, E; Levinson, B; Hochster, H S
2011 01 Feb 2011;29(4):-, Journal of clinical oncology
— id: 161217, year: 2011, vol: 29, page: , stat: Journal Article,

Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
Manegold, Christian; Gravenor, Donald; Woytowitz, Donald; Mezger, Jorg; Hirsh, Vera; Albert, Gary; Al-Adhami, Mohammed; Readett, David; Krieg, Arthur M; Leichman, Cynthia Gail
2008 Aug;26(24):3979-3986, Journal of clinical oncology
— id: 164134, year: 2008, vol: 26, page: 3979, stat: Journal Article,

Adjuvant therapy for colon cancer 2005: new options in the twenty-first century
Leichman, Cynthia Gail
2006 Jan;15(1):159-173, Surgical oncology clinics of North America
— id: 164128, year: 2006, vol: 15, page: 159, stat: Journal Article,

Expression of genes related to activity of oxaliplatin and 5-fluorouracil in endoscopic biopsies of primary esophageal cancer in patients receiving oxaliplatin, 5-flourouracil and radiation: characterization and exploratory analysis with survival
Leichman, L; Lawrence, D; Leichman, C G; Nava, H; Nava, E; Proulx, G; Clark, K; Khushalani, N I; Berdzik, J; Greco, W; Smith, P; Creaven, P J; Kepner, J L; Javle, M M; Pendyala, L
2006 Oct;18(5):514-524, Journal of chemotherapy
— id: 164130, year: 2006, vol: 18, page: 514, stat: Journal Article,

Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144
Smalley, Stephen R; Benedetti, Jacqueline K; Williamson, Stephen K; Robertson, John M; Estes, Norman C; Maher, Tracy; Fisher, Barbara; Rich, Tyvin A; Martenson, James A; Kugler, John W; Benson, Al B 3rd; Haller, Daniel G; Mayer, Robert J; Atkins, James N; Cripps, Christine; Pedersen, John; Periman, Phillip O; Tanaka, Michael S Jr; Leichman, Cynthia G; Macdonald, John S
2006 Aug;24(22):3542-3547, Journal of clinical oncology
— id: 164129, year: 2006, vol: 24, page: 3542, stat: Journal Article,

Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study
Leichman, Cynthia G; Benedetti, Jacqueline K; Zalupski, Mark M; Hochster, Howard; Shields, Anthony F; Lenz, Heinz-Josef; Wade Iii, James L; Bearden Iii, James D; Macdonald, John S
2005 Jul;5(2):119-123, Clinical colorectal cancer
— id: 69428, year: 2005, vol: 5, page: 119, stat: Journal Article,

Hypersensitivity Reactions to oxaliplatin: incidence and management
Gowda, Aruna; Goel, Ramil; Berdzik, Joanne; Leichman, Cynthia G; Javle, Milind
2004 Nov;18(13):1142-1142, Oncology
— id: 164127, year: 2004, vol: 18, page: 1142, stat: Journal Article,

Phase II clinical trial of 5-fluorouracil, trimetrexate, and leucovorin (NFL) in patients with advanced pancreatic cancer
Garcia, Agustin A; Leichman, Lawrence; Baranda, Joaquina; Pandit, Lalita; Lenz, Heinz-Josef; Leichman, Cynthia G
2003 ;34(2-3):79-86, International journal of gastrointestinal cancer
— id: 164126, year: 2003, vol: 34, page: 79, stat: Journal Article,

Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: a debate
Khushalani, Nikhil I; McKinley, Brian Patrick; Gibbs, John F; Leichman, Cynthia Gail; Petrelli, Nicholas J
2003 Jan;82(1):65-72, Journal of surgical oncology
— id: 164082, year: 2003, vol: 82, page: 65, stat: Journal Article,

On being a medical mom
Leichman, Cynthia Gail
This side of doctoring : reflections from women in medicine Oxford ; New York : Oxford University Press, 2003,
— id: 164232, year: 2003, vol: , page: ?, stat: Chapter,

Definitive and neoadjuvant therapies for esophageal and gastroesophageal junction tumors: a look back and toward the future
Leichman, Lawrence; Pendyala, Lakshmi; Leichman, Cynthia Gail
2003 Aug;30(4 Suppl 11):11-18, Seminars in oncology
— id: 164123, year: 2003, vol: 30, page: 11, stat: Journal Article,

A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863
Venook, A P; Enders Klein, C; Fleming, G; Hollis, D; Leichman, C G; Hohl, R; Byrd, J; Budman, D; Villalona, M; Marshall, J; Rosner, G L; Ramirez, J; Kastrissios, H; Ratain, M J
2003 Dec;14(12):1783-1790, Annals of oncology
— id: 164124, year: 2003, vol: 14, page: 1783, stat: Journal Article,

Phase I and pharmacokinetic study of once daily oral administration of S-1 in patients with advanced cancer
Cohen, Steven J; Leichman, Cynthia G; Yeslow, Gwen; Beard, Mary; Proefrock, April; Roedig, Brian; Damle, Bharat; Letrent, Stephen P; DeCillis, Arthur P; Meropol, Neal J
2002 Jul;8(7):2116-2122, Clinical cancer research
— id: 164079, year: 2002, vol: 8, page: 2116, stat: Journal Article,

Effect of concurrent radiation therapy and chemotherapy on pulmonary function in patients with esophageal cancer: dose-volume histogram analysis
Gergel, Thomas J; Leichman, Lawrence; Nava, Hector R; Blumenson, Leslie E; Loewen, Gregory M; Gibbs, John E; Khushalani, Nikhil I; Leichman, Cynthia G; Bodnar, Lisa M; Douglass, Harold O; Smith, Judy L; Kuettel, Michael R; Proulx, Gary M
2002 Nov-Dec;8(6):451-460, Cancer journal
— id: 164081, year: 2002, vol: 8, page: 451, stat: Journal Article,

Oxaliplatin in combination with protracted-infusion fluorouracil and radiation: report of a clinical trial for patients with esophageal cancer
Khushalani, Nikhil I; Leichman, Cynthia Gail; Proulx, Gary; Nava, Hector; Bodnar, Lisa; Klippenstein, Donald; Litwin, Alan; Smith, Judy; Nava, Enriqueta; Pendyala, Lakshmi; Smith, Patrick; Greco, William; Berdzik, Joanne; Douglass, Harold; Leichman, Lawrence
2002 Jun;20(12):2844-2850, Journal of clinical oncology
— id: 164078, year: 2002, vol: 20, page: 2844, stat: Journal Article,

Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer
Leichman, Cynthia G; Chansky, Kari; Macdonald, John S; Doukas, Michael A; Budd, G Thomas; Giguere, Jeffrey K; Abbruzzese, James L
2002 Nov;20(4):419-424, Investigational new drugs
— id: 164080, year: 2002, vol: 20, page: 419, stat: Journal Article,

Phase II trial of outpatient schedule of paclitaxel in patients with previously untreated metastatic, measurable adenocarcinoma of the stomach
Garcia, A A; Leichman, C G; Lenz, H J; Baranda, J; Lujan, R; Casagrande, Y; Leichman, L
2001 Jun;31(6):275-278, Japanese journal of clinical oncology
— id: 164076, year: 2001, vol: 31, page: 275, stat: Journal Article,

Predictive and prognostic markers in gastrointestinal cancers
Leichman, C G
2001 Jul;13(4):291-299, Current opinion in oncology
— id: 164075, year: 2001, vol: 13, page: 291, stat: Journal Article,

Therapy of disseminated colorectal cancer: the emerging role of intratumoral molecular biology
Leichman, L; Leichman, C G
2001 ;(586):43-48, European journal of surgery. Supplement = Acta chirurgica. Supplement
— id: 164077, year: 2001, vol: , page: 43, stat: Journal Article,

Challenges posed by non-random missing quality of life data in an advanced-stage colorectal cancer clinical trial
Moinpour, C M; Sawyers Triplett, J; McKnight, B; Lovato, L C; Upchurch, C; Leichman, C G; Muggia, F M; Tanaka, L; James, W A; Lennard, M; Meyskens, F L Jr
2000 Jul-Aug;9(4):340-354, Psycho-oncology
— id: 161296, year: 2000, vol: 9, page: 340, stat: Journal Article,

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
Salonga, D; Danenberg, K D; Johnson, M; Metzger, R; Groshen, S; Tsao-Wei, D D; Lenz, H J; Leichman, C G; Leichman, L; Diasio, R B; Danenberg, P V
2000 Apr;6(4):1322-1327, Clinical cancer research
— id: 164074, year: 2000, vol: 6, page: 1322, stat: Journal Article,

Phase I study of AG 331, a novel thymidylate synthase inhibitor, in patients with refractory solid tumors
Koda, R T; Garcia, A A; Chatterjee, D J; Li, W Y; Parimoo, D; Jeffers, S; Rogers, M; Leichman, C G; Leichman, L; Wu, E Y; Shetty, B V; Webber, S; Clendinnin, N; Muggia, F M
1999 ;43(6):489-496, Cancer chemotherapy & pharmacology
— id: 161299, year: 1999, vol: 43, page: 489, stat: Journal Article,

Schedule dependency of 5-fluorouracil
Leichman, C G
1999 Jul;13(7 Suppl 3):26-32, Oncology
— id: 164072, year: 1999, vol: 13, page: 26, stat: Journal Article,

Hepatic chemoembolization combined with systemic infusion of 5-fluorouracil and bolus leucovorin for patients with metastatic colorectal carcinoma: A Southwest Oncology Group pilot trial
Leichman, C G; Jacobson, J R; Modiano, M; Daniels, J R; Zalupski, M M; Doroshow, J H; Fletcher, W S; Macdonald, J S
1999 Sep;86(5):775-781, Cancer
— id: 164073, year: 1999, vol: 86, page: 775, stat: Journal Article,

Thymidylate synthase as a predictor of response
Leichman, C G
1998 Aug;12(8 Suppl 6):43-47, Oncology
— id: 164175, year: 1998, vol: 12, page: 43, stat: Journal Article,

p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site
Lenz, H J; Danenberg, K D; Leichman, C G; Florentine, B; Johnston, P G; Groshen, S; Zhou, L; Xiong, Y P; Danenberg, P V; Leichman, L P
1998 May;4(5):1227-1234, Clinical cancer research
— id: 164173, year: 1998, vol: 4, page: 1227, stat: Journal Article,

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival
Lenz, H J; Hayashi, K; Salonga, D; Danenberg, K D; Danenberg, P V; Metzger, R; Banerjee, D; Bertino, J R; Groshen, S; Leichman, L P; Leichman, C G
1998 May;4(5):1243-1250, Clinical cancer research
— id: 164174, year: 1998, vol: 4, page: 1243, stat: Journal Article,

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil
Metzger, R; Danenberg, K; Leichman, C G; Salonga, D; Schwartz, E L; Wadler, S; Lenz, H J; Groshen, S; Leichman, L; Danenberg, P V
1998 Oct;4(10):2371-2376, Clinical cancer research
— id: 164176, year: 1998, vol: 4, page: 2371, stat: Journal Article,

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy
Metzger, R; Leichman, C G; Danenberg, K D; Danenberg, P V; Lenz, H J; Hayashi, K; Groshen, S; Salonga, D; Cohen, H; Laine, L; Crookes, P; Silberman, H; Baranda, J; Konda, B; Leichman, L
1998 Jan;16(1):309-316, Journal of clinical oncology
— id: 164172, year: 1998, vol: 16, page: 309, stat: Journal Article,

Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy: a final report
Crookes, P; Leichman, C G; Leichman, L; Tan, M; Laine, L; Stain, S; Baranda, J; Casagrande, Y; Groshen, S; Silberman, H
1997 May;79(9):1767-1775, Cancer
— id: 164169, year: 1997, vol: 79, page: 1767, stat: Journal Article,

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
Leichman, C G; Lenz, H J; Leichman, L; Danenberg, K; Baranda, J; Groshen, S; Boswell, W; Metzger, R; Tan, M; Danenberg, P V
1997 Oct;15(10):3223-3229, Journal of clinical oncology
— id: 164171, year: 1997, vol: 15, page: 3223, stat: Journal Article,

A pilot trial of continuous infusion 5-fluorouracil with levamisole for adjuvant therapy of colon cancer
Leichman, C G; Poplin, E; Zalupski, M; Garcia, Y; Grant, A; Angeles, A; DeJong, L; Leichman, L
1996 Spring;6(2):84-86, Journal of infusional chemotherapy
— id: 164168, year: 1996, vol: 6, page: 84, stat: Journal Article,

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival
Lenz, H J; Leichman, C G; Danenberg, K D; Danenberg, P V; Groshen, S; Cohen, H; Laine, L; Crookes, P; Silberman, H; Baranda, J; Garcia, Y; Li, J; Leichman, L
1996 Jan;14(1):176-182, Journal of clinical oncology
— id: 164167, year: 1996, vol: 14, page: 176, stat: Journal Article,

Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil
Muggia, F M; Wu, X; Spicer, D; Groshen, S; Jeffers, S; Leichman, C G; Leichman, L; Chan, K K
1996 Sep;2(9):1461-1467, Clinical cancer research
— id: 161312, year: 1996, vol: 2, page: 1461, stat: Journal Article,

Intraperitoneal 5-fluoro-2'-deoxyuridine (FUDR) and (S)-leucovorin for disease predominantly confined to the peritoneal cavity: a pharmacokinetic and toxicity study
Israel, V K; Jiang, C; Muggia, F M; Tulpule, A; Jeffers, S; Leichman, L; Morrow, C P; Roman, L; Leichman, C G; Chan, K K
1995 ;37(1-2):32-38, Cancer chemotherapy & pharmacology
— id: 161322, year: 1995, vol: 37, page: 32, stat: Journal Article,

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
Johnston, P G; Lenz, H J; Leichman, C G; Danenberg, K D; Allegra, C J; Danenberg, P V; Leichman, L
1995 Apr;55(7):1407-1412, Cancer research
— id: 164163, year: 1995, vol: 55, page: 1407, stat: Journal Article,

Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study
Leichman, C G; Fleming, T R; Muggia, F M; Tangen, C M; Ardalan, B; Doroshow, J H; Meyers, F J; Holcombe, R F; Weiss, G R; Mangalik, A
1995 Jun;13(6):1303-1311, Journal of clinical oncology
— id: 161320, year: 1995, vol: 13, page: 1303, stat: Journal Article,

Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial
Leichman, L; Lenz, H J; Leichman, C G; Groshen, S; Danenberg, K; Baranda, J; Spears, C P; Boswell, W; Silberman, H; Ortega, A
1995 Jul-Aug;31A(7-8):1306-1310, European journal of cancer (1990)
— id: 164162, year: 1995, vol: 31A, page: 1306, stat: Journal Article,

A fixed-ratio combination of uracil and Ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer
Saltz, L B; Leichman, C G; Young, C W; Muggia, F M; Conti, J A; Spiess, T; Jeffers, S; Leichman, L P
1995 Feb;75(3):782-785, Cancer
— id: 161321, year: 1995, vol: 75, page: 782, stat: Journal Article,

Prolonged infusion of fluorinated pyrimidines in gastrointestinal malignancies: a review of recent clinical trials
Leichman, C G
1994 ;12(2):166-175, Cancer investigation
— id: 164161, year: 1994, vol: 12, page: 166, stat: Journal Article,

Intraperitoneal 5-fluoro-2'-deoxyuridine with escalating doses of leucovorin: pharmacology and clinical tolerance
Muggia, F M; Tulpule, A; Retzios, A; Chen, F; Jeffers, S; Leichman, C G; Leichman, L; Spears, C P; Chan, K K
1994 ;12(3):197-206, Investigational new drugs
— id: 161331, year: 1994, vol: 12, page: 197, stat: Journal Article,

Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a phase II study in patients with disseminated colorectal cancer
Leichman, C G; Leichman, L; Spears, C P; Rosen, P J; Jeffers, S; Groshen, S
1993 Jan;85(1):41-44, Journal of the National Cancer Institute
— id: 164166, year: 1993, vol: 85, page: 41, stat: Journal Article,

Phase II trial of amonafide in advanced pancreas cancer. A Southwest Oncology Group study
Leichman, C G; Tangen, C; Macdonald, J S; Leimert, T; Fleming, T R
1993 May-Aug;11(2-3):219-221, Investigational new drugs
— id: 164165, year: 1993, vol: 11, page: 219, stat: Journal Article,

Phase I study of (6R)-5,10-dideazatetrahydrofolate: a folate antimetabolite inhibitory to de novo purine synthesis
Ray, M S; Muggia, F M; Leichman, C G; Grunberg, S M; Nelson, R L; Dyke, R W; Moran, R G
1993 Jul;85(14):1154-1159, Journal of the National Cancer Institute
— id: 161337, year: 1993, vol: 85, page: 1154, stat: Journal Article,

Preoperative systemic chemotherapy followed by adjuvant postoperative intraperitoneal therapy for gastric cancer: a University of Southern California pilot program
Leichman, L; Silberman, H; Leichman, C G; Spears, C P; Ray, M; Muggia, F M; Kiyabu, M; Radin, R; Laine, L; Stain, S
1992 Dec;10(12):1933-1942, Journal of clinical oncology
— id: 161340, year: 1992, vol: 10, page: 1933, stat: Journal Article,

Biological modification of protracted infusion of 5-fluorouracil with weekly leucovorin. A dose seeking clinical trial for patients with disseminated gastrointestinal cancers
Leichman, C G; Leichman, L; Spears, C P; Rosen, P J; Muggia, F; Jeffers, S; Waugh, W
1990 ;26(1):57-61, Cancer chemotherapy & pharmacology
— id: 161264, year: 1990, vol: 26, page: 57, stat: Journal Article,

Nonoperative therapy for squamous-cell cancer of the esophagus
Leichman, L; Herskovic, A; Leichman, C G; Lattin, P B; Steiger, Z; Tapazoglou, E; Rosenberg, J C; Arbulu, A; Asfaw, I; Kinzie, J
1987 Mar;5(3):365-370, Journal of clinical oncology
— id: 164144, year: 1987, vol: 5, page: 365, stat: Journal Article,

Phase I study of echinomycin
Pazdur, R; Haas, C D; Baker, L H; Leichman, C G; Decker, D
1987 Dec;71(12):1217-1219, Cancer treatment reports
— id: 164147, year: 1987, vol: 71, page: 1217, stat: Journal Article,

Phase II trial of tamoxifen in malignant melanoma
Leichman, C G; Samson, M K; Baker, L H
1982 Jun;66(6):1447-1447, Cancer treatment reports
— id: 164159, year: 1982, vol: 66, page: 1447, stat: Journal Article,