Ruth Lehmann

Biosketch / Results /

Ruth Lehmann, Ph.D.

Laura and Isaac Perlmutter Professor of Cell Biology; Chair of the Department of Cell Biology
Departments of Skirball (Skirball), Cell Biology (Cell Biology) and Administration (Administration)

Contact Info

Address
540 First Avenue
Floor 4 Room Lab 10
Skirball Institute
New York, NY 10016

212-263-5360, 212-263-8071
212-263-7760
Ruth.Lehmann@med.nyu.edu


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Education

— University of Tubingen, PostDoctoral Training
— Dr. Lehmann received her Ph.D. from the University of Tubingen, Germany, Graduate Education

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Research Summary

In most organisms, primordial germ cells (PGCs) are set-aside early during embryogenesis. Subsequently, PGCs migrate through the embryo, associate with somatic gonadal cells and form the gonad. While PGCs seem highly specialized, their products are the ultimate stem cells that generate a complete organism generation after generation. Our long-term goal is to functionally dissect the germ cell life cycle in Drosophila. Projects in the lab focus on three areas. 1) PGC specification. Early Drosophila germ cells form in a specialized germplasm and upon formation are transcriptionally silent. We are interested how RNAs localized to germ plasm are regulated and contribute to germ cell formation and fate, how gene expression is regulated during germ cell development and how the reproductive success of individual PGCs is determined. 2) PGC migration. Taking advantage of in vitro migration assays and live imaging, we study molecular and cellular aspects of germ cell migration to understand how the migratory program is established, how phospholipid signals contribute guidance cues to PGCs and how PGCs cease migration once they reach the somatic gonad. 3) Germ cell genome protection. Germ cells give rise to a new generation, thus integrity of the germ cell genome has to be protected while at the same time there has to be room for improvement via mutation and recombination. We study how host mechanisms evolved to protect the genome against transposable elements and how other intruders such as bacteria influence germ line function and reproductive success.

Research Interests

Germ cell development, Translational Regulation, RNA Localization and Transport, Germ Plasm Assembly, Cell Migration, Germ line stem cells, piRNAs, Transposable elements, Wolbachia

Research Keywords

germ cell migration, germ plasm assembly, gonad formation, translational regulation, RNA localization, polarity, pattern formation

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Structure and domain organization of Drosophila Tudor
Ren, Ren; Liu, Haiping; Wang, Wenjia; Wang, Mingzhu; Yang, Na; Dong, Yu-Hui; Gong, Weimin; Lehmann, Ruth; Xu, Rui-Ming
2014 May;:1146-1149, Cell research
— id: 967592, year: 2014, vol: , page: 1146, stat: Journal Article,

Translational control in germline stem cell development
Slaidina, Maija; Lehmann, Ruth
2014 Oct;207(1):13-21, Journal of cell biology
— id: 1310092, year: 2014, vol: 207, page: 13, stat: Journal Article,

A spindle-independent cleavage pathway controls germ cell formation in Drosophila
Cinalli, Ryan M; Lehmann, Ruth
2013 Jul;15(7):839-845, Nature cell biology
— id: 415062, year: 2013, vol: 15, page: 839, stat: Journal Article,

Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway
Hurd, Thomas Ryan; Leblanc, Michelle Gail; Jones, Leonard Nathaniel; Degennaro, Matthew; Lehmann, Ruth
2013 ;528:197-215, Methods in enzymology
— id: 438942, year: 2013, vol: 528, page: 197, stat: Journal Article,

Modeling human disease
Gitler, Aaron D; Lehmann, Ruth
2012 Jul;337(6092):269-269, Science
— id: 174443, year: 2012, vol: 337, page: 269, stat: Journal Article,

Redox regulation of cell migration and adhesion
Hurd, Thomas Ryan; DeGennaro, Matthew; Lehmann, Ruth
2012 Feb;22(2):107-115, Trends in cell biology
— id: 159830, year: 2012, vol: 22, page: 107, stat: Journal Article,

Germline stem cells: origin and destiny
Lehmann, Ruth
2012 Jun;10(6):729-739, Cell stem cell
— id: 169491, year: 2012, vol: 10, page: 729, stat: Journal Article,

The Drosophila Actin Regulator ENABLED Regulates Cell Shape and Orientation during Gonad Morphogenesis
Sano, Hiroko; Kunwar, Prabhat S; Renault, Andrew D; Barbosa, Vitor; Clark, Ivan B N; Ishihara, Shuji; Sugimura, Kaoru; Lehmann, Ruth
2012 ;7(12):e52649-e52649 e52649, PLoS one
— id: 211522, year: 2012, vol: 7, page: e52649, stat: Journal Article,

Drosophila primordial germ cell migration requires epithelial remodeling of the endoderm
Seifert, Jessica R K; Lehmann, Ruth
2012 Jun;139(12):2101-2106, Development
— id: 167511, year: 2012, vol: 139, page: 2101, stat: Journal Article,

Rap1 localization is dynamically controlled during immune cell transmigration in Drosophila
Siekhaus, D; Moffitt, O; Haesemeyer, M; Lehmann, R
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884452, year: 2012, vol: 23, page: , stat: Journal Article,

Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion
Degennaro, Matthew; Hurd, Thomas Ryan; Siekhaus, Daria Elisabeth; Biteau, Benoit; Jasper, Heinrich; Lehmann, Ruth
2011 Feb 15;20(2):233-243, Developmental cell
— id: 123213, year: 2011, vol: 20, page: 233, stat: Journal Article,

Derivation of novel genetically diverse human embryonic stem cell lines
Hansis C.; Lehmann R.
2011 ;96(3 SUPPL 1):S87-S87, Fertility & sterility
— id: 150887, year: 2011, vol: 96, page: S87, stat: Journal Article,

Ruth Lehmann: germ cells do things differently. Interview by Caitlin Sedwick
Lehmann, Ruth
2011 Sep;194(5):660-661, Journal of cell biology
— id: 914642, year: 2011, vol: 194, page: 660, stat: Journal Article,

piRNA Production Requires Heterochromatin Formation in Drosophila
Rangan, Prashanth; Malone, Colin D; Navarro, Caryn; Newbold, Sam P; Hayes, Patrick S; Sachidanandam, Ravi; Hannon, Gregory J; Lehmann, Ruth
2011 Aug 23;21(16):1373-1379, Current biology. CB
— id: 136942, year: 2011, vol: 21, page: 1373, stat: Journal Article,

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
Zamparini, Andrea L; Davis, Marie Y; Malone, Colin D; Vieira, Eric; Zavadil, Jiri; Sachidanandam, Ravi; Hannon, Gregory J; Lehmann, Ruth
2011 Sep;138(18):4039-4050, Development
— id: 136943, year: 2011, vol: 138, page: 4039, stat: Journal Article,

Lifespan extension by preserving proliferative homeostasis in Drosophila
Biteau, Benoit; Karpac, Jason; Supoyo, Stephen; Degennaro, Matthew; Lehmann, Ruth; Jasper, Heinrich
2010 Oct;6(10):e1001159-e1001159, PLoS genetics
— id: 139620, year: 2010, vol: 6, page: e1001159, stat: Journal Article,

Structural basis for methylarginine-dependent recognition of Aubergine by Tudor
Liu, Haiping; Wang, Ju-Yu S; Huang, Ying; Li, Zhizhong; Gong, Weimin; Lehmann, Ruth; Xu, Rui-Ming
2010 Sep 1;24(17):1876-1881, Genes & development
— id: 113782, year: 2010, vol: 24, page: 1876, stat: Journal Article,

Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila
Renault, Andrew D; Kunwar, Prabhat S; Lehmann, Ruth
2010 Jun;137(11):1815-1823, Development
— id: 109675, year: 2010, vol: 137, page: 1815, stat: Journal Article,

Mechanisms guiding primordial germ cell migration: strategies from different organisms
Richardson, Brian E; Lehmann, Ruth
2010 Jan;11(1):37-49, Nature reviews. Molecular cell biology
— id: 105988, year: 2010, vol: 11, page: 37, stat: Journal Article,

Rhol controls invasion and the localization of the integrin activator, Rap1, during immune cell transmigration in drosophila
Siekhaus, D; Haesemeyer, M; Moffitt, O; Lehmann, R
2010 15 Dec 2010;21(24):-, Molecular biology of the cell
— id: 157720, year: 2010, vol: 21, page: , stat: Journal Article,

RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila
Siekhaus, Daria; Haesemeyer, Martin; Moffitt, Olivia; Lehmann, Ruth
2010 Jun;12(6):605-610, Nature cell biology
— id: 109852, year: 2010, vol: 12, page: 605, stat: Journal Article,

A functional antagonism between the pgc germline repressor and torso in the development of somatic cells
de Las Heras, Jose Manuel; Martinho, Rui Goncalo; Lehmann, Ruth; Casanova, Jordi
2009 Sep;10(9):1059-1065, EMBO reports
— id: 113783, year: 2009, vol: 10, page: 1059, stat: Journal Article,

Novel highly efficient generation of disease-specific human embryonic stem cells from genetically abnormal embryos
Hansis C.; Rice C.E.; Grifo J.A.; Lehmann R.
2009 ;92(3 SUPPL 1):S86-S86, Fertility & sterility
— id: 127243, year: 2009, vol: 92, page: S86, stat: Journal Article,

Altered dynein-dependent transport in piRNA pathway mutants
Navarro, Caryn; Bullock, Simon; Lehmann, Ruth
2009 Jun 16;106(24):9691-9696, Proceedings of the National Academy of Sciences of the United States of America
— id: 100481, year: 2009, vol: 106, page: 9691, stat: Journal Article,

Temporal and spatial control of germ-plasm RNAs
Rangan, Prashanth; DeGennaro, Matthew; Jaime-Bustamante, Kean; Coux, Remi-Xavier; Martinho, Rui G; Lehmann, Ruth
2009 Jan 13;19(1):72-77, Current biology. CB
— id: 95817, year: 2009, vol: 19, page: 72, stat: Journal Article,

Hedgehog does not guide migrating Drosophila germ cells
Renault, Andrew D; Ricardo, Sara; Kunwar, Prabhat S; Santos, Ana; Starz-Gaiano, Michelle; Stein, Jennifer A; Lehmann, Ruth
2009 Apr 15;328(2):355-362, Developmental biology (Orlando)
— id: 99590, year: 2009, vol: 328, page: 355, stat: Journal Article,

An ABC transporter controls export of a Drosophila germ cell attractant
Ricardo, Sara; Lehmann, Ruth
2009 Feb 13;323(5916):943-946, Science
— id: 93230, year: 2009, vol: 323, page: 943, stat: Journal Article,

Germ cells are forever
Cinalli, Ryan M; Rangan, Prashanth; Lehmann, Ruth
2008 Feb 22;132(4):559-562, Cell
— id: 76157, year: 2008, vol: 132, page: 559, stat: Journal Article,

Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin
Kunwar, Prabhat S; Sano, Hiroko; Renault, Andrew D; Barbosa, Vitor; Fuse, Naoyuki; Lehmann, Ruth
2008 Oct 6;183(1):157-168, Journal of cell biology
— id: 93374, year: 2008, vol: 183, page: 157, stat: Journal Article,

Regulating gene expression in the Drosophila germ line
Rangan, P; DeGennaro, M; Lehmann, R
2008 ;73:1-8, Cold Spring Harbor symposia on quantitative biology
— id: 99230, year: 2008, vol: 73, page: 1, stat: Journal Article,

Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins
Thomson, Travis; Liu, Niankun; Arkov, Alexey; Lehmann, Ruth; Lasko, Paul
2008 Sep-Oct;125(9-10):865-873, Mechanisms of development
— id: 95819, year: 2008, vol: 125, page: 865, stat: Journal Article,

A maternal screen for genes required for Drosophila oocyte polarity uncovers new steps of meiotic progression
Barbosa, Vitor; Kimm, Naomi; Lehmann, Ruth
2007 Aug;176(4):1967-1977, Genetics
— id: 72703, year: 2007, vol: 176, page: 1967, stat: Journal Article,

Germ versus soma decisions: lessons from flies and worms
Strome, Susan; Lehmann, Ruth
2007 Apr 20;316(5823):392-393, Science
— id: 71607, year: 2007, vol: 316, page: 392, stat: Journal Article,

The role of Tudor domains in germline development and polar granule architecture
Arkov, Alexey L; Wang, Ju-Yu S; Ramos, Andres; Lehmann, Ruth
2006 Oct;133(20):4053-4062, Development
— id: 69223, year: 2006, vol: 133, page: 4053, stat: Journal Article,

Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad
Gilboa, Lilach; Lehmann, Ruth
2006 Sep 7;443(7107):97-100, Nature
— id: 68783, year: 2006, vol: 443, page: 97, stat: Journal Article,

In Vivo Migration: A Germ Cell Perspective
Kunwar, Prabhat S; Siekhaus, Daria E; Lehmann, Ruth
2006 Nov 10;22:237-265, Annual review of cell & developmental biology
— id: 69224, year: 2006, vol: 22, page: 237, stat: Journal Article,

Can quality of movement be measured? Rasch analysis and inter-rater reliability of the Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES)
Van de Winckel, Ann; Feys, Hilde; van der Knaap, Suzan; Messerli, Ruth; Baronti, Fabio; Lehmann, Ruth; Van Hemelrijk, Bart; Pante, Franca; Perfetti, Carlo; De Weerdt, Willy
2006 Oct;20(10):871-884, Clinical rehabilitation
— id: 72704, year: 2006, vol: 20, page: 871, stat: Journal Article,

twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis
Morris, Jason Z; Hong, Amy; Lilly, Mary A; Lehmann, Ruth
2005 Mar;132(6):1165-1174, Development
— id: 52627, year: 2005, vol: 132, page: 1165, stat: Journal Article,

Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2
Sano, Hiroko; Renault, Andrew D; Lehmann, Ruth
2005 Nov 21;171(4):675-683, Journal of cell biology
— id: 59239, year: 2005, vol: 171, page: 675, stat: Journal Article,

Repression of primordial germ cell differentiation parallels germ line stem cell maintenance
Gilboa, Lilach; Lehmann, Ruth
2004 Jun 8;14(11):981-986, Current biology. CB
— id: 44965, year: 2004, vol: 14, page: 981, stat: Journal Article,

A noncoding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells
Martinho, Rui Goncalo; Kunwar, Prabhat S; Casanova, Jordi; Lehmann, Ruth
2004 Jan 20;14(2):159-165, Current biology. CB
— id: 42611, year: 2004, vol: 14, page: 159, stat: Journal Article,

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
Navarro, Caryn; Puthalakath, Hamsa; Adams, Jerry M; Strasser, Andreas; Lehmann, Ruth
2004 Jun;6(5):427-435, Nature cell biology
— id: 46181, year: 2004, vol: 6, page: 427, stat: Journal Article,

Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival
Renault, A D; Sigal, Y J; Morris, A J; Lehmann, R
2004 Sep 24;305(5692):1963-1966, Science
— id: 48212, year: 2004, vol: 305, page: 1963, stat: Journal Article,

Germ cell specification and migration in Drosophila and beyond
Santos, Ana C; Lehmann, Ruth
2004 Aug 27;14(14):R578-R589, Current biology. CB
— id: 46096, year: 2004, vol: 14, page: R578, stat: Journal Article,

Isoprenoids control germ cell migration downstream of HMGCoA reductase
Santos, Ana C; Lehmann, Ruth
2004 Feb;6(2):283-293, Developmental cell
— id: 42591, year: 2004, vol: 6, page: 283, stat: Journal Article,

Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state
Gilboa, Lilach; Forbes, Alexandria; Tazuke, Salli I; Fuller, Margaret T; Lehmann, Ruth
2003 Apr;130(26):6625-6634, Development
— id: 46248, year: 2003, vol: 130, page: 6625, stat: Journal Article,

Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells
Kunwar, Prabhat S; Starz-Gaiano, Michelle; Bainton, Roland J; Heberlein, Ulrike; Lehmann, Ruth
2003 Dec;1(3):E80-E80, PLoS biology
— id: 52647, year: 2003, vol: 1, page: E80, stat: Journal Article,

The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival
Molyneaux, Kathleen A; Zinszner, Helene; Kunwar, Prabhat S; Schaible, Kyle; Stebler, Jurg; Sunshine, Mary Jean; O'Brien, William; Raz, Erez; Littman, Dan; Wylie, Chris; Lehmann, Ruth
2003 Sep;130(18):4279-4286, Development
— id: 52649, year: 2003, vol: 130, page: 4279, stat: Journal Article,

An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control
Staeva-Vieira, Eric; Yoo, Siuk; Lehmann, Ruth
2003 Nov 3;22(21):5863-5874, EMBO journal
— id: 39008, year: 2003, vol: 22, page: 5863, stat: Journal Article,

l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation
Yohn, Christopher B; Pusateri, Leslie; Barbosa, Vitor; Lehmann, Ruth
2003 Mar 15;165(4):1889-1900, Genetics
— id: 46006, year: 2003, vol: 165, page: 1889, stat: Journal Article,

Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo
Chagnovich D; Lehmann R
2001 Sep 25;98(20):11359-11364, Proceedings of the National Academy of Sciences of the United States of America
— id: 26613, year: 2001, vol: 98, page: 11359, stat: Journal Article,

Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells
Starz-Gaiano M; Cho NK; Forbes A; Lehmann R
2001 Mar;128(6):983-991, Development
— id: 20566, year: 2001, vol: 128, page: 983, stat: Journal Article,

HMG-CoA reductase guides migrating primordial germ cells
Van Doren M; Broihier HT; Moore LA; Lehmann R
1998 Dec 3;396(6710):466-469, Nature
— id: 57275, year: 1998, vol: 396, page: 466, stat: Journal Article,

Regulation of zygotic gene expression in Drosophila primordial germ cells
Van Doren M; Williamson AL; Lehmann R
1998 Feb 12;8(4):243-246, Current biology. CB
— id: 57276, year: 1998, vol: 8, page: 243, stat: Journal Article,

Translational regulation of nanos by RNA localization
Gavis ER; Lehmann R
1994 May 26;369(6478):315-318, Nature
— id: 20576, year: 1994, vol: 369, page: 315, stat: Journal Article,

Induction of germ cell formation by oskar
Ephrussi A; Lehmann R
1992 Jul 30;358(6385):387-392, Nature
— id: 20585, year: 1992, vol: 358, page: 387, stat: Journal Article,

PHENOTYPIC COMPARISON BETWEEN MATERNAL AND ZYGOTIC GENES-CONTROLLING THE SEGMENTAL PATTERN OF THE DROSOPHILA EMBRYO
LEHMANN, R
1988 ;104:17-27, Development
— id: 113790, year: 1988, vol: 104, page: 17, stat: Journal Article,

Involvement of the pumilio gene in the transport of an abdominal signal in the Drosophila embryo
Lehmann R.; Nusslein-Volhard C.
1987 ;329(6135):167-170, Nature
— id: 113786, year: 1987, vol: 329, page: 167, stat: Journal Article,

FINGER PROTEIN OF NOVEL STRUCTURE ENCODED BY HUNCHBACK, A 2ND MEMBER OF THE GAP CLASS OF DROSOPHILA SEGMENTATION GENES
TAUTZ, D; LEHMANN, R; SCHNURCH, H; SCHUH, R; SEIFERT, E; KIENLIN, A; JONES, K; JACKLE, H
1987 ;327(6121):383-389, Nature
— id: 113788, year: 1987, vol: 327, page: 383, stat: Journal Article,

CROSS-REGULATORY INTERACTIONS AMONG THE GAP GENES OF DROSOPHILA
JACKLE, H; TAUTZ, D; SCHUH, R; SEIFERT, E; LEHMANN, R
1986 ;324(6098):668-670, Nature
— id: 113789, year: 1986, vol: 324, page: 668, stat: Journal Article,

SEGMENTAL ORGANIZATION OF THE HEAD IN THE EMBRYO OF DROSOPHILA-MELANOGASTER A BLASTODERM FATE MAP OF THE CUTICLE STRUCTURES OF THE LARVAL HEAD
JUERGENS G; LEHMANN R; SCHARDIN M; NUESSLEIN-VOLHARD C
1986 ;195(6):359-377, Wilhelm Roux's archives of developmental biology
— id: 113787, year: 1986, vol: 195, page: 359, stat: Journal Article,

Regionsspezifische Segmentierungsmutanten bei Drosophila melanogaster Meigen
Lehmann, Ruth
[S.l. : s.n.], 1985,
— id: 2192, year: 1985, vol: , page: , stat: ,

On the phenotype and development of mutants of early neurogensis in Drosophila melanogaster
Lehmann R.; Jimenez F.; Dietrich U.; Campos Ortega J.A.
1983 ;192(2):62-74, Wilhelm Roux's archives of developmental biology
— id: 113784, year: 1983, vol: 192, page: 62, stat: Journal Article,

Mutations of early neurogenesis in Drosophila
Lehmann R.; Dietrich U.; Jimenez F.; Campos-Ortega J.A.
1981 ;190(4):226-229, Wilhelm Roux's archives of developmental biology
— id: 113785, year: 1981, vol: 190, page: 226, stat: Journal Article,