Ruth Lehmann

Biosketch / Results /

Ruth Lehmann

Laura and Isaac Perlmutter Professor of Cell Biology, Department of Cell Biology
Skirball Institute

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212/263-5360
Ruth.Lehmann@med.nyu.edu


Education

— University of Tubingen, PostDoctoral Training
— Dr. Lehmann received her Ph.D. from the University of Tubingen, Germany, Graduate Education

Research Summary

In most organisms, primordial germ cells (PGCs) are set-aside early during embryogenesis. Subsequently, PGCs migrate through the embryo, associate with somatic gonadal cells and form the gonad. While PGCs seem highly specialized, their products are the ultimate stem cells that generate a complete organism generation after generation. Our long-term goal is to functionally dissect the germ cell life cycle in Drosophila. Projects in the lab focus on three areas. 1) PGC specification. Early Drosophila germ cells form in a specialized germplasm and upon formation are transcriptionally silent. We are interested how RNAs localized to germ plasm are regulated and contribute to germ cell formation and fate, how gene expression is regulated during germ cell development and how the reproductive success of individual PGCs is determined. 2) PGC migration. Taking advantage of in vitro migration assays and live imaging, we study molecular and cellular aspects of germ cell migration to understand how the migratory program is established, how phospholipid signals contribute guidance cues to PGCs and how PGCs cease migration once they reach the somatic gonad. 3) Germ cell genome protection. Germ cells give rise to a new generation, thus integrity of the germ cell genome has to be protected while at the same time there has to be room for improvement via mutation and recombination. We study how host mechanisms evolved to protect the genome against transposable elements and how other intruders such as bacteria influence germ line function and reproductive success.

Research Interests

Germ cell development, Translational Regulation, RNA Localization and Transport, Germ Plasm Assembly, Cell Migration, Germ line stem cells, piRNAs, Transposable elements, Wolbachia

Structure and domain organization of Drosophila Tudor
Ren, Ren; Liu, Haiping; Wang, Wenjia; Wang, Mingzhu; Yang, Na; Dong, Yu-Hui; Gong, Weimin; Lehmann, Ruth; Xu, Rui-Ming
2014-05-10; 1001-0602,Cell research - id: 967592, year: 2014 JOURNAL ARTICLE

Translational control in germline stem cell development
Slaidina, Maija; Lehmann, Ruth
2014-10-19; 0021-9525,Journal of cell biology - id: 1310092, year: 2014 REVIEW

A spindle-independent cleavage pathway controls germ cell formation in Drosophila
Cinalli, Ryan M; Lehmann, Ruth
2013-07-08; 1465-7392,Nature cell biology - id: 415062, year: 2013 Journal Article

Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway
Hurd, Thomas Ryan; Leblanc, Michelle Gail; Jones, Leonard Nathaniel; Degennaro, Matthew; Lehmann, Ruth
2013-07-22; 0076-6879,Methods in enzymology - id: 438942, year: 2013 Journal Article

Modeling human disease
Gitler, Aaron D; Lehmann, Ruth
2012-08-20; 0036-8075,Science - id: 174443, year: 2012 Editorial; Research Support, Non-U.S. Gov't